iiinova — where your digital self keeps evolving

Princess Margaret Cancer Centre @pmresearch-uhn.bsky.social · 30/09/2026

In people with age-related blood stem cell mutations, our study found early pre-fibrosis and inflammatory regions in the bone marrow, that may set the stage for blood cancer development. The @natimmunol.nature.com study was led by Dr. Anastasia Tikhonova: www.nature.com/articles/s41...

122

Princess Margaret Cancer Centre @pmresearch-uhn.bsky.social · 28/09/2026

A new lipid nanoparticle, LC-1, overcame gene editing barriers and efficiently delivered large RNA tools to the preclinical models of liver, lungs, and brain. The Nature Biotechnology study was led by Dr. Bowen Li @uhn.ca Princess Margaret Cancer Centre: www.nature.com/articles/s41...

063

Princess Margaret Cancer Centre @pmresearch-uhn.bsky.social · 25/09/2026

Congratulations to our Senior Scientist Dr. Tak Mak for receiving the German Immunology Prize from the German Society for Immunology! Learn more about the transformative discovery of T cell receptor here: www.uhn.ca/corporate/Ne...

000

Princess Margaret Cancer Centre @pmresearch-uhn.bsky.social · 21/09/2026

Congratulations to Dr. @benlok.bsky.social on receiving the Heine H. Hansen Lectureship Award for Small Cell Lung Cancer (SCLC) from @iaslc.bsky.social for his sustained practice-changing contributions in understanding DNA repair mechanisms & improving patient outcomes. www.iaslc.org/lectureship-...

061

Princess Margaret Cancer Centre @pmresearch-uhn.bsky.social · 18/09/2026

Our researchers identified a set of 94 regulatory proteins that can help predict survival outcomes and treatment response in triple-negative breast cancer, paving the way for more personalized therapy for patients with this aggressive disease. www.nature.com/articles/s41... @uhnresearch.ca @uhn.ca

072

Princess Margaret Cancer Centre @pmresearch-uhn.bsky.social · 17/09/2026

Congratulations to Dr. Long Nguyen on being named Canada's Top 40 Under 40 by @financialpost.com for leading a research program uncovering how cancer cells evolve, adapt, and develop resistance to treatment, to improve patient outcomes. @uhnresearch.ca @uhn.ca

032

Princess Margaret Cancer Centre @pmresearch-uhn.bsky.social · 16/09/2026

Finding immune cells that naturally recognize cancer has been a barrier to developing T cell-based therapies. Our study used AI to decode what makes γδ T cells respond to tumour cells, unlocking new therapeutic potentials. @nature.com : www.nature.com/articles/s41... @uhnresearch.ca @uhn.ca

110

Princess Margaret Cancer Centre @pmresearch-uhn.bsky.social · 10/09/2026

Instead of manually counting and drawing boundaries around micronuclei, tiny DNA-containing structures that signal genome instability, we developed an AI-based tool that automates the process and helps researchers study how cells accumulate genetic damage. www.cell.com/cell-reports...

020

Reposted by Princess Margaret Cancer Centre

Carbon to Metal Coating Institute (C2MCI) @c2mci.bsky.social · 09/09/2026

C2MCI invites you to join us for our upcoming Virtual Seminar Series public lecture with Dr. Nahyun Kwon of Dr. Gang Zheng’s lab @pmresearch-uhn.bsky.social @uhn.ca ➡️ Register today to learn about the application and design of gold nanoclusters for biomedicine: bit.ly/4zRiBmU #NFRF

011

Princess Margaret Cancer Centre @pmresearch-uhn.bsky.social · 09/09/2026

Congratulations to Drs. Laura Dawson and Jan Seuntjens on being elected Fellows of the Royal Society of Canada! Their research has advanced precision radiation treatment and improved cancer care in Canada and around the world. rsc-src.ca/en/about/pub...

040

Princess Margaret Cancer Centre @pmresearch-uhn.bsky.social · 03/09/2026

Our study reveals a key cause of lasting bone marrow damage after doxorubicin: the chemotherapy activates CD8 T cells to produce interferon-γ, which fuels chronic inflammation and disrupts the bone marrow environment. doi.org/10.1182/bloo... @uhnresearch.ca @uhn.ca

020

Princess Margaret Cancer Centre @pmresearch-uhn.bsky.social · 01/09/2026

We are proud to host the Toronto-Tokyo Joint Medical Technology Innovation Symposium, an Allan Slaight Breakthrough Forum in partnership with the University of Tokyo's Core-to-Core Program to advance innovation at the intersection of medicine, engineering, and technology 🇨🇦🇯🇵! @uhn.ca @uhnresearch.ca

030

Reposted by Princess Margaret Cancer Centre

Research at UHN @uhnresearch.ca · 27/08/2026

1/ Researchers at @pmresearch-uhn.bsky.social have developed an RNA-based therapy that can repair disease-causing genetic "stop" signals. Out today in @science.org, the approach has the potential to treat certain genetic disorders such as cystic fibrosis. 🔗: www.uhnresearch.ca/news/8-27-20...

