Nuclear pore complexes are the only gateway between the nucleus and cytoplasm in eukaryotic cells during interphase. Specificity of transport is ensured by a size-dependent permeability barrier, which...

How intrinsically disordered regions (IDRs) shape chromatin binding and nuclear organization of transcription factors (TFs) remains unclear. We used proximity-assisted photoactivation (PAPA), a single...

HIV-1 capsid nuclear import at the nuclear pore complex is a bottleneck to resting T cell infection, but HIV-1 overcomes this by triggering receptor-mediated signalling during cell–cell spread to driv...

The Institute of Human Genetics invites applications for a Principal Investigator position in its main research areas. Read more...

Université de Montpellier, CNRS, UMR9002. This protocol describes how to efficiently set up and perform automated analyses of live cell imaging data obtained from tracking the nucleocytoplasmic trans...

McCreery, Stubb et al. show that mechano-osmotic changes in the nucleus induce general transcriptional repression and prime chromatin for cell fate transitions by relieving repression of specific differentiation genes.

Genome function requires regulated genome motion. However, tools to directly observe this motion in vivo have been limited in coverage and resolution. Here we introduce an approach to tile mammalian c...

The Max Planck Institute for Molecular Biomedicine in Münster, Germany, has an opening for a

The nuclear lamins are extremely long-lived proteins in most cell types. As a consequence, lamin function cannot be effectively dissected with temporal precision using standard knock-down approaches. ...

The nuclear pore complex (NPC), composed of proteins termed nucleoporins (Nups), intercalates the nu

Discovery of a molecular glue promoting TRIM21 and NUP98 interaction enables the rational design of TRIM21-based PROTAC degraders for the selective elimination of multimeric proteins.

All cells must fold their chromosomes. The combined action of a small set of conserved molecular and biophysical mechanisms fold chromosomes in a variety of ways across the cell cycle and tree of life...