iiinova — where your digital self keeps evolving

Reposted by Allegretti Lab

Casper Berger @casperberger.bsky.social · 23/09/2026

We developed Adaptive Polishing for the consistent preparation of ~150 nm thin FIB-lamellae. This was done by using imaging feedback to adjust parameters for each lamella, or Adaptive Milling, rather than applying a fixed recipe. Preprint: doi.org/10.64898/202...

24117

Reposted by Allegretti Lab

MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 01/09/2026

Using advanced microscopy @piotrkolata.bsky.social @a-dsantos.bsky.social @tomdendooven.bsky.social @matteoall.bsky.social have identified the molecular anatomy & organisation of proteasomes in the sperm nucleus. Read more about the study here: mrclmb.ac.uk/news-events/... #LMBResearch 🧪

02712

Reposted by Allegretti Lab

Tanmay Bharat @tbharat-lab.bsky.social · 08/06/2026

Disrupting phage liquid crystalline droplets restores antibiotic susceptibility in Pseudomonas aeruginosa biofilms out in @plosbiology.org by @abultarafder.bsky.social and team. Exciting collaboration with @geiselbiofilm.bsky.social @pearce-maths.bsky.social and others

14215

Allegretti Lab @matteoall.bsky.social · 27/05/2026

We're happy to announce our new preprint! 🐸 easymode: general pretrained networks for cellular cryo-ET. Segment ~20 cellular features – ribosomes, microtubules, mitochondria, nuclei & more – with zero model training. 🔗 doi.org/10.64898/202... 🧵👇

116755

Reposted by Allegretti Lab

Sjors Scheres @sjorsscheres.bsky.social · 16/10/2025

I just made an account and voted for this biology laboratory made of LEGO to "promote biological research and inspire more people into the world of biology". They need 10K votes. Reposting and/or voting below would be helpful. 🤗 beta.ideas.lego.com/product-idea...

beta.ideas.lego.com

Biological Laboratory | LEGO® Ideas

This is a two-floor realistic Biological Laboratory building. In this design, I try to tell stories about biologists, introduce biology concepts to general publ…

8223131

Reposted by Allegretti Lab

Lori Passmore @lapassmore.bsky.social · 25/02/2026

We are excited to be recruiting a new tenure track group leader in the Structural Studies Division at MRC LMB! It is an amazing place to start your own lab. @mrclmb.bsky.social Please get in touch if you have any questions. www.nature.com/naturecareer...

nature.com

Research Group Leader Tenure Track - Structural Studies - LMB 2775 - Cambridge, Cambridgeshire (GB) job with MRC Laboratory of Molecular Biology (LMB) | 12854636

Research Group Leader Tenure Track Starting Salary £67,979 to £76,868 per annum MRC Laboratory of Molecular Biology, Cambridge, UK The MRC Laborato...

15254

Reposted by Allegretti Lab

Wilfling Lab @wilflinglab.bsky.social · 13/01/2026

We are excited to share our new preprint which is now available to read on biorXiv: doi.org/10.64898/202... 🎉🎉🎉

212139

Allegretti Lab @matteoall.bsky.social · 19/12/2025

We are thrilled to share our new pre-print on the molecular anatomy of nuclear proteasome in human sperm cells! #In-cellcryo-ET + #SPA + #LM! @piotrkolata.bsky.social @a-dsantos.bsky.social, @tomdendooven.bsky.social!! doi.org/10.64898/202...

38921

Reposted by Allegretti Lab

Ben Barad @baradlab.com · 12/12/2025

Holy cow the Zhou lab at UCLA is cooking with Isonet 2 - www.biorxiv.org/content/10.6... Averaging-free direct visualization of ribosome translational state! #teamtomo #cryoet

210235

Reposted by Allegretti Lab

Kiarash Jamali @kjamali.bsky.social · 09/12/2025

I’m excited to announce that I will be starting my research group on computational enzyme design at the Generative Biology Institute, Oxford, UK (@eitoxford.bsky.social)! PhD applications are open, deadline is Jan 8th (www.chem.ox.ac.uk/genbio-dtp). Email kiarash.jamali@eit.org with any questions!

chem.ox.ac.uk

GenBio DTP

Optional supporting text

96114

Reposted by Allegretti Lab

James Briscoe @jamesbriscoe.bsky.social · 07/10/2025

Very sad news, John Gurdon has died. A developmental biologist's developmental biologist, Nobel prize winner His work is the foundation of much of today's dev & stem cell bio. An inspiration to many, including me. Always asking questions & wanting the answers www.magd.cam.ac.uk/news/profess...

magd.cam.ac.uk

Professor Sir John Gurdon FRS (1933-2025) | Magdalene College

Magdalene College is deeply saddened to announce the death of Professor Sir John Gurdon FRS, who served as Master of the College from 1995 to 2002.