121

Princess Margaret Cancer Centre @pmresearch-uhn.bsky.social · 27/08/2026

Check out the new tRNA-based lipid nanoparticle therapy, led by Dr. Bowen Li. The tRNA nanoparticle overcomes nonsense mutations in lung cells that lead to cystic fibrosis, holding promise to be adapted for a wide range of genetic diseases, including cancer. doi.org/10.1126/scie...

030

Princess Margaret Cancer Centre @pmresearch-uhn.bsky.social · 25/08/2026

Congratulations to our scientists Drs. Gang Zheng and Michael Milosevic on being elected as Fellows of Canadian Academy of Health Sciences! www.uhnresearch.ca/news/8-25-20...

040

Princess Margaret Cancer Centre @pmresearch-uhn.bsky.social · 24/08/2026

Our study found a new way to trigger AML cancer cell death: blocking LONP1 enzymes stops leukemia cells from properly importing proteins into their mitochondria for energy support. The study was led by Dr. Aaron Schimmer. @uhnresearch.ca @uhnresearch.ca www.jci.org/articles/vie...

042

Reposted by Princess Margaret Cancer Centre

Journal of Clinical Investigation @jci.org · 16/08/2026

Elevated mitochondrial protein import in acute myeloid leukemia increases reliance on mitochondrial protease LONP1: doi.org/10.1172/JCI1... By Aaron D. Schimmer & team @pmresearch-uhn.bsky.social @the-asci.org

doi.org

JCI - Elevated mitochondrial protein import in acute myeloid leukemia increases reliance on mitochondrial protease LONP1

032

Reposted by Princess Margaret Cancer Centre

Journal of Clinical Investigation @jci.org · 16/08/2026

ICYMI💫: Revealing a vulnerability in AML: doi.org/10.1172/JCI1... Tcheng et al. @pmresearch-uhn.bsky.social discover AML cells upregulate mitochondrial protein import & rely more on the mitochondrial protease LONP1 to maintain mitochondrial protein solubility compared to normal hematopoietic cells

165

Princess Margaret Cancer Centre @pmresearch-uhn.bsky.social · 19/08/2026

Our study evaluated 12 leading AI models for identifying organs in head and neck scans. The top performer accurately outlined 16 of 19 critical organs at a clinically acceptable level, highlighting AI's potential to streamline radiation therapy planning. doi.org/10.1016/j.ph...

143

Princess Margaret Cancer Centre @pmresearch-uhn.bsky.social · 18/08/2026

Our researchers developed a new CAR T-cell, that targets a cancer-driving protein called WT1, which is found inside many leukemia cells and several other cancers. This potentially extends CAR T-cell applications to new cancer types and patient populations. aacrjournals.org/bloodcancerd...

110

Reposted by Princess Margaret Cancer Centre

Research at UHN @uhnresearch.ca · 13/08/2026

1/ A new blood test-based method developed by researchers at @pmresearch-uhn.bsky.social could detect and classify metastatic breast cancer without the need for invasive tissue biopsies. 🔗 Read more: www.uhnresearch.ca/news/8-04-20...

141

Reposted by Princess Margaret Cancer Centre

Research at UHN @uhnresearch.ca · 12/08/2026

Through UHN STEM Pathways, 37 high school students gained hands-on research experience and explored their future STEM aspirations. 🔗 This #YouthDay, learn about 4 of these summer students and their experiences at @uhn.ca: www.uhnresearch.ca/news/8-12-20... #NextGenUHN

142

Princess Margaret Cancer Centre @pmresearch-uhn.bsky.social · 12/08/2026

Instead of relying only on traditional tissue biopsies, our study showed that a simple blood test could detect and classify advanced breast cancer. Led by Drs. Dave Cescon and Sasha Main @uhn.ca Princess Margaret Cancer Centre: doi.org/10.1158/0008...

120

Princess Margaret Cancer Centre @pmresearch-uhn.bsky.social · 11/08/2026

Congratulations to Dr. Gilla Shapiro on being named one of the Emerging Leaders in Health Sciences by CAHS! Dr. Shapiro's research in psychosocial oncology, behavioural science, and cancer prevention, has influenced policy, practice, and equitable care in Canada and internationally.

210

Reposted by Princess Margaret Cancer Centre

Terry Fox Research Institute (TFRI) @terryfoxresearch.bsky.social · 04/08/2026

🎉 Congratulations to the 2026 Terry Fox New Frontiers Program Project Grant teams who are launching ambitious new #cancerresearch projects with $33M in support from TFRI! Learn more: www.tfri.ca/updates/news...

