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Samrat Mukhopadhyay @samratmukhopadhyay.bsky.social · 13/08/2026

My lab's 16th PhD thesis was submitted today by peerless Anuja Walimbe @anujawalimbe.bsky.social. Anuja utilized an array of molecular, cellular, and single-molecule biophysical approaches and delved deeper into the intriguing phase behavior of TDP-43 associated with ALS and frontotemporal dementia.

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Samrat Mukhopadhyay @samratmukhopadhyay.bsky.social · 09/08/2026

20 years ago (August 2006): During my postdoc @scripps.edu, I presented a poster on my ongoing/unpublished work at the @proteinsociety.bsky.social meeting in San Diego. The paper was published in @pnas.org in February 2007 (cited ~ 370). This was the first single-molecule FRET study of an IDP/prion.

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Samrat Mukhopadhyay @samratmukhopadhyay.bsky.social · 08/08/2026

Happy to share that the postdoctoral work of my former PhD student, Priyanka Dogra, has made it to the cover page of the latest issue of Molecular Cell. Congratulations, Priyanka, on your truly amazing work. www.cell.com/molecular-ce...

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Samrat Mukhopadhyay @samratmukhopadhyay.bsky.social · 02/08/2026

My seven-year term on the Editorial Advisory Panel of Essays in Biochemistry, a review journal of the Biochemical Society, London, UK @biochemsoc.bsky.social, is coming to a close. I'm also sharing a 2022 issue of Essays I edited. Thank you all at Essays! portlandpress.com/essaysbioche...

Samrat Mukhopadhyay @samratmukhopadhyay.bsky.social · 31/07/2026

Fluorescence Friday sneak peek: A picosecond time-resolved confocal fluorescence image & decay profiles of nucleoli (granular component) in a live mammalian cell recorded on a time-resolved single-molecule confocal fluorescence microscope in our lab by @arpitasingh.bsky.social @roopsiek.bsky.social.

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Samrat Mukhopadhyay @samratmukhopadhyay.bsky.social · 15/07/2026

Many congratulations to my former PhD student, Priyanka Dogra on her brilliant, tour de force, postdoctoral work from St. Jude on ribosome biogenesis in nucleolar granular component sub-phases, just out in Molecular Cell. www.cell.com/molecular-ce...

cell.com

Granular component sub-phases direct ribosome biogenesis in the nucleolus

Dogra et al. use super-resolution microscopy to uncover the molecular origins of spatial heterogeneity in the nucleolar granular component (GC). They show that differential interactions of nucleolar p...

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Samrat Mukhopadhyay @samratmukhopadhyay.bsky.social · 30/06/2026

About two weeks ago, my mother, Namita Mukhopadhyay, passed away. As a family, we are still coming to terms with this profound loss. This tribute is a humble attempt to remember her remarkable life, her achievements, and the enduring values she left behind. www.linkedin.com/pulse/tribut...

linkedin.com

A Tribute to My Mother: Namita Mukhopadhyay (1945–2026)

About two weeks ago, on June 18, my mother, Namita Mukhopadhyay, passed away at the age of 80. She is survived by her husband, Ashok Kumar Mukhopadhyay (my father), her daughter, Shatarupa Mukhopadhya...

Samrat Mukhopadhyay @samratmukhopadhyay.bsky.social · 06/06/2026

This is my second lecture on the basics of fluorescence, which explains the processes of excitation and emission, vibrational & solvent relaxation, Stokes shift, quantum yield, fluorescence lifetime, etc., using the Jablonski diagram. Hope this lecture is useful. www.youtube.com/watch?v=S_lB...

youtube.com

Lecture 2: Fluorescence in Biology Lectures by Samrat Mukhopadhyay

YouTube video by Samrat Mukhopadhyay

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Samrat Mukhopadhyay @samratmukhopadhyay.bsky.social · 06/06/2026

After many requests, I've now decided to share a few lectures from my Fluorescence in Biology course, which I've been teaching at IISER Mohali. This is the first lecture (recorded in Jan 2022) on the basics of fluorescence. I hope this will be useful to the students. www.youtube.com/watch?v=716z...

youtube.com

Lecture 1: Fluorescence in Biology Lectures by Samrat Mukhopadhyay

YouTube video by Samrat Mukhopadhyay

Samrat Mukhopadhyay @samratmukhopadhyay.bsky.social · 04/06/2026

The month of June always reminds me of the (cliff-hanging) life-changing journey I undertook in June 1997. I narrated this story on Twitter in June 2022 on the occasion of 25 years of my expedition (now 29 years). Now sharing my story in a short LinkedIn article. www.linkedin.com/pulse/my-fai...

linkedin.com

My fairy-tale journey to IISc Bangalore that changed my life forever

My cliff-hanging journey to the Indian Institute of Science (IISc) Bangalore in June 1997. I hope that some youngsters will draw inspiration from my story.

