Sign in

Nezha Benabdallah

@nsbenab.bsky.social
1.2K followers 451 following 22 posts

Group leader at the University of Edinburgh. Chromatin, Gene Regulation & Sarcoma www.benabdallah-lab.com

PostsRepliesMedia
Reposted by Nezha Benabdallah
Alexis Verger 🧬🧫🧪 @alexis-verger.cpesr.fr · 03/09/2026
Effet matilda, invisibilisation ou mentrification, je connaissais Je découvre aujourd'hui le mot cryptogynie #womeninstem #womeninscience olivia.science/cryptogyny/ fr.wikipedia.org/wiki/Effacem...
olivia.science
Cryptogyny
On the systematic obfuscation of women's contributions.
015
Reposted by Nezha Benabdallah
Institute of Genetics and Cancer @uoe-igc.bsky.social · 02/09/2026
A study led by @andrewwood.bsky.social's lab has found the way cancer-causing proteins accumulate in tumours may influence how effectively a promising new generation of medicines can remove them. Read more here 👉 edin.ac/4cWw7Mh @cp-cellchembiol.bsky.social @cmvm-edinburghuni.bsky.social
edin.ac
Protein build-up may shape cancer drug response | Institute of Genetics and Cancer | Institute of Genetics and Cancer
The way cancer-causing proteins accumulate in tumours may influence how effectively a promising new generation of medicines can remove them, a study has found.
033
Reposted by Nezha Benabdallah
Miki Ebisuya @ebisuyamiki.bsky.social · 13/08/2026
And here's a beautifully complementary work from @trayon.bsky.social and @jamesbriscoe.bsky.social group, showing broad differences in protein stability in human and mouse neural progenitors - again, protein degradation is slower in human cells! authors.elsevier.com/sd/article/S... 5/
authors.elsevier.com
Proteasome-dependent protein degradation shapes developmental tempo in mouse and human neural progenitors
The pace of embryonic development differs between mammalian species, yet the molecular basis for this remains unknown. By comparing protein dynamics i…
072
Reposted by Nezha Benabdallah
Miki Ebisuya @ebisuyamiki.bsky.social · 13/08/2026
New paper from the lab! authors.elsevier.com/sd/article/S... We find that protein degradation is broadly slower in human segmentation clock cells than in mouse cells, regardless of the degradation pathway or protein category! 1/
authors.elsevier.com
Systematic differences in protein stability underlie species-specific developmental tempo
Human embryonic development proceeds more slowly than in mice. The segmentation clock offers a tractable model for studying species-specific developme…
49127
Reposted by Nezha Benabdallah
Margarita Parada-Kusz @margaritapk.bsky.social · 26/07/2026
Reactivation of mammalian regeneration by turning on an evolutionarily disabled genetic switch www.science.org/doi/10.1126/...
science.org
Reactivation of mammalian regeneration by turning on an evolutionarily disabled genetic switch
Mammals display prominent diversity in the ability to regenerate damaged ear pinna, but the genetic changes underlying the failure of regeneration remain elusive. We performed comparative single-cell ...
02913
Reposted by Nezha Benabdallah
Princess Margaret Cancer Centre @pmresearch-uhn.bsky.social · 15/07/2026
Our new study led by Dr. David Kirsch @uhn.ca @uhnresearch.ca describes an innovative dual recombinase preclinical model of CIC::DUX4 sarcoma, an aggressive cancer affecting young adults, and identifies a promising treatment approach in lab models. doi.org/10.1172/jci2...
032
Reposted by Nezha Benabdallah
Cathy Abbott @cathyabbott.bsky.social · 15/07/2026
"Somewhere in a university shared drive, there is probably an Athena Swan action plan that took months to produce, drew on years of data, involved hours of unpaid or under-recognised labour, and identified inequalities that everyone agreed mattered." This really hit home.
