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Ali Twelvetrees

@dozenoaks.bsky.social
1.2K followers 1K following 189 posts

Sir Henry Dale Fellow | Sheffield | cell & molecular neurobiology | kinesin, dynein, slow transport and neurodegeneration | preferably one molecule at a time | my opinions | she/her

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Reposted by Ali Twelvetrees
Iris van Rooij 💭 @irisvanrooij.bsky.social · 29/09/2026
Dear @erc.europa.eu , we DO already have common standards & frameworks. 'AI' likes to pose itself as 'special' but we do not need to reinvent the wheel. We already have established codes of conduct for research integrity. We just need to apply them. See below + more resources in thread🧵
Protecting the Ecosystem of Human Knowledge: Five Principles
We must protect and cultivate the ecosystem of human knowledge. AI models can mimic
the appearance of scholarly work, but they are (by construction) unconcerned with truth
— the result is a torrential outpouring of unchecked but convincing-sounding “informa-
tion”. At best, such output is accidentally true, but generally citationless, divorced from
human reasoning and the web of scholarship that it steals from. At worst, it is confidently
wrong. Both outcomes are dangerous to the ecosystem.
Olivia Guest, Iris van Rooij, Marcela Suarez, et al. (2025, n.p.)
Knowledge production is supposed to be safeguarded by (inter)national codes of conduct for research
integrity (ALLEA 2023; KNAW et al. 2018). Such codes forbid, for instance, fabrication of data,
falsification of results, plagiarism, and, generally, distortion of the scientific record. Many argue that
new rules are required to regulate academic AI use, but pre-existing guidelines fit the bill (cf. Tafani
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Nivedita Sarveswaran @neuroniv.bsky.social · 11/09/2026
And it did not disappoint! Thank you for the welcoming experience to York and the inspiring breadth of mol/cell neurobiology #NeuroBioUK26 - already looking to next time, September 17th 2027!
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Prof Anthony Isles @profantisles.bsky.social · 09/09/2026
📢I have a #PhD position available!📢 This is an exciting project, building on our recent paper in the current issue of @dmmjournal.bsky.social, that will examine placental programming of fetal #brain in #PraderWilliSyndrome 🧠🧬 🙏 re-post gw4biomed.ac.uk/investigatin...
gw4biomed.ac.uk
Investigating placental function and fetal programming in Prader–Willi Syndrome - GW4 BioMed MRC DTP
Project Code NMH27Ca Isles Project Type Wet lab Research Theme Neuroscience and Mental Health Project Summary Download Summary By bringing together transcriptomics and cutting edge imaging, and dataan...
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Cytoskeleton Journal @cytoskeljournal.bsky.social · 10/08/2026
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Jonny Nixon-Abell @abelljonny.bsky.social · 23/07/2026
🚨🚨Final reminder for abstract submission deadline next Tuesday (28th)! Please RT 🙏
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Ali Twelvetrees @dozenoaks.bsky.social · 22/07/2026
Delighted to see the latest preprint progress to publication with Advanced Science. We built the protein FRET ruler as a bridge between biophysicists and cell biologists - realising the potential of FRET link measurements from molecules to cells. advanced.onlinelibrary.wiley.com/doi/10.1002/...
Histogram of the FRET protein ladder below with the corresponding structural predictions of the ladder molecules above.
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Robin Bisson @robinbisson.bsky.social · 22/07/2026
Almost exactly 6 months ago, RPN was leaked a document presented to STFC staff that said the council had to reduce spending by £162m by 2029-30 That kicked off months of debate on how cuts would be made But only now has it become clear the total cost savings needed over 4 years is in fact £684m 🧵
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Ali Twelvetrees @dozenoaks.bsky.social · 16/07/2026
Time is running out!! Last couple of days…. #neuroskyence
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Stephen Royle @steveroyle.bsky.social · 15/07/2026
VolcanoPlotR: a new package for visualising proteomic data in R. Explainer: quantixed.org/2026/07/15/e... Code: github.com/quantixed/Vo... Docs: quantixed.github.io/VolcanoPlotR/
The hexsticker for the package. It has a lilac background and the emoji for Vulcan hand salute (vulcan, get it?) and VolcanoPlotR is in black letters at the top.