7190100

Reposted by Allegretti Lab

Martin Pacesa @martinpacesa.bsky.social · 27/08/2025

Exciting to see our protein binder design pipeline BindCraft published in its final form in @Nature ! This has been an amazing collaborative effort with Lennart, Christian, @sokrypton.org, Bruno and many other amazing lab members and collaborators. www.nature.com/articles/s41...

14305109

Reposted by Allegretti Lab

MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 11/08/2025

We’re looking for a Research Support Officer to join @matteoall.bsky.social’s group, working with @piotrkolata.bsky.social to investigate nuclear-cytoskeletal coupling in mammalian cells using #cryoEM, #cryoET & other biochemical approaches. www.jobs.ac.uk/job/DOE317/r... Closes 31 AUG #ScienceJobs

073

Reposted by Allegretti Lab

A. Reza Mehdipour @rezamehdipour.bsky.social · 05/08/2025

We discovered that the SUN5-Nesprin3 LINC complex forms a hexagonal lattice at the sperm HTCA, which radically reshapes the nuclear membrane locally! Our findings also provide the structural basis for understanding the severe ASS (Acephalic Sperm Syndrome) male infertility phenotype.

171

Reposted by Allegretti Lab

A. Reza Mehdipour @rezamehdipour.bsky.social · 05/08/2025

This work is the result of a fantastic collaboration with@matteoall.bsky.social! @warred.bsky.social, @a-dsantos.bsky.social , @alisterburt.bsky.social , @tom-hale.bsky.social, @mrclmb.bsky.social,

142

Reposted by Allegretti Lab

A. Reza Mehdipour @rezamehdipour.bsky.social · 05/08/2025

We are excited to announce the first in-cell structure of a LINC complex within a native nuclear envelope at subnanometer resolution!! #In-cell cryo-ET + #atomistic MD simulations! @tomdendooven.bsky.social et al!! www.biorxiv.org/content/10.1...

24314

Allegretti Lab @matteoall.bsky.social · 01/08/2025

Dear all, we are looking for a research assistant in protein biochemistry / cell biology to support our work on nuclear reshaping in human cells. Here the link to the call, please spread: mrc.tal.net/vx/mobile-0/...

mrc.tal.net

Research Support Officer - Structural Studies - Dr Matteo Allegretti - LMB 2674 - Medical Research Council

Location: Cambridge. Vacancy: Research Support Officer - Structural Studies - Dr Matteo Allegretti - LMB 2674. Closing Date: 31/08/2025, 23:55

074

Reposted by Allegretti Lab

Ricardo D. Righetto @lifeonthewedge.bsky.social · 27/07/2025

Using #cryoET to investigate plant cell-cell communication 🤩🌿

1141

Reposted by Allegretti Lab

Tanmay Bharat @tbharat-lab.bsky.social · 23/06/2025

Structure of the virulence-associated Neisseria meningitidis filamentous bacteriophage MDAphi Out in @pnas.org Congrats @janboehning.bsky.social @abultarafder.bsky.social Miles Graham @mathieucoureuil.bsky.social @mrclmb.bsky.social @hopitalnecker.bsky.social www.pnas.org/doi/10.1073/...

15718

Reposted by Allegretti Lab

Derivery Lab - MRC LMB @deriverylab.bsky.social · 23/06/2025

🚨 JOB ALERT 🚨 We're hiring a Research Assistant – no PhD needed! Join us to explore the molecular mechanisms of receptor sorting in endosomes. Experience in protein expression/purification, cloning & cell culture desired 🧫🔬 Apply now 👉 www.nature.com/naturecareer... #STEMCareers #ResearchJobs

A picture of 3 rows of people on steps at the MRC LMB. From left to right - top row: Akaash, Vic, Lara - Middle row: Kerrie, Manu, Paddy - bottom row: Meg and Julie