Samrat Mukhopadhyay @samratmukhopadhyay.bsky.social · 28/05/2026

Happy to share our latest preprint. www.biorxiv.org/content/10.6...

biorxiv.org

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Samrat Mukhopadhyay @samratmukhopadhyay.bsky.social · 19/05/2026

Dr. Arpita Singh @arpitasingh.bsky.social, a National Postdoctoral Fellow in our lab, is attending an EMBO Symposium on "Cellular Mechanisms Driven by Phase Separation" starting today at EMBL Heidelberg, Germany. She will present her new results on nucleolar condensates. www.embl.org/about/info/c...

embl.org

Cellular mechanisms driven by phase separation

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Samrat Mukhopadhyay @samratmukhopadhyay.bsky.social · 23/04/2026

We welcome Apurva Mishra, who joined our lab as a postdoctoral fellow after completing her PhD with Prof. Pramit K. Chowdhury at the Indian Institute of Technology (IIT) Delhi. Apurva will delve deeper into biomolecular condensates using single-molecule FRET/FCS and other emerging tools.

Samrat Mukhopadhyay @samratmukhopadhyay.bsky.social · 23/03/2026

In a collaborative study led by Krishanpal Karmodiya, published in Cell Reports, we show that phase separation of Plasmodium falciparum Heterochromatin Protein 1 is essential for heterochromatin formation and key to malaria virulence gene control. Congrats to the team!! www.cell.com/cell-reports...

cell.com

Phase separation of heterochromatin protein 1 regulates virulence gene expression in Plasmodium falciparum

Mamatharani et al. show that Plasmodium falciparum HP1 undergoes phase separation in a highly tunable manner. The phase-separated condensates organize heterochromatin and silence virulence (var) genes...

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Samrat Mukhopadhyay @samratmukhopadhyay.bsky.social · 08/03/2026

This afternoon, I arrived in Imphal to speak at a conference at Manipur University. Breathtaking view of the snow-capped Himalayas from the aircraft while flying from Chandigarh —》Delhi —》Imphal (7-10x zoom).

Samrat Mukhopadhyay @samratmukhopadhyay.bsky.social · 22/02/2026

Three of my students (two former PhD students, Shruti Arya and Ashish Joshi @ashishjoshi.bsky.social, and a current PhD student, Anuja Walimbe @anujawalimbe.bsky.social are currently attending the Biophysical Society meeting in San Francisco @biophysicalsoc.bsky.social.

Samrat Mukhopadhyay @samratmukhopadhyay.bsky.social · 19/02/2026

What an incredible day for my lab! The latest work from the lab of my first PhD student, Neha Jain, now an Associate Professor at the Indian Institute of Technology (IIT), Jodhpur, has just been published in PNAS @pnas.org. Congratulations to Neha and your amazing team! www.pnas.org/doi/10.1073/...

Samrat Mukhopadhyay @samratmukhopadhyay.bsky.social · 13/02/2026

Happy #FluorescenceFriday. My lab is presenting a sneak peek of cancer-related transcription condensates in the nucleus of two human cell lines expressing a transcription factor fused with enhanced Green Fluorescent Protein. Prepared & imaged by my postdoc, Dr. Arpita Singh @arpitasingh.bsky.social.

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Samrat Mukhopadhyay @samratmukhopadhyay.bsky.social · 08/02/2026

It was wonderful to visit the Birla Institute of Technology and Science (BITS), Pilani, Rajasthan, to deliver a biology colloquium. I had a great interaction with the students & faculty members and learned about the amazing science being done at BITS Pilani. Thank you, Biological Sciences at BITS.

Samrat Mukhopadhyay @samratmukhopadhyay.bsky.social · 31/01/2026

As part of our biophysics lab class, yesterday before experiments, I taught FRET (Förster resonance energy transfer). Shown here are two seminal papers: Theodor Förster (1946) & Stryer & Haugland (1967). My colleague, Amar Deep, took photos of me describing the 'kappa square' problem in FRET.