111
Reposted by Nezha Benabdallah
American Association for Cancer Research (AACR) @theaacr.bsky.social · 14/07/2026
The @US_FDA granted traditional approval to the targeted therapy selpercatinib for patients 2 and older with advanced solid tumors that have a RET gene fusion whose disease progressed on or following systemic treatment or who have no alternative options: buff.ly/Od4Phzl
fda.gov
FDA grants traditional approval to selpercatinib for locally advanced
FDA grants traditional approval to selpercatinib for locally advanced or metastatic RET fusion-positive solid tumors
112
Reposted by Nezha Benabdallah
Memorial Sloan Kettering Cancer Center @mskcancercenter.bsky.social · 09/07/2026
The FDA has granted full approval for an engineered cell therapy called afamitresgene autoleuecel (Tecelra®, also known as afami-cel) for treating advanced synovial sarcoma. More about the clinical trials resulting in the drug’s approval, led by MSK's Dr. Sandra D’Angelo: bit.ly/4eVcTZ4
032
Reposted by Nezha Benabdallah
Alex Radzisheuskaya @a-radzisheuskaya.bsky.social · 08/07/2026
1/ Very excited to share the first publication from my lab! In this work, we developed an efficient strategy to precisely mutate mammalian histone genes in their native genomic context using CRISPR prime editing: www.nature.com/articles/s41...
nature.com
Identifying critical lysines in mammalian histone H3 with high-throughput CRISPR prime editing - Nature Genetics
This study uses a precise and efficient clustered regularly interspaced short palindromic repeats (CRISPR) prime editing system to substitute lysine residues in histone H3, individually or in combinat...
1112044
Reposted by Nezha Benabdallah
Wendy Bickmore @wbickmor.bsky.social · 04/07/2026
Very honoured that the lab has been selected as the first UK Center for Excellence by the CdLS foundation www.cdlsusa.org/centers-for-.... We aim to advance knowledge about this genetic condition and to explore similarities to other rare genetic disorders that affect gene regulation.
cdlsusa.org
Centers for Excellence | CdLS Foundation
Our expanded Centers of Excellence network is here — 8 designated centers, 10+ lead investigators, and the people turning lived experience into discovery. See who's part of Mission Possible.
5443
Reposted by Nezha Benabdallah
Nature Biotechnology @natbiotech.nature.com · 02/07/2026
Each year, we highlight companies that received sizeable early-stage funding in the previous year. Trogenix's platform for generating ‘synthetic super-enhancers’ could drive highly cell-specific gene therapy-based treatment of solid tumors such as glioblastoma www.nature.com/articles/s41...
nature.com
Editor’s pick: Trogenix - Nature Biotechnology
Each year, Nature Biotechnology highlights companies that received sizeable early-stage funding in the previous year. Trogenix has developed a platform for generating ‘synthetic super-enhancers’ that ...
041
Reposted by Nezha Benabdallah
David Brückner @davidbrueckner.bsky.social · 02/07/2026
How do cells combine cell-intrinsic & tissue-level cues create stable patterns during intestinal regeneration? 🤔 Our paper w/ @cschwayer.bsky.social @silviabarbiero.bsky.social @ehannezo.bsky.social @priscaliberali.bsky.social is out! 🥳 A thread on the theory part 🧵⬇️ www.cell.com/cell/fulltex...
cell.com
Multiscale integration of tissue and chromatin context converts cell heterogeneity into stable intestinal patterning
During regeneration, tissues must translate transient cellular variability into stable spatial organization. Tissue architecture generates a density-dependent window of heterogeneity in the mechanosen...
