iiinova — where your digital self keeps evolving

Reposted by Matthew Clark

Casper Berger @casperberger.bsky.social · 23/09/2026

We developed Adaptive Polishing for the consistent preparation of ~150 nm thin FIB-lamellae. This was done by using imaging feedback to adjust parameters for each lamella, or Adaptive Milling, rather than applying a fixed recipe. Preprint: doi.org/10.64898/202...

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Reposted by Matthew Clark

Rasmus Jensen @rasmusjensen.bsky.social · 25/09/2026

🎉 Out today in Cell: the paper I've been looking forward to sharing for a long time 🎉 We used cryo-ET to find a molecular machine nobody knew existed on the surface of a minimal bacterium, and worked out what it does. 🧵(1/7) #TeamTomo #cryoET

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simon-alkema.bsky.social @simon-alkema.bsky.social · 17/09/2026

Releasing TOMATO, the TOMogram Annotation TOol! A lightweight Python GUI for going through hundreds of cryo-ET tomograms. Flag what's in each one, grade its quality, and end up with a table you can filter and act on. github.com/alkemasimon/...

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Brady Johnston @bradyajohnston.bsky.social · 21/08/2026

I'm running a 2-day in-person Blender / #MolecularNodes workshop in London next month - if you are interested be sure to register!

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Reposted by Matthew Clark

Elliott Lab @elliottlab.bsky.social · 14/08/2026

Huge effort from the Lab into the mechanics of the mysterious #ubiquitin like protein FAT10 – taking structural snapshots of FAT10 activation by UBA6 and transfer onto UBE2Z plus really interesting insights into InsP6 regulating FAT10 conjugation pathways: www.nature.com/articles/s41...

nature.com

Structural determinants for FAT10 activation and transfer from UBA6 to E2 enzymes - Nature Communications

Cryo-EM captures FAT10 activation and transfer from UBA6 to E2 UBE2Z, revealing FAT10 monopolises UBA6. Efficient transfer requires E2 engagement of both FAT10 UBL domains, particularly UBL2, and co-o...

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Reposted by Matthew Clark

Wieczorek Lab @mike-wieczorek.bsky.social · 05/08/2026

New preprint! In collaboration with the Yogev lab (Yale), we characterized and determined structures of various gamma-tubulin complexes from C. elegans, showing how divergent worm subunits evolved to template non-canonical (11-pf) and possibly canonical (13-pf!) microtubules: tinyurl.com/2sapyx2b

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Matthew Clark @matthew-batisio.bsky.social · 29/07/2026

I have just finished the Project Hail Mary audiobook and I loved it! So I finally watched the movie. It was fun to draw my imagination of what Rocky looks like, then the movie’s interpretation. #art #drawing #painting

Watercolour paint coloured drawings of the Alien, Rocky, from the Project Hail Mary story. On the left is a blue crystalline starfish/spider with 5 legs and on the right is a 5 legged creature made of brown boulders.

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Reposted by Matthew Clark

Aafke Gros @aafkegros.bsky.social · 24/07/2026

Microscopy Nodes 3.1 is out for Blender 5.2! 🎉 This has cool new features for conditional masking, working with even larger data (regional upscaling), and data manipulation! Watch the new youtube tutorials that explain the features: www.youtube.com/playlist?lis...

A FIB-SEM plankton visualization where the top shows only the volumetric data of the chromosomes, and the bottom a normally sliced region of the cell.

A fluorescence microscopy dataset where a region has been reloaded to be much higher resolution

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Reposted by Matthew Clark

Tanmay Bharat @tbharat-lab.bsky.social · 15/07/2026

Structural basis of biofilm formation mediated by the Pseudomonas aeruginosa fibrillar adhesin CdrA led by @olivia--smith.bsky.social Collaboration with @alexbateman1.bsky.social , Andres Floto and @geiselbiofilm.bsky.social labs

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Reposted by Matthew Clark

Sophia Paul @sophia-pa.bsky.social · 08/07/2026

Excited to share my paper! 🥳 Today in #Nature we reveal an 8 MDa Hdr electron bifurcating super-assembly in class I methanogens that couples the first and last steps of hydrogenotrophic methanogenesis. A lineage-specific adaptation to anaerobic niches. www.nature.com/articles/s41...

