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Haley Lab

@labohaley.bsky.social
757 followers 802 following 109 posts

We develop and apply advanced genetic manipulation technologies to make sense of biological complexity. Formerly @Genentech now @umontreal.ca. More about our lab and research here: labohaley.com

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Reposted by Haley Lab
Matthew Freeman @mjafreeman.bsky.social · 30/09/2026
Yet another opportunity @dunnschool.bsky.social! We are looking for an Associate Professor If you have exciting research plans, @dunnschool.bsky.social is a great place: excellent science (and lovely people, obvs) www.path.ox.ac.uk/vacancy/asso...
path.ox.ac.uk
Associate Professorship of Cancer Biology - Sir William Dunn School of Pathology in association with the Queen’s College. - Dunn School
We are seeking to appoint an Associate Professor working in the area of the cellular and/or molecular biology of cancer, to be based in Oxford University’s Sir William Dunn School of Pathology. The ro...
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Michel Cayouette @michelcayouette.bsky.social · 28/09/2026
If you are a postdoc looking for opportunities to present your latest results, apply to our Early-Career Scientists Seminar Series (ECS3) to get invited to our Institute, all expenses paid. A unique opportunity! Apply here: www.ircm.qc.ca/en/ecs3
ircm.qc.ca
ECS3
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Institute of Molecular Biotechnology @imbavienna.bsky.social · 23/09/2026
Can “jumping genes” spread like viruses? New research from the Brennecke lab at IMBA shows that, in fruit flies, certain transposable elements can break out of their own cell and slip into developing eggs—securing their passage to the next generation. Published in Cell: imba.science/4jdMuYQ
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Doudna Lab @doudna-lab.bsky.social · 19/09/2026
Out now in Science: Two papers from our lab reveal VIPR, an RNA-guided DNA-targeting system in bacteriophages, providing clues to the origins of CRISPR www.science.org/doi/10.1126/... www.science.org/doi/10.1126/... Congrats to Peter Yoon, @kenjmloi.bsky.social @terryzzy.bsky.social, T.Docter & team
science.org
A noncontiguous code for RNA-guided DNA recognition at the origin of CRISPR-Cas
CRISPR-Cas provides RNA-mediated adaptive immunity, but how its first RNA-guided effector arose is unclear. In this study, we report the discovery of Viral Interference Programmable Repeat (VIPR) syst...
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Department of Biochemistry & Cell Biology at Dartmouth @dartmouthbcb.bsky.social · 14/09/2026
BCB is recruiting a senior faculty member! We seek internationally recognized candidates at the Full Professor level with outstanding records of solving broad biological problems. Learn more and apply here: apply.interfolio.com/192850
apply.interfolio.com
Apply - Interfolio {{$ctrl.$state.data.pageTitle}} - Apply - Interfolio
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Ben Martin @benjaminmartin.bsky.social · 04/09/2026
Come be my colleague! Montreal is a great place to live and work! Tenure Track position at @mcgill.ca in quantitative cell biology with a research program to address fundamental questions in biology. @futurepislack.bsky.social mcgill.wd3.myworkdayjobs.com/McGill_Caree...
mcgill.wd3.myworkdayjobs.com
Assistant Professor in Quantitative Cell Biology - Department of Biology
Please refer to the How to Apply for a Job (for External Candidates) job aid for instructions on how to apply. If you are an active McGill employee (ie: currently in an active contract or position at ...
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Shawn Burgess @burgesslab.bsky.social · 10/08/2026
Call for papers for a cool new special issue of Genetics focused on Functional Genomics: academic.oup.com/genetics/art...
academic.oup.com
Using functional genomics to explore biological networks: a call for papers
The journal GENETICS is calling for submission of papers for a Special Issue on “Using functional genomics to explore biological networks.”
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Ran Blekhman @blekhman.bsky.social · 09/08/2026
Huge faculty recruitment effort at the University of Chicago -- a division-wide, open-rank search looking to hire about 20 faculty across 5 research areas in biology. Come be our colleague! Full announcement: uchicago.app.box.com/s/ckih9zv3rj...
