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Reposted by Yuri Pritykin

bioRxiv Immunology @biorxiv-immuno.bsky.social · 16/09/2026

Dendritic cell PD-L2 restrains intratumoral CD8+ T cell immunity www.biorxiv.org/content/10.64898/20…

Reposted by Yuri Pritykin

Yuri Pritykin @yuripritykin.bsky.social · 02/06/2026

Excited to share our new paper at Cell Reports @cp-cellreports.bsky.social led by fantastic Gabe Dolsten! We characterized multi-megabase and interchromosomal chromatin interactions in primary T cells, revealing a previously underappreciated layer of genome organization: doi.org/10.1016/j.ce...

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uncited @uncited.org · 21/06/2026

Wang et al. in @yuripritykin.bsky.social's lab at Princeton University present Domino, a deep learning framework that maps genomic sequences to insulation scores, revealing a comprehensive insulation grammar defined by 24 motifs that account for 59% of Drosophila chromatin boundaries.

biorxiv.org

bioRxiv (Genomics)

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Reposted by Yuri Pritykin

bioRxiv Genomics @biorxiv-genomic.bsky.social · 20/06/2026

Sequence-to-function modeling uncovers the context-specific grammar of Drosophila chromatin insulation www.biorxiv.org/content/10.64898/20…

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Yuri Pritykin @yuripritykin.bsky.social · 02/06/2026

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Yuri Pritykin @yuripritykin.bsky.social · 18/02/2026

Happy to present Gloss, our new computational method for the analysis of multi-modal LIPSTIC + scRNA-seq data coupling cell-cell interaction measurements with intracellular transcriptomes. Paper: doi.org/10.1016/j.cr... Led by an amazing PhD student Tamjeed Azad, with @victora.bsky.social

doi.org

Redirecting

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Reposted by Yuri Pritykin

bioRxiv Genomics @biorxiv-genomic.bsky.social · 15/01/2026

Benchmarking cell type deconvolution in spatial transcriptomics and application to cancer immunotherapy www.biorxiv.org/content/10.64898/20…

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Yuri Pritykin @yuripritykin.bsky.social · 24/12/2025

Thrilled to announce a new PhD from the lab, Dr. Sarah Walker! A well-deserved congratulations on a successful defense last week! The amazing work speaks for itself: doi.org/10.1101/2025... doi.org/10.1038/s415... doi.org/10.1038/s415... and more coming soon Excited to follow her future success!

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Yuri Pritykin @yuripritykin.bsky.social · 12/11/2025

Huge congrats to Gabe Dolsten on a fantastic PhD defense last week!!! The 1st PhD from the lab! So proud of his many research achievements e.g.: doi.org/10.1038/s415... doi.org/10.1101/2025... doi.org/10.1016/j.xg... He's bound to do amazing things ahead!

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Yuri Pritykin @yuripritykin.bsky.social · 18/10/2025

Happy to present today at AAI Introduction to Computational Immunology Course today at UPenn

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Reposted by Yuri Pritykin

Waggoner Lab @labwaggoner.bsky.social · 08/10/2025

Temporal and context-dependent requirements for the transcription factor Foxp3 expression in regulatory T cells @natimmunol.nature.com @yuripritykin.bsky.social Rudensky @princetonupress.bsky.social @mskcancercenter.bsky.social www.nature.com/articles/s41...

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Yuri Pritykin @yuripritykin.bsky.social · 08/10/2025

Our paper is out today at @natimmunol.nature.com! Very timely! We performed extensive exploration of Foxp3 in Treg cells, using inducible protein degradation in vivo. Wonderful collaboration led by Sasha Rudensky and Wei Hu, computation led by talented Gabe Dolsten. Read it here: rdcu.be/eJ0hH

nature.com

Temporal and context-dependent requirements for the transcription factor Foxp3 expression in regulatory T cells - Nature Immunology

Rudensky and colleagues demonstrate a context-dependent differential requirement for Foxp3 for Treg cell transcriptional and functional programs.

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Yuri Pritykin @yuripritykin.bsky.social · 07/10/2025

Extremely happy about the Nobel prize recognizing regulatory T cells! A fascinating concept with so many potential clinical applications. Very lucky to have been working on the genomics of Treg cells in collaboration with the giant in the field, Sasha Rudensky @mskcc.bsky.social !