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Reposted by Matthew Clark

Esther van Hulsen wildlife art @esthervanhulsen.bsky.social · 06/07/2026

4 down, 21 more to go Working on illustrations for a new book!These are Epidexipteryx, Jeholornis, Confuciusornis and Yi Qi. More to follow! Copic Marker and colored pencil on Fabriano paper 13.8" x 9.8" (35 x 25 cm) #paleoart #SciArt #dinosaurart #paleoillustration

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Reposted by Matthew Clark

SAHASA 🐙🪸 @sculptedreef.com · 05/07/2026

This is why the pupils of my octos are the way they are, showing them as correctly as I can in my sculptures! This pupil shape might be doing the actual work of letting them see color at all and continue to be amazing camo artists 🐙👁️

Close up of a clay octopus, showing off the odd shaped pupil.

A starry night octopus, sculpted from clay, showing the specific shape of the pupil.

A hand sculpted clay octopus showing off the shape of the eye.

A Blue ringed octopus sculpted from clay, showing off the shape of the pupil.

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Reposted by Matthew Clark

Emma Slack @mucosalimmunology.bsky.social · 01/07/2026

We are recruiting a lab manager for my group in Oxford. This is a lovely team doing great things, and you could be an important part of it! See here: www.path.ox.ac.uk/vacancy/lab-... Please spread the word!

path.ox.ac.uk

Lab Manager - Molecular Immunology - Dunn School

Laboratory Manager/Senior Scientist position in the Molecular Mucosal Immunology group at Oxford

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Reposted by Matthew Clark

Chi-Min Ho @cmholab.bsky.social · 30/06/2026

Incredibly proud of Messi Haile @mehsehret.bsky.social, a founding member of the Ho Lab, for her beautiful work uncovering the inner workings of a central piece of the malaria parasite invasion machinery: the malarial moving junction, out today in @cellpress.bsky.social! tinyurl.com/4p3md2eb 🦠❄️🔬

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Reposted by Matthew Clark

Nogales Lab @nogaleslab.bsky.social · 29/06/2026

Excited to share our new preprint with the Yildiz and Janke labs on how Ndc80 and Ska complexes cooperate on microtubules through a SKA3 tether and tubulin tail interface to stabilize attachment! Congrats to Ju and Ipsita for leading this exciting study! www.biorxiv.org/content/10.6...

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Reposted by Matthew Clark

Jon from Stated Clearly @statedclearly.bsky.social · 05/06/2026

The animation I'm working on shows how flagella work and assemble. I'm very excited!

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Reposted by Matthew Clark

Ali Twelvetrees @dozenoaks.bsky.social · 16/06/2026

Our latest review is out. We take a deep dive into the human mutations in microtubule motors that drive devastating neurodevelopmental and neurodegenerative diseases. Taking in motor protein biophysics, animal models of disease as well as patient phenotypes. onlinelibrary.wiley.com/doi/full/10....

Graphical abstract summarising the impact of defective microtubule motors on axonal transport. Kinesins (green) and dyneins (magenta) maintain balance along the length of the axon. When disease causing mutations cause either hyper or hypo activity, the loss of balance results in axon dieback.

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Reposted by Matthew Clark

Vanni Lab at UNIFR, Switzerland @labvanni.bsky.social · 15/06/2026

Beautiful cover on our Atg2-Atg18 work (with @ungermannlab.bsky.social, @arnemoeller.bsky.social and reggiori lab) by lab PhD student @yarasayed1.bsky.social. Congrats Yara! #lipidtime

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Reposted by Matthew Clark

Wieczorek Lab @mike-wieczorek.bsky.social · 14/06/2026

New preprint! In collaboration with @xujwet.bsky.social, @pedrobeltrao.bsky.social, and Akhmanova and Beekman groups, we determined the structure of the transition zone microtubule doublet in mammalian motile cilia, providing potential insights into the regulation of IFT: tinyurl.com/fssnevuc

tinyurl.com

Structure of the mammalian ciliary transition zone microtubule doublet

The ciliary transition zone gates bidirectional protein trafficking to maintain the specialized ciliary proteome using microtubule doublets as a scaffold. While ciliary axonemal doublets are well-char...

