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Chlanda lab

@chlandalab.bsky.social
1K followers 497 following 23 posts

Membrane Biology of Viral Infection cryo-ET, cryo-CLEM, cryo-FIB, influenza, Ebola virus, SARS-CoV-2

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Bloom lab @jbloomlab.bsky.social · 23/07/2026
In new study led by @bdadonaite.bsky.social, we show many influenza HAs (H5, H7, H9, H1, H2, H3) can use avian or human MHC-II to enter cells. We then use novel combo of deep mutational scanning & cryoEM to define how H5 HA binds to avian MHC-II. Preprint: doi.org/10.64898/202...
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Chlanda lab @chlandalab.bsky.social · 01/05/2026
Join us at the 24th Workshop Cell Biology of Viral Infections @gesvirologie.bsky.social, Schöntal Monastery, 28–30.10.2026 cellviro.g-f-v.org “Cellular Routes and Roadblocks in Viral Genome Trafficking” Speakers: @beatesodeiklab.bsky.social · Alba Diz-Muñoz · @carogoujon.bsky.social · Redmond Smyth
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Helena Watson @helenawatson.bsky.social · 25/04/2026
Preprint 🧵! I’m really excited to introduce BIGSMALL, an interleaved multi-magnification cryo-ET scheme bridging molecular and cellular scales in a single acquisition! BIGSMALL = 𝐁road 𝐈nformation 𝐆athering 𝐒trategy by 𝐌ultiscale 𝐀cquisition of lame𝐋𝐋a www.biorxiv.org/content/10.6... (1/6)
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KaufmannLab @kaufmannlab.bsky.social · 24/04/2026
Happy to see the preprint of our VULCROM setup online! Thanks to our amazing collaborators we've managed to get some pretty cool cryo-CLEM images by combining cryo super-resolution and cryo-ET: doi.org/10.64898/202...
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joe dobbs @joedobbs.bsky.social · 22/04/2026
Big news for correlative cryogenic SMLM/ET! With my colleague Soheil, we (Mahamid and @jonasries.bsky.social labs) indicate lamella-specific illumination can allow 500-1500x higher laser intensities, opening massive new possibilities for correlative imaging #teamtomo www.biorxiv.org/content/10.6...
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Chlanda lab @chlandalab.bsky.social · 23/04/2026
First steps into cryo-lamella imaging by cryo-secondary ion mass spectrometry using helium and neon ion microscopy! We look forward to continuing with correlative cryo-EM-SIMS. Great work: Antje Biesemeier and colleagues - Luxembourg Institute of Science and Technology. pubs.acs.org/doi/10.1021/...
pubs.acs.org
Cryo-HIM-SIMS on the npSCOPE: Correlative Topographic, Transmitted and SIMS Imaging at Cryogenic Temperatures
Multimodal helium ion microscopy (HIM) and secondary ion mass spectrometry (SIMS) provide in situ spatial imaging and chemical analysis at nanoscale resolution. Operation at cryogenic temperatures is ...
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Tom Peacock @peacockflu.bsky.social · 14/04/2026
Excited to advertise a fully funded PhD with @socialinfluenza.bsky.social investigating how influenza virus evolution differs between different avian hosts (and how this impacts pandemic potential). Joint between @pirbrightinst.bsky.social + @cvrinfo.bsky.social www.findaphd.com/phds/project...
findaphd.com
FULLY FUNDED PhD - Visualising avian influenza virus tropism and co-infection in avian hosts at University of Glasgow on FindAPhD.com
PhD Project - FULLY FUNDED PhD - Visualising avian influenza virus tropism and co-infection in avian hosts at University of Glasgow, listed on FindAPhD.com
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Chlanda lab @chlandalab.bsky.social · 14/04/2026
Congratulations to Dao Thi lab @daothilab.bsky.social and collaborators! Beautiful work! @ciid-heidelberg.bsky.social
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Health + Life Science Alliance Heidelberg Mannheim @hlsalliance.bsky.social · 08/04/2026
Meet our new #AllianceFellow Jack Whitehead! The short interview about his work in the @chlandalab.bsky.social and Mahamid lab at @embl.org can be found on our LinkedIn account. @jackwh18.bsky.social
linkedin.com
Meet our new Alliance Fellow Jack Whitehead! Q: Could you tell us a bit about the work you do? Which field do you work in and who are your PIs? A: I am a structural biologist, and my work looks at… |...