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Avezov lab @avezovlab.bsky.social · 14/07/2026
Thrilled to see our paper now featured on the cover, as part of the highlight “Neurodegeneration Through the Lens of Selective Brain Cell Vulnerability.” advanced.onlinelibrary.wiley.com/share/4YDKRX...
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James N. Sleigh @jamessleigh.bsky.social · 13/07/2026
In our latest pre-print, we show that mice with the neuropathy-causing GARS1 ∆ETAQ mutation display robust pathology in subsets of peripheral nerves: www.biorxiv.org/content/10.6... Well done @beccasimkin.bsky.social and Aurélie Paulo-Ramos! @uclqsneuromuscular.bsky.social @uclqsion.bsky.social
The images depicts a graphical abstract of the paper. Text abstract: Charcot-Marie-Tooth disease type 2D (CMT2D) results from gain-of-function mutations in GARS1, which encodes glycyl-tRNA synthetase (GlyRS), the enzyme responsible for charging transfer RNA (tRNA) with glycine. There are several CMT2D mouse models, but Gars∆ETAQ/+ is the only one that bears a patient-sourced mutation. Created using CRISPR/Cas9 to model a 12-nucleotide de novo GARS1 deletion identified in an unusually severe CMT2D patient, Gars∆ETAQ/+ mice have previously been shown to display several neuromuscular phenotypes; motor axon loss, denervated neuromuscular junctions (NMJs) and reduced muscle function. Here, we extend these analyses to provide a more comprehensive understanding of both motor and sensory nerve deficits across hind- and fore-limbs. At 3 months, Gars∆ETAQ/+ mice possess sex-independent alterations in the levels of neuropathy biomarkers – including decreased NfL and increased periaxin – alongside reduced muscle endurance and strength, and impairments in the sensory modalities of mechanosensation, proprioception and nociception. Underpinning these dysfunctions, we identified site-specific defects comprising altered sensory neuron populations, muscle spindle loss, reduced motor neuron size, disrupted NMJ innervation and maturation, and reduced axonal transport of signalling endosomes in vivo. Together, these experiments show that Gars∆ETAQ/+ mice display robust and selective peripheral nerve pathology that manifests in a general distal-to-proximal fashion, priming this CMT2D allele for testing treatments and evaluating mechanisms underlying peripheral nerve vulnerability.
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Ali Twelvetrees @dozenoaks.bsky.social · 13/07/2026
Absolutely beautiful work from the Bradke lab here. As an aside, I'm also genuinely stunned to see fundamental neuronal cell biology like this in Nature! An intrinsic cytoskeletal oscillator establishes neuronal polarityhttps://www.nature.com/articles/s41586-026-10755-6
nature.com
An intrinsic cytoskeletal oscillator establishes neuronal polarity - Nature
The ARP2/3 complex works together with actomyosin in an oscillatory program at the soma to govern neuronal polarization.
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Jonny Nixon-Abell @abelljonny.bsky.social · 09/07/2026
Reminder all that the deadline for sign up and abstract submissions is July 28th!!
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Ali Twelvetrees @dozenoaks.bsky.social · 07/07/2026
🚨 Early bird registration deadline for NeuroBioUK26 is fast approaching! Register by July 17th to secure your discounted rate (£35) AND remember to submit your abstract to be in the running for a talk slot. You're faithful organising committee have some hard deadlines this year, so please submit!
neurobiouk.sites.sheffield.ac.uk
NeuroBioUK - Registration
Step 1: Register through our event page. All attendees should register to attend through our event page. Early bird registration deadline is the 17th of July (£35) and late registration deadline is th...
