iiinova — where your digital self keeps evolving

Reposted by Suliana Manley

Minczuk Lab @mitogene.bsky.social · 05/08/2026

Delighted to share the launch of the Cambridge-led, £50m MRC Centre of Research Excellence in Mitochondrial Genome Therapeutics (CoRE-MitoGT). Over 14 years, we will unite international expertise to understand mtDNA disease & develop therapies targeting its root causes. www.ukri.org/news/mrc-fun...

ukri.org

MRC funds world-class research into fatal genetic diseases

The Medical Research Council (MRC) has invested £50 million into the study of mitochondrial diseases to improve treatments.

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Reposted by Suliana Manley

Quentin Smith @qmsmith.bsky.social · 25/03/2026

Excited to share our story published today @nature.com! 🔗 www.nature.com/articles/s41... Read about how we uncover the molecular mechanisms that enable Cas9 to bind and cleave negatively supercoiled ((-)SC) off-targets! Have a quick read of some of the key events in the thread below🧵:

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Reposted by Suliana Manley

Julius Winter @julius-w.bsky.social · 08/06/2026

I made a video summary of our recent paper on mitochondrial trafficking. 🔬🧫🧬Check out the paper here: doi.org/10.1083/jcb.... @jclandoni.bsky.social @sulianamanley.bsky.social @jcb.org youtu.be/Az8xzdO0nVU?... #mitochondria #imaging #fluorescence #organelle

youtu.be

Mitochondrial trafficking to maintain network morphology

YouTube video by Julius Winter

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Reposted by Suliana Manley

Rockefeller University Press @rupress.org · 03/06/2026

In @jcb.org, the @sulianamanley.bsky.social group reveal that perinuclear #mitochondria form a source population, w/ biased anterograde transport spreading material to maintain network connectivity & balanced mitochondrial mass across the cell rupress.org/jcb/article/...

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Reposted by Suliana Manley

Journal of Cell Biology @jcb.org · 03/06/2026

@julius-w.bsky.social @jclandoni.bsky.social @sulianamanley.bsky.social et al reveal that perinuclear #mitochondria form a source population, w/ biased anterograde transport spreading material to maintain network connectivity & balanced mitochondrial mass across the cell rupress.org/jcb/article/...

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Suliana Manley @sulianamanley.bsky.social · 22/05/2026

We had such a fun ERC Synergy @erc.europa.eu kickoff workshop for our 6-year MitoContact collaborative project with our partners Kai Johnsson and Wanda Kukulski! Wonderful to share science, ideas, and play games together 💚 fantastic organization by @zimmerli.bsky.social @jclandoni.bsky.social

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Suliana Manley @sulianamanley.bsky.social · 19/02/2026

Thanks for highlighting our work on combining AI-based organelle dynamics detection in phase contrast with fluorescence! www.nature.com/ncomms/edito... @natcomms.nature.com and Nelio Rodriguez. Spearheaded by @wl-stepp.bsky.social with collaborators @jclandoni.bsky.social @maweigert.bsky.social

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Suliana Manley @sulianamanley.bsky.social · 23/01/2026

I’m honored to be part of the next GRS Single Molecule Approaches to Biology, thanks Chairs @qmsmith.bsky.social and Alba Gomez Segalas for organizing this great event! The GRS is a wonderful opportunity for young scientists to share their exciting science and build communities. See you there!

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Suliana Manley @sulianamanley.bsky.social · 20/01/2026

@lycasworks.bsky.social developed quantitative expansion (qExM) to estimate endogenous protein quantities in situ. His ExM protocols offer epitope preservation and accessibility so that standard Western Blot antibodies can be used. Also, check out the cristae, supercomplexes, specialized mitos 🤩

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Suliana Manley @sulianamanley.bsky.social · 28/11/2025

Ultra excited to launch an ERC Synergy project with amazing partners Kai Johnsson @mpi-mr.bsky.social & Wanda Kukulski @unibe.ch! MitoContact will reveal how contacts between identical organelle partners can yield a diversity of important functions, via dynamics, structure and physiology.

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Suliana Manley @sulianamanley.bsky.social · 17/11/2025

I’m excited about this unique meeting, which will bring together some of my favorite scientists working on organelle biophysics and mechanics! I hope to see some of you in beautiful Barcelona in February. Deadlines have been extended: Dec. 8 abstracts Dec. 20 registration

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Suliana Manley @sulianamanley.bsky.social · 30/05/2025

This was a delightful meeting, thank you @nynkedekkerlab.bsky.social, @achilleskap.bsky.social , & @lumicks.bsky.social . I had a great time meeting UK’s young single molecule enthusiasts, so many exciting posters!

