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Jason McLellan

@mclellanlab.bsky.social
3.7K followers 204 following 508 posts

Structural virology / Structure-based vaccine design mclellanlab.org Professor of Molecular Biosciences The University of Texas at Austin Opinions are my own and not the views of my employer

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Jason McLellan @mclellanlab.bsky.social · 20/07/2026
Always nice to see some of our work featured in the PDB's Molecule of the Month: pdb101.rcsb.org/motm/319
pdb101.rcsb.org
PDB101: Molecule of the Month: Hantavirus
Family of rodent-borne viruses that can cause severe illness in humans
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Jason McLellan @mclellanlab.bsky.social · 17/07/2026
I enjoyed this article. Interesting statistical comparisons. www.expectinggoals.com/p/messi-rona...
expectinggoals.com
Why Messi keeps thriving as Ronaldo fades: The GOAT's always been the best
I'm not proud, or tired
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Jason McLellan @mclellanlab.bsky.social · 22/06/2026
Had a great time at the match watching Messi score 2!!
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Jason McLellan @mclellanlab.bsky.social · 15/04/2026
My daughter was invited on stage to help Neil deGrasse Tyson @neildegrassetyson.com post a Tweet!
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Reposted by Jason McLellan
Zunlong Ke @zunlongke.bsky.social · 04/03/2026
#PostdocRecruiting: My group at the University of Texas at Austin is recruiting a Postdoc in virology and structural biology. Please see more details here: utaustin.wd1.myworkdayjobs.com/UTstaff/job/... Informal inquiries are encouraged, and see more lab info here: zunlongke-lab.org
utaustin.wd1.myworkdayjobs.com
Postdoctoral Fellow
Job Posting Title: Postdoctoral Fellow ---- Hiring Department: Molecular Biosciences ---- Position Open To: All Applicants ---- Weekly Scheduled Hours: 40 ---- FLSA Status: Exempt ---- Earliest Start ...
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Jason McLellan @mclellanlab.bsky.social · 02/03/2026
Our fourth installment on prefusion herpesvirus gB proteins is available as a preprint: doi.org/10.64898/202.... Working with Ivelin Georgiev's group, we isolated and characterized prefusion-specific HSV gB antibodies from humans!
Cryo-EM structures of prefusion HSV-2 gB in complex with human antibodies.
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Jason McLellan @mclellanlab.bsky.social · 27/01/2026
Our third installment on prefusion stabilization of herpesvirus gB proteins is available as a preprint: doi.org/10.64898/202.... A great collaboration with colleagues at Merck. Our prefusion HSV-2 gB protein adopts a more closed conformation than has been observed for HSV-1 gB in recent papers.
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Jason McLellan @mclellanlab.bsky.social · 01/01/2026
New Year's Eve Red Wings game with the family!
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Jason McLellan @mclellanlab.bsky.social · 10/11/2025
Excited for Adam Klivans and my other colleagues at UT working in the AI space!
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Jason McLellan @mclellanlab.bsky.social · 31/10/2025
Happy Halloween! My daughter is dressed as Hornet from Silksong, the game I've spent 60 hours playing the past two months
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Jason McLellan @mclellanlab.bsky.social · 08/10/2025
I'm honored to receive a MacArthur Fellowship. As always, I extend my sincerest thanks to all my wonderful mentors, colleagues, collaborators, admins, and trainees who make this work possible. #MacFellow
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Jason McLellan @mclellanlab.bsky.social · 19/08/2025
Our preprint, in collaboration with Rino Rappuoli & Emanuele Andreano, is out! Co-led by colleagues at TLS, my grad student Ling Zhou @lingzhou.bsky.social, and postdoc Emily Rundlet @cryoemily.bsky.social, we identified OPG153 as a poxvirus bnAb target via B cell isolation & AlphaFold3 prediction.
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Jason McLellan @mclellanlab.bsky.social · 18/06/2025
Our latest preprint is now available doi.org/10.1101/2025...! Led by my postdoc, Luqiang Guo @luqiang.bsky.social, we determined a ~2.4 A resolution structure of the hantavirus glycoprotein tetramer on the surface of VLPs. Also determined structures of dimers of tetramers and Fab-bound tetramers.