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Ali Twelvetrees @dozenoaks.bsky.social · 07/07/2026
🚨 Early bird registration deadline for NeuroBioUK26 is fast approaching! Register by July 17th to secure your discounted rate (£35) AND remember to submit your abstract to be in the running for a talk slot. You're faithful organising committee have some hard deadlines this year, so please submit!
neurobiouk.sites.sheffield.ac.uk
NeuroBioUK - Registration
Step 1: Register through our event page. All attendees should register to attend through our event page. Early bird registration deadline is the 17th of July (£35) and late registration deadline is th...
155
Reposted by Ali Twelvetrees
Robin Bisson @robinbisson.bsky.social · 07/07/2026
For 6 months the line from DSIT & UKRI on STFC cuts has been that no final decisions have been taken That is no longer the case, after DSIT approved UKRI's proposal for how to save £162m British research at Cern will be hit, along with UK science facilities Scoop by me & @francesjones.bsky.social
researchprofessionalnews.com
UK research at Cern to shrink as government approves STFC cuts - Research Professional News
Exclusive: Science department approves UKRI’s cost-saving proposal, with major UK facilities also facing cutbacks
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Ali Twelvetrees @dozenoaks.bsky.social · 03/07/2026
It’s the weekend!
Sunset over the Peak District from the edge of the city of Sheffield.
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Kirsty Grainger @kirstygrainger.bsky.social · 01/07/2026
This is really rough news for everyone who works at RP. I'm so sorry to read this and hope impacted colleagues have good support networks to lean on. It will create a huge hole in a sector for which the timing couldn't be worse. www.researchprofessionalnews.com/rr-news-uk-o...
researchprofessionalnews.com
Research Professional News to discontinue publication at end of 2026 - Research Professional News
A message for readers about the publication’s closure and continued community access to past reporting
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Ali Twelvetrees @dozenoaks.bsky.social · 01/07/2026
Disappointed but not surprised that the University of Sheffield are not signatories on this charter. Their policies are already amongst the poorest in the sector and no doubt set to get worse now.
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Ran Blekhman @blekhman.bsky.social · 27/06/2026
I looked at this but left it out of the post, because the gender inference tool could only classify 44% of first authors and 31% of last authors. But given this caveat, this is the distribution: First authors: 71% male, 29% female Last authors: 83% male, 17% female
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Kris Willis @kawillis.bsky.social · 26/06/2026
As you might imagine, as someone who studies science and works on metrics, I have some thoughts on qed myself. I fully agree that the messaging can be described as tone-deaf and problematic. I don’t think it had to be. ripplingideas.org/2026/06/26/t...
ripplingideas.org
The 1% club and the rocky road ahead for bioRxiv
The recent launch of qed’s “top 1%” preprint ranking has sparked controversy, with concerns about its arbitrary nature, potential harm to authors, and low-quality inclusions. Whil…
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Alex Eve @amjeve.uk · 24/06/2026
Noticeable underrepresentation of women as corresponding authors in the 1%. Almost as if AI has been trained on years of discriminatory behaviours and is perpetuating that bias.
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Ali Twelvetrees @dozenoaks.bsky.social · 22/06/2026
If one more person who is not 35+ weeks pregnant tells me they are hot I am going to lose it
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Prof Jenny Rohn @jennyrohn.bsky.social · 18/06/2026
Buckle up for the ride, ladies. It’s not going to get better. #AI #LLM #WomenInSTEM #AcademicSky
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Prof Jenny Rohn @jennyrohn.bsky.social · 17/06/2026
Horrific #AcademicSky #WomenInSTEM
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Nature Methods @natmethods.nature.com · 15/06/2026
We are very excited to bring back our popular Points of View column, written by @helenajambor.bsky.social! Check out her first column in our July issue about the usage of color scales in scientific figures. www.nature.com/articles/s41...
nature.com
Color scales and the birth of viridis - Nature Methods
The color palette viridis is replacing rainbow color schemes in scientific figures, for good reason.
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Ali Twelvetrees @dozenoaks.bsky.social · 16/06/2026
Our latest review is out. We take a deep dive into the human mutations in microtubule motors that drive devastating neurodevelopmental and neurodegenerative diseases. Taking in motor protein biophysics, animal models of disease as well as patient phenotypes. onlinelibrary.wiley.com/doi/full/10....