3439
Reposted by Nezha Benabdallah
Kai Kupferschmidt @kakape.bsky.social · 01/07/2026
“It’s just a microscopic water droplet surrounded by a fatty membrane and stuffed with chemicals and snippets of DNA encoding a mere 36 genes. But it’s also arguably the closest researchers have come to building a living cell from scratch.”🧪 My story in @science.org on a fascinating preprint:
science.org
Lab-created ‘SpudCell’ marks ‘stunning’ step toward building life from scratch
A synthetic cell can now grow and divide—but it’s still far from alive
612451
Reposted by Nezha Benabdallah
MwahahahahahadScientist @mads100tist.bsky.social · 29/06/2026
Where Igor Ademeyko @adameykolab.bsky.social walks us through a beautiful scenario of what the hell neural crest cells are, co-option, and the camouflage hypothesis. With special mention of Rohon-Beard neurons! 🧪🐟
science.org
Co-option and innovation in neural crest evolution
Neural crest evolution reassembled ancient programs in pigment cell lineage, resulting in vertebrate innovations.
22711
Reposted by Nezha Benabdallah
Aydan Bulut-Karslioglu @bulutkarslioglu.bsky.social · 26/06/2026
I have been thinking since yesterday about why I find the 1% thing so, so disturbing. It's a visceral reaction of 'just no', which goes beyond the general yuck towards the enshittification of/via AI. I have finally put my finger on it: it is the feeling you get when
610931
Reposted by Nezha Benabdallah
Institute of Genetics and Cancer @uoe-igc.bsky.social · 23/06/2026
Congratulations to Professor Andrew Jackson who has been awarded a 2.5 million euros @erc.europa.eu Advanced Grant to study the 'Mechanisms of Epigenetic Ageing and Sizing' #ERCAdG Read more 👉 edin.ac/4uMJULv @cmvm-edinburghuni.bsky.social
062
Reposted by Nezha Benabdallah
Harmit Singh Malik @harmitmalik.bsky.social · 24/06/2026
I know it seems like a heretical idea, but one way to figure out if a preprint is really interesting (to you) is... to read the preprint. Then, in the spirit of sharing, send a note to authors: a simple kudos or a more detailed question. I do this a dozen times a year. It's awesome. Try it.
1229264
Reposted by Nezha Benabdallah
Abbey @abbeyarletto.bsky.social · 23/06/2026
When reality surpasses fiction! Top: fictional forecast for August 2050, broadcast by French TV in 2014 to warn about the consequences of global warming. Bottom: Real French forecast for yesterday, June 22, 2026.
236168337554
Reposted by Nezha Benabdallah
Max Delbrück Center @mdc-berlin.bsky.social · 17/06/2026
Programming and reprogramming living systems take center stage at the #mdcBerlin Bioengineering Symposium 2026. Our speakers will share insights from synthetic biology, immunology, and systems biology. 🗓️ July 6 | Berlin-Buch More info and registration: 👉 www.mdc-berlin.de/BioE-2026 👈

Graphic with background image and text for the Max Delbrück Center Bioengineering Symposium 2026. The image shows a fluorescent microscopy image in blue, green, and red.

The text reads: “Afternoon Session II. Programming and Reprogramming Living Systems. Bioengineering Symposium 2026. 3:30 PM | July 6 | Berlin-Buch.”
042
Reposted by Nezha Benabdallah
Matthew L. Kraushar @matthewkraushar.bsky.social · 16/06/2026
Let's step inside a neuron together, and ask, "how did all this get here?" 🤔 In this review, I trace the history and transformations of a neuron's molecules, pay homage to major discoveries in brain development ... and make a call to action for neuroscience. www.annualreviews.org/content/jour...
annualreviews.org
The Translation of Genetic Information in Neurodevelopment
Neurodevelopment is the transformation of genetic information into diverse neuronal phenotypes. Developmental signals initiate patterns of gene transcription and translation that drive progenitors tow...
1178
Reposted by Nezha Benabdallah
Paul Bernal @paulbernal.bsky.social · 13/06/2026
Scotland has colonised the U.S.
18561121
Reposted by Nezha Benabdallah
Johns Hopkins Department of Biochemistry and Molecular Biology @johnshopkinsbmb.bsky.social · 11/06/2026
Online today @natcellbio.nature.com! The Cai Lab discovered a type of large condensate in the nucleus of renal cell carcinoma cells with high levels of the TEAD1 transcription factor that are different than previously characterized transcriptional condensates (1/3)
publichealth.jhu.edu
Discovery of Condensate ‘Storage Units’ in Cells Points to New Cancer Research and Treatment Targets | Johns Hopkins Bloomberg School of Public Health
Clusters storing gene activators near inactive regions of DNA in cell nuclei could illuminate cancer biology.
