Nezha Benabdallah @nsbenab.bsky.social · 03/09/2026Huge congrats Lena!! super nice to see your name on the list! 100
Reposted by Nezha BenabdallahAlexis Verger 🧬🧫🧪 @alexis-verger.cpesr.fr · 03/09/2026Effet matilda, invisibilisation ou mentrification, je connaissais Je découvre aujourd'hui le mot cryptogynie #womeninstem #womeninscience olivia.science/cryptogyny/ fr.wikipedia.org/wiki/Effacem...olivia.scienceCryptogynyOn the systematic obfuscation of women's contributions. 015
Reposted by Nezha BenabdallahInstitute of Genetics and Cancer @uoe-igc.bsky.social · 02/09/2026A study led by @andrewwood.bsky.social's lab has found the way cancer-causing proteins accumulate in tumours may influence how effectively a promising new generation of medicines can remove them. Read more here 👉 edin.ac/4cWw7Mh @cp-cellchembiol.bsky.social @cmvm-edinburghuni.bsky.socialedin.acProtein build-up may shape cancer drug response | Institute of Genetics and Cancer | Institute of Genetics and CancerThe way cancer-causing proteins accumulate in tumours may influence how effectively a promising new generation of medicines can remove them, a study has found. 033
Reposted by Nezha BenabdallahMiki Ebisuya @ebisuyamiki.bsky.social · 13/08/2026And here's a beautifully complementary work from @trayon.bsky.social and @jamesbriscoe.bsky.social group, showing broad differences in protein stability in human and mouse neural progenitors - again, protein degradation is slower in human cells! authors.elsevier.com/sd/article/S... 5/authors.elsevier.comProteasome-dependent protein degradation shapes developmental tempo in mouse and human neural progenitorsThe pace of embryonic development differs between mammalian species, yet the molecular basis for this remains unknown. By comparing protein dynamics i… 072
Reposted by Nezha BenabdallahMiki Ebisuya @ebisuyamiki.bsky.social · 13/08/2026New paper from the lab! authors.elsevier.com/sd/article/S... We find that protein degradation is broadly slower in human segmentation clock cells than in mouse cells, regardless of the degradation pathway or protein category! 1/authors.elsevier.comSystematic differences in protein stability underlie species-specific developmental tempoHuman embryonic development proceeds more slowly than in mice. The segmentation clock offers a tractable model for studying species-specific developme… 49127
Reposted by Nezha BenabdallahMargarita Parada-Kusz @margaritapk.bsky.social · 26/07/2026Reactivation of mammalian regeneration by turning on an evolutionarily disabled genetic switch www.science.org/doi/10.1126/...science.orgReactivation of mammalian regeneration by turning on an evolutionarily disabled genetic switchMammals display prominent diversity in the ability to regenerate damaged ear pinna, but the genetic changes underlying the failure of regeneration remain elusive. We performed comparative single-cell ... 02913
Reposted by Nezha BenabdallahPrincess Margaret Cancer Centre @pmresearch-uhn.bsky.social · 15/07/2026Our new study led by Dr. David Kirsch @uhn.ca @uhnresearch.ca describes an innovative dual recombinase preclinical model of CIC::DUX4 sarcoma, an aggressive cancer affecting young adults, and identifies a promising treatment approach in lab models. doi.org/10.1172/jci2... 032
Reposted by Nezha BenabdallahCathy Abbott @cathyabbott.bsky.social · 15/07/2026"Somewhere in a university shared drive, there is probably an Athena Swan action plan that took months to produce, drew on years of data, involved hours of unpaid or under-recognised labour, and identified inequalities that everyone agreed mattered." This really hit home. 111
Reposted by Nezha BenabdallahAmerican Association for Cancer Research (AACR) @theaacr.bsky.social · 14/07/2026The @US_FDA granted traditional approval to the targeted therapy selpercatinib for patients 2 and older with advanced solid tumors that have a RET gene fusion whose disease progressed on or following systemic treatment or who have no alternative options: buff.ly/Od4Phzlfda.govFDA grants traditional approval to selpercatinib for locally advancedFDA grants traditional approval to selpercatinib for locally advanced or metastatic RET fusion-positive solid tumors 112