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Jason McLellan @mclellanlab.bsky.social · 20/05/2025
Check out our latest study, led by grad student Ryan McCool @rmccool.bsky.social‬, in collaboration with Vaccine Company. We were able to stabilize EBV gB in the prefusion conformation, determine its cryo-EM structure to 3.1 A, and assess its immunogenicity in mice. www.biorxiv.org/cgi/content/...
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Jason McLellan @mclellanlab.bsky.social · 18/05/2025
Getting ready for the Viruses and Cells GRC in Castelldefels
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Jason McLellan @mclellanlab.bsky.social · 07/05/2025
New exhibit at the National Inventors Hall of Fame 👀
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Jason McLellan @mclellanlab.bsky.social · 25/04/2025
Very cool! www.nature.com/articles/d41...
nature.com
Century-old genetics mystery of Mendel’s peas finally solved
Researchers pinpoint the genes responsible for the final three pea traits studied by the famed citizen scientist.
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Reposted by Jason McLellan
Carl Zimmer @carlzimmer.com · 26/03/2025
"Angry, disappointed, frustrated"--Scientists were making progress on vaccines and antivirals for the next pandemic--until this week, when the Trump administration abruptly told them to stop. Here's my story with @apoorvanyt.bsky.social Gift link: nyti.ms/43Xz77q
nyti.ms
H.H.S. Scraps Studies of Vaccines and Treatments for Future Pandemics (Gift Article)
Federal officials cited the end of the Covid-19 pandemic in halting the research. But much of the work was focused on preventing outbreaks of other pathogens.
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Jason McLellan @mclellanlab.bsky.social · 25/03/2025
We just had our first grant terminated. This was a U19 AViDD grant (grants.nih.gov/grants/guide...). It was set to end next month, although many in the consortia were hoping for NCEs.
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Reposted by Jason McLellan
Texas Science @texasscience.bsky.social · 17/01/2025
Wow! UT Austin’s Jason McLellan will be inducted into the National Inventors Hall of Fame for his work on structure-based vaccine design that led to development of vaccines to fight COVID-19 & RSV. @mclellanlab.bsky.social @utaustin.bsky.social #COVIDVaccine cns.utexas.edu/news/announc...
cns.utexas.edu
UT Vaccine Scientist Will Be Inducted Into National Inventors Hall of Fame
McLellan, who will be inducted in Washington, D.C. on May 8, is among the youngest new inductees in hall of fame history.
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Reposted by Jason McLellan
Jim Hurley @jimhurley.bsky.social · 09/01/2025
PhDs in biochemistry, structural biology, pharmacology, or similar, located in the US and with strong publication track records and a high motivation to solve Parkinson's, please send CV directly to me at jimhurley@berkeley.edu. Repost appreciated.
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Jason McLellan @mclellanlab.bsky.social · 29/12/2024
Taking the family to their first Red Wings game!
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Jason McLellan @mclellanlab.bsky.social · 20/12/2024
Congratulations Elizabeth! Great collaborative effort with our colleagues Kartik Chandran, Andrew Herbert, Stephanie Monticelli and more!
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Jason McLellan @mclellanlab.bsky.social · 06/12/2024
Register now to hear some cool vaccine science! I'll be speaking at this conference, so come hang out!
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Jason McLellan @mclellanlab.bsky.social · 30/11/2024
Time for a name change?
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Jason McLellan @mclellanlab.bsky.social · 28/11/2024
Let's go Lions!
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Jason McLellan @mclellanlab.bsky.social · 13/11/2024
My graduate student Nasim Abdi just won 2nd place for her poster at the International Conference for Pandemic Preparedness in Trieste, Italy! www.pathogen-ri.eu/conference/. Great collaboration with @drjimmydale.bsky.social at Houston Methodist🤝
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Jason McLellan @mclellanlab.bsky.social · 12/11/2024
Austin now has some Michelin-rated restaurants! guide.michelin.com/us/en/articl...
guide.michelin.com
All The Stars From The MICHELIN Guide Texas 2024
15 new One Stars and 2 new Green Stars land in the Lone Star state.
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Jason McLellan @mclellanlab.bsky.social · 12/10/2024
ACL Music Festival! Teddy Swims on stage.
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Jason McLellan @mclellanlab.bsky.social · 22/04/2024
Check out our pre-print describing a CCHFV glycoprotein complex in the pre-fusion conformation! We used several engineering tricks to design our final construct, GP38-GnH-DS-Gc. Great collaborative effort, led by graduate student @Eliza4Science!...