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Harmit Singh Malik @harmitmalik.bsky.social · 06/08/2026
Come be our colleague. I have been in this Division for 27 years (4 as a postdoc and 23 as a PI). It is an amazing place to work, collaborate, and be inspired. If you are applying to be an Assistant or Associate Professor this Fall, don't miss this deadline.
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Noah Whiteman @nkwhiteman.bsky.social · 06/08/2026
I’m thrilled to share that our search for a tenure-track colleague in my *truly wonderful and collegial* Genetics, Genomics, Evolution and Development Division in the MCB Department at Berkeley @berkeleymcb.bsky.social is live! Please share this broad search widely: aprecruit.berkeley.edu/JPF05481
aprecruit.berkeley.edu
Assistant Professor -Genetics, Genomics, Evolution, and Development - Molecular and Cell Biology
University of California, Berkeley is hiring. Apply now!
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George O'Toole (he/him/his) @geiselbiofilm.bsky.social · 31/07/2026
Pls share. Assistant Professor of Biological Sciences - Genetics/Genomics at Smith College. apply.interfolio.com/190342
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Baptiste Lacoste @blacoste.bsky.social · 21/07/2026
🚨 Now available on Nature Careers ! #Recruitment #Ottawa
nature.com
Tier 2 Canada Research Chair in Vascular Links to Neurodevelopment - Ottawa, Ontario (CA) job with University of Ottawa, Ontario CANADA | 12861923
uOttawa, in partnership with the OHRI, invites applications for a Tier 2 CRC in Vascular Links to Neurodevelopment and their impact on brain health.
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Matthew Taliaferro @jmtali.bsky.social · 11/06/2026
New paper! How do RNAs "know" where to go inside a cell? We dug into the sequence elements that route RNAs to the right place. It turns out that, in mammals, they're surprisingly massive (>200 nt), multipartite, and wonderfully complicated. 🧵
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Haley Lab @labohaley.bsky.social · 02/06/2026
Beyond excited to share our latest publication in Nature Portfolio/Nature Communications, where we aimed to overcome barriers that have thus far prevented widespread application of Cas12a — Cas9’s highly versatile cousin — for single-cell screening applications. www.nature.com/articles/s41...
nature.com
A tunable Cas12a platform for single-cell perturbation screening and CRISPRi - Nature Communications
Cas12a self-processing of guide RNA transcripts limits its use for Perturb-seq by preventing guide capture. Here, authors develop a chemically degradable Cas12a platform enabling accurate guide assign...
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American Society of Gene + Cell Therapy @asgct.bsky.social · 02/06/2026
Ready to take your research to the next level? Early-career researchers and emerging investigators are invited to apply for these $100K grant opportunities: ✔️ Career Development Award: asgct.org/cda ✔️ Expanding Pathways Fellowship: asgct.org/expanding
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Roberto Vázquez Núñez @robertovn.bsky.social · 29/05/2026
🚨 New preprint: GATO-seq did it again! ELOF1 is the missing promoter-proximal factor that confers RNA Pol II resistance to TFIIF. Including ELOF1, DSIF, and NELF in GATO-seq reactions recapitulates promoter-proximal pausing in vitro at physiological conditions for the 1st time. tinyurl.com/ELOF1
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Waggoner Lab @labwaggoner.bsky.social · 09/05/2026
Review @natrevimmunol.nature.com @mcgilluniversity.bsky.social Calibrating T cell responsiveness through interactions with self www.nature.com/articles/s41...
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Amar Sahay @amarsahay.bsky.social · 06/05/2026
It takes a village, every step matters. Basic science, NIH funding, Biotech, Patient advocacy, FDA, and Insurance. In a Milestone for A.L.S., a Treatment Helps Some Patients Improve www.nytimes.com/2026/05/06/w...
nytimes.com
In a Milestone for A.L.S., a Treatment Helps Some Patients Improve
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Haley Lab @labohaley.bsky.social · 05/05/2026
Excited to share that our #NSERC CREATE / #CRSNG FONCER program, GENE ENGINEER, has been funded! nouvelles.umontreal.ca/article/2026... nserc-crsng.canada.ca/en/news/nser...
nouvelles.umontreal.ca
Deux chercheurs de l’UdeM obtiennent un financement majeur du CRSNG pour former la relève
Deux professeurs de l’UdeM reçoivent 1,65 M$ du programme FONCER du CRSNG pour concevoir des formations en recherche axées sur la collaboration, l’innovation et l’employabilité.