Reposted by Nezha BenabdallahMemorial Sloan Kettering Cancer Center @mskcancercenter.bsky.social · 09/07/2026The FDA has granted full approval for an engineered cell therapy called afamitresgene autoleuecel (Tecelra®, also known as afami-cel) for treating advanced synovial sarcoma. More about the clinical trials resulting in the drug’s approval, led by MSK's Dr. Sandra D’Angelo: bit.ly/4eVcTZ4 032
Reposted by Nezha BenabdallahAlex Radzisheuskaya @a-radzisheuskaya.bsky.social · 08/07/20261/ Very excited to share the first publication from my lab! In this work, we developed an efficient strategy to precisely mutate mammalian histone genes in their native genomic context using CRISPR prime editing: www.nature.com/articles/s41...nature.comIdentifying critical lysines in mammalian histone H3 with high-throughput CRISPR prime editing - Nature GeneticsThis study uses a precise and efficient clustered regularly interspaced short palindromic repeats (CRISPR) prime editing system to substitute lysine residues in histone H3, individually or in combinat... 1112044
Reposted by Nezha BenabdallahWendy Bickmore @wbickmor.bsky.social · 04/07/2026Very honoured that the lab has been selected as the first UK Center for Excellence by the CdLS foundation www.cdlsusa.org/centers-for-.... We aim to advance knowledge about this genetic condition and to explore similarities to other rare genetic disorders that affect gene regulation.cdlsusa.orgCenters for Excellence | CdLS FoundationOur expanded Centers of Excellence network is here — 8 designated centers, 10+ lead investigators, and the people turning lived experience into discovery. See who's part of Mission Possible. 5443
Reposted by Nezha BenabdallahNature Biotechnology @natbiotech.nature.com · 02/07/2026Each year, we highlight companies that received sizeable early-stage funding in the previous year. Trogenix's platform for generating ‘synthetic super-enhancers’ could drive highly cell-specific gene therapy-based treatment of solid tumors such as glioblastoma www.nature.com/articles/s41...nature.comEditor’s pick: Trogenix - Nature BiotechnologyEach year, Nature Biotechnology highlights companies that received sizeable early-stage funding in the previous year. Trogenix has developed a platform for generating ‘synthetic super-enhancers’ that ... 041
Reposted by Nezha BenabdallahDavid Brückner @davidbrueckner.bsky.social · 02/07/2026How do cells combine cell-intrinsic & tissue-level cues create stable patterns during intestinal regeneration? 🤔 Our paper w/ @cschwayer.bsky.social @silviabarbiero.bsky.social @ehannezo.bsky.social @priscaliberali.bsky.social is out! 🥳 A thread on the theory part 🧵⬇️ www.cell.com/cell/fulltex...cell.comMultiscale integration of tissue and chromatin context converts cell heterogeneity into stable intestinal patterningDuring regeneration, tissues must translate transient cellular variability into stable spatial organization. Tissue architecture generates a density-dependent window of heterogeneity in the mechanosen... 3439
Reposted by Nezha BenabdallahKai Kupferschmidt @kakape.bsky.social · 01/07/2026“It’s just a microscopic water droplet surrounded by a fatty membrane and stuffed with chemicals and snippets of DNA encoding a mere 36 genes. But it’s also arguably the closest researchers have come to building a living cell from scratch.”🧪 My story in @science.org on a fascinating preprint:science.orgLab-created ‘SpudCell’ marks ‘stunning’ step toward building life from scratchA synthetic cell can now grow and divide—but it’s still far from alive 612451
Reposted by Nezha BenabdallahMwahahahahahadScientist @mads100tist.bsky.social · 29/06/2026Where Igor Ademeyko @adameykolab.bsky.social walks us through a beautiful scenario of what the hell neural crest cells are, co-option, and the camouflage hypothesis. With special mention of Rohon-Beard neurons! 🧪🐟science.orgCo-option and innovation in neural crest evolutionNeural crest evolution reassembled ancient programs in pigment cell lineage, resulting in vertebrate innovations. 22711