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Reposted by Matthew Clark

Teresa Thurston @thurstonlab.bsky.social · 31/05/2026

One week left to apply for two 3-year postdocs in the lab on molecular mechanisms of Burkholderia pathogenesis. Posts associated with Magdalen College. Our lab is based in the Dunn School of Pathology with amazing collaborators at Oxford and MORU magdalencareers.pinpointhq.com/postings/c90...

magdalencareers.pinpointhq.com

Calleva Centre Postdoctoral Researchers- The deadly enigma of melioidosis: Decoding the pathogenesis of Burkholderia pseudomallei.

Job Opening: Calleva Centre Postdoctoral Researchers- The deadly enigma of melioidosis: Decoding the pathogenesis of Burkholderia pseudomallei. at Magdalen College in Central Oxford.

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Reposted by Matthew Clark

Karolin Luger @nucleosomepolice.bsky.social · 18/05/2026

Out today - structure of the human HIRA histone chaperone complex bound to nucleosomes. Ever wondered how nucleosomes are assembled in the wake of transcription? It takes a 'hulk of a protein complex'. Work by the amazing Wei Tian weetian558.bsky.social. www.biorxiv.org/content/10.6... 🧵

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Reposted by Matthew Clark

Matt Higgins @parasitematt.bsky.social · 16/05/2026

Our latest study of the scavenger receptor CD163, led by Richard Zhou. This follows our previous study of how CD163 uses its remarkable molecular architecture to bind haptoglobin-haemoglobin. We now show how its flexible arms allow haemoglobin binding, revealing how ligand promiscuity works.

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Reposted by Matthew Clark

Higor Rosa @hvdrosa.bsky.social · 14/05/2026

Thrilled to share the updated video of my paper in Nature with Maciej (under supervision of @simonemattei.bsky.social & @jomaalab.bsky.social) Proud to use Cryo-ET to uncover how hibernation factors are key to translation restart! To model PTMs in situ and render animations fulfilled my PhD dream!🥹🎉

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Matthew Clark @matthew-batisio.bsky.social · 12/05/2026

With the recent news about the Andes hantavirus (ANDV), here is a drawing to show its structure: ssRNA genome divided into 3 segments for the RNA polymerase, glycoprotein precursor and nucleocapsid genes. ANDV contains an additional NS protein that inhibits immune response. #hantavirus #sciart

A drawing of the Andes hantavirus showing 3 segments of single stranded RNA genome packaged up in nucleocapsid proteins. This is enclosed by a lipid bilayer which is covered in tetrameric glycoproteins.

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Reposted by Matthew Clark

Aryan Taheri @aryantaheri.bsky.social · 08/05/2026

How do #tubulin dimers assemble and disassemble to form the #microtubule #cytoskeleton? Our recent #cryo-EM structures, published in #ScienceAdvances, demonstrate the processes of tubulin biogenesis and degradation. Click on the video and link below to learn more! www.science.org/doi/10.1126/...

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Reposted by Matthew Clark

Julio Abril Garrido @jabrilgarrido.bsky.social · 12/05/2026

Excited to share a preprint which is currently under revision! Together with the amazing @ymzhan.bsky.social in @patrick-cramer.maxplanck.de lab, we describe that the +1 nucleosome actively regulates the transition from transcription initiation to elongation www.biorxiv.org/content/10.6... 1/

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Raimon Sunyer @raimonsunyer.bsky.social · 08/05/2026

Interested in molecular motors? Don’t miss this wonderful symposium in Salamanca on "The Structure and Workings of Molecular Machines" with an outstanding lineup of speakers. 📍 Salamanca, Spain 📅 Monday, June 22, 2026 🎟️ Attendance is free, but registration is required 👇👇👇

Poster for “The Structure and Workings of Molecular Machines” international symposium, taking place Monday, June 22, 2026, at the Centro Internacional del Español, CIE-USAL, in Salamanca, Spain. The poster shows a colorful molecular-structure background and lists invited speakers Carlos Bustamante, Adam Frost, Taekjip Ha, Fernando Moreno, Eva Nogales, Félix Ritort, José M. Valpuesta, and Elizabeth Villa. It includes a QR code for the full program and registration and notes that attendance is free but registration is required.