Meet our new Alliance Fellow Jack Whitehead! Q: Could you tell us a bit about the work you do? Which field do you work in and who are your PIs? A: I am a structural biologist, and my work looks at th...
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Karim Majzoub @karimaj.bsky.social · 06/03/2026
We found a viral Trojan Horse: a virus can hide inside another virus.This one surprised us: deltaviruses don’t just borrow a helper virus. They can travel inside it. A literal Trojan Horse “virus-in-a-virus” route into cells. 🤯 Kudos to 1st author @viroscope.bsky.social and co-authors !
sciencedirect.com
Deltaviruses spread through a viral Trojan Horse
Hepatitis D-like satellite viruses, known as deltaviruses, have been recently discovered in a wide range of animals. These viruses are thought to expr…
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Jason McLellan @mclellanlab.bsky.social · 18/06/2025
Our latest preprint is now available doi.org/10.1101/2025...! Led by my postdoc, Luqiang Guo @luqiang.bsky.social, we determined a ~2.4 A resolution structure of the hantavirus glycoprotein tetramer on the surface of VLPs. Also determined structures of dimers of tetramers and Fab-bound tetramers.
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Cell Biology J-Club @cellclub.bsky.social · 18/02/2026
www.biorxiv.org/content/10.6... Structural basis of caveolin-driven membrane bending
biorxiv.org
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Multidisciplinary Center for Infectious Diseases (MCID) @mcid-unibe.bsky.social · 13/02/2026
Afterwards a panel discussion was moderated by Caroline Schlaufer featuring film director Christian Frei, biosafety expert Kathrin Summermatter & virologist @profvolkerthiel.bsky.social. The audience posed great questions on funding, biosafety & media polarisation.
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Ulrich Schwarz @ulrichschwarz.bsky.social · 30/01/2026
📢Job alert📢 @uniheidelberg.bsky.social has an opening for a full W3-position on “Modeling of Biological Processes” 😀👍 Here is the call tinyurl.com/3w9e9dtf and application deadline is March 15. The group would be located at the beautiful #BioQuant center right in the middle of Neuenheimer Feld.
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Chlanda lab @chlandalab.bsky.social · 07/02/2026
Trapozoid cryo-FIB milling allows to prepare a lamella for dual-axis cryo-ET and assessment of different deep-learning missing-wedge restoration algorithms. rdcu.be/e2nXE
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Nature Protocols @natprot.nature.com · 30/01/2026
New Article! Integrated fluorescence light microscopy-guided cryo-focused ion beam-milling for in situ montage cryo-ET
dlvr.it
Integrated fluorescence light microscopy-guided cryo-focused ion beam-milling for in situ montage cryo-ET
Nature Protocols, Published online: 30 January 2026; doi:10.1038/s41596-025-01284-zA protocol for cryogenic 3D correlative focused ion beam milling using an integrated fluorescence light microscope and montage cryo-ET for nonadherent and adherent mammalian cells, as well as primary Drosophila melanogaster neurons.
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Mari de Sautu @maridesautu.bsky.social · 27/01/2026
Check out our new preprint! We uncover the full molecular mechanism of rotavirus membrane penetration and cytosolic escape using cryo-ET, live-cell imaging, and single-molecule assays. (1/3) 🔗 biorxiv.org/content/10.6...
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Ervin Fodor @efodor.bsky.social · 24/01/2026
Cryo-EM structure reveals how influenza A virus NEP binds the viral polymerase at a regulatory hotspot, coordinating RNA synthesis and nuclear export. Fantastic collaboration with @loiccarrique.bsky.social and Jon Grimes. www.science.org/doi/10.1126/...