Reposted by Nezha BenabdallahAydan Bulut-Karslioglu @bulutkarslioglu.bsky.social · 26/06/2026I have been thinking since yesterday about why I find the 1% thing so, so disturbing. It's a visceral reaction of 'just no', which goes beyond the general yuck towards the enshittification of/via AI. I have finally put my finger on it: it is the feeling you get when 610931
Reposted by Nezha BenabdallahInstitute of Genetics and Cancer @uoe-igc.bsky.social · 23/06/2026Congratulations to Professor Andrew Jackson who has been awarded a 2.5 million euros @erc.europa.eu Advanced Grant to study the 'Mechanisms of Epigenetic Ageing and Sizing' #ERCAdG Read more 👉 edin.ac/4uMJULv @cmvm-edinburghuni.bsky.social 062
Reposted by Nezha BenabdallahHarmit Singh Malik @harmitmalik.bsky.social · 24/06/2026I know it seems like a heretical idea, but one way to figure out if a preprint is really interesting (to you) is... to read the preprint. Then, in the spirit of sharing, send a note to authors: a simple kudos or a more detailed question. I do this a dozen times a year. It's awesome. Try it. 1229264
Reposted by Nezha BenabdallahAbbey @abbeyarletto.bsky.social · 23/06/2026When reality surpasses fiction! Top: fictional forecast for August 2050, broadcast by French TV in 2014 to warn about the consequences of global warming. Bottom: Real French forecast for yesterday, June 22, 2026. 236168277553
Reposted by Nezha BenabdallahMax Delbrück Center @mdc-berlin.bsky.social · 17/06/2026Programming and reprogramming living systems take center stage at the #mdcBerlin Bioengineering Symposium 2026. Our speakers will share insights from synthetic biology, immunology, and systems biology. 🗓️ July 6 | Berlin-Buch More info and registration: 👉 www.mdc-berlin.de/BioE-2026 👈 042
Reposted by Nezha BenabdallahMatthew L. Kraushar @matthewkraushar.bsky.social · 16/06/2026Let's step inside a neuron together, and ask, "how did all this get here?" 🤔 In this review, I trace the history and transformations of a neuron's molecules, pay homage to major discoveries in brain development ... and make a call to action for neuroscience. www.annualreviews.org/content/jour...annualreviews.orgThe Translation of Genetic Information in NeurodevelopmentNeurodevelopment is the transformation of genetic information into diverse neuronal phenotypes. Developmental signals initiate patterns of gene transcription and translation that drive progenitors tow... 1178
Reposted by Nezha BenabdallahPaul Bernal @paulbernal.bsky.social · 13/06/2026Scotland has colonised the U.S. 18561121
Reposted by Nezha BenabdallahJohns Hopkins Department of Biochemistry and Molecular Biology @johnshopkinsbmb.bsky.social · 11/06/2026Online today @natcellbio.nature.com! The Cai Lab discovered a type of large condensate in the nucleus of renal cell carcinoma cells with high levels of the TEAD1 transcription factor that are different than previously characterized transcriptional condensates (1/3)publichealth.jhu.eduDiscovery of Condensate ‘Storage Units’ in Cells Points to New Cancer Research and Treatment Targets | Johns Hopkins Bloomberg School of Public HealthClusters storing gene activators near inactive regions of DNA in cell nuclei could illuminate cancer biology. 155
Reposted by Nezha BenabdallahCathy Abbott @cathyabbott.bsky.social · 10/06/2026Really good well balanced piece about the place of interviewing in grants (well, my remarks are not particularly well balanced, but the piece is!). Featuring @kirstygrainger.bsky.social too 🙂 www.researchprofessionalnews.com/rr-news-worl...researchprofessionalnews.comCan ‘high-stress’ interviews for grants save a system under pressure? - Research Professional NewsFunders are using interviews to manage demand, but some worry about the consequences for applicants 131
