Nature Reviews Genetics, Published online: 10 September 2026; doi:10.1038/s41576-026-01007-4Comparative functional genetics and genomics across Danio, Devario and Danionella species reveal molecular and cellular bases of phenotypic divergence, establishing danionin fishes as powerful model systems for understanding a wide range of evolutionary innovations.

Nature Reviews Genetics, Published online: 08 September 2026; doi:10.1038/s41576-026-01004-7Programmed DNA elimination is a developmentally regulated process in which specific DNA sequences are reproducibly removed from particular cell lineages. Here, the authors review the mechanistic diversity and evolutionary dynamics of DNA elimination, spanning chromosome breakage, whole-chromosome elimination and whole-genome elimination.

Nature Reviews Genetics, Published online: 28 September 2026; doi:10.1038/s41576-026-01022-5In this Journal Club, Kamila Naxerova reflects on two landmark studies by Knouse et al. and Davoli et al. that helped explain how disrupted epithelial tissue architecture promotes aneuploidy and why particular patterns of chromosome gain and loss recur across cancers.

Nature Reviews Genetics, Published online: 07 September 2026; doi:10.1038/s41576-026-01002-9The programmable insertion of large DNA sequences could overcome fundamental limitations of current genome-editing technologies. In this Review, Lampe, King and Sternberg describe recent advances in recombinases, retrotransposons and CRISPR-associated transposases, and discuss how these systems are enabling mutation-agnostic genome modification.

Molecular quantitative trait loci (molQTLs) provide key insights into how non-coding variants shape complex traits and disease. In this Review, the authors outline statistical and machine learning app...

Nature Reviews Genetics, Published online: 18 September 2026; doi:10.1038/s41576-026-01013-6In this Journal Club, Elena Gómez-Díaz highlights two studies that established the Malaria Cell Atlas, demonstrating how single-cell transcriptomics can resolve parasite heterogeneity across development, transmission and natural infections to advance malaria research.

Nature Reviews Genetics, Published online: 18 September 2026; doi:10.1038/s41576-026-01018-1Undiagnosed disease networks advance the discovery of genes associated with rare diseases. However, a considerable gap in discovery remains, and genomic resources continue to exhibit population bias. A collaborative initiative in the Middle East could harness unique population structure, extensive family lineages and underrepresented genomic diversity to enhance local diagnostic capabilities and facilitate global gene discovery.

Nature Reviews Genetics, Published online: 17 September 2026; doi:10.1038/s41576-026-01008-3In this Review, Buckley et al. discuss how DNA methylation is interpreted in mammals and plants, focusing on the reader proteins and transcription factors that bind to methylated DNA and the downstream mechanisms by which they regulate transcriptional and epigenetic states.

In this Review, Li and Durbin discuss how to generate telomere-to-telomere assemblies for large haploid or diploid genomes using currently available data types and algorithms, and outline remaining ch...

In this Review, the authors provide an overview of the roles of individual histone variants in multiple processes, including gene regulation, DNA replication and DNA repair, and the cellular consequen...

Spatial omics has empowered the discovery of developmental and disease-associated molecular signatures, cell states and multicellular niches, as well as the evaluation of disease heterogeneity within and across organs. The authors review spatially resolved molecular changes across diseases and discuss the potential of spatial multi-omics for clinical applications, including the recent impact of artificial intelligence.

Proteoforms are the diverse protein molecules produced from a single gene whose primary sequence and composition can be diversified by genetic, transcriptomic, translational and post-translational var...

Nature Reviews Genetics, Published online: 02 September 2026; doi:10.1038/s41576-026-01011-8Large-scale genome initiatives are transforming biodiversity genomics, but genomes remain taxonomically sparse and difficult to compare across species. Kapli and colleagues argue that natural history collections should play a central role in building species-dense genomic resources, creating the foundation needed for comparative and predictive biodiversity genomics.

Nature Reviews Genetics, Published online: 10 March 2025; doi:10.1038/s41576-025-00825-2This Review explores how experimental models of metastasis, such as mouse models and cell cultures, can complement the (multi)omics analysis of human metastasis…

Nature Reviews Genetics, Published online: 01 September 2026; doi:10.1038/s41576-026-01001-wIn this Review, the authors discuss recent data showing that telomere attrition is a powerful tumour-suppressor mechanism that limits the development of a wide variety of human cancers.

