Jha et al. show that the transmembrane protein CD44 restricts EGFR mobility to maintain an EGFR–PI3K–Rac gradient during bleb-based cell migration.

Magnetic resonance control of spin-correlated radical pairs alters red fluorescent protein emission in transgenic Caenorhabditis elegans, demonstrating in vivo magnetic field modulation of biomolecula...

Learn about using Optogenetics plasmids in your lab, including microbial opsins and optical switch systems.

Inducible translocation to subcellular compartments is a common strategy for protein switches that control a variety of cell behaviors. However, existing switches achieve translocation through induced...

A recently developed class of magneto-sensitive fluorescent proteins are engineered to alter the properties of their response to magnetic fields and radio frequencies, enabling multimodal sensing of b...

Quitting projects in science is hard, but we should be doing a lot more of it.

Primary Work Address: 4000 Jones Bridge Road, Chevy Chase, MD, 20815 Current HHMI Employees, click here to apply via your Workday account. The Howard Hughes Medical Institute (HHMI) advances the disco...

Cell extrusion is essential for homeostatic self-renewal of the intestinal epithelium. Extrusion is thought to be triggered by crowding-induced compression of cells at the intestinal villus tip. In th...

NIH has issued NOT-OD-25-132 Supporting Fairness and Originality in NIH Research Applications which informs us that NIH will only accept six new, renewal, resubmission, or revision applications fro…

Molecular recorders based on kinase activity-dependent protein labeling track specific kinase activities to understand their link to cellular phenotypes in heterogeneous cell populations and in vivo.

Experiments in fission yeast show that cyclin-dependent kinase is first activated in the nucleus, from which the mitotic signal is propagated from CDK at the centrosome to the cytoplasm.

US science funder also plans to screen grant applications for compliance with ‘agency priorities’.