Reposted by Nezha BenabdallahLara Krüger @lara-kruger.bsky.social · 09/06/2026📢 We are looking for a Junior Group Leader to join us at @institutcurie.bsky.social! Having joined the department just over a year ago, I can honestly say that it is an exceptionally stimulating and supportive scientific environment, filled with outstanding colleagues — all in the heart of Paris. 19698
Reposted by Nezha BenabdallahJon Henninger @jhenninger.bsky.social · 08/06/2026Excited to share the first pre-print from our lab!! Check it out here! www.biorxiv.org/content/10.6... We found that many RNA-binding proteins canonically understood to regulate RNA processing can also function like transcription factors and cofactors to directly regulate transcription. 37827
Reposted by Nezha BenabdallahYuri Pritykin @yuripritykin.bsky.social · 02/06/2026Excited to share our new paper at Cell Reports @cp-cellreports.bsky.social led by fantastic Gabe Dolsten! We characterized multi-megabase and interchromosomal chromatin interactions in primary T cells, revealing a previously underappreciated layer of genome organization: doi.org/10.1016/j.ce... 1132
Reposted by Nezha BenabdallahSeychelle Vos @voslab.org · 29/05/2026⚡New preprint from the lab⚡: A key early checkpoint in gene expression is promoter proximal pausing of RNA polymerase II. For over 20 years, we as field have not been able to recreate pausing under realistic cellular conditions. @robertovn.bsky.social shows that ELOF1 is the missing piece. 16430
Reposted by Nezha BenabdallahRob Klose @robklose.bsky.social · 29/05/2026Help please! We need to do some large(ish) cell culture inhibiting E-cadherin with a monoclonal antibody. Does anyone have the DECMA-1 hybridoma cell line so we could purify our own antibody? or a similar monoclonal that would do the job. Any help greatly appreciated, just DM me. Please repost! 01241
Reposted by Nezha BenabdallahGrand Lab @grandlab.bsky.social · 07/05/2026Excited to share our first story led by @martinacapriati.bsky.social! How do cells control the expression of viability genes? We find that single transcription factors can drive both chromatin opening and gene activation from densely co-bound CpG island promoters, including at essential genes 25127
Reposted by Nezha BenabdallahAxel Visel @axelvisel.bsky.social · 08/05/2026If it walks like a duck and develops like a duck ... the enhancers might still align to humans 🥚🦆 (chicken, actually, but you get the picture) Fun collaboration led by Stella Kyomen and @marketa-kau.bsky.social at @mpi-evolbio.bsky.social 1175
Reposted by Nezha BenabdallahChristine Mayr @christinemayr.bsky.social · 08/05/2026If you want to know what 3′UTRs with long conserved sequence stretches do, check out our BioRxiv preprint doi.org/10.64898/202.... They form functional intermolecular 3′UTR-3′UTR interactions that enable co-folding of proteins to rapidly induce transcriptional programs. 513956
Reposted by Nezha BenabdallahAlexis Verger 🧬🧫🧪 @alexis-verger.cpesr.fr · 07/05/2026#RIP Pierre Chambon (1931-2026) 1963 PARP 1970 RNA Pol II 1975 Nucleosome 1977 Split genes 1980 Promoter 1983 enhancer 1986 Nuclear receptor 27631
Reposted by Nezha BenabdallahMaxim Greenberg @maxvcg.bsky.social · 01/05/2026This a very important, and extremely well-executed study from Ralph Grand’s group @uniheidelberg.bsky.social. Congrats to all the authors! www.biorxiv.org/content/10.6... 614643
Reposted by Nezha BenabdallahSam Freedman @samfr.bsky.social · 26/04/2026I'm in @theobserveruk.bsky.social today looking at why so many unis are in financial trouble and what the government needs to do to save HE. observer.co.uk/news/columni...observer.co.ukWhy saving universities is far more than academicModern Britain needs young people with degrees – here’s how to make sure they still have somewhere to study them 38425161
Reposted by Nezha BenabdallahNetherlands Cancer Institute @nkinl.bsky.social · 24/04/2026Our researchers are exploring whether radiotherapy for soft tissue sarcoma can be delivered in a shorter, less burdensome way without compromising outcomes. The SCOPES studies mark an exciting step forward in rethinking long‑standing treatment standards. Read more ➡️ www.nki.nl/news-events/... 011