Nature Reviews Genetics, Published online: 15 September 2026; doi:10.1038/s41576-026-01016-3In this Journal Club, Xiaoyu Song discusses a landmark paper by Gamazon et al. that introduced PrediXcan, which enabled the integration of tissue-specific transcriptomic information with population-scale genetic studies, laying the foundation for transcriptome-wide association studies.

Loss of Y chromosome (LOY), the most commonly occurring post-zygotic (somatic) mutation in male individuals, affects immune activity and is associated with cancer, neurodegeneration, cardiovascul...

Nature Reviews Genetics, Published online: 14 September 2026; doi:10.1038/s41576-026-01012-7Plasmids in bacteria and extrachromosomal DNA in cancer both generate copy-number variation, alter gene expression and promote rapid adaptation. In this Perspective, Shaw and Henssen explore their shared evolutionary capacities and argue that these extrachromosomal genetic elements can be viewed as convergent contingency loci with implications for evolution, drug resistance and therapeutic opportunities.

Nature Reviews Genetics, Published online: 18 September 2026; doi:10.1038/s41576-026-01013-6In this Journal Club, Elena Gómez-Díaz highlights two studies that established the Malaria Cell Atlas, demonstrating how single-cell transcriptomics can resolve parasite heterogeneity across development, transmission and natural infections to advance malaria research.

Nature Reviews Genetics, Published online: 18 September 2026; doi:10.1038/s41576-026-01018-1Undiagnosed disease networks advance the discovery of genes associated with rare diseases. However, a considerable gap in discovery remains, and genomic resources continue to exhibit population bias. A collaborative initiative in the Middle East could harness unique population structure, extensive family lineages and underrepresented genomic diversity to enhance local diagnostic capabilities and facilitate global gene discovery.

Nature Reviews Genetics, Published online: 11 September 2026; doi:10.1038/s41576-026-01010-9Advances in genome-wide selection scans and ancient DNA have greatly expanded our ability to study human evolution. This Review discusses the conceptual and statistical challenges in identifying and interpreting selection signals, and how recent approaches are reshaping our understanding of human evolution over the past 10,000 years.

Nature Reviews Genetics, Published online: 28 August 2026; doi:10.1038/s41576-026-01000-xIn this Review, Liu et al. describe advances that are enabling comparative genetic studies of humans and farmed animals, which have the potential to generate insights that are beneficial for both biomedical research and agriculture.

Nature Reviews Genetics, Published online: 10 September 2026; doi:10.1038/s41576-026-01007-4Comparative functional genetics and genomics across Danio, Devario and Danionella species reveal molecular and cellular bases of phenotypic divergence, establishing danionin fishes as powerful model systems for understanding a wide range of evolutionary innovations.

Nature Reviews Genetics, Published online: 17 September 2026; doi:10.1038/s41576-026-01008-3In this Review, Buckley et al. discuss how DNA methylation is interpreted in mammals and plants, focusing on the reader proteins and transcription factors that bind to methylated DNA and the downstream mechanisms by which they regulate transcriptional and epigenetic states.

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Nature Reviews Genetics, Published online: 08 September 2026; doi:10.1038/s41576-026-01004-7Programmed DNA elimination is a developmentally regulated process in which specific DNA sequences are reproducibly removed from particular cell lineages. Here, the authors review the mechanistic diversity and evolutionary dynamics of DNA elimination, spanning chromosome breakage, whole-chromosome elimination and whole-genome elimination.

Nature Reviews Genetics, Published online: 15 September 2026; doi:10.1038/s41576-026-01016-3In this Journal Club, Xiaoyu Song discusses a landmark paper by Gamazon et al. that introduced PrediXcan, which enabled the integration of tissue-specific transcriptomic information with population-scale genetic studies, laying the foundation for transcriptome-wide association studies.

Nature Reviews Genetics, Published online: 14 September 2026; doi:10.1038/s41576-026-01012-7Plasmids in bacteria and extrachromosomal DNA in cancer both generate copy-number variation, alter gene expression and promote rapid adaptation. In this Perspective, Shaw and Henssen explore their shared evolutionary capacities and argue that these extrachromosomal genetic elements can be viewed as convergent contingency loci with implications for evolution, drug resistance and therapeutic opportunities.