15033

Reposted by Allegretti Lab

MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 05/06/2025

Congratulations to @tbharat-lab.bsky.social, Group Leader in the LMB’s Structural Studies Division, who has received the Gold Medal from @embo.org for his research on prokaryotic surface molecules. Read more here: www2.mrc-lmb.cam.ac.uk/tanmay-bhara... #LMBNews

36212

Reposted by Allegretti Lab

Phil Holliger @philholliger.bsky.social · 29/05/2025

New paper from my group rdcu.be/eoaRr "Trinucleotide substrates under pH–freeze–thaw cycles enable open-ended exponential RNA replication by a polymerase ribozyme" in Nature Chemistry — great collaboration with attwaterlab.uk.

rdcu.be

Trinucleotide substrates under pH–freeze–thaw cycles enable open-ended exponential RNA replication by a polymerase ribozyme

Nature Chemistry - Models of abiotic RNA replication suffer from inherent product inhibition arising from the high stability of RNA duplexes. Now, it has been shown that RNA trinucleotide...

03013

Reposted by Allegretti Lab

Ben Engel @cellarchlab.com · 07/05/2025

“The Website” is here! It can be intimidating getting into analysis of #CryoET data, and software is evolving all the time👩‍💻🚀. @phaips.vd.st & @florentwaltz.bsky.social put our lab’s workflows into an online guide. We hope this helps lower the bar to joining #TeamTomo. Feedback much appreciated! 🧪🧶🧬🔬

38720

Reposted by Allegretti Lab

Gaia Pigino @gaiapigino.bsky.social · 19/02/2025

“Join the Pigino Lab! We’re hiring a PhD student to explore primary cilia biology using advanced imaging, spatial ‘omics, and AI. Apply now at www.cilia-ai.eu and be part of the Cilia-AI Doctoral Network!”

02827

Reposted by Allegretti Lab

Tanmay Bharat @tbharat-lab.bsky.social · 23/04/2025

Finally in peer-reviewed form: Mapping the ultrastructural topology of the corynebacterial cell surface. @bupbuse.bsky.social @vikramalva.bsky.social Please also see concurrent beautiful work from @adriasogues.bsky.social and Han Remaut.

47229

Reposted by Allegretti Lab

Suyang Zhang @suyangzhang.bsky.social · 24/03/2025

Excited to share our new preprint on co-transcriptional splicing! U1 snRNP is recruited to RNA polymerase II through multiple interaction sites, with elongation factor SPT6 binding directly to the U1 snRNP protein. www.biorxiv.org/content/10.1... #cryoEM #transcription #splicing

35020

Reposted by Allegretti Lab

Sven Klumpe @svenklumpe.bsky.social · 05/03/2025

Happy to share our manuscript on the in situ visualization of the copia retrotransposon in its final form today published in @cellcellpress.bsky.social www.cell.com/cell/fulltex.... What’s new?

1219679

Reposted by Allegretti Lab

GW Gant Luxton @gwgl.bsky.social · 21/02/2025

science.org/doi/10.1126/... Just published! We uncovered a molecular machine that connects the cell's two major structural networks revealing how cells accomplish precise internal reorganization - a process disrupted in diseases ranging from cancer to multiple sclerosis.

science.org

Active microtubule-actin cross-talk mediated by a nesprin-2G–kinesin complex

Nesprin-2 Giant links the nucleus to the cytoskeleton, enabling actin transport and nuclear movement through kinesin-1 activation.

1439

Reposted by Allegretti Lab

Sjors Scheres @sjorsscheres.bsky.social · 27/01/2025

We have an exciting opportunity for a new independent group leader with an interest in structural/molecular biology and machine learning to join our Division of Structural Studies at the @mrclmb.bsky.social! 🥳 Re-posts appreciated. www.nature.com/naturecareer...

nature.com

Research Group Leader Tenure Track - Structural Studies - LMB 2549 - Cambridgeshire job with MRC Laboratory of Molecular Biology | 12835196

Research Group Leader Tenure Track Starting Salary £65,940 to £74,448 per annum MRC Laboratory of Molecular Biology, Cambridge, UK

17371

Allegretti Lab @matteoall.bsky.social · 20/01/2025

Ever wondered how the chemotherapeutic drug paclitaxel can target slow-dividing tumours? Check out our preprint Hale et al! @tom-hale.bsky.social found a novel non-mitotic mechanism of action for paclitaxel involving nuclear-cytoskeletal coupling via the LINC complex! www.biorxiv.org/content/10.1...

