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Daan de Groot

@dhdegroot.bsky.social
183 followers 104 following 14 posts

Group leader at IMBA at Vienna BioCenter. How do single cells decide what to become? What to do? When? Where? www.oeaw.ac.at/imba/groups/daan-de-…

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Reposted by Daan de Groot
Peter @biotechpedro.bsky.social · 21/08/2026
I've tried Bonsai in various datasets through the web server. It has always added some insights to my understanding of the data. Totally recommended, especially seeing the new additions 🤩
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Anton Goloborodko @golobor.bsky.social · 24/08/2026
trees >> umaps
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Erik van Nimwegen @erikvannimwegen.bsky.social · 21/08/2026
Remember this? bsky.app/profile/did:... Rigorous visualization of the structure in your high-dimensional data. Fantastic work by @dhdegroot.bsky.social With help of the reviewers of Nat Biotech it is now updated, extended an officially published here: www.nature.com/articles/s41... 1/n
nature.com
Bonsai reconstructs tree representations for distortion-free visualization and exploration of high-dimensional data - Nature Biotechnology
High-dimensional data are visualized through representation on tree structures.
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Biozentrum, University of Basel @biozentrum.unibas.ch · 21/08/2026
How do you visualize highly complex data without losing important information? Prof. Erik van Nimwegen’s team developed a new tool, Bonsai, that provides a faithful picture of the structure in the data. @erikvannimwegen.bsky.social @unibas.ch @dhdegroot.bsky.social @imbavienna.bsky.social
biozentrum.unibas.ch
Seeing the Unseen: A new tool for exploring complex biological data
Modern biology research can now generate valuable data on an unprecedented scale. But there is one major obstacle: making sense of these complex high-dimensional datasets. Prof. Erik van Nimwegen’s te...
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Institute of Molecular Biotechnology @imbavienna.bsky.social · 12/08/2026
We are hiring! Join the de Groot Lab as a Master's Student / Research Intern in Computational Biology and Theoretical Modeling to develop a Bayesian method for comparing single-cell datasets by explicitly modeling measurement noise to bring out true biological variability.
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Kristina Stapornwongkul @kstapornwongkul.bsky.social · 27/05/2026
You're a devbio and stem cell enthusiast in Vienna? Come meet the community at #DevStem26 @istaresearch.bsky.social on June 16th! Only 3 days left to register & submit your abstract! Free registration 👇 devstem.pages.ist.ac.at
devstem.pages.ist.ac.at
Development and Stem Cells Regional Meeting
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Daan de Groot @dhdegroot.bsky.social · 28/03/2026
We're looking for people with a solid computational background (Math, Physics, Computer science, Computational Biology, etcetera) to dive into biology! Come study the physical principles of cell-fate decisions using Bayesian data analysis and biophysical modeling!
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Vienna BioCenter Scientific Training @vbcscitraining.bsky.social · 23/03/2026
Our Spring PhD call is OPEN. English is the program language and open to all nationalities. 30+ fully funded positions & diverse life science subjects. 👉 www.vbcphd.at Apply now! Institute of Molecular Biotechnology, Max Perutz Labs Vienna, IMP, Gregor Mendel Institute of Molecular Plant Biology
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Eva Hörmanseder @evahoermanseder.bsky.social · 03/03/2026
Have a look at this PhD program in Vienna- most interesting science and the best training program:
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Paul Francois @pfrancois.bsky.social · 17/02/2026
From Pankaj’s Mehta group www.biorxiv.org/content/10.6... “Our findings highlight the need for rigorous benchmarking and suggest that the biology of cell identity can be captured by simple linear representations of single cell gene expression data.” 🔥🔥🔥
biorxiv.org
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Kristina Stapornwongkul @kstapornwongkul.bsky.social · 17/02/2026
We‘re looking for a motivated Master student to join our team! Do you want to optogenetically control metabolic activity to see how metabolism affects patterning and morphogenesis? 💡🧫🧬🔬 Then please apply! #optogenetics #metabolism #devbio #hESCs Please RT. Thank you!🙏
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Anton Goloborodko @golobor.bsky.social · 27/01/2026
this is a **unique** opportunity - Daan de Groot, our new neighbor at @imbavienna.bsky.social , is hiring
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Daan de Groot @dhdegroot.bsky.social · 27/01/2026
Big news! At least for me. I'll start building my own research group at the amazing IMBA in Vienna. Starting from single-cell omics data, we will develop computational tools and theoretical models to understand how single cells make decisions, in particular during development. I think that IMBA is
