The Arp2/3 complex in mammals, consists of 8 iso-complexes with different properties as there are two isoforms of the Arp3, ArpC1 and ArpC5 subunits. All iso-complexes still generate actin branches wh...

The Department of Biological Sciences at Columbia University invites applications for a tenure-track, Assistant Professor position. The successful ...

The actin-rich cell cortex is a viscoelastic structure essential for processes such as cell migration and division, yet the full spectrum of actin assembly factors that build and regulate the cortex i...

Anoxic live-cell imaging shows actin-dependent crawling motility and dynamic protrusions in Asgard archaea, providing insights into cellular innovations that may have contributed to eukaryotic evoluti...

Ramanathan et al. show that the shape changes during mitosis actively reorganize epithelial packing. Withdrawal of the dividing cell from the basal region and the geometry of daughter reinsertion rear...

The actin cytoskeleton drives shape changes and transport in cells and supports mechanical signal transmission. However, how cells control and use active cytoskeletal flows at the mesoscale is not wel...

As cells polarize and migrate, numerous molecular events critical for immunity and cancer metastasis dynamically self-organize. This study identifies a universal symmetry-breaking mechanism where loca...

Cells migrating through three-dimensional (3D) tissues adapt their mechanical properties in response to extracellular matrix architecture through migratory plasticity. In primary human dermal fibrobla...

The actin-related protein 2/3 (Arp2/3) complex is a central nucleator of branched actin filaments, essential for numerous cellular processes. Using superresolution imaging, we demonstrate that Arp2/3 ...

To clean tissue from tumorigenic and infected cells, cytotoxic T lymphocytes (CTLs) must navigate confined environments in vivo, locate the infected cells and eliminate them. Impaired CTL migration to...

Department of Developmental NeurobiologyCenter of Excellence for Structural Cell Biology and Neuronal Cell Biology DivisionSt. Jude Children’s Research HospitalThe Center of Excellence for...

Kage et al. report a novel phosphorylation-dependent interaction between INF2 and VAP proteins. Increased cytoplasmic calcium stimulates INF2 phosphorylation, which, in turn, allows VAP binding. The I...

A newly discovered family of microbial autoproteolytic domains suggests that bacteria and animals may share a common strategy for responding to physical forces. Beyond uncovering an ancient protein fo...

Author summary The first division of the C. elegans embryo is asymmetric and establishes its anterior and posterior ends, along the long axis of the elongated, ellipsoid egg. Polarization relies on a ...

During cytokinesis in amphibian and echinoderm embryos, propagating waves of Rho activity and F-actin assembly - cortical excitability - are amplified and focused at the equatorial cortex by the mitot...

In genetic cardiomyopathies, a frequently described phenomenon is how similar mutations in one protein can lead to discrete clinical phenotypes. One example is illustrated by two mutations in beta myo...

Abstract. Sorghum (Sorghum bicolor), a C4 grass adapted to hot semi-arid environments, depends on reinforced xylem vessels to maintain hydraulic conductanc

Author summary From development to wound healing to immune responses, cell movement is essential, and to move, a cell must first decide where its “front” and “back” are, a process known as polarizatio...