Nature Reviews Genetics, Published online: 07 September 2026; doi:10.1038/s41576-026-01002-9The programmable insertion of large DNA sequences could overcome fundamental limitations of current genome-editing technologies. In this Review, Lampe, King and Sternberg describe recent advances in recombinases, retrotransposons and CRISPR-associated transposases, and discuss how these systems are enabling mutation-agnostic genome modification.

Nature Reviews Genetics, Published online: 21 August 2026; doi:10.1038/s41576-026-01009-2In this Journal Club, Hongqing Liang reflects on a landmark study by Macfarlan et al. that linked endogenous retrovirus activity to totipotent-like cell states, reshaping our understanding of developmental plasticity and cell fate specification.

Nature Reviews Genetics, Published online: 11 September 2026; doi:10.1038/s41576-026-01010-9Advances in genome-wide selection scans and ancient DNA have greatly expanded our ability to study human evolution. This Review discusses the conceptual and statistical challenges in identifying and interpreting selection signals, and how recent approaches are reshaping our understanding of human evolution over the past 10,000 years.

In this Review, James et al. provide an overview of approaches for planning, constructing, and fine-tuning synthetic genomes and describe their potential applications.

Nature Reviews Genetics, Published online: 10 September 2026; doi:10.1038/s41576-026-01007-4Comparative functional genetics and genomics across Danio, Devario and Danionella species reveal molecular and cellular bases of phenotypic divergence, establishing danionin fishes as powerful model systems for understanding a wide range of evolutionary innovations.

Nature Reviews Genetics, Published online: 20 August 2026; doi:10.1038/s41576-026-00998-4Proteogenomics integrates genomic and proteomic data to reveal how genetic variation influences protein abundance and contributes to human disease. In this Review, the authors focus on protein quantitative trait loci (pQTL), highlighting advances in pQTL mapping, biological interpretation and emerging applications.

Nature Reviews Genetics, Published online: 02 September 2026; doi:10.1038/s41576-026-01011-8Large-scale genome initiatives are transforming biodiversity genomics, but genomes remain taxonomically sparse and difficult to compare across species. Kapli and colleagues argue that natural history collections should play a central role in building species-dense genomic resources, creating the foundation needed for comparative and predictive biodiversity genomics.

Nature Reviews Genetics, Published online: 01 September 2026; doi:10.1038/s41576-026-01001-wIn this Review, the authors discuss recent data showing that telomere attrition is a powerful tumour-suppressor mechanism that limits the development of a wide variety of human cancers.

Nature Reviews Genetics, Published online: 18 August 2026; doi:10.1038/s41576-026-01005-6In this Journal Club, Wulan Deng highlights a landmark paper by Elf et al. that used single-molecule imaging in living bacteria to reveal how transcription factors locate specific DNA targets through a dynamic, largely stochastic search process.

Nature Reviews Genetics, Published online: 18 August 2026; doi:10.1038/s41576-026-01006-5In this Journal Club, Camille Berthelot highlights a 2011 paper by Brawand et al. that used early RNA-sequencing data across several mammalian species to determine how gene expression evolves, identifying tissue-specific rates of change and signatures of adaptation.

Nature Reviews Genetics, Published online: 08 September 2026; doi:10.1038/s41576-026-01004-7Programmed DNA elimination is a developmentally regulated process in which specific DNA sequences are reproducibly removed from particular cell lineages. Here, the authors review the mechanistic diversity and evolutionary dynamics of DNA elimination, spanning chromosome breakage, whole-chromosome elimination and whole-genome elimination.

Nature Reviews Genetics, Published online: 17 August 2026; doi:10.1038/s41576-026-01003-8In this Journal Club, Pamela Yeh recalls a landmark study by Bollenbach et al. that used genetic perturbations in Escherichia coli to uncover the mechanism underlying a classic suppressive drug interaction.

Nature Reviews Genetics, Published online: 07 September 2026; doi:10.1038/s41576-026-01002-9The programmable insertion of large DNA sequences could overcome fundamental limitations of current genome-editing technologies. In this Review, Lampe, King and Sternberg describe recent advances in recombinases, retrotransposons and CRISPR-associated transposases, and discuss how these systems are enabling mutation-agnostic genome modification.