iiinova — where your digital self keeps evolving

Amar Sahay @amarsahay.bsky.social · 02/10/2026

Sunrise run in Middlesex Fells reservation, reservoir and tower trails, beautiful morning for it.

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Amar Sahay @amarsahay.bsky.social · 21/09/2026

Reactivating athorny CA3 neurons to recall childhood memories one madeleine at a time..

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Amar Sahay @amarsahay.bsky.social · 21/09/2026

Gotta say that reading the news on X & delays caused by closure of Omani airspace wasn’t calming. 😂 But the Boston bound flight took off and escape velocity was reached before the next chaotic decision and events could unfold..whatever they might be. Zoom in to picture to find your favorite strait!

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Amar Sahay @amarsahay.bsky.social · 12/09/2026

Grateful for this land. Great Meadows, Concord MA. Long run in a big mileage week. Slow run, trail running shoes were great on 16 trail miles but no fun on the 5 road miles. Yet, when I looked around and up at this beautiful blue sky and sunshine, the “am I done?” was forgotten.

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Amar Sahay @amarsahay.bsky.social · 10/09/2026

What a great choice. As a grad student, I remember reading this paper in Cell which featured a doberman asleep on the cover..

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Amar Sahay @amarsahay.bsky.social · 06/09/2026

Transience. A Saco river beach, ME.

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Amar Sahay @amarsahay.bsky.social · 04/09/2026

Enjoy the last weekend of summah. Not a Vogue reader, but couldnt resist including this issue in my long weekend reading list.

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Amar Sahay @amarsahay.bsky.social · 02/09/2026

Onward Professor @travisgoode.bsky.social I have no doubt that you will be an awesome mentor, colleague and asset to your department and look forward to hearing about your lab’s discoveries!

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Amar Sahay @amarsahay.bsky.social · 01/09/2026

Do you get a ticket for FUI?

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Amar Sahay @amarsahay.bsky.social · 31/08/2026

Your obligatory Boston landing picture. You are welcome.

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Amar Sahay @amarsahay.bsky.social · 31/08/2026

A Streetcar named Vanity. Circa 2026

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Amar Sahay @amarsahay.bsky.social · 29/08/2026

Wompatuck state park, Hingham, MA. Beautiful trails. MA has so much beautiful conservation land. Take care of the land for a good life! Thank you @ Mass DCR!

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Amar Sahay @amarsahay.bsky.social · 28/08/2026

100% one of my all time favs: The starkness, stillness, and a dash of piercing loneliness…

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Amar Sahay @amarsahay.bsky.social · 27/08/2026

Witness hounds guarding their witness home of 1776

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Reposted by Amar Sahay

Harvard Brain Science Initiative @harvardbrainsci.bsky.social · 26/08/2026

@amarsahay.bsky.social shares his lab’s discovery that many ultra-high confidence risk genes for autism, bipolar disorder, schizophrenia, and epilepsy may be regulators of experience-dependent plasticity of inhibitory neurons in the hippocampus of adult mice. brain.harvard.edu/hbi_news/a-s...

brain.harvard.edu

A Shared Mechanism for Cognitive Restoration and Seizure Suppression in Neurodevelopment Disorders

Amar Sahay shares his lab’s discovery that many ultra-high confidence risk genes for autism, bipolar disorder, schizophrenia, and epilepsy may be regulators of experience-dependent plasticity of inhib...

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Amar Sahay @amarsahay.bsky.social · 22/08/2026

Many miles morning run to round off a big mileage week after a supination sprain. So much of training is adapting and evolving, learning when and how to return to the training plan. And when you do the joy is infinite.. Plan the runs. Run the plan.

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Amar Sahay @amarsahay.bsky.social · 12/08/2026

Excited to share our discovery of a convergent mechanism for cognitive restoration and seizure suppression in neurodevelopment disorders in Nature (Open Access www.nature.com/articles/s41...). Led by two amazing neuroscientists, @yutzushih.bsky.social and @jasonalipio.bsky.social + a great team 1/2

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Reposted by Amar Sahay

The Transmitter @thetransmitter.bsky.social · 12/08/2026

Experience-dependent interneuron plasticity may represent a convergent circuit mechanism for these neurodevelopmental risk genes that reflects a shared genetic architecture, a new study suggests. By @claudia-lopez.bsky.social www.thetransmitter.org/spectrum/los...

thetransmitter.org

Neurodevelopmental conditions may share faulty plasticity

Restoring expression of an experience-dependent interneuron plasticity gene aids memory and cuts seizures in CNTNAP2 knockout mice, a new study shows.

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Reposted by Amar Sahay

André Nadler @nadlerlab.bsky.social · 29/07/2026

Lipids build the membranes of all cells, but identifying their precise functions is extremely challenging. Here’s our attempt to change that: How to find and understand lipid-protein interactions, by Katelyn Cook & company. www.biorxiv.org/content/10.6...

