Increased RNA polymerase III (Pol III) activity and tRNA abundance are widely linked to cancer cell growth, yet the functional requirement for individual Pol III genes and core components remains uncl...

Complex traits that span multiple tissues and systems often integrate large numbers of genes across development, physiology, and behavior, making it challenging to identify their essential components....

The Dorrity group at EMBL Heidelberg is seeking a motivated and skilled molecular biologist to join as a Laboratory Officer. Our group uses cutting-edge single-cell genomic techniques to study how cel...

Nature Reviews Molecular Cell Biology - Single-molecule genomics methods are used to study the activity of regulatory factors on individual DNA molecules genome-wide, thereby enabling...

The lab investigates the molecular mechanisms that control biological timing in mouse and human stem cells (Azzi & Rayon, Curr Opinions 2024; Nakanoh et al., Dev Cell 2026). The central aim of this ex...

Development depends on gene regulation by enhancers across long genomic distances. This Perspective discusses mechanisms enabling long-range enhancer–promoter communication and the potential advantage...

Single-cell omics methods promise to revolutionize our understanding of gene regulatory processes during cell differentiation, but analysis of such data continues to pose a major challenge. Apart from...

The differentiation variability of human pluripotent stem cell lines is diagnosed and corrected.

This book covers diverse aspects of stem cell research and exemplifies some of the developments and improvements in the field.

Mereu et al. present ESPACE, a single-cell multi-omic atlas of the human pancreas spanning fetal development, adulthood, and type 2 diabetes. Combining transcriptomics, chromatin accessibility, and spatial imaging, they uncover a rare population of plastic centroacinar cells and hidden diversity among hormone-producing islet cells, informing pancreas regeneration and disease.

The Medical Research Council (MRC) has invested £50 million into the study of mitochondrial diseases to improve treatments.

We seek a highly motivated Postdoctoral Research Associate to join the laboratory of Professor Kathy Niakan. We are based in the Loke Centre for Trophoblast Research (LCTR), in the Department of Physi...

Coral reefs depend on an intracellular symbiosis between cnidarian hosts and photosynthetic dinoflagellates that is disrupted by ocean warming, causing coral bleaching. Yet how these responses are dis...

Evaluation of infants’ spontaneous motor activity with at-home wearables helps construct detailed growth charts of early gross motor development.

The human pancreas contains diverse endocrine and exocrine cell populations whose spatial organization is essential for tissue physiology. While single-cell and spatial transcriptomics revealed molecu...

Urbaser ha colocado, en El Bayo, la primera piedra de una planta pionera en España en la que se procesarán entre 60.000 y 200.000 baterías al año para extraer metales valiosos como aluminio, cobre, ní...

Understanding pluripotency

Several of those escorted out were scheduled to present at the American Diabetes Association conference this weekend.

How VEGF-C drives functional lymphangiogenesis was unclear. Schoofs et al. show VEGFR2 is required for VEGF-C-VEGFR3-dependent sprouting while VEGFR3 alone drives growth, revealing coordinated receptor signalling in lymphatic network formation.

A team of researchers from the University of Helsinki and the University of Turku has shown that heart muscle cells derived from patients with hypoplastic left heart syndrome carry molecular vulnerabi...

Islets of Langerhans are highly structured mini-organs containing hormone-producing cells of the pancreas that regulate glucose metabolism. Studies of…

Banerjee and colleagues performed liver-targeted recombinant adeno-associated virus (rAAV)-mediated gene replacement in a mouse model of mitochondrial complex III deficiency. rAAVs restored CIII assem...

Nature Reviews Genetics, Published online: 17 April 2026; doi:10.1038/s41576-026-00952-4In this Review, Sousa-Luís and Carmo-Fonseca discuss the various tools available to detect and quantify alternative splicing, functionally test splice isoforms and investigate the link between genetic variation, splicing and disease.