192

Princess Margaret Cancer Centre @pmresearch-uhn.bsky.social · 30/07/2026

Congratulations to Dr. Amit Oza on receiving 2026 International Gynecologic Cancer Society (IGCS) Lifetime Achievement Award, for his exceptional contributions to gynecologic oncology through research, clinical leadership, mentorship and international collaboration. www.uhn.ca/corporate/ne...

000

Princess Margaret Cancer Centre @pmresearch-uhn.bsky.social · 29/07/2026

How do we ensure AI is safe, trustworthy and effective in cancer care and research? Meet Dr. @bhaibeka.bsky.social Executive AI Scientific Director @uhn.ca, Senior Scientist and Scientific Director of Cancer Digital Intelligence program at Princess Margaret Cancer Centre. youtu.be/yIOPi6EK3DM?...

youtu.be

Meet Dr. Benjamin Haibe Kains: Transparent AI Research for Safe Health Care

YouTube video by UHN Research

132

Princess Margaret Cancer Centre @pmresearch-uhn.bsky.social · 24/07/2026

Check out the interview with our Senior Scientist Dr. Lillian Siu to get to know more about our SHERLOCK trial!

020

Reposted by Princess Margaret Cancer Centre

Research at UHN @uhnresearch.ca · 24/07/2026

Take a look at how @uhn.ca’s SHERLOCK study—supported by the Peter Gilgan Foundation—is lighting a new path in #PrecisionCare and helping detect cancer recurrence earlier with a blood test. 🔗 Learn more: www.uhn.ca/corporate/Ne... @pmresearch-uhn.bsky.social

052

Princess Margaret Cancer Centre @pmresearch-uhn.bsky.social · 23/07/2026

We are proud to host the 2nd Annual Allan Slaight Breakthrough Forum on Cancer Neuroscience, bringing researchers from @pmresearch-uhn.bsky.social @kbi-uhn.bsky.social @camhnews.bsky.social and for the first time, @sickkidsto.bsky.social to explore the exciting frontiers in medicine.

020

Princess Margaret Cancer Centre @pmresearch-uhn.bsky.social · 15/07/2026

Our new study led by Dr. David Kirsch @uhn.ca @uhnresearch.ca describes an innovative dual recombinase preclinical model of CIC::DUX4 sarcoma, an aggressive cancer affecting young adults, and identifies a promising treatment approach in lab models. doi.org/10.1172/jci2...

032

Reposted by Princess Margaret Cancer Centre

Research at UHN @uhnresearch.ca · 08/07/2026

After cancer treatment, one question remains: Is it truly gone? Backed by the Peter Gilgan Foundation, SHERLOCK at @pmresearch-uhn.bsky.social is uncovering cancer earlier—through a simple blood test. 🔗 Read the CBC exclusive: www.cbc.ca/news/health/...

cbc.ca

Can you ever truly cure cancer? Canadian researchers are using blood biopsies to find out | CBC News

A Toronto-based team is launching a massive, years-long research project to study liquid biopsies, a novel technology meant to catch tiny traces of tumour DNA in the blood. The goal? Finding better wa...

011

Princess Margaret Cancer Centre @pmresearch-uhn.bsky.social · 08/07/2026

Check out our new clinical trial called SHERLOCK that investigates how liquid biopsy can be used to detect cancer recurrence, and seeks to figure out how to use this emerging technology in routine patient care. www.cbc.ca/news/health/...

021

Princess Margaret Cancer Centre @pmresearch-uhn.bsky.social · 29/06/2026

New hope for anaplastic thyroid cancer, one of the most aggressive and lethal cancers: our study with @lhsccanada.bsky.social shows combining naporafenib and trametinib effectively shuts down cancer growth in lab models, better than standard therapies: doi.org/10.1016/j.xc... @uhnresearch.ca @uhn.ca

020

Reposted by Princess Margaret Cancer Centre

Research at UHN @uhnresearch.ca · 26/06/2026

1/ New findings from @pmresearch-uhn.bsky.social reveal how DNA sequences called transposable elements can help leukemia stem cells survive treatment and drive relapse, paving the way for new therapeutic strategies. 🔗 Read more: www.uhnresearch.ca/news/6-26-20...

121

Princess Margaret Cancer Centre @pmresearch-uhn.bsky.social · 25/06/2026

Our researchers developed an artificial intelligence (AI)-based biomarker, called ENLIGHT, that shows promise in predicting immunotherapy benefits across many different cancer types. doi.org/10.1038/s416...; www.marathonofhopecancercentres.ca/impact/news-...

