iiinova — where your digital self keeps evolving

Tobias Greisle @tobiasgreisle.bsky.social · 26/09/2025

Happy to share a new tool from the @heikolickert.bsky.social lab! We generated human iPSC fluorescent reporter lines to monitor Wnt/PCP signaling activity by Flattop in stem cell derived β-cells. doi.org/10.1016/j.sc... Thanks to all the co-authors that helped in the present and the past!

doi.org

Redirecting

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Reposted by Tobias Greisle

Christos Karampelias @ckarampelias.bsky.social · 14/03/2025

Happy to share our work on pancreatic ductal organoids from the human-relevant pig model across developmental stages ranging from embryonic to adult animals and using them for drug screening applications from the @heikolickert.bsky.social lab. #PancSky #devbio 🧪🧬 www.biorxiv.org/content/10.1... /1

biorxiv.org

Benchmarking porcine pancreatic ductal organoids for drug screening applications

Primary human pancreatic ductal organoids (HPDO) have emerged as a model to study pancreas biology and disease. Yet, donor material availability, and a lack of extensive benchmarking limits the range ...

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Reposted by Tobias Greisle

Jorge Ferrer @jorge-ferrer.bsky.social · 21/12/2024

Join us in a beautiful location for this multidisciplinary experience. Top speakers linking topics such as organoid modeling, synthetic biology, gene regulation or genetics with disease mechanisms & new therapies for T1D, T2D, and MASLD meetings.embo.org/event/25-liver-pancreas

meetings.embo.org

Liver and pancreas in metabolic disease: from pathways to therapies

The liver and pancreas arise from a common developmental origin and are controlled by shared gene regulatory programs.These organs are central to two of the most common and devastating metabolic dise…

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Reposted by Tobias Greisle

Heiko Lickert @heikolickert.bsky.social · 25/11/2024

Thrilled to share one of our biggest discoveries: “Inceptor binds to and directs insulin towards lysosomal degradation in beta cells”. doi.org/10.1038/s422... A tremendous collaborative effort led by JohannaSiehler, Sara Bilekova and other members of the Lickert lab @heikolickert.bsky.social

doi.org

Inceptor binds to and directs insulin towards lysosomal degradation in β cells - Nature Metabolism

The insulin inhibitory receptor (inceptor) is found to bind to insulin and to regulate insulin stores by directing proinsulin and insulin towards lysosomal degradation.

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