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Reposted by Matthew Clark

Carter Lab @carter-lab.bsky.social · 05/05/2026

Our story on RNA recognition by Egl-BicD is now published! Also delighted to share the accompanying News & Views article by Florence Besse and Andres Ramos, which beautifully highlights the work. Paper: www.nature.com/articles/s41... News & Views: www.nature.com/articles/s41...

nature.com

Structural basis for recognition of diverse localizing mRNAs by Egl–BicD - Nature Structural & Molecular Biology

Singh et al. combine cryo-electron microscopy and functional studies to reveal how a single protein complex selects diverse mRNAs for subcellular localization using a combination of shape, positional ...

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Reposted by Matthew Clark

Chlanda lab @chlandalab.bsky.social · 01/05/2026

Join us at the 24th Workshop Cell Biology of Viral Infections @gesvirologie.bsky.social, Schöntal Monastery, 28–30.10.2026 cellviro.g-f-v.org “Cellular Routes and Roadblocks in Viral Genome Trafficking” Speakers: @beatesodeiklab.bsky.social · Alba Diz-Muñoz · @carogoujon.bsky.social · Redmond Smyth

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Reposted by Matthew Clark

Journal of Cell Biology @jcb.org · 17/04/2026

Assembly and phospho-regulatory mechanisms of the budding yeast outer #kinetochore KMN complex. New study from Noah N. Turner (@noahnturner.bsky.social), David Barford and colleagues @mrclmb.ac.uk: rupress.org/jcb/article/... #CellDivision #StructuralBiology #kinetochores #centromeres #cryoEM

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Reposted by Matthew Clark

The Daum Lab @daumlab.bsky.social · 15/04/2026

An exciting PhD opportunity investigating ribosome hibernation in cancer is available in my lab, in collaboration with Steffen Scholpp and Ke Li! The interdisciplinary project will span cell biology, structural biology, and AI-guided modelling. Please get in touch if you are interested!

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Reposted by Matthew Clark

Tomas Pascoa @tomaspascoa.bsky.social · 14/04/2026

1/ Excited to share our preprint! 🥳 Degradation of aromatic compounds, including BTEX pollutants, requires highly endergonic aromatic ring reduction. Using #cryoEM and in situ #cryoET, we show how BCRII couples electron bifurcation modules in one giant redox machine www.biorxiv.org/content/10.6...

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Caitie McCafferty @computingcaitie.bsky.social · 08/04/2026

I am excited to share our most recent work collaborating with @centriolelab.bsky.social and @stearnslab.bsky.social to look at the ciliary base of mammalian multiciliated cells w/ cryo-ET, XL/MS, and U-ExM www.biorxiv.org/content/10.6...

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Alexey Amunts @amunts.bsky.social · 07/04/2026

65 years after Peter Mitchell’s chemiosmotic theory, we report an association between ATP synthase and the electron transport chain. In the preprint led by @longzhou88.bsky.social, we describe a large supercomplex and show how the supramolecular organization contribute to oxidative phosphorylation 🧵

langtaosha.org.cn

A Supercomplex Incorporating Both Electron Transport Chain and ATP Synthase

The mitochondrial oxidative phosphorylation system powering most aerobic organisms is typically depicted as two spatially segregated machineries(1): electron transport chain complexes I-IV (ETC CI-CIV

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Clinton Lau @ckylau.bsky.social · 30/03/2026

Check out our first lab preprint: A real team effort to understand the Plasmodium GAPM proteins, which form part of a essential bridge between the parasite's cytoskeleton and motility apparatus. Below is a sneak peek of some beautiful microscopy - light and electron! www.biorxiv.org/content/10.6...

