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Harry Low’s Lab

@lowlab.bsky.social
3.1K followers 778 following 82 posts

Bacterial pathogenesis. Antibiotic discovery. Membrane remodelling. Structural biology #cryoEM @Imperial College, London thelowlab.org

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Reposted by Harry Low’s Lab
MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 9h
How does neurodegeneration spread across the brain? 🧠 @sjorsscheres.bsky.social, Michel Goedert & Masata Hasegawa’s groups have demonstrated that human misfolded tau filaments act as a molecular template for prion-like propagation in the mouse brain. mrclmb.ac.uk/news-events/... #LMBResearch 🧪
Alzheimer's and corticobasal degeneration tau filaments induce distinct pathologies in mouse brains, with corresponding cryo-EM images and structural models.
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Buzz Baum @buzzbaum.bsky.social · 22/09/2026
We are looking for a research assistant! Come join the team: www.jobs.ac.uk/job/DSZ826/r...
jobs.ac.uk
Research Support Officer | Cell Biology | Dr Buzz Baum | LMB 2904 at MRC Laboratory of Molecular Biology
Start your UK & international job search for academic jobs, research jobs, science jobs and managerial jobs in leading universities and top...
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Reposted by Harry Low’s Lab
Tanmay Bharat @tbharat-lab.bsky.social · 23/08/2026
Molecular architecture of colossal surface layers from hyperthermophilic archaea Led by @idocaspy.bsky.social (Ido) In collaboration with @mkrupovic.bsky.social and @vikramalva.bsky.social labs doi.org/10.64898/202...
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Kenneth Loi @kenjmloi.bsky.social · 18/09/2026
VIPR is now out in Science! What started with a mysterious RNA led us to an unexpected way of recognizing DNA, as well as some clues to CRISPR’s origins. So happy to share these two papers with an incredible team. Links below; original discovery thread here ↓
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Oli Clarke @olibclarke.bsky.social · 19/09/2026
looks pretty impressive
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Anthony Vecchiarelli @cellforganized.bsky.social · 19/09/2026
Applications are now being accepted for the 2027 Bacterial Cell Biology & Development GRC, June 6–11! GRS will be on June 5-6, 2027 We’ll likely be oversubscribed, so please apply early!
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Matthew Freeman @mjafreeman.bsky.social · 09/09/2026
Less than 2 weeks to apply! If you are looking for early career fellowship sponsorship, consider @dunnschool.bsky.social to launch your independent career Great science, great support and, of course, lovely colleagues... www.path.ox.ac.uk/work-with-us...
path.ox.ac.uk
Group Leader Career Development Fellowships - Dunn School
Are you an early career researcher interested in the cell or molecular mechanisms underlying disease? Do you have an outstanding record and an innovative research plan?
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Paul Carini @uncultured.carinilab.com · 08/09/2026
We are happy to support an NSF PRFB application that makes use of AI to advance microbial cultivation for biotechnological purposes. Deadline=Sept 29th. More here: uncultured.carinilab.com/p/were-looki...
uncultured.carinilab.com
We're Looking to Sponsor Postdoc Fellows in AI-Driven Microbial Cultivation
NSF Postdoctoral Research Fellowships in Biology
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Ben Engel @cellarchlab.com · 08/09/2026
MemBrain v2 is on @natmethods.nature.com now? I never had a @biorxivpreprint.bsky.social with 164 citations before😅 ...Which is also to say: Thank you to the amazing #TeamTomo community, many of whom not only beta tested, but also contributed diverse training data. This one belongs to all of us! 🤗🔬🧪
BioRxiv FTW
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Lars-Anders Carlson @lacarlson.bsky.social · 03/09/2026
"We employed a fleet of seven customized eFIB-SEM machines to separately image each of the 66 hot-knife slabs over the course of a year."