010

Princess Margaret Cancer Centre @pmresearch-uhn.bsky.social · 24/06/2026

Congratulations to Dr. @bhaibeka.bsky.social on receiving the 2026 inaugural Francis Ouellette Community Award! 🎉 Recognized for his leadership in open science, community building & advancing inclusive, bias-aware AI in computational biology. @uhnresearch.ca @uhn.ca www.linkedin.com/posts/canadi...

042

Reposted by Princess Margaret Cancer Centre

Research at UHN @uhnresearch.ca · 24/06/2026

AI is transforming health care—but how do we ensure it’s safe, fair, and trustworthy? The Cancer Digital Intelligence team from @pmresearch-uhn.bsky.social has developed AFFRM-AI, a practical framework for responsible #AI in clinical care. 🔗 Read more: www.uhnresearch.ca/news/6-23-20...

122

Princess Margaret Cancer Centre @pmresearch-uhn.bsky.social · 23/06/2026

Congratulations to our Medical Oncologist & Clinician Investigator Dr. Natasha Leighl on receiving the 2026 Gandara Clinical Research Award from International Society of Liquid Biopsy! This award recognizes outstanding contributions to liquid biopsy research and clinical impact.

020

Princess Margaret Cancer Centre @pmresearch-uhn.bsky.social · 22/06/2026

Our study shows porphrin-lipid nanoparticles can spot tiny, hidden cancer in the neck more accurately in preclinical models that standard scans often miss, potentially improving how surgeons plan treatment for oral cancer patients. @uhn.ca @uhnresearch.ca www.thno.org/v16p7108.htm

070

Princess Margaret Cancer Centre @pmresearch-uhn.bsky.social · 19/06/2026

Our new study found that a ctDNA blood test could help identify which patients with early-stage lung cancer (stage I non-small cell lung cancer, NSCLC) are at higher risk of their cancer returning after surgery. doi.org/10.1016/j.jt... @uhnresearch.ca @uhn.ca

020

Princess Margaret Cancer Centre @pmresearch-uhn.bsky.social · 18/06/2026

Our new study shows that a methylation-based blood test measuring tumour DNA can accurately monitor treatment response & detect signs of treatment failure a median of six months before clinical progression in metastatic breast cancer patients. www.nature.com/articles/s41... @uhn.ca @uhnresearch.ca

021

Reposted by Princess Margaret Cancer Centre

Terry Fox Research Institute (TFRI) @terryfoxresearch.bsky.social · 16/06/2026

Terry Fox-funded researchers have identified blood stem cells that can remember inflammation long after an infection is gone. Stress from inflammation may alter cells behaviour, drive blood cell aging and raise cancer risk. Learn more about this bold Terry Fox-funded research: tinyurl.com/yxwmx88f

192

Princess Margaret Cancer Centre @pmresearch-uhn.bsky.social · 04/06/2026

Our new study discovered a way to make AML cancer cells behave more normal-like: they differentiate, lose stemness, and become easier to be detected and killed by immune cells—by changing RNA degradation in cancer cell mitochondria. www.nature.com/articles/s41... @uhnresearch.ca @uhn.ca

040

Princess Margaret Cancer Centre @pmresearch-uhn.bsky.social · 01/06/2026

A new study by @uhn.ca Princess Margaret Cancer Centre and University of Oxford identified a subset of blood stem cells that are shaped by past inflammatory events. These cells can accumulate with age and are linked to mutations with a higher risk of leukemia. www.nature.com/articles/s41...

182

Princess Margaret Cancer Centre @pmresearch-uhn.bsky.social · 29/05/2026

“People often come out of cancer with a very different lens. They think more about how they want to spend their time and who they want to spend it with,” says Dr. Jennifer Jones. Jennifer's research is reshaping life after cancer: www.uhnresearch.ca/news/5-29-20... www.youtube.com/watch?v=98Y4...

youtube.com

Meet Dr. Jennifer Jones: Reshaping Life after Cancer

YouTube video by UHN Research

030

Reposted by Princess Margaret Cancer Centre

Research at UHN @uhnresearch.ca · 27/05/2026

🚨 #NewPublication alert! A new @nature.com study from scientists at @pmresearch-uhn.bsky.social and @ox.ac.uk has discovered that human blood-forming stem cells can “remember” past inflammation—memory that may influence health and disease outcomes. 🔗 Read more: www.uhnresearch.ca/news/5-27-20...

134

Princess Margaret Cancer Centre @pmresearch-uhn.bsky.social · 25/05/2026

This month, the 15th Annual Princess Margaret Cancer Centre Research Retreat took place to build collaborations among scientists and clinicians, and to accelerate discoveries that will address patient needs. Congratulations to all our 2026 research award winners! www.linkedin.com/feed/update/...

021