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Kelly Nguyen @kellythd-nguyen.bsky.social · 26/03/2026

Proud to share the yeast telomerase structure, led by the talented @hongmiaohu.bsky.social in collaboration with the Wellinger and Chartrand labs. Discovered 37 years ago and took us nearly 7 years but totally worth the wait 😍. www.science.org/doi/10.1126/... www.youtube.com/watch?v=gFE4...

youtube.com

Cryo-EM structure of yeast telomerase

YouTube video by MRC Laboratory of Molecular Biology

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Suyang Zhang @suyangzhang.bsky.social · 24/03/2026

Our lab @mrclmb.ac.uk in Cambridge is seeking a passionate PhD student to explore transcription-coupled splicing! Join our team for an exciting project to understand human gene regulation 🧬 Feel free to get in touch directly #PhD #cryoEM #biochemistry mrclmb.ac.uk/careers-and-...

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Carter Lab @carter-lab.bsky.social · 24/03/2026

Excited to share our work on the structure and function of cytoplasmic lattices within mouse embryos. A collaborative effort with @niakanlab.bsky.social and work led by @kashishsingh.bsky.social and @inaharasimov.bsky.social . It is now out on BioRxiv: www.biorxiv.org/content/10.6...

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MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 13/02/2026

How did life arise from simple chemical building blocks? New #LMBResearch led by @edogia.bsky.social in @philholliger.bsky.social group has identified a small self-replicating ribozyme that could be the answer. Read more: mrclmb.ac.uk/news-events/...

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Gaia Pigino @gaiapigino.bsky.social · 09/02/2026

Proud and excited to share our work with the community! Helen @helenfoster.bsky.social Foster et al. study how #cilia axonemes are built. 👀 Don't miss the gorgeous and insightful movies by @margotriggi.bsky.social, they really show our discoveries in full action! www.biorxiv.org/content/10.6...

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Florent Waltz @florentwaltz.bsky.social · 19/12/2025

Final version is out! Our large-scale cryo-ET dataset 🔬 of Chlamydomonas reinhardtii 🦠 is now published in @cp-molcell.bsky.social Huge collaborative effort! So glad to see the community already using it to develop new resources & tools. Check it out here: shorturl.at/z4i4c #CryoEM #CryoET

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Allegretti Lab @matteoall.bsky.social · 19/12/2025

We are thrilled to share our new pre-print on the molecular anatomy of nuclear proteasome in human sperm cells! #In-cellcryo-ET + #SPA + #LM! @piotrkolata.bsky.social @a-dsantos.bsky.social, @tomdendooven.bsky.social!! doi.org/10.64898/202...

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Reposted by Matthew Clark

Arnaud Martin @evolvwing.bsky.social · 16/11/2025

🚨New paper! 🚨 @jasminealqassar.bsky.social led this work on the silk glands of the pantry moth. These two long tubes inside the caterpillar continuously make a ton of silk How does this special organ work? www.cell.com/iscience/ful... @cp-iscience.bsky.social 🧵THREAD🧵

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Ben Engel @cellarchlab.com · 10/12/2025

Happy to share our fun team-up with @centriolelab.bsky.social & @stearnslab.bsky.social to reveal the architecture of the mammalian centriole’s Distal Ring 🛟. Very cool multiscale integration of #UExM 📏🔬with #CryoET ❄️🔬. Congrats to @ebertiaux.bsky.social & @computingcaitie.bsky.social #TeamTomo 🧪

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Reposted by Matthew Clark

Syma Khalid @sykhalid.bsky.social · 05/12/2025

Our paper on polymyxin interacting with the E. coli outer membrane is out! Simulations by the very talented @dheerajprakaash.bsky.social www.nature.com/articles/s42... To scale outer membrane protein island simulated at coarse-grained resolution with portions refined at all atom resolution.

nature.com

Polymyxins slow down lateral diffusion of proteins and lipopolysaccharide in the E. coli outer membrane - Communications Biology

Multi-scale molecular dynamics simulations reveal that polymyxins form polymyxin-protein aggregates upon associating with the E. coli outer membrane thereby reducing lateral mobility of outer membrane...

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