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Wilbert Bitter @wilbertbitter.bsky.social · 02/09/2026
Please have a look at our review on a very interesting and underappreciated group of proteins... Getting a grip on StAR-related lipid-transfer (START) domain proteins in bacteria academic.oup.com/femsre/artic...
academic.oup.com
Getting a grip on StAR-related lipid-transfer (START) domain proteins in bacteria
Bacterial START domain proteins have a conserved helix-grip fold, but diverge from mammalian lipid transporters by utilizing a more versatile array of proc
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Ben Engel @cellarchlab.com · 31/08/2026
LAST WEEK TO APPLY!!! 🧪 @biozentrum.unibas.ch seeks a new group👩‍🔬 exploring molecular questions relevant to climate 🌍, including biogeochemical cycles (e.g., carbon, nitrogen) ♻️, bioenergetic energy conversion (e.g., photosynthesis, chemosynthesis) ☀️⚗️, and the adaptation to environmental change 🌊🌡️🦠🌾
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Silvia Ramundo @sramundo.bsky.social · 19/08/2026
A stress response can be a great starting point for discovering new biology! By following genes regulated during the chloroplast unfolded protein response, we’re discovering novel factors involved in chloroplast homeostasis. Here’s the first one we characterized: www.pnas.org/doi/10.1073/...
pnas.org
VIA1 is a conserved regulator of thylakoid membrane integrity that acts through VIPP1 | PNAS
Thylakoid membranes are indispensable for oxygenic photosynthesis, yet the mechanisms that protect these membranes from photooxidative damage remai...
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Ákos T Kovács @evolvedbiofilm.bsky.social · 21/08/2026
Bacterial nanotubes extend from a tubeosome organelle to establish an intercellular bridge bioRxiv by @mkguria24.bsky.social et al from Sigal Ben-Yehuda www.biorxiv.org/content/10.6...
biorxiv.org
Bacterial nanotubes extend from a tubeosome organelle to establish an intercellular bridge
Bacterial nanotubes are widespread intercellular membranous bridges mediating molecular exchange among neighboring cells, yet their formation and dynamics remain largely unexplored. By combining live-...
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Stephen Curry @scurry.bsky.social · 06/08/2026
“It is biology’s Wright Brothers moment, where we stop looking over our shoulder at the entities that evolution has created . . . and are confronted with the vast expanses of future biological possibility.” giftarticle.ft.com/giftarticle/... Holy shit.
giftarticle.ft.com
AI creates first synthetic viruses
Genomic language model has huge potential to redesign organisms such as bacteria
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Shamphavi Sivabalasarma @sshamphavi.bsky.social · 06/08/2026
Hot, acidic and an endlessly fascinating archaeal model organism! Check out our review on Sulfolobus acidocaldarius🥳
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BejaLabTechnion @bejalab.bsky.social · 30/07/2026
Eukaryotic-like microtubules and dynamic instability of Asgard archaeal tubulins www.science.org/doi/full/10....
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Prof Paula Salgado @pssalgado.bsky.social · 24/07/2026
I signed an Open Letter to @ukri.org in defense of @diamondlightsource.bsky.social funding. It's an internationally leading facility, any cuts to its funding, from operations to staff will have disastrous consequences to #UKscience. Pls sign & share! openletter.earth/open-letter-...
openletter.earth
Open Letter in Response to Funding Pressures Affecting Diamond Light Source
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Juan Martin Serrano @juanmartin-serrano.bsky.social · 15/07/2026
Very proud to see this paper out. This is an incredible collaboration with the labs of Wes Sundquist and Adam Frost. @uofubiochem.bsky.social @kingslsm.bsky.social www.nature.com/articles/s41...
nature.com
ESCRT-III assembles around mis-segregated DNA to protect genome stability - Nature Structural & Molecular Biology
The authors show that persistent ultrafine DNA bridges become coated by membranes and the ESCRT-III proteins CHMP1B and IST1, which protect the genome within from damage.
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Géraldine Laloux @lalouxlab.bsky.social · 09/07/2026
New preprint! We show that the bacterial predator B. bacteriovorus deploys a unipolar Tad nanomachine for irreversible attachment to prey and invasion. @coralietesseur.bsky.social used CRISPRi+microfluidics to overcome barriers associated with essential systems in an obligate predatory lifestyle 🦠
biorxiv.org
A polarity-controlled Tad nanomachine enables prey invasion in a bacterial predator
Type IV pili are dynamic surface appendages assembled by envelope-spanning nanomachines that mediate diverse bacterial interactions, yet how these systems are adapted to predatory lifestyles remains p...
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Daniel Gorelick @danielgorelick.bsky.social · 01/07/2026
Paying peer reviewers works. Benefits authors, editors & reviewers. Hopefully other journals will try this.
