Daan Noordermeer lab @daannoordermeerlab.bsky.social · 01/07/2026But most of all, I remember his kindness, humor (sometimes sharp) and generosity. 020
Daan Noordermeer lab @daannoordermeerlab.bsky.social · 01/07/2026It’s with great sadness that I hear about the passing of Frank Grosveld. I did my PhD in the dpt he was directing. His scientific vision, involvement in all projects and capacity to create a vibrant international community were truly inspiring and one of the reasons why I am where I’m now (1/2) 071
Reposted by Daan Noordermeer labAydan Bulut-Karslioglu @bulutkarslioglu.bsky.social · 26/06/2026I have been thinking since yesterday about why I find the 1% thing so, so disturbing. It's a visceral reaction of 'just no', which goes beyond the general yuck towards the enshittification of/via AI. I have finally put my finger on it: it is the feeling you get when 610931
Reposted by Daan Noordermeer labMaxim Greenberg @maxvcg.bsky.social · 15/06/2026🚨Preprint Drop🚨 We are very pleased to release our study on DNA methylation dynamics at enhancers during ESC differentiation! This work was led by Marlet Morales-Franco and Priscillia Lhoumaud 🧵(1/13) www.biorxiv.org/content/10.6...biorxiv.orgDual profiling of DNA modifications with enhancer features during the exit of naive pluripotencyCis-regulatory elements, such as enhancers, play an essential role in coordinating gene expression programs during cellular transitions. As such, substantial efforts have been made to characterize enh... 411238
Reposted by Daan Noordermeer labMarieke Oudelaar @mariekeoudelaar.bsky.social · 26/05/2026📣 Preprint alert! We developed a method to analyze concurrent interactions between multiple chromatin regions at single alleles at sub-nucleosome resolution (multi-way Micro-Capture-C, mwMCC) & used this to study structural synergy within super-enhancers. 1/14 www.biorxiv.org/content/10.6... 17332
Reposted by Daan Noordermeer labMC Gambetta @mcgambetta.bsky.social · 04/05/2026Hello all, our lab is recruiting a PhD candidate to study how 3D genome folding impacts gene regulation in development. We're located at the Center for Integrative Genomics department of the University of Lausanne, Switzerland. Please email me if interested. #PhDPosition, #PhDOpportunity 05844
Reposted by Daan Noordermeer labIGMM-Montpellier @igmm-montpel.bsky.social · 17/04/2026🔬IGMM (CNRS/ Univ Montpellier) is hiring Group Leaders in Innovative Biology. @cnrsbiologie.bsky.social @cnrs.fr @umontpellier.bsky.social 📅 1 May–15 June 2026 📩 search2026@igmm.cnrs.fr 📎Full information 👇 #LifeScience #MolecularBiology #Research #PI #CNRS 12428
Reposted by Daan Noordermeer labKasia Siudeja @ksiudeja.bsky.social · 08/04/2026📣📣 Deadline approaching 📣📣 (Please re-post) If you are thinking of starting (or moving) your lab, do not miss the opportunity to apply to join us at the @i2bcparissaclay.bsky.social Diversity of topics, interdisciplinary environment and excellent platform support! Recommended! 0912
Reposted by Daan Noordermeer labPeter Andersen @germline.bsky.social · 01/04/2026Germ cells have their own versions of core transcription factors and fertility depends on them. We're hiring a PhD student to figure out how! 📢 Fly genetics + proteomics + genomics. Fully funded. Aarhus University 🇩🇰 Deadline May 1 👇 Please share with anyone who might be interested!phd.nat.au.dk 03442
Reposted by Daan Noordermeer labAurele Piazza @aurelepiazza.bsky.social · 23/03/2026Delighted to see our work now published at the EMBO Journal! Check also this concomitant paper by the Bai and Mirny labs with an orthogonal approach that aligns well with our measurements www.nature.com/articles/s41... Great system to study how SMCs facilitate/regulate target search in chromatin!nature.comCondensin accelerates long-range intra-chromosomal interactions - Nature CommunicationsLong‑range chromosome encounters in cells are hard to quantify. Here, the authors induce artificial contacts in yeast and show that intra‑chromosomal interactions form faster than inter‑chromosomal on... 12715