Graphical abstract summarising the impact of defective microtubule motors on axonal transport. Kinesins (green) and dyneins (magenta) maintain balance along the length of the axon. When disease causing mutations cause either hyper or hypo activity, the loss of balance results in axon dieback.
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Exciting Instruments @ei-science.bsky.social · 05/06/2026
🐮 What lies between the “spherical cow” of purified proteins and live-cell imaging? The messy middle. Explore single-molecule biophysics in crude lysates and serum, with real-world case studies and practical workflows. excitinginstruments.com/resource-lib... #biophysics #singlemolecule
excitinginstruments.com
Embracing biophysics in cell lysates or serum | Exciting Instruments
Explore how the 'messy middle' of biophysics, namely cell lysates and serum, combines single-molecule sensitivity with biological context.
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Elena Scarpa & The Squeezable Cells Lab @squeezycellslab.bsky.social · 10/06/2026
We are thrilled to announce our new preprint from the wonderful @sorayavillaseca.bsky.social Ever wondered how cells squeeze through tiny spaces in embryos? Neural crest cells use Dynein to transport their nucleus along microtubules. Check out the preprint!! www.biorxiv.org/content/10.6...
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Ali Twelvetrees @dozenoaks.bsky.social · 08/06/2026
Gutted not to be at the Cell Biology of the Neuron GRC this week - please do check out Emma Turner’s poster if you’re there. The next part of our kinesin-1 odyssey will be a preprint soon, but you can get a sneak peek this week :)
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Reese Richardson @reeserichardson.bsky.social · 05/06/2026
The Thermo Fisher situation keeps getting worse. We've now collected 450+ problematic images presented as verification data in TF's antibody catalog. This includes: 🖌️ Dozens more images with duplications or painting 🖨️ Hundreds of blots that all share the same background (behold slideshow below)
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Robin Bisson @robinbisson.bsky.social · 22/05/2026
Patrick Vallance has twice written to MPs saying the budget for curiosity-driven research “will grow as the economy grows” But UKRI has flat cash for curiosity-led research through to 2030 When @isaacbarbosa1.bsky.social asked DSIT where the growth would come from, they had no answer A mystery
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Ali Twelvetrees @dozenoaks.bsky.social · 31/05/2026
Sunday. Third trimester. I have a mountain of work to get through and there is not one chair in the house that’s comfortable. Meanwhile my passenger is pulling yoga moves inside me.
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Dan Bose @danbose.bsky.social · 28/05/2026
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Melanie I Stefan @melanieistefan.bsky.social · 27/05/2026
As long as Elon Musk is a member and Dorothy Bishop is not, they should talk neither about diversity nor excellence.
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Prof Ben Britton @bmatb.expmicromech.com · 22/05/2026
Not just chemistry - one of the UK's major departments of materials science & engineering department is facing a 20% reduction in full time academic faculty positions - or to be more specific 8 Faculty positions are due to be cut. 🔬🧪 www.timeshighereducation.com/news/sheffie...
timeshighereducation.com
Sheffield’s renowned chemistry department at risk in latest cuts
Plans to cut staff numbers in department that has produced four Nobel prizewinners will harm university’s research reputation, warns UCU
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Ali Twelvetrees @dozenoaks.bsky.social · 20/05/2026
Guess what neurobiology fans?!? Registration is open!! More info on the website neurobiouk.sites.sheffield.ac.uk/registration #neurobiology #neurobiouk #neuronalcellbiology #molecularneurobiology #cellularneuroscience #neuroscience
neurobiouk.sites.sheffield.ac.uk
NeuroBioUK - Registration
Step 1: Register through our event page. All attendees should register to attend through our event page. Early bird registration deadline is the 17th of July (£35) and late registration deadline is th...
