Local fibroblast development and densities influence organ health and disease, although it remains unclear how tissue fibroblast topography is controlled in situ. Here, we defined Group 2 innate lymph...

Local fibroblast development and densities influence organ health and disease, although it remains unclear how tissue fibroblast topography is controlled in situ. Here, we defined Group 2 innate lymph...

OverviewLymph node (LN) metastasis is a hallmark of disease progression in most solid tumors and remains one of the most consistent predictors of poor prognosis and reduced overall survival. In partic...

Join us at the Keystone Symposia on Stromal Immunology in Health and Disease, February 2026, in Banff, with field leaders!

Secondary lymphoid tissues develop specialized reticular networks to facilitate immune cell communication and efficient activation of adaptive immunity. This stromal network architecture is robust, ma...

Makris et al. show that podoplanin regulates the transcription profile of lymph node fibroblasts. Podoplanin deletion drives inflammation, disrupts lymph node architecture, and attenuates stromal/immu...

Makris et al. show that podoplanin regulates the transcription profile of lymph node fibroblasts. Podoplanin deletion drives inflammation, disrupts lymph node architecture, and attenuates stromal/immu...

Join one of our online open day sessions to find out more about UCL's Computational Cell Biophysics MRes.

A preprint by Makris et al. shows that podoplanin is a key regulator of the functions of fibroblastic reticular cells in lymph nodes, by modulating interactions with immune cells.

Lymph nodes are uniquely organised niches for immune interactions. Fibroblastic reticular cells (FRCs) facilitate immune cell communication and regulate immune function by producing growth factors, ch...

Registration for the 2024 UK Membrane Trafficking Meeting, held at KCL.  Registration per person, to include sandwich lunch and coffee breaks and even

The Lung Cancer Centre of Excellence will continue its groundbreaking research with up to £4m of funding support from ScottishPower.

UCL is consistently ranked as one of the top ten universities in the world (QS World University Rankings 2010-2022) and is No.2 in the UK for research power (Research Excellence Framework 2021).

UCL is consistently ranked as one of the top ten universities in the world (QS World University Rankings 2010-2022) and is No.2 in the UK for research power (Research Excellence Framework 2021).

At the forefront of interdisciplinary research

Bock and colleagues perform integrative analysis of JAK-STAT mutant mice and find JAK-STAT signaling regulates CD8+ T cell and macrophage homeostasis by contributing to a poised epigenetic and transcr...