Reposted by Daan Noordermeer labCharlène Boumendil (She/Her) @charleneboumendil.bsky.social · 20/03/2026We are looking for a new group leader to join the IGH (Montpellier, France). I can’t wait to meet my future colleague! Apply :-) More infos here: igh.cnrs.fr/join-igh-as-...igh.cnrs.frJoin IGH as Group Leader - IGHThe Institute of Human Genetics invites applications for a Principal Investigator position in its main research areas. Read more... 05262
Reposted by Daan Noordermeer labNetherlands Cancer Institute @nkinl.bsky.social · 20/02/2026We;re hiring Junior Group Leaders! 🔬✨ We’re looking for researchers in immunology, chemical biology, AI in biology, or protein design to launch their own independent groups in our collaborative, international environment. www.nki.nl/news-events/... 01829
Reposted by Daan Noordermeer labi2bcparissaclay.bsky.social @i2bcparissaclay.bsky.social · 17/03/2026We are looking for outstanding scientists to develop ambitious research programs in molecular and cellular biology, with special interest in multidisciplinary projects and computational biology.More info: www.i2bc.paris-saclay.fr #MolecularBiology #CellBiology #ComputationalBiology #TeamLeaders#I2BC 02034
Reposted by Daan Noordermeer labRob Klose @robklose.bsky.social · 13/03/2026We are excited to be recruiting into 3 Associate Professorship's in @oxfordbiochemistry.bsky.social. Come join us as a colleague and benefit from our vibrant and multidisciplinary environment. Reach out to me if you have any questions. Please repost! (tinyurl.com/48deybuu) (tinyurl.com/4pdvjaft). 1106125
Daan Noordermeer lab @daannoordermeerlab.bsky.social · 13/03/2026🚨🚨🚨 My institute, the @i2bcparissaclay.bsky.social in beautiful Gif-sur-Yvette and part of @univparissaclay.bsky.social, is recruiting group leaders! Announcement here: www.i2bc.paris-saclay.fr/join-i2bc/te... Open to early career scientist from anywhere or mid-career already in France. Please RB! 11216
Reposted by Daan Noordermeer labYarui Diao @yaruidiao.bsky.social · 20/02/2026Happy to share scHiCAR, an ultra-high throughout (millions of cells), low cost (5 cents/cell including NGS), and trimodal platform for integrated single-cell level analysis of mRNA, open chromatin, and 5-kb resolution looping with ground-truth data the same individual cell. 08133
Reposted by Daan Noordermeer labSeychelle Vos @voslab.org · 09/02/2026🧪🧬New preprint We present cryo-EM structures of reconstituted CTCF–nucleosome complexes, showing CTCF dimerization drives nucleosome oligomerization into defined higher-order assemblies. Disrupting CTCF–CTCF interfaces in mESCs reduces looping and impairs differentiation. tinyurl.com/CTCF-nucleos... 412553
Reposted by Daan Noordermeer labLucas Farnung @lucas.farnunglab.com · 09/02/2026🚨Preprint alert🚨 How does chromatin “architecture” form at CTCF sites? Our new preprint with @voslab.org and @andersshansen.bsky.social shows CTCF dimerization promotes nucleosome oligomerization on chromatin. tinyurl.com/CTCF-nucleos... 06918
Reposted by Daan Noordermeer labThe EMBO Journal @embojournal.org · 03/02/2026How do compartmentalization & loop extrusion organize eukaryotic genomes beyond classical model organisms? Hi-C analysis of silkworm chromosomes by Drinnenberg, Muller, Mirny et al reveals new combination of these mechanisms, and a new, secluded “S” compartment link.springer.com/article/10.1...link.springer.comUnique territorial and compartmental organization of chromosomes in the holocentric silkworm - The EMBO JournalHallmarks of multicellular eukaryotic genome organization are chromosome territories, compartments, and loop-extrusion-mediated structures, including TADs. However, these have mainly been observed in ... 03825
Reposted by Daan Noordermeer labIGMM-Montpellier @igmm-montpel.bsky.social · 22/01/2026New paper from the Feil lab! congratulations🍾👏 Great thread below ⤵️ @agencerecherche.bsky.social @frm-officiel.bsky.social Thank you for your support @cnrs.fr @cnrsbiologie.bsky.social @cnrsoccitanieest.bsky.social @umontpellier.bsky.social @biolum-montpellier.bsky.social #epigenetics 053