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Kenneth Loi @kenjmloi.bsky.social · 27/04/2026
Excited to share our discovery of a new programmable RNA-guided DNA-targeting system hiding inside bacteriophages that predates CRISPR. We call it VIPR (Viral Interference Programmable Repeat), and it uses an entirely new logic to find its targets. Thread + link below.
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Mariko Bennett @nachoriko.bsky.social · 24/03/2026
I defended my PhD 10 years ago today. That was the least remarkable thing that happened that day. Sharing something I wrote about it last year. Since then "the horrors persist but so do we." And with dignity.
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EMBL-EBI @ebi.embl.org · 16/03/2026
You asked, we listened. Millions of AI-predicted protein complex structures are now available in the #AlphaFold Database. This spans homodimers from 20 of the most studied species, including humans, as well as the World Health Organization’s priority pathogens list. www.ebi.ac.uk/about/news/t...
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Stanford Medicine @stanfordmedicine.bsky.social · 14/03/2026
Spotlight on Alistair Boettiger, assistant professor of developmental biology: He studies how the structure and movement of DNA molecules are linked to gene activity and, ultimately, cells’ identities and behaviors. stan.md/4kS38vU
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Páll Melsted @pmelsted.bsky.social · 06/03/2026
Excited to share this preprint that describes my latest work on using GPUs to accelerate processing of RNA-seq data. The title says it all: "RNA-seq analysis in seconds using GPUs" now on biorxiv www.biorxiv.org/content/10.6... and github github.com/pachterlab/k... Figure 1 shows they key result
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Ming Tommy Tang @tommytang.bsky.social · 06/03/2026
Data visualization is a critical step in data analysis. 8 links to bookmark for better data visualization:🧵
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Haley Lab @labohaley.bsky.social · 28/02/2026
Wonderful and inspiring news article about Dr. Yvette Bonny (former @umontreal.ca professor and clinician at our host institute), who pioneered pediatric bone marrow transplants in Quebec. www.cbc.ca/news/canada/...
cbc.ca
She did Quebec’s 1st pediatric bone marrow transplant. At 87, she still has some imposter syndrome | CBC News
Dr. Yvette Bonny is featured by the Government of Canada for Black History Month as one of nine remarkable figures who have helped shape Canadian heritage and identity. In 1980, she performed the firs...
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Lori Passmore @lapassmore.bsky.social · 24/02/2026
The most important #RNA conference of the year with lots of amazing science and a really friendly atmosphere. This year in beautiful Montreal 🇨🇦 ! www2.rnasociety.org
www2.rnasociety.org
RNA Society
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Manuel Kaulich @manuelkaulich.bsky.social · 24/02/2026
Our thoughts, impressions, and presentations of the "2nd EuroDepMap symposium" in Milan (Nov 2025) are online at @febsletters.bsky.social. febs.onlinelibrary.wiley.com/doi/10.1002/...
febs.onlinelibrary.wiley.com
FEBS Press
Held on 20 November 2025 at Human Technopole in Milan, the 2nd European Cancer Dependency Map Symposium convened experimental and computational scientists to discuss how cancer dependency mapping in ...
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Haley Lab @labohaley.bsky.social · 15/02/2026
Useful!
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Xuebing Wu @xuebingwu.bsky.social · 31/01/2026
Does the noncoding genome actually carry more genetic information than coding seqs? Motivated by this question we mutated every bp in the 10kb MYC locus. Results are even more exciting: Decoding the MYC locus reveals a druggable ultraconserved RNA element www.biorxiv.org/content/10.6...
biorxiv.org
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Martin Turner @martint-babraham.bsky.social · 27/01/2026
Just out @natrevimmunol.nature.com RNA-binding proteins and ribonucleoproteins as determinants of immunity www.nature.com/articles/s41... gives our perspective on this growing area of research. Special thanks to the editor Alexandra, for streamlining the manuscript.
nature.com
RNA-binding proteins and ribonucleoproteins as determinants of immunity - Nature Reviews Immunology
RNA-binding proteins (RBPs) considerably expand the information content of the genome and can determine the lifespan, localization and function of RNA, thereby controlling when, where and how much pro...