Reposted by Nezha BenabdallahWendy Bickmore @wbickmor.bsky.social · 22/04/2026Calling all alumni of the MRC Human Genetics Unit Join us on Wednesday 23rd Sept to mark the last ever intake of PhD students to the HGU, and to celebrate the achievements of our alumni, and current PhD cohort. To secure a place, please registerat: www.eventbrite.co.uk/e/mrc-hgu-ph...eventbrite.co.ukMRC HGU PhD Student Alumni DayWe hope you can join us for a fun and inspiring in-person gathering. 083
Reposted by Nezha BenabdallahNaomi Moris @nmoris.bsky.social · 20/04/2026I am giving a "Crash Course in Embryo Development" for the general public (no science background needed! pitched around GCSE-level) in London on 21st May www.crick.ac.uk/whats-on/cri... We'll dip into development, with a splash of embryo models, and a pinch of ethics. And it's free! Book online 👍crick.ac.ukCrick Crash Course: Embryo development 07025
Reposted by Nezha BenabdallahJohanna Joyce @johannajoyce.bsky.social · 16/04/2026What does it take to truly understand #cancer in all of its complexity? Delighted to share our Review in Cell "Cancer ecosystems: A dynamic interplay across scales" with Daniela Quail, where we propose a multi-scale framework connecting tumor ecology with physiology 🧪⚕️ www.cell.com/cell/fulltex... 77433
Reposted by Nezha BenabdallahKarolin Luger @nucleosomepolice.bsky.social · 17/04/2026there goes the central dogma, i guess. is nothing sacred anymore? 3519
Reposted by Nezha BenabdallahIGMM-Montpellier @igmm-montpel.bsky.social · 15/04/2026🧬📖 En page de couverture de Development : publication de Louise Maillard @lmaillard.bsky.social (équipe Mounia Lagha @laghalab.bsky.social) et ses collaborateurs ! 🔬✨ Un très beau travail d’équipe 👏 @dev-journal.bsky.social @biologists.bsky.social journals.biologists.com/dev/article/...journals.biologists.comMitotic reactivation and transcriptional bursting govern transcriptional noise in the early Drosophila embryoSummary: Transcriptional variability in developing Drosophila embryos is time dependent, peaking after mitosis due to nucleus-to-nucleus differences in post-mitotic reactivation timings, and declining... 0155
Nezha Benabdallah @nsbenab.bsky.social · 03/04/2026Congratulations Ernest, Aude and team!! Beautiful work 🤩 120
Reposted by Nezha BenabdallahAude Bernheim @audeber.bsky.social · 02/04/2026How diverse is bacterial immunity ? We report in @science.org how language models allowed us to predict 2.4M antiphage proteins spanning >23K novel potential systems. 👏 @emordret.bsky.social, @alexhv.bsky.social & al doi.org/10.1126/scie... Explore them here defensefinder.mdmlab.fr/wiki/refseq_...science.org 10229115
Reposted by Nezha BenabdallahChris Tape @christophertape.bsky.social · 31/03/2026We are recruiting! We are searching for an exceptional postdoctoral fellow to lead the single-cell phenoscaping efforts of the REWIRE-CAN Cancer Grand Challenge @cancergrand.bsky.social For more information and to apply please visit: www.ucl.ac.uk/work-at-ucl/... 097
Reposted by Nezha BenabdallahCharlène Boumendil (She/Her) @charleneboumendil.bsky.social · 20/03/2026We are looking for a new group leader to join the IGH (Montpellier, France). I can’t wait to meet my future colleague! Apply :-) More infos here: igh.cnrs.fr/join-igh-as-...igh.cnrs.frJoin IGH as Group Leader - IGHThe Institute of Human Genetics invites applications for a Principal Investigator position in its main research areas. Read more... 05262
Reposted by Nezha BenabdallahDaan Noordermeer lab @daannoordermeerlab.bsky.social · 13/03/2026🚨🚨🚨 My institute, the @i2bcparissaclay.bsky.social in beautiful Gif-sur-Yvette and part of @univparissaclay.bsky.social, is recruiting group leaders! Announcement here: www.i2bc.paris-saclay.fr/join-i2bc/te... Open to early career scientist from anywhere or mid-career already in France. Please RB! 11216