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Ali Twelvetrees @dozenoaks.bsky.social · 21/05/2026
I have literally never seen anything even 10% as awesome as this on LinkedIn, and this is why BlueSky wins. Unless you want all the joy extracted from your science of course…
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Ali Twelvetrees @dozenoaks.bsky.social · 20/05/2026
Guess what neurobiology fans?!? Registration is open!! More info on the website neurobiouk.sites.sheffield.ac.uk/registration #neurobiology #neurobiouk #neuronalcellbiology #molecularneurobiology #cellularneuroscience #neuroscience
neurobiouk.sites.sheffield.ac.uk
NeuroBioUK - Registration
Step 1: Register through our event page. All attendees should register to attend through our event page. Early bird registration deadline is the 17th of July (£35) and late registration deadline is th...
01110
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Robin Bisson @robinbisson.bsky.social · 01/05/2026
The MRC budget is £799m in 26/27, of which £415m is for curiosity-driven research Lots of that CDM budget is accounted for by funding for institutes (LMB, Crick, etc.), so there is £113m for applicant-led schemes Chinnery indicated these schemes will be "down a bit" compared to previous years
 “It is still going to be down a bit compared [with] where it was—it is part and parcel of redirecting and readjusting our funding into some of the other buckets and preparing those schemes in order to allow bucket two to deliver.”
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WebDesignMuseum @webdesignmuseum.org · 28/04/2026
The Hampster Dance website in 1999 This website was one of the earliest examples of an Internet meme and it was created by Deidre LaCarte in 1998. #InternetHistory
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Andrew G. York @andrewgyork.bsky.social · 24/04/2026
I've been getting questions about this paper all week: www.cell.com/cell/abstrac... They make EXTRAORDINARY claims - fortunately, these are trivial to verify/falsify. Unfortunately, there's other concerns.
cell.com
Electromagnetic field-inducible in vivo gene switch for remote spatiotemporal control of gene expression
The EMF-inducible gene switch (Ei) platform provides precise spatiotemporal control of gene expression through Cyb5b-mediated calcium oscillations. This system enables Ei-OSK-driven in vivo rejuvenati...
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Stephen Royle @steveroyle.bsky.social · 19/04/2026
Obituary of Annette Dolphin @annieneuro.bsky.social written by her sister in The Guardian. www.theguardian.com/science/2026...
theguardian.com
Annette Dolphin obituary
Other lives: Neuroscientist whose research showed how individual molecules can affect neurological disorders
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Ali Twelvetrees @dozenoaks.bsky.social · 19/04/2026
Signs of spring emerging in Sheffield finally…
Handsworth Sword performing their traditional Yorkshire longsword dance in Kelham Island, Sheffield.Five Rivers Morris performing, hankies raised, in Kelham Island, SheffieldCutlers Gate morris side performing in Kelham Island, SheffieldWakefield Morris performing in Kelham Island, Sheffield
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Joachim Goedhart @joachimgoedhart.bsky.social · 13/04/2026
📣 New preprint alert! Co-authored by @spalaciosm.bsky.social and @andreacaldarola.bsky.social : Quantitative imaging of calcium dynamics with a green fluorescent biosensor and fluorescence lifetime imaging www.biorxiv.org/content/10.6...
Image of a calcium calibration curve, calcium concentration traces of individual cells and lifetime images of cells
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Ali Twelvetrees @dozenoaks.bsky.social · 10/04/2026
No shit. Looking forward to tanking my career once and for all when number 2 arrives this summer.
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Nature Structural & Molecular Biology @natsmb.nature.com · 08/04/2026
New online: Microtubules in the axon are GDP bound but adopt a stable GTP-like expanded state
dlvr.it
Microtubules in the axon are GDP bound but adopt a stable GTP-like expanded state
Nature Structural & Molecular Biology, Published online: 08 April 2026; doi:10.1038/s41594-026-01787-7Zehr et al. revealed the 2.7-Å cryo-electron microscopy reconstruction of human microtubules in situ in the axon of induced pluripotent stem cell (iPS cell)-derived neurons. It shows an expanded microtubule lattice yet bound to GDP, in contrast to the compacted lattice observed at the iPS cell stage.
