Nuclear protein homeostasis relies on proteasome import into the nucleus. Here the authors identify how assembled human proteasomes are transported across the nuclear pore complex and reveal a mechani...

Nature Protocols, Published online: 30 January 2026; doi:10.1038/s41596-025-01284-zA protocol for cryogenic 3D correlative focused ion beam milling using an integrated fluorescence light microscope and montage cryo-ET for nonadherent and adherent mammalian cells, as well as primary Drosophila melanogaster neurons.

Discover the 1st German Fish Model Research Meeting—uniting global experts on zebrafish, cavefish, killifish, medaka & more. Join us to collaborate, share breakthroughs, and advance fish biology resea...

EMBL and its community are deeply saddened by the death of Peer Bork, the organisation’s Interim Director General.

Cryo-focused ion beam/scanning electron microscopy (cryo-FIB/SEM) and cryo-electron tomography (cryo-ET) are emerging, versatile tools for structural cell biologists, aiming at the exploration of mol…

The layoffs jeopardize this resource, which has served more than 4,000 labs for about three decades.

A step-by-step Cryo-ET guide

Ubiquitin chains determine the fates of their modified proteins, including proteasomal degradation. Kiss et al. present UbiREAD, a technology to monitor cellular degradation and deubiquitination at hi...

Long interspersed element-1 (LINE-1) retrotransposons are the only active autonomous transposable elements in humans. They propagate by reverse transcribing their mRNA into new genomic locations by a ...