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Reposted by Yuri Pritykin

bioRxiv Genomics @biorxiv-genomic.bsky.social · 21/09/2025

Metadomain and metaloop genome interactions in mammalian T cells www.biorxiv.org/content/10.1101/202…

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Reposted by Yuri Pritykin

bioRxiv Genomics @biorxiv-genomic.bsky.social · 17/09/2025

ArchVelo: Archetypal Velocity Modeling for Single-cell Multi-omic Trajectories www.biorxiv.org/content/10.1101/202…

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Yuri Pritykin @yuripritykin.bsky.social · 16/09/2025

Happy to share our new paper! We present high-resolution Micro-C maps across Drosophila embryogenesis, integrated with 149 ChIP-seq datasets. This systematic analysis enabled clustering of loops & boundaries into 4 distinct classes with distinct regulatory roles. www.cell.com/cell-genomic...

cell.com

3D chromatin structures precede genome activation in Drosophila embryogenesis

Dolsten et al. map the 3D chromatin architecture across early Drosophila development using high-resolution Micro-C, and, by integrative analysis with 149 public ChIP-seq datasets, identify four classe...

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Reposted by Yuri Pritykin

bioRxiv Immunology @biorxiv-immuno.bsky.social · 14/09/2025

Single-cell multiomics reveals archetypal regulatory programs shared across CD4 and CD8 T cell subsets in viral infection www.biorxiv.org/content/10.1101/202…

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Yuri Pritykin @yuripritykin.bsky.social · 23/07/2025

Comp bio postdoc positions available! Come work with us at Princeton University on computational method development and applications in regulatory genomics, genome editing, immunology and cancer, in mouse and human: pritykinlab.github.io#jobs Please share among all those who may be interested!

pritykinlab.github.io

Pritykin Lab

Pritykin Lab at the Lewis-Sigler Institute for Integrative Genomics and the Department of Computer Science at Princeton University.

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Reposted by Yuri Pritykin

Ferhat Ay @ferhatay.bsky.social · 21/07/2025

After a long trip and a long sleep, i am ready to enjoy the rich scientific program at #ISMBECCB2025 in Liverpool. This is also the first year of our new COSI in Computational and System Immunology (CSI) happening on Tuesday. And of course looking forward RegSys, as usual with fantastic organizers

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Reposted by Yuri Pritykin

Ferhat Ay @ferhatay.bsky.social · 21/07/2025

For CSI COSI, I am very thankful to my co-chair Jishnu Das and steering committee @yuripritykin.bsky.social, Hatice Ulku Osmanbeyoglu, Aly Azeem Khan. And everyone who submitted their for consideration for this session www.iscb.org/ismbeccb2025...

iscb.org

CSI: Computational Systems Immunology

ISCB - International Society for Computational Biology

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Reposted by Yuri Pritykin

Yuri Pritykin @yuripritykin.bsky.social · 08/07/2025

A belated announcement about our GuideScan2 paper finally out in Genome Biology: doi.org/10.1186/s130... GuideScan2 is a new flexible and efficient CRISPR gRNA design and analysis tool with command line and web interfaces. Please let us know what you think!

doi.org

Genome-wide CRISPR guide RNA design and specificity analysis with GuideScan2 - Genome Biology

We present GuideScan2 for memory-efficient, parallelizable construction of high-specificity CRISPR guide RNA (gRNA) databases and user-friendly design and analysis of individual gRNAs and gRNA librari...

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Yuri Pritykin @yuripritykin.bsky.social · 08/07/2025

doi.org

Genome-wide CRISPR guide RNA design and specificity analysis with GuideScan2 - Genome Biology

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Reposted by Yuri Pritykin

Stephen Turner @stephenturner.us · 28/02/2025

Genome-wide CRISPR guide RNA design and specificity analysis with GuideScan2 genomebiology.biomedcentral.com/articles/10.... 🧬🖥️🧪 CLI github.com/pritykinlab/... Web app guidescan.com

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Yuri Pritykin @yuripritykin.bsky.social · 03/12/2024

Excited to host @jianma.bsky.social today at Princeton CS and looking forward to his talk: cs.princeton.edu/events/26752 Come to CS 105 at 12:30 today if you are around!

cs.princeton.edu

Learning Multiscale Genome and Cellular Organization | Computer Science Department at Princeton University

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