Establishment of cell lineages during development is regulated by transcription factors binding at cis-regulatory elements to activate gene regulatory programs. Many transcription factors require chro...

Summary: The placenta is the only mammalian organ that harbors a cancer-like genome while remaining functional and healthy. This Review highlights its high mutational load, structural variants, aneupl...

Cavanaugh et al. show that embryos from aged mice have increased contractility and tissue viscosity on embryonic day 4.5, which leads to poor spreading and attachment. Similar age-associated mechanica...

This book covers diverse aspects of stem cell research and exemplifies some of the developments and improvements in the field.

High-resolution spatial transcriptome analysis of a human embryo at Carnegie stage 6 reveals three distinct developmental trajectories from the epiblast towards amnion, primitive streak and axial meso...

Ethical discussions are urgently needed as genome-editing science advances, some researchers say.

Summary: This Editorial offers an honest look at impact factor trends in developmental biology, explains how Development serves its community, and makes the case that sustaining developmental biology ...

A primate embryoid system is established from cynomolgus totipotent blastomere-like cells. This fertilization-independent system recapitulates development from a totipotent-like state through an inter...

Since the discovery of induced pluripotent stem cells (iPSCs) 20 years ago, iPSC technology has transformed stem cell research and regenerative medicine. This perspective reviews key advances in reprogramming mechanisms and highlights the growing clinical, translational, and societal applications of iPSCs.

Nature Communications - Reversibility, regulation, and the community of development: the legacy of Sir John B. Gurdon

A stem-cell-based monkey embryo model that self-organizes into a comprehensive body plan could lead the way to more-sophisticated models of early human development.

Dosage compensation of sex chromosomes through X-chromosome inactivation (XCI) is required for mice extra-embryonic tissue growth and embryo development. The species specificity in mechanisms and timi...

He showed that specialized cells retain the genes to form an organism.

Nature - Genetic manipulation of blastoids reveals the role of recently emerged transposable elements and genes in human development.

Onderzoekers van KU Leuven en Erasmus MC hebben aangetoond dat cellen het verlies van genen op het X-chromosoom kunnen compenseren door de andere kopie van dat gen actiever te maken. Opvallend is dat ...

Researchers from KU Leuven and Erasmus MC (the Netherlands) have shown that cells can compensate for the loss of genes on the X chromosome by increasing the expression of the other gene copy. Surprisi...

This review explores the advances in stem cell and organoid models of the endometrium, placenta, and embryo, outlining challenges in integrating them to capture spatiotemporal dynamics and functional ...

In the Rougeulle lab, we study the emblematic process of X chromosome inactivation. We aim at elucidating how such a chromosome-wide epigenetic silencing is achieved and regulated during early human d...

Developmental timing differs strikingly between mammals. All embryonic and some placental lineages emerge from the pluripotent epiblast in a temporally defined sequence, lasting about two weeks in the...