1357

Reposted by Allegretti Lab

Lander Lab @landerlab.bsky.social · 16/01/2025

Protein production for cryoEM structure determination just got a lot cheaper - high resolution structure from half a plate of HEK cells with the "MIcro ISolation (MISO)" microfluidics-based approach. Congrats to the Brunner and Efremov labs in Brussels! www.biorxiv.org/content/10.1...

04411

Reposted by Allegretti Lab

Ben Engel @cellarchlab.com · 06/01/2025

Towards community-driven visual proteomics! Excited to finally share this large-scale curated & annotated dataset of 1829 high-quality #cryoET tomograms of the little green alga that just keeps giving— Chlamydomonas! 🧪🧶🧬🌾🌊🌍 Preprint📜: www.biorxiv.org/content/10.1... A short thread🧵👇

7338128

Reposted by Allegretti Lab

jankosinski.bsky.social @jankosinski.bsky.social · 04/12/2024

Crosslinks can sometimes improve AlphaFold3 models. Crosslinking is an experimental method often used as a source of distance restraints in modeling. In AlphaFold3, instead of using restraints, crosslinks can be included as covalent ligands. Thanks to Agnieszka Obarska-Kosinska for the idea.

310323

Reposted by Allegretti Lab

MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 03/12/2024

Congratulations to @marta-shahbazi.bsky.social, Group Leader in @cellbiol-mrclmb.bsky.social, who has joined the EMBO Young Investigator Programme! Read more here about the programme and Marta’s research here: www2.mrc-lmb.cam.ac.uk/marta-shahba... #LMBNews

Marta Shahbazi, sitting in front of a lab bench

1342

Reposted by Allegretti Lab

MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 22/11/2024

🌟 Welcome to the MRC Laboratory of Molecular Biology on Bluesky! We’re thrilled to connect with you and share our research insights, job opportunities, events, and more. Join us on this journey as we advance science and improve human health together! #MolecularBiology #Research #Innovation

04816

Reposted by Allegretti Lab

Ute Hellmich @hellmichgroup.bsky.social · 16/11/2024

Ok, trying to bring my community back together... I created a starter pack for lipids and membrane protein aficionados! Feel free to share, add and distribute, so we can come together again! 😍 go.bsky.app/AEeXh86

7112565

Reposted by Allegretti Lab

Rémi Fronzes @fronzeslab.bsky.social · 08/11/2024

Here is a starter pack for CryoEM/ET enthousiasts To be completed go.bsky.app/JmQksC

7211076

Allegretti Lab @matteoall.bsky.social · 13/11/2024

Join us! Ill present some of our recent tomo work on sperm cells!

000

Allegretti Lab @matteoall.bsky.social · 01/11/2024

Ever wondered if nuclear pore architecture and function changes during germ cell differentiation? In human spermatogenesis it does, and radically!! Check out our first lab preprint @AliaCSantos et al! www.biorxiv.org/content/10.1...

0177

Reposted by Allegretti Lab

Sven Klumpe @svenklumpe.bsky.social · 24/02/2024

Over 4 years in the making, I am extremely happy to share our pre-print on the “In-cell structure and snapshots of copia retrotransposons in intact tissue”. We used cryo-ET to resolve the copia capsid structure to subnanometer resolution inside cells: www.biorxiv.org/content/10.1...

56226

Reposted by Allegretti Lab

Jim Hurley @jimhurley.bsky.social · 02/02/2024

Join us @berkeleyMCB Mar. 25 for Cell Biology at the Nanoscale with @cellarchlab @bronwynalucas.bsky.social @thevillalab.bsky.social and more. Register at tinyurl.com/5n7jd7mr.

0103

Reposted by Allegretti Lab

Ben Barad @baradlab.com · 24/01/2024

The Barad lab is hiring across all levels. Open positions here: baradlab.com/join/. If you are interested in doing cutting edge tomography and computational methods development to study intracellular bacterial infection, and living in Portland, OR, but don't fit the openings, reach out anyway!

baradlab.com

Join the Barad Lab

The Barad Lab is a cryo-electron tomography and computational structural biology lab at Oregon Health & Science University

069