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Zen Faulkes @doctorzen.net · 07/04/2026
Another fake disease AI thought was real was "Kyloren syndrome." It showed up in Google's AI Overview. It was from a hoax paper that @neuroskeptic.bsky.social wrote to expose a predatory journal. See "The garbage'll do", July 2017, in my hoax anthology, Stinging the Predators: bit.ly/StingPred
bit.ly
Stinging the Predators: A collection of papers that should never have been published
This ebook collects academic papers and conference abstracts that were meant to be so terrible that nobody in their right mind would publish them. All were submitted to journals and conferences to expose weak or non-existent peer review and other exploitative practices. Each paper has a brief introduction. Short essays round out the collection.440 pages (version 24.1).Version 1.0 released 26 July 2017.Version 2.0 released 28 July 2017 (two new entries).Version 3.0 released 31 July 2017 (two new entries).Version 3.1 released 7 August 2017 (error corrected).Version 4.0 released 16 February 2018 (one new entry).Version 4.1 released 16 February 2018 (journal PDF replaced copied text).Version 5.0 released 4 July 2018 (one new entry).Version 6.0 released 26 July 2018 (one new entry).Version 6.1 released 28 July 2018 (journal PDF replaced copied text).Version 7.0 released 29 September 2018 (one new entry).Version 8.0 released 3 October 2018 (one new entry with three new papers).Version 8.1 released 4 October 2018 (one new paper added associated with v 8.0 entry; PDF bookmarks fixed).Version 8.2 released 7 October 2018 (expanded introduction associated with v 8.0 entry).Version 8.3 released 30 October 2018 (expanded introduction associated with v 8.0 entry; minor addition to earlier entries).Version 9.0 released 16 March 2019 (new entry).Version 10.0 released 7 April 2019 (new entry; minor update to previous entry).Version 11.0 released 31 March 2020 (two new entries; minor update to previous entry).Version 12.0 released 4 April 2020 (new entry; various minor updates to earlier entries, including updated link, corrected date, corrected name, etc.).Version 12.1 released 5 April 2020 (excerpts from hoaxed paper replaced with full PDF).Version 13.0 released 1 June 2020 (two new entries).Version 14.0 released 15 August 2020 (one new entry).Version 14.1 released 15 August 2020 (expanded newest entry).Version 15.0 released 16 August 2020 (one new entry).Version 16.0 released 26 December 2020 (one new entry).Version 17.0 released 12 January 2021 (one new entry; Introduction restored).Version 18.0 released 20 March 2021 (one new entry).Version 19.0 released 1 January 2022 (four new entries).Version 20.0 released 20 May 2022 (one new entry).Version 21.0 released 25 April 2023 (one new entry; one expanded entry).Version 22.0 released 16 January 2024 (one new entry; minor corrections).Version 23.0 released 11 November 2024 (one new entry).Version 24.0 released 18 May 2025 (two new entries).Version 24.1 released 23 May 2025 (two updated entries).Version 25.0 released 1 February 2026 (one new entry).
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Avezov lab @avezovlab.bsky.social · 02/04/2026
🚨📜Our new paper out in @AdvSciNews: ER shape matters for neuronal health - disrupting ER continuity halts neuro-firing as it slows Ca2+ store refill, explaining selective neuronal vulnerability to ER problems in neurodegeneration 🧠 a thread to follow advanced.onlinelibrary.wiley.com/doi/10.1002/...
advanced.onlinelibrary.wiley.com
Endoplasmic Reticulum Geometry Dictates Neuronal Bursting via Calcium Store Refill Rates and Exposes Selective Neuronal Vulnerability
The ER's continuous tubular network is maintained by ER-shaping proteins whose mutation or dysregulation contributes to neurodegenerative diseases. Here, we show that ER morphology sets the speed of ...
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Ali Twelvetrees @dozenoaks.bsky.social · 06/04/2026
Finally, a GABA-A receptor question on University Challenge. Knew that PhD was good for something. Sadly only the dog around to witness my prowess and she’s asleep…
A golden retriever asleep on a green sofa
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