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rmmege.bsky.social

@rmmege.bsky.social
65 followers 34 following 2 posts
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CNRS Biologie @cnrsbiologie.bsky.social · 17/03/2025
#RésultatScientifique🔎 La force cachée des cellules @bladoux.bsky.social et @rmmege.bsky.social et leurs collaborateurs révèlent que l’adhésion intercellulaire joue un rôle clé dans la compétition cellulaire, influençant le développement et la lutte contre le cancer.
buff.ly
La compétition cellulaire : quand les forces mécaniques sculptent nos tissus
La compétition cellulaire est un mécanisme de surveillance essentiel qui élimine les cellules indésirables, jouant un rôle clé dans le développement, la répon
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Institut Jacques Monod @ijmonod.bsky.social · 24/03/2025
✍️ The @bladoux.bsky.social / @rmmege.bsky.social Lab published a new article 📖 Nature materials 📃 Force transmission is a master regulator of mechanical cell competition 🔗 www.nature.com/articles/s41...
nature.com
Force transmission is a master regulator of mechanical cell competition - Nature Materials
Differences in force transmission capabilities between competing cells create large stress fluctuation at their interface, resulting in upward forces and cell elimination, which might have implication...
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Benoit Ladoux @bladoux.bsky.social · 14/03/2025
Happy to share our new publication in @naturematerials.bsky.social on mechanical cell competition! Great collaboration between our CAM team, Chavrier's and Doostmohammadi's. Special congrats @luanger.bsky.social, @andreasschoenit.bsky.social, Siavash Monfared! 🎉 www.nature.com/articles/s41...
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epithelial mechanics fan club @epimechfc.bsky.social · 16/02/2025
A stress describes forces applied in a given location regarding all the directions of space. As a tensor, it consists of several components expressing different deformations. Its isotropic part (pressure) creates compressive (shrinkage) or tensile (expansion) stresses describing the mechanical state
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epithelial mechanics fan club @epimechfc.bsky.social · 16/02/2025
Tissues are dynamic and investigating cellular mechanical states can be crucial for understanding biological processes. But how to do it? We are @andreasschoenit.bsky.social and @luanger.bsky.social from @bladoux.bsky.social / @rmmege.bsky.social lab highlighting ways to assess tissue stresses.
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Benoit Ladoux @bladoux.bsky.social · 08/01/2025
Shared link to our paper: Dynamic forces shape the survival fate of eliminated cells rdcu.be/d5AD6
rdcu.be
Dynamic forces shape the survival fate of eliminated cells
Nature Physics - Tissues eliminate unwanted cells through cell extrusion, but the factors determining whether these extuded cells live or die are not fully understood. Now force transmission across...
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Benoit Ladoux @bladoux.bsky.social · 08/01/2025
Happy to share our new publication in @naturephysics.bsky.social on life and death of eliminated cells! Great collaboration between our CAM team and Doostmohammadi's. Special congrats @lakshmib02.bsky.social and Siavash Monfared! 🎉 www.nature.com/articles/s41...
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rmmege.bsky.social @rmmege.bsky.social · 08/01/2025
So happy to share at the start of 2025 our publication in @naturephysics.bsky.social with @bladoux.bsky.social and Amin Doostmohammadion on the impact of E-cadherin adhesion on live-dead cell extrusion; first authors @lakshmib02.bsky.social and S. Monfared. see www.nature.com/articles/s41...
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Andreas Schoenit @andreasschoenit.bsky.social · 21/12/2024
Multiple groups have reported that losing cells are eliminated through being compressed by the winners. Directly measuring these forces, we confirmed this for most experimental conditions. Surprisingly, however, in the case of MDCK WT competing against E-cad KO cells, we observed the opposite!
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Andreas Schoenit @andreasschoenit.bsky.social · 21/12/2024
Exerting high forces, losing E-cad KO cells compress the winning WT cells, but are eliminated anyway. But why? Combining simulations and experiments, we found that E-cad KO elimination occurrs at the mechanically highly active interface between the tissues, due to large stress fluctuations
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Andreas Schoenit @andreasschoenit.bsky.social · 21/12/2024
We show that cells with increased cell-cell adhesion benefit from increased force transmission capabilities and exhibit a higher resistance to these stress fluctuations, while the opposing cells are removed. Thus, force transmission can provide the crucial advantage in mechanical cell competition
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