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Rémi Fronzes @fronzeslab.bsky.social · 26/05/2026
New preprint. In S. sanguinis, a C5a peptidase-like protease (ScpH) polymerizes along eDNA, turning it into a catalytic biofilm scaffold. Great work from @robinanger.bsky.social in our lab, with Pelicic lab @lcbofficiel.bsky.social www.biorxiv.org/content/10.6...
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Cascales Lab @cascaleslab.bsky.social · 18/06/2026
Extension of the deadline for latecomers. Register to the Secretion Days in Marseille !
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Vanni Lab at UNIFR, Switzerland @labvanni.bsky.social · 12/01/2026
Finally, @danialv.bsky.social used CG simulations to show that VPS13A can deliver lipids to an acceptor membrane that is bound at the C-terminal of VPS13A, and that XKR1 is proximal, but not continuous, to the delivery site. (6/7)
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Tiago Costa @tcostalab.bsky.social · 05/06/2026
📢 We are recruiting! I’m looking for a Research Associate in Structural Biology to join my lab at Imperial College London to study horizontal gene transfer using cryo-EM, biochemistry and microbiology. Please share with interested candidates! Apply: shorturl.at/gmJGS
imperial.ac.uk
Description
Please note that job descriptions are not exhaustive, and you may be asked to take on additional duties that align with the key responsibilities ment...
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Reposted by Harry Low’s Lab
Tiago Costa @tcostalab.bsky.social · 28/05/2026
Our new study reveals how bacterial toxins are physically captured through a sequential, concentration-dependent assembly mechanism before secretion via the T6SS. Fantastic collaboration with @fillouxlab.bsky.social. Congrats Patricia & Ambre for leading this work. Paper here: shorturl.at/O31Vn
shorturl.at
Molecular basis of type VI secretion system effector loading - Nature Microbiology
Structural analysis reveals that the type VI secretion system effector cargo is enclosed within hexameric Hcp3 rings that form sequentially to enable effector loading and delivery by the Pseudomonas aeruginosa H3-type VI secretion system.
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Clausen Lab @clausenlab.bsky.social · 21/05/2026
Open Postdoc Position - Giant E3 ligases: mysterious mechanisms & non‑protein substrates. Interested? Join us to uncover how these molecular giants tag lipids, RNAs, sugars beyond proteins, on organelles and pathogens, to defend the cell. Details & Application here www.imp.ac.at/career/open-...
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Sonja-Verena Albers @archaellum.bsky.social · 20/05/2026
New preprint! Cell division has to happen at the right place but how Archaea pick that place is unknown. We now identified a three-protein system, Dip, that positions the divisome at midcell in H. volcanii and is broadly conserved across Archaea. A thread 🧵 www.biorxiv.org/content/10.6...
biorxiv.org
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Régis Joulia @regisjoulia.bsky.social · 15/05/2026
🔬 PhD position at Imperial College London! Uncover how pericytes, mysterious vascular cells, drive asthma inflammation. Use spatial transcriptomics, 3D imaging & transgenic models to unlock new therapies. 3-year funded PhD | Oct 2026 start 👉 www.findaphd.com/phds/project... 📧r.joulia@imperial.ac.uk
findaphd.com
Defining the Immune Functions of Lung Pericytes and Their Dysregulation in Asthma at Imperial College London on FindAPhD.com
PhD Project - Defining the Immune Functions of Lung Pericytes and Their Dysregulation in Asthma at Imperial College London, listed on FindAPhD.com
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Harry Low’s Lab @lowlab.bsky.social · 16/05/2026
Big thanks to This Week in Microbiology (TWiM) podcast for featuring our Enhanced Domestication (EDEN) method - designed to cultivate microbial ‘dark matter’ and discover new antibiotics 🦠 💊 Have a listen.. asm.org/podcasts/twi... And here’s the recent paper doi.org/10.1093/isme...