Daan Noordermeer lab @daannoordermeerlab.bsky.social · 21/01/2026🔔 New paper alert 🔔 www.nature.com/articles/s41... Some regions in the genome replicate early and some late, but the why and how remain poorly understood. DNA replication and 3D genome organization appear linked, raising the question if one may regulate the other? (1/n)nature.comDNA methylation and lncRNA control asynchronous DNA replication at specific imprinted gene domains - Nature CommunicationsIt is not fully understood why genomic loci show asynchronous DNA replication. Here, the authors show that two imprinted gene domains replicate asynchronously between the parental chromosomes due to d... 33115
Reposted by Daan Noordermeer labAnne Lopes @anne-lopes.bsky.social · 11/01/2026Fresh news on de novo genes! Happy to present our latest work published in Nature communications: www.nature.com/articles/s41... Keywords not in specific order: intergenic ORFs, de novo genes, GC content, foldability, genetic code, ancestral sequence reconstruction and more :) 24824
Reposted by Daan Noordermeer labFena Ochs @fenaochs.bsky.social · 02/01/2026We are looking for a Postdoc at the Center for Gene Expression in Copenhagen. Deadline for applications is the 11th of January. If you are interested in 3D chromatin, SMC complexes, and super-resolution microscopy, join us. www.nature.com/naturecareer...nature.comPostdocs at Center for Gene Expression in Department of Cellular and Molecular Medicine - Copenhagen, Hovedstaden (DK) job with University of Copenhagen | 12849488We are looking for 2 or more highly motivated postdocs interested in ribosome biology, 3D chromatin organisation, or regulation of protein turnove... 02225
Reposted by Daan Noordermeer labJoshua G. Schraiber @jgschraiber.bsky.social · 25/12/2025This story is absolutely wild. Did you know that avocados change sex over the course of a day? And that it's controlled by a single ancient balanced polymorphism? This is flat our crazy 521377
Reposted by Daan Noordermeer labStandplaats Kraków could really use some cash! @standplaatskrk.pl · 01/12/2025 1945286
Reposted by Daan Noordermeer labElphege Nora Lab at UCSF @elphegenoralab.bsky.social · 27/11/2025Here is a copy of last year's Twitter thread explaining our preprint - jump to (21) for the new stuff 👀 Synergy between cis-regulatory elements can render cohesin dispensable for distal enhancer function now revised and journal accepted at www.science.org/doi/10.1126/... 🧵👇 49045
Daan Noordermeer lab @daannoordermeerlab.bsky.social · 14/11/2025It’s been an immense pleasure to present and discuss our work on genome organization and genomic imprinting with the Canadian community at the CEEHRC Epigenetics meeting #CanEpi25 in beautiful Banff. Immensely grateful to the trainee committee for their kind invitation 0141
Reposted by Daan Noordermeer labMax Perutz Labs Vienna @maxperutzlabs.ac.at · 05/11/2025📢 Open Call! The Max Perutz Labs invite applications for a Tenure-Track Professorship in Genome Biology. We are particularly interested in researchers investigating the molecular and biophysical mechanisms underlying genome function and regulation. More details ➡️ tinyurl.com/3t7vvdct 03135
Reposted by Daan Noordermeer labOlivier Namy 🧬🧪 @onamy.bsky.social · 06/11/2025I am very proud to announce that our team has received an ERC synergy grant from @erc.europa.eu. A wonderful recognition of a truly collaborative effort with friends (Julius Lukes, Leos Valasek and Mark Osborn). Excited to begin this journey at @i2bcparissaclay.bsky.social @cnrs.fr 7265
Reposted by Daan Noordermeer labJames Davies @jojdavies.bsky.social · 05/11/2025Our latest paper has just been published in Cell! doi.org/10.1016/j.ce... We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size. 621079
Reposted by Daan Noordermeer labValter Tucci @valtertucci.bsky.social · 27/10/2025We’re pleased to share our new bioRxiv preprint: “The Pre-clinical Animal Network (PCAN)...t” www.biorxiv.org/content/10.1... #PraderWilliSyndrome #MouseGenetics #Phenotyping #FPWR #TranslationalResearch #OpenScience #DigitalTwin #IMPC #INFRAFRONTIER #MRC #RareDiseaselnkd.inLinkedInThis link will take you to a page that’s not on LinkedIn 021
