Reposted by Joan Camunas-Soler
Xie et al. combined single-nucleus RNA sequencing, spatial transcriptomics, and functional calcium imaging across pancreatic samples from healthy and metabolic disease states.
www.biorxiv.org/content/10.6...
biorxiv.org
Spatial and functional mapping of the human pancreas reveals endocrine and exocrine cell states in health and metabolic disease
The human pancreas contains diverse endocrine and exocrine cell populations whose spatial organization is essential for tissue physiology. While single-cell and spatial transcriptomics revealed molecu...