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Samrat Mukhopadhyay @samratmukhopadhyay.bsky.social · 30/01/2026

Happy #FluorescenceFriday. My lab is featuring fluorescence microscopy images of C. elegans worms expressing a stress granule-forming protein fused to RFP (Red Fluorescent Protein).🪱🔬 Left: A single worm. Right: An egg containing oxidative stress-induced granules in the embryo.

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Samrat Mukhopadhyay @samratmukhopadhyay.bsky.social · 31/12/2025

To all our dear friends, colleagues, students, staff, collaborators, supporters, well-wishers, and academic associates: Wish you and your family a very happy, prosperous, productive, peaceful, joyous, and healthy New Year 2026. - The Mukhopadhyay Lab

Samrat Mukhopadhyay @samratmukhopadhyay.bsky.social · 29/12/2025

On this day, 17 years ago, December 29, 2008, I joined the IISER Mohali faculty. It's been an exciting journey. I learned a lot from many whom I interacted with. My students have made my scientific expedition very enjoyable. My experience has surpassed my expectations. Thank you all🙏

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Samrat Mukhopadhyay @samratmukhopadhyay.bsky.social · 25/12/2025

My 6-year term (two 3-year terms) on the editorial board of the Biophysical Journal @biophysj.bsky.social @biophysicalsoc.bsky.social will end on December 31. I truly enjoyed my role, which has immensely broadened my horizon. I thank all the reviewers and my amazing BJ colleagues. Thank you all!

Samrat Mukhopadhyay @samratmukhopadhyay.bsky.social · 20/12/2025

It was wonderful to speak at the polypeptide folding & assembly symposium at the Pacifichem 2025 conference in Honolulu, Hawaii. Thanks to all the attendees for your kind words & for asking brilliant questions. It was nice to get an invitation to visit Seoul, South Korea, next year. Mahalo, Hawaii!

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Reposted by Samrat Mukhopadhyay

Samrat Mukhopadhyay @samratmukhopadhyay.bsky.social · 17/12/2025

Arrived in Honolulu, Hawaii two days ago and greatly enjoying the Pacifichem 2025 conference at this stunning location. If you're attending Pacifichem, you're welcome to attend my talk tomorrow, Dec 17 (Wed) at 1:40 PM in Ilima Room at Sheraton Princess Kaiulani Waikiki Beach, Honolulu. See you!

Samrat Mukhopadhyay @samratmukhopadhyay.bsky.social · 17/12/2025

Samrat Mukhopadhyay @samratmukhopadhyay.bsky.social · 13/12/2025

Looking forward to attending and speaking at Pacifichem 2025 @pacifichem.bsky.social, the International Chemical Congress of Pacific Basin Societies, next week in Honolulu, Hawaii. Thanks, Masaki Okumura (Tohoku Univ) and Takahiro Muraoka (Tokyo Univ), for the invitation. pacifichem.org

pacifichem.org

Pacifichem 2025

The 2025 International Chemical Congress of Pacific Basin Societies will be held December 15-20, 2025. Pacifichem 2025 will be the ninth in the series of successful cosponsored scientific conferences ...

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Samrat Mukhopadhyay @samratmukhopadhyay.bsky.social · 13/12/2025

Congratulations to my PhD student, Anuja Walimbe @anujawalimbe.bsky.social, on receiving the Biophysical Society Travel Award to attend @biophysicalsoc.bsky.social meeting in San Francisco, California, in February 2026. She will present her exciting research on TDP-43, which is associated with ALS.

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Samrat Mukhopadhyay @samratmukhopadhyay.bsky.social · 13/12/2025

It was wonderful to host Shiv Grewal @grewalsh.bsky.social from NIH earlier this week. Shiv gave a beautiful talk on heterochromatin propagation and the epigenetic landscape. We had a stimulating discussion after his lecture. It was also great to have him visit my single-molecule biophysics lab.

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Samrat Mukhopadhyay @samratmukhopadhyay.bsky.social · 13/12/2025

Sonia Longhi @sonia-longhi.bsky.social from @cnrs.fr Marseille visited my lab at IISER Mohali as part of our Indo-French Centre for the Promotion of Advanced Research (IFCPAR/CEFIPRA) project. We had great scientific discussions and interactions with my students and colleagues.