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Jason McLellan @mclellanlab.bsky.social · 08/04/2024
View from Austin, TX
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Jason McLellan @mclellanlab.bsky.social · 09/03/2024
Saw Road House with the cast at SXSW!
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Jason McLellan @mclellanlab.bsky.social · 14/12/2023
Promising results for a third PreF-based RSV vaccine: www.nejm.org/doi/10.1056/NEJMoa2307…
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Jason McLellan @mclellanlab.bsky.social · 02/10/2023
My babies are the October Molecule of the Month pdb101.rcsb.org/motm/286
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Jason McLellan @mclellanlab.bsky.social · 02/10/2023
My babies are the October Molecule of the Month pdb101.rcsb.org/motm/286
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Jason McLellan @mclellanlab.bsky.social · 09/07/2023
Flight to BOS to attend FASEB conference canceled by @united. Going to miss your keynote @HarmitMalik ☹️
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Jason McLellan @mclellanlab.bsky.social · 09/07/2023
www.threads.net/t/CuexVInO7bZ/?igsh…
threads.net
Jason McLellan (@jason.s.mclellan) on Threads
Hopefully we can get some good science updates and discus...
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Jason McLellan @mclellanlab.bsky.social · 08/07/2023
Had a blast at the @blink182 concert last night at @MoodyCenterATX!
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Jason McLellan @mclellanlab.bsky.social · 23/05/2023
Positive Phase I results for @icosavax's bivalent RSV/HMPV vaccine candidate displaying prefusion F-based antigens on their protein nanoparticles ir.icosavax.com/news-releases/news-…
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Jason McLellan @mclellanlab.bsky.social · 14/05/2023
Arrived in Montreux, ready for @nidovirus2023!
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Jason McLellan @mclellanlab.bsky.social · 03/05/2023
It's an incredible day for structure-based vaccine design, and I'm thrilled to see our prefusion RSV F antigen get approved as the first RSV vaccine. Still more work to do to reduce the RSV disease burden, but this will help! Congrats @BarneyGrahamMD!...
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Jason McLellan @mclellanlab.bsky.social · 17/03/2023
Well, this is new (to me). Seems like a low bar for authorship...
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Jason McLellan @mclellanlab.bsky.social · 12/03/2023
Great to see some old friends from the Vaccine Research Center days
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Jason McLellan @mclellanlab.bsky.social · 16/12/2022
Pretty cool that our coronavirus spike stabilization (2P) patent was one of the winners of the USPTO Patents for Humanity award in the COVID-19 category: www.uspto.gov/blog/director/entry/r… @BarneyGrahamMD @WardLab1 @goodwish916
uspto.gov
Recognizing life-saving COVID-19 innovations
It’s a privilege to announce the five winners of our Pate...
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Jason McLellan @mclellanlab.bsky.social · 16/12/2022
RSV wave hammers hospitals — but vaccines and treatments are coming www.nature.com/articles/d41586-022-…
nature.com
RSV wave hammers hospitals — but vaccines and treatments ...
As the respiratory illness helps to fuel a ‘tripledemic’,...
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Jason McLellan @mclellanlab.bsky.social · 05/12/2022
Checked in and ready for the start of #AVS11 @AusVirologySoc! Amazing view from the room😍
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Jason McLellan @mclellanlab.bsky.social · 01/11/2022
More great news for RSV vaccines (and structure-based vaccine design), this time for maternal immunization! apnews.com/article/science-health-b…
apnews.com
Strong RSV vaccine data lifts hopes after years of futility
A new study suggests vaccinating pregnant women protects ...
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Jason McLellan @mclellanlab.bsky.social · 31/10/2022
Happy Halloween from the McLellan Lab:)
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Jason McLellan @mclellanlab.bsky.social · 10/10/2022
Great article in the @washingtonpost by @Carolynyjohnson on the development of structure-based RSV vaccines! It's an exciting time in the field given the recent positive phase III results from @GSK and @pfizer. www.washingtonpost.com/health/2022/…
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Jason McLellan @mclellanlab.bsky.social · 17/09/2022
Being an associate editor is really frustrating. It takes forever to find even 2 reviewers. I'm well over 10 invites for some manuscripts. Maybe corresponding authors should be required to review at least two manuscripts for each manuscript they submit to that journal?
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