Lewis Kay, a senior scientist at the Hospital for Sick Children (SickKids) and University Professor in the University of Toronto's Temerty Faculty of Medicine, has been honoured with a Royal Medal by ...

Personal thoughts on the passing of Peer Bork

Replication-dependent histone mRNA decay involves the RNA helicase UPF1, the histone stem-loop binding protein SLBP and the exoribonuclease 3’hExo. Here, the authors present evidence for assembly of a...

TRIM2 is a mammalian E3 ligase with particularly high expression in Purkinje neurons, where it contributes to neuronal development and homeostasis. The understanding of ubiquitin E3 ligase function hi...

Gaber et al. identify a direct protein-protein interaction between the oskar mRNA transport particle components Staufen and Tropomyosin1-I/C. They map the interaction surface at amino acid resolution ...

imageimageAlphaDesign combines hallucination and sequence generation to design various classes of proteins, from monomers to oligomers and site-specific binders. AlphaDesign was applied to design in v...

Billionaires and corporations are tightening their grip on our democracies — and silencing dissent. They weaken protections for people and the planet, bankroll politicians who serve their interests, c...

The goal is to finish one of the biggest bike events of the world in under 9:00 h (315 km, average riding speed 37 km/h, on the 14th of June 2025), while supporting cancer research (specifically breas...

mRNA synthesis requires extensive pre-mRNA maturation, the organisation of which remains unclear. Here, we directly sequence pre-mRNA without metabolic labelling or amplification to resolve transcript...

Subcellular RNA organization can affect critical cellular functions. However, our understanding of RNA microenvironments, particularly biomolecular condensates, remains limited, largely due to a lack ...

Further studies are needed to determine whether K2-18b, which orbits a star 120 light-years away, is inhabited, or even habitable.

Further studies are needed to determine whether K2-18b, which orbits a star 120 light-years away, is inhabited, or even habitable.

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