Cyclin-dependent kinases (CDK) dynamically regulate RNA Polymerase (Pol) II during each stage of transcription. Phosphorylation of RNA Pol II and associated transcription factors by CDKs enables stage...

The nucleotide addition cycle (NAC) of multisubunit DNA-dependent RNA polymerases (RNAPs) involves coordinated conformational changes in conserved ...

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Thank you for your interest in our seminar series! We use a variety of different session formats but, in general, trainees can plan for a ~15 min talk + 5min Q/A and PIs can plan for a ~25min talk +...

Froom et al. address a central challenge in gene regulation: untangling direct effects from indirect cellular network effects. They introduce cell-free genomics, a genome-scale biochemical approach that isolates direct transcription mechanisms. Applied to Mycobacterium tuberculosis, it reveals fundamental principles of transcription initiation and termination with broad relevance.

New research has helped to explain how DNA is shaped into loops, a process critical for ensuring chromosomes are properly distributed...