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Lars-Anders Carlson @lacarlson.bsky.social · 23/01/2026
I am super happy to share this paper in its final form. We used FIB milling to "dig in to" cell lines and mouse brains infected with tick-borne flaviviruses, followed by cryo-ET to study the virus replication. It's open access, so have a look! #virology #teamtomo www.nature.com/articles/s41...
nature.com
Cryo-electron tomography reveals coupled flavivirus replication, budding and maturation - Nature Communications
In this study, Dahmane et al use a method called cryo-electron tomography to uncover new details of how tick-borne flaviviruses transform cells into virus factories.
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Lars-Anders Carlson @lacarlson.bsky.social · 09/01/2026
Open #postdoc fellowship in my group. Virus replication and cryo-ET. Projects can be tailored to ambitious candidates with diverse backgrounds, so don't hold back from applying! DM for more info. Deadline 8 Feb. Apply here: umustipendie.varbi.com/en/what:job/... #virus #virology #teamtomo #cryoEM
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Jason Kindrachuk @kindrachukjason.bsky.social · 18/12/2025
Sharing this here at the request of Dr. Florian Krammer: semmelweisinstitute.ac.at/training-car...
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PLOS Biology @plosbiology.org · 09/12/2025
Spillover of #influenza A viruses from animals to humans represents a threat to our health. In this Perspective, Silke Stertz @virology.uzh.ch discusses emerging research that suggests some influenza A viruses can enter host cells via MHC-II receptors across species 🧪 #virology plos.io/4pP3Gnq
journals.plos.org
A new path to spillover: MHC-II entry of influenza A viruses
Spillover of influenza A viruses from animals to humans represents a threat to our health. This Perspective discusses emerging research that suggests some influenza A viruses can enter host cells via…
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Harry Low’s Lab @lowlab.bsky.social · 04/11/2025
Please RT. Post-doc opportunity alert! 💥 closing 10th December.. Come join our team (www.thelowlab.org) at Imperial, London, working on the structure and mechanism of bacterial secretion systems. For more details and to apply please see www.imperial.ac.uk/jobs/search-...
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Max Renner @maxrenner.bsky.social · 03/11/2025
Our new preprint is out 🥳🥳🥳 Henipaviruses, like Nipah and Hendra, package their genomes inside helical shells built by thousands of nucleoproteins. These nucleocapsids are essential to protect the viral RNA, but how do they ever let the polymerase in to read the sequence? 👇
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Harry Low’s Lab @lowlab.bsky.social · 29/10/2025
Please RT. Post-doc opportunity alert! 💥 closing 10th December.. Come join our team (www.thelowlab.org) at Imperial, London, working on the structure and mechanism of bacterial secretion systems. For more details and to apply please see www.imperial.ac.uk/jobs/search-...
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Jeremy Keown @jeremykeown.bsky.social · 24/10/2025
warwick.ac.uk/fac/cross_fa... I am advertising for a PhD position in my group. We'll be investigating how pathogenic RNA viruses replicate in the nucleus. The project will teach cryoEM/ET, virus culture, and in vitro assays. If you're interested reach out and I'd be happy to have a chat.
warwick.ac.uk
Dr Jeremy Keown
Dr Jeremy Keown
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Chlanda lab @chlandalab.bsky.social · 24/10/2025
Mysteries of trafficking of the vRNP segmented genome and assembly of influenza A virus revealed by in situ cryo-ET! 🔗 rdcu.be/eMmct We are very excited that our paper is finally out! 🎉 Big congratulations to Moritz Wachsmuth-Melm and to everyone involved.
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Cell Biology J-Club @cellclub.bsky.social · 16/10/2025
“Kiss-shrink-run” unifies mechanisms for synaptic vesicle exocytosis and hyperfast recycling | Science www.science.org/doi/10.1126/...
science.org
“Kiss-shrink-run” unifies mechanisms for synaptic vesicle exocytosis and hyperfast recycling
Synaptic vesicle (SV) exocytosis underpins neuronal communication, yet its nanoscale dynamics remain poorly understood owing to limitations in visualizing rapid events in situ. Here, we used optogenet...
