What I told early-career researchers about prediction, rigour, failure, priors — and the tyranny of bar graphs.

CAMBRIDGE, MA—Molecular biologist and social media influencer Dr.

Anthropic is an AI safety and research company that's working to build reliable, interpretable, and steerable AI systems.

Nature Structural & Molecular Biology - Mammalian life begins with oocytes and sperm cells, but our understanding of the molecular mechanisms endowing these cells with their unique properties...

Nature Structural & Molecular Biology, Published online: 11 September 2026; doi:10.1038/s41594-026-01892-7Mammalian life begins with oocytes and sperm cells, but our understanding of the molecular mechanisms endowing these cells with their unique properties has lagged behind. In this Editorial, our team emphasizes the need and our wish to improve our knowledge in how these cells operate.

The ciliary transition zone (TZ) regulates ciliary proteome composition, yet its molecular architecture, protein content, and contribution to motile ciliopathies remain poorly defined. We applied in situ cryo-electron tomography and subtomogram averaging ...

CHICAGO, IL—A manuscript that has remained in a tote bag since the 2025 ASBMB conference confirmed Tuesday that it still remembers when it was freshly printed and full of hope.

During replisome assembly of monkeypox virus, the hexameric helicase–primase E5 undergoes large-scale conformational changes that allow two of its primase domains to interact with the polymerase F8 th...

Proteasomes are essential for male fertility. Kolata, dos Santos, Dendooven and colleagues show large nuclear proteasomal assemblies segregated from DNA in human sperm, forming after meiosis and with ...

Nature Structural & Molecular Biology, Published online: 01 September 2026; doi:10.1038/s41594-026-01870-zProteasomes are essential for male fertility. Kolata, dos Santos, Dendooven and colleagues show large nuclear proteasomal assemblies segregated from DNA in human sperm, forming after meiosis and with a unique α4s isoform. A native substrate is bound at the 20S catalytic site.

Proteasomes are essential for male fertility. Kolata, dos Santos, Dendooven and colleagues show large nuclear proteasomal assemblies segregated from DNA in human sperm, forming after meiosis and with ...

From pursuing an impossible dream to uncovering one of the cell’s best-kept secrets and advancing the design of improved antibiotics

Cryo-electron tomography reveals the architecture of cell interiors, but the small field of view of the resulting images limits the appreciable cellular context. Montage tomography solves this, but ex...

SEATTLE, WA—Holding her breath as the analytical balance stabilized Monday morning, University of Washington graduate student Aubrey Smith, 27, experienced a fleeting moment of pure joy as the digital...

Drebrin regulates crucial cellular processes through its F-actin binding and regulating functions. Here, the authors report cryo-EM structures of drebrin’s actin-binding domains complexed with F-actin...

In the aftermath of pandemics, people either try to forget them or find others to blame for them.

SBGrid webinars are hosted with partial support from the NIH R25 Continuing Education for Structural Biology Mentors #GM151273, in collaboration with Co-PI Jamaine Davis of Belmont…

Fischer et al. uncover a fundamental mechanism of membrane fusion during nuclear pore complex (NPC) assembly. Brl1 and Brr6 form ring-shaped, membrane-remodeling complexes that interact and bridge the...

The cryo‑EM structure of the Oryza sativa photosystem II–light harvesting complex II supercomplex in its native membrane reveals the intact plant photosystem architecture, retaining physiologically relevant proteins and lipids that are otherwise lost during purification.

Nature - Model modifies existing proteins using probability approach.

Focused ion beam (FIB)-milling has been adapted to thin frozen cells for visualization of macromolecular structures in situ with cryogenic electron microscopy. However, only a few large and abundant c...

Cryo-electron microscopy sheds light on the architecture of the Trypanosoma brucei mitochondrial editosome and reveals how this assembly mediates mRNA editing through the insertion and deletion of uridine nucleotides.

A ketogenic diet promotes tumour growth in the small intestine in susceptible mice. In people, diet advice might need to be tailored to individual cancer risks.

DURHAM, NC—A high-performance liquid chromatography column passed away Tuesday at approximately 3:47 PM, surrounded by the very people who had caused its death, sources confirmed.

The EUROPE-IGM-ATLAS reveals spatiotemporal trends that characterize the changing geography of opportunity in Europe and its relationship with regional innovation.

The recent launch of qed’s “top 1%” preprint ranking has sparked controversy, with concerns about its arbitrary nature, potential harm to authors, and low-quality inclusions. Whil…

The recent launch of qed’s “top 1%” preprint ranking has sparked controversy, with concerns about its arbitrary nature, potential harm to authors, and low-quality inclusions. Whil…