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Michael Hendricks 🇨🇦 @michaelhendricks.bsky.social · 26/01/2026
I was maybe 2.5 years into my position as an Assistant Professor when my phone rang, and it was Kirsty Duncan, the new federal science minister, calling out of the blue. I had never met her. She asked me what she could do for early career investigators. /1
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Ars Technica @arstechnica.com · 21/01/2026
arstechnica.com
mRNA cancer vaccine shows protection at 5-year follow-up, Moderna and Merck say
The vaccines are tailor-made to target each patient's unique cancer.
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Stem Cell Reports @stemcellreports.bsky.social · 14/01/2026
Stem Cell Reports is calling for applications to serve on its editorial team as an Early Career Editor, a prestigious opportunity for outstanding, early-career scientists to help shape the future of stem cell publishing. The deadline to apply is 13 March 2026. ow.ly/8iiP50XWscj
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Seema Grewal @seemagrewal.bsky.social · 09/01/2026
We’re hiring! @jcellsci.bsky.social is looking for a Reviews Editor to join the team. This is a fantastic opportunity for someone who loves #cellbiology and wants to stay connected with the field. A great chance to work for an organisation that believes in helping the community! Details below👇
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Stem Cell Network @stemcellnetwork.ca · 07/01/2026
📣 Calling all trainees and HQP working in #StemCell or #RegenerativeMedicine in Canada! The 2026–2027 SCN International Travel Awards are now open. Conference travel taking place April 1, 2026 – March 15, 2027, is eligible. Apply by February 17, 2026: stemcellnetwork.ca/training/wor...
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Nature Biotechnology @natbiotech.nature.com · 02/01/2026
Sensitive and unbiased genome-wide profiling of base-editor-induced off-target activity using CHANGE-seq-BE - @stjuderesearch.bsky.social go.nature.com/4qB6qp8
go.nature.com
Sensitive and unbiased genome-wide profiling of base-editor-induced off-target activity using CHANGE-seq-BE - Nature Biotechnology
Base editor off-target effects are profiled with high precision in a tailored approach.
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McGill University @mcgill.ca · 18/12/2025
McGill is recruiting top-tier researchers working abroad through the federally funded Canada Impact+ Research Chairs program, addressing global and national challenges. The first round is due in early 2026. Learn more and submit your candidacy: mcgill.ca/x/5Zh
McGill’s Arts Building on campus, featuring its stone façade and green dome, with the McGill flag raised and autumn foliage surrounding the building.
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Stem Cell Network @stemcellnetwork.ca · 17/12/2025
📢 NEW exciting opportunity! Join Queen’s University as a tenure-track Assistant Professor in Cell Engineering and Biomanufacturing, with opportunities for interdisciplinary research across #ChemicalEngineering and #Biomedical and #MolecularSciences. 🔬 🔗 stemcellnetwork.ca/career-oppor...
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Waggoner Lab @labwaggoner.bsky.social · 17/12/2025
Delivery of DLL1+FLT3L+IL-7 mRNA to hepatocytes boosted thymopoiesis to rejuvenate aged T cells & enhance DC abundance/function to restore immune function @nature.com @hhmi-science.bsky.social @broadinstitute.org @zhangf.bsky.social www.nature.com/articles/s41... www.nature.com/articles/d41...
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Haley Lab @labohaley.bsky.social · 15/12/2025
Now in @natcomms.nature.com! Expanded well beyond the preprint, w/new experiments in iPSCs, kinetic analysis at the DNA & protein levels, & more. Kudos to the team (esp. Rajini Srinivasan, Tao Sun, and Andrew Ng) & the editor + reviewers for strengthening this work! www.nature.com/articles/s41...
nature.com
Chemically-inducible CRISPR/Cas9 circuits for ultra-high dynamic range gene perturbation - Nature Communications
Achieving tight Cas9 regulation without sacrificing activity remains difficult. Here, the authors design multi-level circuits combining anti-CRISPRs, splice sites, chemical induction, and degron contr...