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Amar Sahay @amarsahay.bsky.social · 27/07/2026

Amazing! Allelle-specific ASO-dependent disease modifying effects in 9 and 14 year old Ms carrying causal SCN2A (GOF and LOF/mixed variants): Ameliorative effects seen on seizures, cognitive impairments, autistic behaviors, + autonomic (GI) dysfunction! www.nature.com/articles/s41...

nature.com

Individualized antisense oligonucleotides for SCN2A-related developmental epileptic encephalopathy - Nature Medicine

In two patients with SCN2A epileptic encephalopathy, treatment with personalized allele-selective antisense oligonucleotides led to a decrease in seizure frequency with a positive safety profile.

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Amar Sahay @amarsahay.bsky.social · 12/07/2026

Anyway you cut it, the match of the last five decades! Inglaterra y Argentina: Avenging the hand of God. Period. Karma! Boom!

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Reposted by Amar Sahay

Jake Watson @jakefwatson.bsky.social · 11/07/2026

We have a new preprint! By studying neuronal heterogeneity in CA3, we found a weird but powerful new feature in the hippocampal circuitry! 🧠 #neuroskyence 🧵.. Morse-Mora et al. | Hippocampal CA3 forms a two-layer network of molecularly distinct cell types in mice and humans doi.org/10.64898/202...

Mouse hippocampal slice with deep cells labelled blue, patch-clamp recorded cells in yellow, and deep CA3 projections labelled purple

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Amar Sahay @amarsahay.bsky.social · 11/07/2026

Shark week coming up: Wait for your moment of Zen. Location: Off NC coast, sunken U352 is a feeding station / haven for these beautiful sand tigers. Water temps: 75-80F, Depth 80-120 feet. Nitrox.

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Amar Sahay @amarsahay.bsky.social · 07/07/2026

The choice to VAR Is what makes it subPAR Many a goal is denied And ruling decried. Even Ogden Nash Wouldnt bet Cash On a VAR bet Without Regret.

static.klipy.com

Var Vargr: Blue Flame Skull

ALT: Var Vargr: Blue Flame Skull

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Amar Sahay @amarsahay.bsky.social · 06/07/2026

Sad and painful to see the cost of assault on graduate programs in Biomedical Research across our nation. We MUST regain our trajectory before it is too late. #sciencematters Research Universities Are Admitting Fewer Ph.D.s, a Bad Sign for Science www.nytimes.com/2026/07/06/u...

nytimes.com

Research Universities Are Admitting Fewer Ph.D.s, a Bad Sign for Science

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Amar Sahay @amarsahay.bsky.social · 05/07/2026

Cant get enuf of Canyon maxxing! Thank U Ut-aah!

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Amar Sahay @amarsahay.bsky.social · 04/07/2026

“Bust or dust” she said.

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Amar Sahay @amarsahay.bsky.social · 02/07/2026

“Out of frame”, Circa 2026, Arizona

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Amar Sahay @amarsahay.bsky.social · 01/07/2026

Good Morning beautiful Zion! Utah lands rock!

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Reposted by Amar Sahay

Darya Frank @darya-frank.bsky.social · 29/06/2026

📣 Thrilled to share our recent work in @natneuro.nature.com. Using direct recordings from the human hippocampus and visual cortex, we asked how the brain prepares to encode information when upcoming events are unpredictable, and what ripples do in that process. www.nature.com/articles/s41...

nature.com

Human hippocampal ripples tune cortical responses based on predicted uncertainty - Nature Neuroscience

Using direct recordings from the human brain, Frank et al. show that hippocampal ripples increase ahead of unpredictable events and tune the visual cortex to respond faster and more strongly to surpri...

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Amar Sahay @amarsahay.bsky.social · 20/06/2026

Incredible energy but even the light from a higher authority couldn’t save Scotland from a stronger Morocco. @fifaworldcup-x.bsky.social

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Amar Sahay @amarsahay.bsky.social · 19/06/2026

A terrific must listen podcast for all trainees at all career stages in science (and highschoolers and UGs). DO NOT OUTSOURCE YOUR THINKING to AI. 1/n podcasts.apple.com/us/podcast/w...

podcasts.apple.com

What 400,000 Essays Reveal About AI and Creativity

Podcast Episode · Plain English with Derek Thompson · June 5 · 56m

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Amar Sahay @amarsahay.bsky.social · 17/06/2026

Watching England win this battle decidedly (against Croatia) where they lost that other war (Buckman Tavern, April 19, 1775, Lexington, MA). @ FIFA @onlyinbos.bsky.social

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Amar Sahay @amarsahay.bsky.social · 13/06/2026

The poignant vignettes in this book from many years ago reminds us that snipping viscera and tissue for therapeutic relief will gradually become a thing of the past…as snipping nucleic acids and biologics for genetic medicines take shape. #timetraveltoseethefuture

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Amar Sahay @amarsahay.bsky.social · 06/06/2026

When I stare at a modern art canvas, I dont think, thats one reason I find it cathartic. You?

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Amar Sahay @amarsahay.bsky.social · 05/06/2026

Celebrating milestones on this journey with this great group of scientists. Engaged & excited about discoveries even with the assault on science at all levels. @travisgoode.bsky.social @jasonalipio.bsky.social @aloknm.bsky.social and Yu-Tzu S, Cinzia V, Iyanah M and Trey M, not on platform.

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