155
Reposted by Nezha Benabdallah
Cathy Abbott @cathyabbott.bsky.social · 10/06/2026
Really good well balanced piece about the place of interviewing in grants (well, my remarks are not particularly well balanced, but the piece is!). Featuring @kirstygrainger.bsky.social too 🙂 www.researchprofessionalnews.com/rr-news-worl...
researchprofessionalnews.com
Can ‘high-stress’ interviews for grants save a system under pressure? - Research Professional News
Funders are using interviews to manage demand, but some worry about the consequences for applicants
131
Reposted by Nezha Benabdallah
Lara Krüger @lara-kruger.bsky.social · 09/06/2026
📢 We are looking for a Junior Group Leader to join us at @institutcurie.bsky.social! Having joined the department just over a year ago, I can honestly say that it is an exceptionally stimulating and supportive scientific environment, filled with outstanding colleagues — all in the heart of Paris.
19698
Reposted by Nezha Benabdallah
Jon Henninger @jhenninger.bsky.social · 08/06/2026
Excited to share the first pre-print from our lab!! Check it out here! www.biorxiv.org/content/10.6... We found that many RNA-binding proteins canonically understood to regulate RNA processing can also function like transcription factors and cofactors to directly regulate transcription.
37827
Reposted by Nezha Benabdallah
Yuri Pritykin @yuripritykin.bsky.social · 02/06/2026
Excited to share our new paper at Cell Reports @cp-cellreports.bsky.social led by fantastic Gabe Dolsten! We characterized multi-megabase and interchromosomal chromatin interactions in primary T cells, revealing a previously underappreciated layer of genome organization: doi.org/10.1016/j.ce...
1132
Reposted by Nezha Benabdallah
Seychelle Vos @voslab.org · 29/05/2026
⚡New preprint from the lab⚡: A key early checkpoint in gene expression is promoter proximal pausing of RNA polymerase II. For over 20 years, we as field have not been able to recreate pausing under realistic cellular conditions. @robertovn.bsky.social shows that ELOF1 is the missing piece.
16430
Reposted by Nezha Benabdallah
Rob Klose @robklose.bsky.social · 29/05/2026
Help please! We need to do some large(ish) cell culture inhibiting E-cadherin with a monoclonal antibody. Does anyone have the DECMA-1 hybridoma cell line so we could purify our own antibody? or a similar monoclonal that would do the job. Any help greatly appreciated, just DM me. Please repost!
01241
Reposted by Nezha Benabdallah
Grand Lab @grandlab.bsky.social · 07/05/2026
Excited to share our first story led by @martinacapriati.bsky.social! How do cells control the expression of viability genes? We find that single transcription factors can drive both chromatin opening and gene activation from densely co-bound CpG island promoters, including at essential genes
25127
Reposted by Nezha Benabdallah
Axel Visel @axelvisel.bsky.social · 08/05/2026
If it walks like a duck and develops like a duck ... the enhancers might still align to humans 🥚🦆 (chicken, actually, but you get the picture) Fun collaboration led by Stella Kyomen and @marketa-kau.bsky.social at @mpi-evolbio.bsky.social
1175
Reposted by Nezha Benabdallah
Christine Mayr @christinemayr.bsky.social · 08/05/2026
If you want to know what 3′UTRs with long conserved sequence stretches do, check out our BioRxiv preprint doi.org/10.64898/202.... They form functional intermolecular 3′UTR-3′UTR interactions that enable co-folding of proteins to rapidly induce transcriptional programs.