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Suliana Manley @sulianamanley.bsky.social · 07/05/2025

Interesting! Scientists outside of Europe looking to move to the EU or Switzerland can benefit from this funding opportunity, it includes up to an additional €2 million beyond the grant cap for setup costs.

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Suliana Manley @sulianamanley.bsky.social · 06/04/2025

Our latest preprint www.biorxiv.org/content/10.1..., describes Willi Stepp’s project to make smart microscopy even gentler by doing event detection in phase contrast. We developed neural networks to detect mito-LD and mito-lysosome contacts, as well as mitochondrial pre-fission constrictions.

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Reposted by Suliana Manley

LUMICKS @lumicks.bsky.social · 24/02/2025

Following the great success of the 2024 event, @ox.ac.uk and LUMICKS proudly present the second UK-Ireland symposium focusing on single-molecule research! The abstract deadline, 7 March, is approaching fast. Secure a talk or poster by registering now > bit.ly/4gYPPpQ

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Suliana Manley @sulianamanley.bsky.social · 06/02/2025

Rockin’ out at EMBO in situ with @lycasworks.bsky.social @jonasries.bsky.social Christian Zimmerli, Mark Bates 🤘🔬

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Suliana Manley @sulianamanley.bsky.social · 05/02/2025

MBL Physiology is totally invigorating, it’s a joyful mixture of: frontier scientific discoveries, kick-a$$ microscopes, and lovely, brilliant, generous ppl. I can’t wait for the summer!

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Suliana Manley @sulianamanley.bsky.social · 23/12/2024

This was an amazing collaboration, we had the luxury of years of great conversations with @wallaceucsf.bsky.social and his team, as well as our other @HFSP partners @anjbadri.bsky.social and Johan Paulsson. Thanks for telling the story here, Wallace!

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Reposted by Suliana Manley

Juan C. Landoni @jclandoni.bsky.social · 23/12/2024

Stoked to share TWO preprints on mitochondrial pearling! 🎉 We uncover how spontaneous #mitochondria pearling drives #mtDNA nucleoid distribution (doi.org/10.1101/2024...), and @gavsturm.bsky.social et al. dissect the biophysics behind it (doi.org/10.1101/2024...). Details below! 🔬🧵🧪

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Suliana Manley @sulianamanley.bsky.social · 23/12/2024

I’m ultra excited about our preprints on mitochondrial pearling. In two concurrent collaborative studies with @wallaceucsf.bsky.social, we investigated its consequences on mtDNA nucleoids (led by @jclandoni.bsky.social) & its biophysical causes (led by @gavsturm.bsky.social). Funders HFSP, ERC, SNSF

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Suliana Manley @sulianamanley.bsky.social · 09/12/2024

I’m excited to join this session organized by Assaf Zaritsky and Megan Driscoll for the "Beyond Pretty Pictures" subgroup. I’ll share our latest on Smart Microscopy and mitochondria. #cellbio2024 @ascbiology.bsky.social Sat. Dec. 14, 11:15am, Rm 30C plan.core-apps.com/ascbembo2024/e…

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Reposted by Suliana Manley

Jennifer Waters @jencwaters.bsky.social · 02/12/2024

We are so excited that @janfunkey.bsky.social has agreed to give the keynote seminar for @qiatcshl.bsky.social 2025 @cshlnews.bsky.social! 🔬🖥️ 🛤️ Applications due 1/31/2025. t.co/x87ngy34UC

t.co

https://meetings.cshl.edu/courses.aspx?course=C-QICM

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Suliana Manley @sulianamanley.bsky.social · 01/12/2024

Still on my oldies kick. Schwann proposed in his MDCCCXLVII monograph that muscle came from cell coalescence. "filaments are formed, which, in some situations, have an appearance like strings of pearls ... At a subsequent period, all trace of granules or division in the filament vanishes ..."

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Suliana Manley @sulianamanley.bsky.social · 28/11/2024

I’m reading some old mito classics, Margaret Reed and Walter Harmon Lewis with their camera lucida renderings. From various sources I thought the 1914 Science paper was ‘the one’, but on jstor there were no figures. Instead, it’s the 1915 AJA paper that’s a goldmine (Figs 6 & 10). Am I mistaken?

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Suliana Manley @sulianamanley.bsky.social · 18/11/2024

Here is a blue sky — an auspicious sign for the day I joined bluesky? Enjoying lovely Puerto Varas for the Chilean Cell Biology Meeting with my host Veronica Eisner. 💚

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