Reposted by Daan Noordermeer labElzo de Wit lab @ NKI @dewitlab.bsky.social · 16/10/2025The TArgeted Cohesin Loader (TACL) paper was just published. Happy that we were able to contribute to this really exciting project! If you want to learn how targeting cohesin to defined loci in the genome affects the local chromatin environment and transcription, look no further! rdcu.be/eLiT5rdcu.beCharacterization of induced cohesin loop extrusion trajectories in living cellsNature Genetics - This study introduces a system called TArgeted Cohesin Loader (TACL) that recruits cohesin complexes at defined genomic regions and induces loop extrusion events in living cells,... 05821
Reposted by Daan Noordermeer labDaniel Ibrahim @danielibrahim.bsky.social · 16/10/2025What is a promoter? And how does it work? We very happy to share our latest work trying to understand enhancer-promoter compatibility. I am very excited about the results of @blanka-majchrzycka.bsky.social, which changed the way I think about promoters www.biorxiv.org/content/10.1...biorxiv.orgEnhancer-promoter compatibility is mediated by the promoter-proximal regionGene promoters induce transcription in response to distal enhancers. How enhancers specifically activate their target promoter while bypassing other promoters remains unclear. Here, we find that the p... 217374
Reposted by Daan Noordermeer labDr. Sedona Murphy @sedonamurphy.bsky.social · 08/10/2025If you’re interested in exploring the relationship between chromatin organization and epigenetic memory using chromatin tracing microscopy, my group is recruiting a talented PhD student 🥳 02821
Reposted by Daan Noordermeer labDr Kathleen Millen @neurodevkathy.bsky.social · 20/09/2025🚨🚨🚨🧪 H1B scientists who are traveling outside the USA. Please be aware that current advice is to return to the USA IMMEDIATELY 0810
Reposted by Daan Noordermeer labmathiaseder.bsky.social @mathiaseder.bsky.social · 19/09/2025✨Exciting news: the main story of my PhD is out in Science! Together with Christine Moene @cmoene.bsky.social, we explored what happens when you scramble the genome—revealing how Sox2’s position shapes enhancer activation. 📖 Read the full story here: www.science.org/doi/10.1126/...science.orgFunctional maps of a genomic locus reveal confinement of an enhancer by its target geneGenes are often activated by enhancers located at large genomic distances, and the importance of this positioning is poorly understood. By relocating promoter-reporter constructs into thousands of alt... 39637
Reposted by Daan Noordermeer labStacey Ogden 🦔 @labogden.bsky.social · 18/09/2025Trainees: Struggling to find the best figure arrangement for a manuscript draft? Do the 🧪 equivalent of an arts and crafts project: 1. Print draft figures and cut each panel into its own square. 2. Find a big table. 3. Move the panels around until you see the story. This is your paper. 🤓 3172
Reposted by Daan Noordermeer labGurdon Institute, University of Cambridge @gurdoninstitute.bsky.social · 18/09/2025Thrilled to share that our Group Leader Prof. Azim Surani, together with Prof. Davor Solter, has been awarded the 2026 Paul Ehrlich & Ludwig Darmstaedter Prize 🎉 for discovering genomic imprinting—a breakthrough that reshaped genetics and launched modern epigenetics. 03713
Reposted by Daan Noordermeer labJop Kind @jopkind.bsky.social · 17/09/20251/ 🧵 I am excited to share a new preprint from our group: Single-cell Dam&T-seq during mouse corticogenesis reveals how genome–lamina interactions regulate long neuronal genes. doi.org/10.1101/2025... #Neurodevelopment #Epigenetics @hubrechtinstitute.bsky.social @oncodeinstitute.bsky.socialdoi.orgMeCP2 binding and genome–lamina reorganization precede long gene activation during mouse corticogenesisDuring corticogenesis, neural gene expression is tightly coordinated by chromatin and epigenetic changes, whose misregulation can lead to neurodevelopmental disorders[1][1]–[4][2]. The role of spatial... 24015