513956
Reposted by Nezha Benabdallah
Alexis Verger 🧬🧫🧪 @alexis-verger.cpesr.fr · 07/05/2026
#RIP Pierre Chambon (1931-2026) 1963 PARP 1970 RNA Pol II 1975 Nucleosome 1977 Split genes 1980 Promoter 1983 enhancer 1986 Nuclear receptor
27631
Reposted by Nezha Benabdallah
Maxim Greenberg @maxvcg.bsky.social · 01/05/2026
This a very important, and extremely well-executed study from Ralph Grand’s group @uniheidelberg.bsky.social. Congrats to all the authors! www.biorxiv.org/content/10.6...
614643
Reposted by Nezha Benabdallah
Sam Freedman @samfr.bsky.social · 26/04/2026
I'm in @theobserveruk.bsky.social today looking at why so many unis are in financial trouble and what the government needs to do to save HE. observer.co.uk/news/columni...
observer.co.uk
Why saving universities is far more than academic
Modern Britain needs young people with degrees – here’s how to make sure they still have somewhere to study them
38425161
Reposted by Nezha Benabdallah
Netherlands Cancer Institute @nkinl.bsky.social · 24/04/2026
Our researchers are exploring whether radiotherapy for soft tissue sarcoma can be delivered in a shorter, less burdensome way without compromising outcomes. The SCOPES studies mark an exciting step forward in rethinking long‑standing treatment standards. Read more ➡️ www.nki.nl/news-events/...
011
Reposted by Nezha Benabdallah
Wendy Bickmore @wbickmor.bsky.social · 22/04/2026
Calling all alumni of the MRC Human Genetics Unit Join us on Wednesday 23rd Sept to mark the last ever intake of PhD students to the HGU, and to celebrate the achievements of our alumni, and current PhD cohort. To secure a place, please registerat: www.eventbrite.co.uk/e/mrc-hgu-ph...
eventbrite.co.uk
MRC HGU PhD Student Alumni Day
We hope you can join us for a fun and inspiring in-person gathering.
083
Reposted by Nezha Benabdallah
Naomi Moris @nmoris.bsky.social · 20/04/2026
I am giving a "Crash Course in Embryo Development" for the general public (no science background needed! pitched around GCSE-level) in London on 21st May www.crick.ac.uk/whats-on/cri... We'll dip into development, with a splash of embryo models, and a pinch of ethics. And it's free! Book online 👍
crick.ac.uk
Crick Crash Course: Embryo development
07025
Reposted by Nezha Benabdallah
Johanna Joyce @johannajoyce.bsky.social · 16/04/2026
What does it take to truly understand #cancer in all of its complexity? Delighted to share our Review in Cell "Cancer ecosystems: A dynamic interplay across scales" with Daniela Quail, where we propose a multi-scale framework connecting tumor ecology with physiology 🧪⚕️ www.cell.com/cell/fulltex...
77433
Reposted by Nezha Benabdallah
Karolin Luger @nucleosomepolice.bsky.social · 17/04/2026
there goes the central dogma, i guess. is nothing sacred anymore?
3519
Reposted by Nezha Benabdallah
IGMM-Montpellier @igmm-montpel.bsky.social · 15/04/2026
🧬📖 En page de couverture de Development : publication de Louise Maillard @lmaillard.bsky.social (équipe Mounia Lagha @laghalab.bsky.social) et ses collaborateurs ! 🔬✨ Un très beau travail d’équipe 👏 @dev-journal.bsky.social @biologists.bsky.social journals.biologists.com/dev/article/...
journals.biologists.com
Mitotic reactivation and transcriptional bursting govern transcriptional noise in the early Drosophila embryo
Summary: Transcriptional variability in developing Drosophila embryos is time dependent, peaking after mitosis due to nucleus-to-nucleus differences in post-mitotic reactivation timings, and declining...
