How VEGF-C drives functional lymphangiogenesis was unclear. Schoofs et al. show VEGFR2 is required for VEGF-C-VEGFR3-dependent sprouting while VEGFR3 alone drives growth, revealing coordinated receptor signalling in lymphatic network formation.

Skeletal muscle atrophy in response to pathophysiological stimuli or disuse includes loss of muscle mass and strength. Targeting signaling pathways regulating muscle growth can counteract muscle loss,...