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Xuebing Wu @xuebingwu.bsky.social · 29/06/2026

Proposal: preprints should not be double-spaced. I often want to print an interesting preprint, only to discover it's 40+ pages because of double spacing. Margins already provide plenty of room for notes. @biorxivpreprint.bsky.social

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Xuebing Wu @xuebingwu.bsky.social · 12/06/2026

An elegant study deciphering the RNA localization code in neurons! congrats Matt!

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John Prensner @johnprensner.bsky.social · 06/05/2026

Major new work by the #TransCODE Consortium out today in @nature.com. Read all about our efforts to shed light onto the forgotten areas of the human proteome. #Microproteins #Peptideins #DarkProteome This was a huge global collaboration, in part funded via #NIH www.nature.com/articles/s41... 1/

nature.com

Expanding the human proteome with microproteins and peptideins - Nature

A large-scale proteomics analysis of the dark proteome by the TransCODE Consortium reveals many translated non-canonical open reading frames to encode microproteins and peptideins.

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Iain Cheeseman @iaincheeseman.bsky.social · 23/01/2026

First preprint of the year! New work from @jimmy-ly.bsky.social revealing unexpected roles for 5' UTR length in controlling alternate translational isoforms - important implications for both physiological cell function and rare disease. Small changes -> big impacts. www.biorxiv.org/content/10.6...

biorxiv.org

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David Bartel's Lab @bartellab.bsky.social · 23/01/2026

We’re excited to share our latest preprint on the mechanism of excised linear intron stabilization in yeast! This work was led by PhD student @glennli.bsky.social and was a wonderful collaboration with @maxewilkinson.bsky.social. Link: www.biorxiv.org/content/10.6... (1/4)

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Xuebing Wu @xuebingwu.bsky.social · 01/02/2026

Why do I believe noncoding DNA carry more genetic information than coding DNA in the human genome? One argument beyond our MYC data: >70% of the conserved DNA are noncoding. While a lack of conservation does not mean lack of function, the presence of conservation often indicates function.

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Xuebing Wu @xuebingwu.bsky.social · 31/01/2026

Does the noncoding genome actually carry more genetic information than coding seqs? Motivated by this question we mutated every bp in the 10kb MYC locus. Results are even more exciting: Decoding the MYC locus reveals a druggable ultraconserved RNA element www.biorxiv.org/content/10.6...

biorxiv.org

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Xuebing Wu @xuebingwu.bsky.social · 18/01/2026

#ScienCV useful tips below. also you can drag to re-order Products list

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Xuebing Wu @xuebingwu.bsky.social · 13/01/2026

Research Briefing featuring our work @natcardiovascres.nature.com : Hotspot RPL3L variants drive early onset heart failure through a dual mechanism www.nature.com/articles/s44...

nature.com

Client Challenge

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Xuebing Wu @xuebingwu.bsky.social · 10/01/2026

Excited to publish our work on how mutations in the muscle-specific ribosomal protein RPL3L drive severe heart disease. This is Part I of a larger body of work led by Michael - stay tuned for Part II on how specialized ribosomes function in normal physiology www.nature.com/articles/s44...

nature.com

Client Challenge

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David Bartel's Lab @bartellab.bsky.social · 06/01/2026

We are thrilled to share our latest work uncovering the mechanistic basis of target-directed microRNA degradation (TDMD). This work was driven by @jakobfarnung.bsky.social and @elenaslo.bsky.social in a fantastic collaboration with Brenda Schulman's lab. tinyurl.com/E3TDMD (1/5)

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Harris Wang @harriswang.bsky.social · 15/11/2025

📢 Our Dept. of Systems Biology at Columbia University has an open tenure-track Assistant Professor position in the broad area of quantitative biology. Come join our awesome department in NYC! Please circulate. apply.interfolio.com/177622 Suggested deadline: 12/15/2025. @columbiasysbio.bsky.social

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David Bartel's Lab @bartellab.bsky.social · 15/03/2025

Check out the latest study from our lab, led by @mhall98.bsky.social : www.biorxiv.org/content/10.1... (1/2)

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Sri Kosuri @srikosuri.bsky.social · 08/02/2025

It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS or other (non-LCH) dendritic or histiocytic sarcomas cases.

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Xuebing Wu @xuebingwu.bsky.social · 03/02/2025

very interesting work on ribosome cooperativity

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Xuebing Wu @xuebingwu.bsky.social · 29/01/2025

Glad to be in the "conversation" about microproteins and other non-canonical proteins arising from noncoding translation. I look forward to continuing the discussion at the upcoming keystone symposium on microproteins

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BWJones @bwjones.bsky.social · 13/01/2025

Dear meeting organizers: Picking the same senior PIs to keynote/give talks at meetings, who's talks I've seen a dozen times already, is not a great use of everyone's time. Nor does it highlight all of the rich talent in your field from more junior folks and peeps not at "elite" institutions.

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Xuebing Wu @xuebingwu.bsky.social · 06/01/2025

who said scientists are smart?

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Xuebing Wu @xuebingwu.bsky.social · 02/01/2025

Excited to share our review article "Finding functional microproteins", published in @TrendsGenetics. It was fun writing it together with Alex and @FeiyueYang1 in the lab. #microprotein authors.elsevier.com/a/1kNCscQbJB...

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Xuebing Wu @xuebingwu.bsky.social · 21/12/2024

somehow this was the first thing came to my mind: Interviewer: Can you explain this gap in your resume? Me: I was updating my biosketch to the new format

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Xuebing Wu @xuebingwu.bsky.social · 20/12/2024

I also believe that the current system of peer review and journal publishing is not working. I hope to witness and experience a system without those in my lifetime

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John Doench @johndoench.bsky.social · 08/12/2024

The total length of human DNA on the planet right now is thus: (3.4x10^-10) • (2 x 3.055x10^9) • (3x10^13) • (8.2x10^9) = 5.11 x 10^23 meters Time to call in NASA! 1 *light-year* – the distance light travels in one year – is 9.46x10^15 meters... So: 54 million light-years of human DNA!

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Xuebing Wu @xuebingwu.bsky.social · 06/12/2024

We are hiring a technician to help with CRISPR screens. Prior experience with CRISPR screens and large-scale cell culture is preferred but not required. Please feel free to share: jobrxiv.org/job/columbia...

jobrxiv.org

Technician in Xuebing Wu lab at Columbia University in New York

Post a job in 3min, or find thousands of job offers like this one at jobRxiv!

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Xuebing Wu @xuebingwu.bsky.social · 04/12/2024

Question for faculty interviewing students for PhD admission: do you give feedback at the end to help them do better in future interviews? eg things they should change/clarify in personal statement/CV, that they need to prepare better/more questions for faculty, their weakness compared to peers, etc

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Xuebing Wu @xuebingwu.bsky.social · 21/09/2023

Honored to receive the inaugural Glenn Foundation Discovery Award from @AFARorg! Also congrats to the other awardee Dr. Ya-Chieh Hsu @HSCRB. Come work with us if you are interested in testing new ideas in aging biology! www.afar.org/news/announc...

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Xuebing Wu @xuebingwu.bsky.social · 20/09/2023

This has to be a great conference, just look at the speaker list! - Katalin Karikó, David Liu, John Maraganore, Chuan He, Melissa Moore, Georg Seelig, and of course my favorite, Phillip Sharp! Cracking the Code: The Dawn of Nucleic Acid Medicines conferences.nature.com/event/27e02c...

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