0155
Reposted by Nezha Benabdallah
Aude Bernheim @audeber.bsky.social · 02/04/2026
How diverse is bacterial immunity ? We report in @science.org how language models allowed us to predict 2.4M antiphage proteins spanning >23K novel potential systems. 👏 @emordret.bsky.social, @alexhv.bsky.social & al doi.org/10.1126/scie... Explore them here defensefinder.mdmlab.fr/wiki/refseq_...
science.org
10229115
Reposted by Nezha Benabdallah
Chris Tape @christophertape.bsky.social · 31/03/2026
We are recruiting! We are searching for an exceptional postdoctoral fellow to lead the single-cell phenoscaping efforts of the REWIRE-CAN Cancer Grand Challenge @cancergrand.bsky.social For more information and to apply please visit: www.ucl.ac.uk/work-at-ucl/...
097
Reposted by Nezha Benabdallah
Charlène Boumendil (She/Her) @charleneboumendil.bsky.social · 20/03/2026
We are looking for a new group leader to join the IGH (Montpellier, France). I can’t wait to meet my future colleague! Apply :-) More infos here: igh.cnrs.fr/join-igh-as-...
igh.cnrs.fr
Join IGH as Group Leader - IGH
The Institute of Human Genetics invites applications for a Principal Investigator position in its main research areas. Read more...
05262
Reposted by Nezha Benabdallah
Daan Noordermeer lab @daannoordermeerlab.bsky.social · 13/03/2026
🚨🚨🚨 My institute, the @i2bcparissaclay.bsky.social in beautiful Gif-sur-Yvette and part of @univparissaclay.bsky.social, is recruiting group leaders! Announcement here: www.i2bc.paris-saclay.fr/join-i2bc/te... Open to early career scientist from anywhere or mid-career already in France. Please RB!
11216
Reposted by Nezha Benabdallah
Max Planck Institute for Molecular Biomedicine @mpi-muenster.bsky.social · 04/03/2026
We are offering 5 Postdoc Positions within the Max Planck Postdoc Program! Take advantage and apply by April 13, 2026 to the positions in the labs of @ralfhadams.bsky.social, @ruibenedito.bsky.social and @katemiro.bsky.social. Link to our website: www.mpi-muenster.mpg.de/max-planck-p...
186
Reposted by Nezha Benabdallah
Sophie Acton @actonlab.bsky.social · 02/03/2026
*Recruiting new group leaders* The @lmcb-ucl.bsky.social at University College London are looking for outstanding candidates to sponsor for career development fellowships. Fellows would then be assessed for tenured positions at the end of the fellowship term.
21314
Reposted by Nezha Benabdallah
Hiroshi Ochiai @hiroshiochiai.bsky.social · 11/02/2026
1/3 New bioRxiv preprint from the lab: “Minute-scale coupling of chromatin marks and transcriptional bursts”. Led by Xiohui Gao & Chaebeen Ko. bioRxiv : www.biorxiv.org/cgi/content/...
14220
Reposted by Nezha Benabdallah
Lena Kutscher @handle.invalid · 10/02/2026
Excited to share our preprint on our new multi-omic atlas of human hindbrain development. Led by postdoc Piyush Joshi, in collaboration with @kaessmannlab.bsky.social and Pfister labs, our atlas represents the first comprehensive view of human hindbrain development. www.biorxiv.org/content/10.6...
Brain with puzzle overlay to show that our study provides missing pieces of the puzzle of human brain development by delivering the most comprehensive picture of hindbrain development to date. We have strived to go beyond just another multi-omics atlas to gain deep insights by:
1. Meticulously annotating cell clusters
2. Extracting regulatory programs in terms of coordinated gene sets and accessible regulatory elements
3. Using deep learning to identify regulatory syntax
4. Resolving context-specific TF activity
23315
Reposted by Nezha Benabdallah
Thiago Carvalho @cyrilpedia.bsky.social · 06/02/2026
'The regularization effort underway in Spain actually began as a citizen-led initiative endorsed by more than 900 nongovernmental organizations, including the Catholic Church, and it has the support of business associations and trade unions alike.' www.nytimes.com/2026/02/04/o...
nytimes.com
Opinion | I’m the Prime Minister of Spain. This Is Why the West Needs Migrants.
066