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NEJM.org @nejm.org · 08/12/2025
In relapsed or refractory T-cell acute lymphoblastic leukemia, off-the-shelf allogeneic base-edited CAR7 T cells mediated responses in 11 patients, enabling stem-cell transplantation in 9 patients in deep remission. Full study results: nej.md/48wiyQL #ASH25 | @ash.hematology.org
67th ASH Annual Meeting 
Original Article | Dec. 8, 2025 | NEJM.org 
Universal Base-Edited CAR7 T Cells for T-Cell Acute Lymphoblastic Leukemia 

Figure 2F. Minimal Residual Disease before and after Receipt of BE-CAR7 T Cells. 

The NEJM identity sits at the bottom.
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Matthew Taliaferro @jmtali.bsky.social · 08/12/2025
Announcing the 2026 edition of the EMBO workshop on RNA localization and local translation! This meeting will be held June 30 - July 4 near Porto, Portugal. Come for exciting updates in the field from both established investigators and trainees. See the link below for details!
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Mike Fainzilber @mfainzilber.bsky.social · 26/11/2025
🧪 @gingraslab.bsky.social compared 10 enzymes used for proximity biotinylation proteomics experiments. UltraID is the winner. www.biorxiv.org/content/10.1...
biorxiv.org
Benchmarking of proximity-dependent biotinylation enzymes across cellular compartments and time windows
Proximity-dependent biotinylation has become a powerful approach for mapping protein interactions and subcellular organization in living cells. Although a growing number of engineered biotin ligases h...
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Haley Lab @labohaley.bsky.social · 22/11/2025
Grateful to the @src-crs.bsky.social for supporting our project using next-gen cell-based models + functional genomics to map how prostate cancer develops + how drug resistance arises! Many thanks to our collaborators + congrats to fellow awardees! cancerresearchsociety.ca/news/100-new...
cancerresearchsociety.ca
100 news Operating Grants - Cancer Research Society
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Stem Cell Network @stemcellnetwork.ca · 20/11/2025
🔊 Career opportunity: Professor / Associate Professor (Tenure) – Dr. Connie Eaves Chair in Cancer Stem Cell Research! This position offers a unique opportunity to drive transformative research integrating cutting-edge technologies to improve patient outcomes. 🔬 🔗 stemcellnetwork.ca/wp-content/u...
Professor / Associate Professor (Tenure) – Dr. Connie Eaves Chair in Cancer Stem Cell Research
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NEJM.org @nejm.org · 19/11/2025
Influenza remains an important cause of illness and death. In a phase 3 trial, a nucleoside-modified mRNA (modRNA) quadrivalent vaccine was found to be superior to a standard quadrivalent vaccine in preventing influenza illness. Full trial results: nej.md/43udoTG #MedSky #IDSky
Original Article | Nov. 20, 2025 
Efficacy, Immunogenicity, and Safety of Modified mRNA Influenza Vaccine 

Figure 1A. Laboratory-Confirmed Cases of Influenza 

The NEJM identity sits at the bottom.
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Mikko Taipale @miketilapia.bsky.social · 18/11/2025
Our new preprint is online! Viruses, bacteria and parasites use effector proteins to evade immunity and rewire host cell pathways. Together with @AlexanderStark8, we wondered if we could systematically map what these effectors, regardless of their origin, do in human cells. 1/8
biorxiv.org
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Nature Biotechnology @natbiotech.nature.com · 11/11/2025
A parts list of promoters and gRNA scaffolds for mammalian genome engineering and molecular recording - @jshendure.bsky.social @troymcdiarmid.bsky.social @uwgenome.bsky.social go.nature.com/49eTPCu
go.nature.com
A parts list of promoters and gRNA scaffolds for mammalian genome engineering and molecular recording - Nature Biotechnology
Prime editing in mammalian cells benefits from a comprehensive list of genetic parts.
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IMP @impvienna.bsky.social · 10/11/2025
🌍Open call: Junior Group Leader positions! Join a world-class biomedical research institute at the heart of the Vienna BioCenter, where curiosity drives discovery. Lead your own lab, pursue bold ideas, and shape the future of science at the IMP: www.imp.ac.at/career/open-...
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