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Jakob Meier-Credo @meiercredo.bsky.social · 19/09/2025
Check out our new preprint on an integrated pipeline combining in situ #cryo-ET with MALDI #MSImaging for single-cell identification and classification from previously analysed EM-grids. Link: www.biorxiv.org/content/10.1...
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Guenter Resch @nexperion.net · 23/09/2025
Happy to announce "Technical Innovations Using #SerialEM: A Community Meeting", a new format of hybrid meeting David Mastronarde and I are organizing in April 2026. For more info, a preliminary list of speakers, pre-registration etc. visit www.nexperion.net/semcm2026
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Lars-Anders Carlson @lacarlson.bsky.social · 22/09/2025
Since it was published at peak holiday season, I'm taking the liberty to re-introduce our recent review article. We hope it will be a useful overview of RNA virus replication strategies, and how in situ cryo-EM have helped us understand them: www.sciencedirect.com/science/arti...
sciencedirect.com
Illuminating druggable dark matter in RNA virus replication using in situ cryo-EM
Viral proteins typically exist in the context of complex virions or in the even more complex host cells in which they replicate. Hence, meaningful ins…
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Tanmay Bharat @tbharat-lab.bsky.social · 31/08/2025
Sub-cellular chemical mapping in bacteria using correlated cryogenic electron and mass spectrometry imaging Congrats Hannah Ochner and authors on this important paper! Strong collaboration with @kiranrpatil.bsky.social www.biorxiv.org/cgi/content/... @mrclmb.bsky.social @wellcometrust.bsky.social
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oleksiykovtun.bsky.social @oleksiykovtun.bsky.social · 21/08/2025
One week left to apply for a fully funded PhD position in my group! Please repost. jobrxiv.org/job/max-plan...
jobrxiv.org
PhD student in cryo-ET of membrane trafficking at MPI-NAT in Göttingen, DE
Post a job in 3min, or find thousands of job offers like this one at jobRxiv!
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François Mayer @francoismayer.bsky.social · 13/06/2025
Awesome malaria study out now in Nature Microbiology: An atypical Arp2/3 complex is required for Plasmodium DNA segregation and malaria transmission By Franziska Hentzschel, Matthias Marti, Freddy Frischknecht & colleagues! @freddyfrischknecht.bsky.social www.nature.com/articles/s41...
nature.com
An atypical Arp2/3 complex is required for Plasmodium DNA segregation and malaria transmission - Nature Microbiology
A unique Arp2/3 complex in malaria parasites enables DNA segregation during the rapid formation of male gametes by safeguarding the attachment of chromosomes to the mitotic spindle.
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Emily Bruce @brucelab.bsky.social · 10/06/2025
Really enjoyed writing about one of my favorite topics (influenza filaments). There is so much exciting new filament research now, it is clearly no longer 'the graveyard of postdocs' Bob Lamb called the topic during my PhD. www.embopress.org/doi/full/10....
embopress.org
Influenza filaments: a graveyard of postdocs no longer? | The EMBO Journal
EMBO Press is an editorially independent publishing platform for the development of EMBO scientific publications.
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Chlanda lab @chlandalab.bsky.social · 11/06/2025
Very nice News&Views summary written by ‪@brucelab.bsky.social‬ about our work and work by Ed Partlow et al. (NIH) that influenza A virus filamentous morphology plays an important role in infection (www.nature.com/articles/s41...) can. ‪Thank you! (www.embopress.org/doi/full/10....)
embopress.org
Influenza filaments: a graveyard of postdocs no longer? | The EMBO Journal
EMBO Press is an editorially independent publishing platform for the development of EMBO scientific publications.
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Chlanda lab @chlandalab.bsky.social · 11/06/2025
We are happy this work by Sarah Peterl et al. is out in EMBO J! It was an exciting collaborative effort of several groups in the SFB1129 consortium on pathogen replication and spread. Check out the correlated light and scanning EM method to study virus morphology changes during spread!