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Tanmay Bharat @tbharat-lab.bsky.social · 15/05/2026
Applications and prospects of cryo-electron tomography in drug discovery and understanding disease Review article by @camilaclemente.bsky.social in our lab www.sciencedirect.com/science/arti...
sciencedirect.com
Applications and prospects of cryo-electron tomography in drug discovery and understanding disease
Cryo-electron tomography (cryo-ET) is emerging as a transformative tool for structural biology. Unlike methods based on purified molecules, cryo-ET en…
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David Bhella @dbhella.bsky.social · 13/05/2026
Wow - this is just amazing. Hui Guo and colleagues from John Briggs’ lab use cryoEM helical reconstruction to discover how filamentous influenza virion assembly is directed by multiple conformations of M1 - explaining how NA is concentrated at the proximal pole. www.biorxiv.org/content/10.6...
biorxiv.org
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Susan Schlimpert @s-lab.bsky.social · 07/05/2026
Dear PhD students and postdocs — we want to hear about your science firsthand at our annual Early Career Microbiologists Mini-Symposium @johninnescentre.bsky.social (UK) this September. For more information and to apply: www.jic.ac.uk/event/early-...
jic.ac.uk
Early Career Microbiologists Mini-Symposium 2026 | John Innes Centre
The Department of Molecular Microbiology is organising a one and a half day Early- Career Microbiologists Mini-Symposium. The symposium will be held from Tuesday 22nd – Wednesday 23rd September 2026.
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Suzanne Hoppins @shoppins.bsky.social · 07/05/2026
Time-resolved tmFRET reveals GTP-coupled conformational changes in Mfn1 rupress.org/jcb/article-...
rupress.org
Time-resolved tmFRET reveals GTP-coupled conformational changes in Mfn1
Hurwitz et al. leverage a novel FRET-based approach to quantify conformational dynamics of Mfn1, a member of the dynamin superfamily that mediates mitochon
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Dimitry Tegunov @dtegunov.bsky.social · 03/05/2026
We're super excited to share MissAlignment: a new ML-based approach to reference-free tilt series alignment, spearheaded by @martenchaillet.bsky.social. We think it's going to make your cryo-ET life a lot better. Preprint: www.biorxiv.org/content/10.6... Code: github.com/warpem/miss-... 🧶 Thread:
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Sjors Scheres @sjorsscheres.bsky.social · 01/05/2026
Come and work with us on #cryoEM of alpha-synuclein amyloid filaments from #Parkinsons disease! 🥳 fa-evzn-saasfaukgovprod1.fa.ocs.oraclecloud.com/hcmUI/Candid...
fa-evzn-saasfaukgovprod1.fa.ocs.oraclecloud.com
Postdoctoral Scientist | Neurobiology | Dr Michel Goedert | LMB 2253
£42,694 per annum | Fixed-term for 3 years | Full-time | Closing date: 17 May 2026
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Lis Lowe @lislowe.bsky.social · 29/04/2026
We have a PhD studentship open! (UK only sadly) but if you are or know a student keen to work on some *really* weird mycobacterial enzymes then get in touch! #glycotime Advert below www.findaphd.com/phds/project...
findaphd.com
Uncovering a new class of toxins in pathogenic mycobacteria at Newcastle University on FindAPhD.com
PhD Project - Uncovering a new class of toxins in pathogenic mycobacteria at Newcastle University, listed on FindAPhD.com
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Bergeron lab @bergeronlab.bsky.social · 23/04/2026
Latest paper from the lab - particularly glad that we managed to get this one out, after getting scooped several times over… more spectacular work from PhD students extraordinaire, Kailin and Rosa, in close collaboration with Marc Erhardt’s group.
nature.com
The structure of the Vibrio alginolyticus flagellar filament suggests molecular mechanism for the rotation of sheathed flagella - Nature Communications
Most bacteria use a flagellum, to swim and disseminate in their environment, and it is essential for virulence. In Vibrio, the flagellum is surrounded by a sheath, a membrane-like shield that protects...
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MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 24/04/2026
Don’t miss the 20th Graduate Student Symposium at the LMB in July, organised by students from the LMB and École Polytechnique Fédérale de Lausanne (EPFL) School of Life Sciences. Registration is open now ➡️ www3.mrc-lmb.cam.ac.uk/sites/gsasym... Follow @lmbphdsymposium.bsky.social for updates!