lnkd.in
LinkedIn
This link will take you to a page that’s not on LinkedIn
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Daan de Groot @dhdegroot.bsky.social · 13/01/2026
Some time ago, we showed that bacterial adaptation is aided a lot by phenotypes becoming increasingly unstable at slow growth (www.pnas.org/doi/10.1073/...), but we didn't know what caused this phenomenon. Over the last years, others continued the search, and you can now read the results!
pnas.org
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
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Erik van Nimwegen @erikvannimwegen.bsky.social · 13/01/2026
What are the main sources of gene expression noise in bacteria, and why do slower growing bacteria exhibit more expression noise? TLDR: we found growth-rate fluctuations are a key driver of gene expression noise that increase as average growth rate decreases. www.biorxiv.org/content/10.6... 1/n
biorxiv.org
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Julius Brennecke @juliusbrennecke.bsky.social · 16/12/2025
find it remarkable that folks upload the unpublished, confidential work of others to those sites.
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Erik van Nimwegen @erikvannimwegen.bsky.social · 18/09/2025
Are you excited to pursue your own research interests and contribute to our group’s experimental research in the quantitative biology of microbes? We have an opening for a potentially permanent position as research associate. Please repost and notify potential candidates!
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Carlos Talavera-López @cartalop.bsky.social · 11/05/2025
Please! No more UMAPs/t-SNEs 👇👇👇
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Daan de Groot @dhdegroot.bsky.social · 09/05/2025
Oh yes, and check out my debut as a failed YouTuber. I'm really much more excited about this than I sound in the video, because look how nice our Bonsai-scout app actually works to explore the data!
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Daan de Groot @dhdegroot.bsky.social · 09/05/2025
Bonsai is out! Finally, we can visually explore high-dimensional data in a distortion-free way. Try it out! It works from scRNA-seq data (bonsai.unibas.ch/bonsai-scout...) up to football statistics (bonsai.unibas.ch/bonsai-scout...). 
Ever wondered why low-dimensional embeddings like t-SNE
bonsai.unibas.ch
First select a node by clicking in the tree, then click the below buttons to indicate if that node is the ancestor or a downstream node of the subtree.
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Daan de Groot @dhdegroot.bsky.social · 04/05/2025
New publication! We identify growth coupled sensitivity: a deceivingly simple mechanism that makes E. coli switch to the best sugar. We combined neat theory (due to @erikvannimwegen.bsky.social, and to which I contributed) with clean experiments (due to @thomasjulou.bsky.social and Theo Gervais).
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Richard Neher @neher.io · 09/02/2025
Um die grossen Herausforderungen unserer Zeit (KI, Klimawandel, Pandemien, etc) richtig beurteilen zu können, brauchen wir fundierten Wissenschaftsjournalismus. Es ist ein Fehler, dass #SRF ausgerechnet hier spart. bajour.ch/a/die-srf-sp...
bajour.ch
Sparmassnahmen treffen SRF Standort in Basel
SRF streicht Formate in den Bereichen Kultur und Wissenschaft. Das wird auch der Standort in Basel zu spüren bekommen. Bei Politiker*innen und in der Bajour-Community lösen die jüngst angekündigten Ma...
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Marco Molari @mmolari.bsky.social · 06/01/2025
Thrilled to announce that our work (w. with fantastic @neher.io and Liam Shaw) has been published on Molecular Biology and Evolution! 🎉 academic.oup.com/mbe/advance-... Are you curious about how fast the genome of E.coli evolves structurally (gains, rearrangements...) ? 🧬 A summary thread [1/N]🧵
academic.oup.com
Quantifying the evolutionary dynamics of structure and content in closely-related E. coli genomes
Abstract. Bacterial genomes primarily diversify via gain, loss, and rearrangement of genetic material in their flexible accessory genome. Yet the dynamics
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Erik van Nimwegen @erikvannimwegen.bsky.social · 15/01/2025
What do bacterial cells do when they run out of nutrients? Although most bacterial studies focus on cells in exponentially growing states, in the wild bacteria likely spend most of their time slowly starving to death. 1/n www.biorxiv.org/content/10.1...
biorxiv.org
E. coli prepares for starvation by dramatically remodeling its proteome in the first hours after loss of nutrients
It is widely believed that due to nutrient limitations in natural environments, bacteria spend most of their life in non-growing states. However, very little is known about how bacteria change their p...
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