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Samrat Mukhopadhyay @samratmukhopadhyay.bsky.social · 08/11/2025

It was a great honor to speak and chair a session in Prion 2025 held in Buzios, Rio de Janeiro, Brazil. I got great feedback on our prion phase separation work and learned a lot about biology, etiology, early diagnosis, and therapeutic strategies for fatal prion diseases (CJD/GSS/FFI). Goodbye, Rio!

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Samrat Mukhopadhyay @samratmukhopadhyay.bsky.social · 12/09/2025

What a terrific recognition of our research field! Dirk Görlich (Max Planck Institute Göttingen) and Steven McKnight (UT Southwestern) received the Lasker Award for their work on low-complexity domains and their phase separation. Read the perspective in PNAS: www.pnas.org/doi/epdf/10....

Samrat Mukhopadhyay @samratmukhopadhyay.bsky.social · 31/08/2025

Last week, I started teaching the freshman biology class (BIO 101), which I'm very excited about. I'm sharing one of my introductory slides on the three pillars of modern biology - evolution, genetics and molecular nature of genetic material. Looking forward to teaching the first-year biology class!

Samrat Mukhopadhyay @samratmukhopadhyay.bsky.social · 20/08/2025

Happy to share our community note published in Nature Communications @natcomms.nature.com. In this 14-page article (34 authors from 9 countries), we discuss current practices in phase separation. We hope it will be useful to the biomolecular condensate community. www.nature.com/articles/s41...

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Samrat Mukhopadhyay @samratmukhopadhyay.bsky.social · 17/08/2025

Breathtaking view of the Shivalik range of the Himalayas from the balcony of our apartment on the 7th floor at IISER Mohali: at 5:30 pm and 7 pm.

Samrat Mukhopadhyay @samratmukhopadhyay.bsky.social · 01/08/2025

Happy to share a sneak peek of our foray into plant proteins: A fluorescence image of phase-separated condensates of an intrinsically disordered protein from Arabidopsis (prepared & imaged by my PhD students Snehasis Sarkar & Muskan Koundal). I'll share more details later. Happy Fluorescence Friday!

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Samrat Mukhopadhyay @samratmukhopadhyay.bsky.social · 04/07/2025

Yesterday, I had a great visit/seminar/discussion at the University of Lorraine, Metz, then arrived in Paris in the evening & had a breathtaking view of Paris from Eiffel Tower. Now at Paris CDG airport & will fly to Delhi. Had a wonderful time in France. Au revoir Paris/France/my friends in France!

Samrat Mukhopadhyay @samratmukhopadhyay.bsky.social · 02/07/2025

Had an amazing 2-day stay in Montpellier & gave 2 seminars at IBMM, Université de Montpellier & CBS (Centre de Biologie Structurale), CNRS. Thanks to my amazing hosts, Joseph Chamieh (IBMM) & Emmanuel Margeat (CBS). I just arrived in Paris and on my way to Metz to visit the Université de Lorraine.

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Samrat Mukhopadhyay @samratmukhopadhyay.bsky.social · 30/06/2025

Goodbye, Marseille! Had an exciting scientific visit & enjoyed breathtaking views of the Mediterranean Sea! Now on the train to Montpellier to visit/speak at the Institut des Biomolécules Max Mousseron (IBMM) CNRS, Université de Montpellier in the next 4 hours. See you all at IBMM, CNRS Montpellier!

Samrat Mukhopadhyay @samratmukhopadhyay.bsky.social · 28/06/2025

Yesterday, I taught biological phase separation at CNRS Marseille (photo credit: my former student, Harshita). Had an amazing lunch with students/postdocs of my host, Sonia Longhi. Had a wonderful dinner with Harshita near Marseille Port. Looking forward to visiting Nice & Cannes during the weekend.

Samrat Mukhopadhyay @samratmukhopadhyay.bsky.social · 27/06/2025

Had busy last two days - gave a seminar at CNRS Marseille (photo credit: Harshita) & had discussions with scientists. Had a quick visit to Prado Beach & an amazing dinner at my host's (Sonia Longhi) beautiful house near Cassis (overlooking the Mediterranean Sea). Today, I'll teach phase separation.

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Samrat Mukhopadhyay @samratmukhopadhyay.bsky.social · 22/06/2025

Flying to Paris tomorrow. Looking forward to visiting and speaking at CNRS (Centre National de la Recherche Scientifique), Aix-Marseille Université, Institut des Biomolécules Max Mousseron, Centre de Biologie Structurale, CNRS/Université de Montpellier, and Université de Lorraine, Metz.