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Utz Ermel @uermel.bsky.social · 20/04/2026
Excited to share our paper about copick, a dataset API and toolkit for collaborative annotation and analysis of #cryoET data! Whether you're picking particles or curating segmentations, copick reduces friction and brings #OME-Zarr to cryoET without breaking pipelines. 🧵👇 doi.org/10.1002/pro.70578
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Arthur Charles-Orszag @acharlesorszag.bsky.social · 20/04/2026
🚨Hear, hear, fellow microbial cell biologists!🚨 🦠 Bacterial and Archaeal Cell Biology will be represented again at this year’s CELL BIO (ASCB-EMBO) meeting! The deadline to be considered for a talk in our Minisymposium is June 9. Help us spread the word! www.ascb.org/cellbio2026/
ascb.org
Cell Bio 2023-An ASCB|EMBO Meeting
Network, learn, and collaborate with top cell biologists from around the globe.
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Harry Low’s Lab @lowlab.bsky.social · 20/04/2026
Most bacteria remain uncultured with vast microbial ‘dark matter’ awaiting discovery.. to address this am excited to share EDEN - an enhanced domestication method to grow uncultured bacteria & new diversity. Using EDEN we isolate a new species active against MDR pathogens.. doi.org/10.1093/isme...
doi.org
An enhanced domestication method for uncultured bacteria
Abstract. When environmental bacteria transition to laboratory conditions, a process termed domestication, the shift from the native habitat to a culture m
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Tung Le @tunglejic.bsky.social · 16/04/2026
Finally published. Many thanks to a wonderful collaborative team and scientific platforms!!! And thanks to editors and reviewers for enthusiasm and a great review. www.nature.com/articles/s41...
nature.com
A bacterial CARD–NLR-like immune system controls the release of gene transfer agents - Nature Microbiology
An immunity-like system functions as a lysis control hub to promote gene transfer agent particle release from host bacterial cells, suggesting that bacterial immune systems may be co-opted to promote ...
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Tominaga K. (tomiken) @pacyc184.bsky.social · 10/04/2026
An Asgard archaeon from a modern analog of ancient microbial mats: Current Biology www.cell.com/current-biology/fullte…
cell.com
An Asgard archaeon from a modern analog of ancient microbial mats
A novel Asgard archaeon, Nerearchaeum marumarumayae, is present in microbial mats in Shark Bay, Australia. Combining genomic and structural analyses, together with high-resolution electron cryotomography, Nobs et al. reveal that these archaea possess unique cellular features that reflect their ancestry as progenitors of the earliest eukaryotic cells.
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Harry Low’s Lab @lowlab.bsky.social · 26/03/2026
👀 a tad pilus machine feast.. 👏
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Quentin Smith @qmsmith.bsky.social · 25/03/2026
1/11 In our story out today in @nature.com , we showcase the molecular mechanisms that enable Cas9 to bind and cleave negatively supercoiled ((-)SC) off-targets! 🧬🧵 🔗 www.nature.com/articles/s41... #CRISPR #Cas9 #DNATopology #AFM #CryoEM #SingleMolecule #Biophysics
nature.com
Structural basis of supercoiling-induced CRISPR–Cas9 off-target activity - Nature
Cas9 structures explain topology sensing and off-target activation.
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Harry Low’s Lab @lowlab.bsky.social · 24/03/2026
Great times!
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Sjors Scheres @sjorsscheres.bsky.social · 09/03/2026
We report the Pick fold and 2 variants thereof for tau filaments from individuals with MAPT mutations encoding for D252V, G272V, S320F and Delta_G389-I39, and we use these to reconstitute the Pick fold with recombinant tau in vitro. By @qcxy8886.bsky.social. 🥳 www.biorxiv.org/content/10.6...
biorxiv.org
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Harry Low’s Lab @lowlab.bsky.social · 09/03/2026
👀 mystery solved for the Tad pilus one motor, two directions conundrum.. brilliant story, brilliant work.. 👏
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Serge Mostowy @sergemostowylab.bsky.social · 20/01/2026
Mapping the ultrastructural topology of septin cage entrapment PhD studentship with @carolynmoores1.bsky.social Direct link here: www.lshtm.ac.uk/study/fees-a...
lshtm.ac.uk
2026-27 Bloomsbury Colleges PhD Studentships | LSHTM
The Bloomsbury Colleges group was set up in 2004 and consists of five institutions: Birkbeck, London School of Hygiene & Tropical Medicine (LSHTM), the Royal Veterinary College (RVC), the School of
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