Mitochondria must sense their environment to enable cells and organisms to adapt to diverse environments and survive during stress. However, during microbial infection, an evolutionary pressure since ...

Liver is the key hub of systemic energy metabolism and growth regulation, yet its roles in mitochondrial disease pathophysiology remain relatively understudied. Bcs1lp.S78G knock-in mice, carrying a p...

imageimageThe human mitochondrial RNase Z complex is essential for the production of mitochondrial tRNAs. This study reveals its complete structural framework, detailing its role in tRNA maturation an...

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The brain uses pyruvate as an energy source, and mitochondrial pyruvate metabolism in nerve terminals controls neurotransmission.

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High-resolution structures of respiratory I:III2 complexes from brown fat adapted to cold temperatures reveal a distinct supercomplex assembly with rotated CIII2 that displays higher electron transfer...