Reposted by Daan Noordermeer labMaxim Greenberg @maxvcg.bsky.social · 15/09/2025Very excited to share an excellent review from @teresa-urli.bsky.social, published one week before her PhD defense! We did a deep dive into the fascinating biology of the variant Polycomb complex, PRC1.6 (1/5) journals.plos.org/plosgenetics...journals.plos.orgEpigenetic relay: Polycomb-directed DNA methylation in mammalian developmentIn mammals, repression of germline-specific gene expression is essential for preserving somatic cell identity and preventing disease. Germline gene silencing is often dependent on the presence of prom... 39135
Daan Noordermeer lab @daannoordermeerlab.bsky.social · 13/09/2025🚨 Happy to see this collaborative work out in @embojournal.org. How is spindle pole detachment at mitotic exit regulated and what happens to nuclear & chromosome organization when it goes wrong? Hint: chromosomes look like kidney beans! 🌮🌯 Tour-de-force by @spindlebehavior.bsky.social and team! 1175
Reposted by Daan Noordermeer labFMI science @fmiscience.bsky.social · 08/09/2025🚨 We're hiring, please share! The FMI seeks a tenure-track Group Leader (Assistant Prof) in Structural Biology 🔬 Innovative scientists in genome regulation, RNA metabolism, or protein homeostasis—especially using cutting-edge approaches—apply now at www.fmi.ch/education-ca... 06166
Reposted by Daan Noordermeer labArnau Sebé-Pedrós @arnausebe.bsky.social · 15/07/2025We are looking for a student to continue our work on chromatin evolution: www.nature.com/articles/s41... www.biorxiv.org/content/10.1... The project with @seanamontgomery.bsky.social will focus on chromatin state readers across eukaryotes. More info: recruitment.crg.eu/content/jobs... 02838
Reposted by Daan Noordermeer labDr. Lucky Tran @luckytran.com · 04/09/2025The “problem” with vaccines? They so effective at preventing deaths that they create generations of people that question whether disease was a problem in the first place because they have never experienced the horrors of a world without vaccines. 570265507762
Reposted by Daan Noordermeer labEva Estébanez-Perpiñá, Ph.D. @estebanezlab.bsky.social · 16/05/2025🎯 We are so thrilled our new paper @narjournal.bsky.social is out! Fantastic collab with the labs of Gordon Hager NIH & Franck Dequiedt. Heaviest lifting from Greg Fettweiss, Kaustub Wagh, Diana Stavreva & Alba Jiménez-Panizo. Big thanks to Andrea Alegre-Marti JdC 🥳✨️ academic.oup.com/nar/article/... 2198
Reposted by Daan Noordermeer labArnaud Krebs @arnaudkr.bsky.social · 18/08/2025This is not a HiC map! Ever wondered if multiple enhancers get activated simultaneously? We measured chromatin accessibility on thousands of molecules by nanopore to create genome-wide co-accessibility maps. Proud of @mathias-boulanger.bsky.social @kasitc.bsky.social Biology in the thread👇 1011334
Reposted by Daan Noordermeer labElphege Nora Lab at UCSF @elphegenoralab.bsky.social · 16/08/2025New preprint with @gfudenberg.bsky.social We find the rate of cohesin loop extrusion in cells is set by NIPBL dosage and tunes many aspects of chromosome folding. This provides a molecular basis for NIPBL haploinsufficiency in humans. 🧵👇 www.biorxiv.org/content/10.1...biorxiv.orgNIPBL dosage shapes genome folding by tuning the rate of cohesin loop extrusionCohesin loop extrusion is a major driver of chromosome folding, but how its dynamics are controlled to shape the genome remains elusive. Here we disentangle the contributions of the cohesin cofactors ... 111854
Reposted by Daan Noordermeer labEpigenome Technologies @epigenometech.bsky.social · 04/08/2025Epigenetics Update - The molecular basis of lamin-specific chromatin interactions go.nature.com/3GRXydB Chiara Lanzuolo (INGM) and Ohad Medalia (University of Zurich) reporting in NSMB #Epigenetics #Chromatin #Lamin --- Gain deeper insights into gene regulation; epigenometech.comgo.nature.comThe molecular basis of lamin-specific chromatin interactions - Nature Structural & Molecular BiologyWang, Kronenberg-Tenga, Rosti and colleagues use several structural approaches to analyze the distribution of nucleosomes at the lamin–chromatin interface, test the impact of lamins on nucleosome dens... 0114