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Yi-Wei Chang @yiweichang.bsky.social · 15/05/2025
Excited to share our new @science.org paper! Led by postdocs Ruchao Peng and Xin Xu, we used cryo-EM/ET to reveal the influenza ribonucleoprotein complex structure and its strand-sliding mechanism for RNA synthesis, paving the way for new antivirals. www.science.org/doi/10.1126/...
science.org
Molecular basis of influenza ribonucleoprotein complex assembly and processive RNA synthesis
Influenza viruses replicate and transcribe their genome in the context of a conserved ribonucleoprotein (RNP) complex. By integrating cryo–electron microscopy single-particle analysis and cryo–electro...
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Harry Low’s Lab @lowlab.bsky.social · 28/04/2025
Please RT. Post-doc opportunity alert! 💥 closing 5th May.. Come join our team (thelowlab.org) at Imperial, London, working on bacterial secretion systems. The position is funded by the Wellcome Trust. For more details and to apply please see www.imperial.ac.uk/jobs/search-...
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Florent Waltz @florentwaltz.bsky.social · 25/04/2025
Check out the latest version of MemBrain, spearheaded by computation superstar @lorenzlamm.bsky.social ! It can segment, pick particles and give you metrics on everything!
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MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 23/04/2025
A colder frontier in cryo-EM 🧪🔬 Chris Russo’s group, inc. Joshua Dickerson, adapted #cryoEM to work at liquid helium temperatures (13 kelvins), where every frame captured contains more information than the equivalent using liquid nitrogen (81 kelvins). Read more: tinyurl.com/mwwcunkc #LMBResearch
The electron cryo-microscope adapted for use at liquid nitrogen temperatures within its custom-made black box.
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Jan Philipp Kreysing @jpkreysing.bsky.social · 11/04/2025
New preprint on 3D heterochromatin architecture in human cells! Great collab with @sergiocruzleon.bsky.social & @johannesbetz.bsky.social from @hummerlab.bsky.social, @marinalusic.bsky.social & the Turoňová lab. Many thanks to my supervisor @becklab.bsky.social. bioRxiv: tinyurl.com/3a74uanv 🧵👇
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Sven Klumpe @svenklumpe.bsky.social · 09/04/2025
Thrilled to share these experiments on shaping focused ion beams to explore different ways of milling. Here, we explore using different beam geometries to generate cellular thin sections/lamellae. The video shows elongating the beam on a charging spot burn www.biorxiv.org/content/10.1...
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Daniel Hurdiss @danielhurdiss.bsky.social · 26/03/2025
I’m delighted that we could contribute the #cryoEM data to this incredible antiviral discovery project from the group of @neytsjohan.bsky.social 💊 "A coronavirus assembly inhibitor that targets the viral membrane protein" www.nature.com/articles/s41... A huge congrats to everyone involved! 🎉
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bioRxivpreprint @biorxivpreprint.bsky.social · 15/03/2025
Automated Removal of Corrupted Tilts in Cryo-Electron Tomography www.biorxiv.org/content/10.1101/202…
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Chlanda lab @chlandalab.bsky.social · 05/03/2025
This is a great opportunity to establish a virology research group at CIID, Heidelberg University!
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Heidelberg University Biochemistry Center @bzh-hd.bsky.social · 02/03/2025
🚨 We are hiring 🚨 We seek to fill a full-time teaching position starting September 1, 2025! We look forward to your application (cover letter, CV, certificates, etc.) in a single PDF. Deadline: March 14, 2025 @uniheidelberg.bsky.social @bzh-hd.bsky.social 👇👇👇👇👇👇👇
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Chlanda lab @chlandalab.bsky.social · 28/02/2025
Very nice work showing fusion intermediates of SARS-CoV-2!
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Jana Kroll @janakroll.bsky.social · 12/02/2025
Excited to share our new preprint "Dynamic nanoscale architecture of synaptic vesicle fusion in mouse hippocampal neurons" www.biorxiv.org/content/10.1... We combine optogenetic stimulation of neurons with in situ cryo-ET to characterize membrane dynamics during synaptic vesicle fusion ❄️🔬⏱️
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