Nature Microbiology, Published online: 15 September 2026; doi:10.1038/s41564-026-02475-4The Rad6B–Tex1 ubiquitination complex drives malaria parasite sexual commitment by monoubiquitinating histone H2B, and thereby enabling gametocyte formation and mosquito transmission.

Nature Microbiology, Published online: 15 September 2026; doi:10.1038/s41564-026-02485-2Structures of Candida albicans class II chitin synthase reveal mechanisms of oligosaccharide translocation and inhibition. The translocation channel is a class II-specific druggable site, and its inhibitor synergizes with a class I inhibitor.

Nature Microbiology, Published online: 16 September 2026; doi:10.1038/s41564-026-02484-3An engineered non-pathogenic bacterium produces lytic phages and is protective in mouse models of Salmonella infection.

Nature Microbiology, Published online: 17 September 2026; doi:10.1038/s41564-026-02473-6This study describes the complex transcriptional regulatory mechanism enabling fine-tuned and rapid regulation of Plasmodium falciparum investment in transmission under changing blood conditions.

Nature Microbiology, Published online: 30 July 2026; doi:10.1038/s41564-026-02409-0In a small case series, combined phage therapy and faecal microbiota transplantation was safe and led to sustained reductions in recurrence, severity and antibiotic use in women with recurrent urinary tract infections, even without complete eradication of Escherichia coli.

Nature Microbiology, Published online: 30 July 2026; doi:10.1038/s41564-026-02452-xNature Microbiology no longer considers presubmission enquiries and instead evaluates all research through full manuscript submissions. This change is intended to improve fairness, rigour and efficiency, ensuring that editorial decisions are based on a complete assessment of the data.

Nature Microbiology, Published online: 05 August 2026; doi:10.1038/s41564-026-02420-5Artemisinin partial resistance is expanding in Ethiopia and, together with a dominant lumefantrine-tolerant PfMDR1 haplotype and co-occurring Pfcrt and Pfk13 mutations, defines a complex multidrug-resistance landscape that may reflect overlapping treatment pressures in Plasmodium vivax and Plasmodium falciparum co-endemic settings.

Nature Microbiology, Published online: 05 August 2026; doi:10.1038/s41564-026-02431-2IL-1 family signalling drives host mucosal defence against Candida albicans and, together with neutrophils, prevents mucosal–systemic dissemination and life-threatening fungal disease.

Nature Microbiology, Published online: 06 July 2026; doi:10.1038/s41564-026-02410-7A genetic cross of Plasmodium falciparum parasites revealed that quinine resistance is polygenic and is associated with mutations in transporter proteins on chromosome 7 (PfCRT and DMT1) and a metalloprotease on chromosome 12 (FtsH1), highlighting key markers for clinical surveillance.

Nature Microbiology, Published online: 06 July 2026; doi:10.1038/s41564-026-02415-2Transposon-associated amplifications are dominated by a previously underappreciated architecture, where the transposon is found only between, not flanking, the amplicons. These amplifications facilitate the evolution of bacteria and their adaptation to antibiotics.

Nature Microbiology, Published online: 21 July 2026; doi:10.1038/s41564-026-02429-wClarifying objectives to strengthen wastewater-based AMR surveillance

Nature Microbiology, Published online: 19 June 2026; doi:10.1038/s41564-026-02401-8Evolved phage cocktails outsmart biofilm defences

Nature Microbiology, Published online: 22 June 2026; doi:10.1038/s41564-026-02390-8The microbiome plays a significant yet underexplored role in antimicrobial resistance by influencing ecological and evolutionary processes. This Perspective proposes a framework to integrate microbiome–AMR interactions into predictive models while highlighting key mechanisms and data gaps to improve resistance understanding and interventions.

The microbiome plays a significant yet underexplored role in antimicrobial resistance by influencing ecological and evolutionary processes. This Perspective proposes a framework to integrate microbiom...

Nature Microbiology, Published online: 26 June 2026; doi:10.1038/s41564-026-02385-5The evolutionary emergence of complex multicellularity in bacteria and fungi, such as the ability for mycelial growth, is strongly associated with increased genomic carriage of biosynthetic machinery for producing specialized chemical metabolites.

Nature Microbiology, Published online: 19 June 2026; doi:10.1038/s41564-026-02408-1Deep learning reveals that prion-related proteins contain hidden ‘prionin’ peptides with antibacterial activity, including two candidates that reduced infections in mice.

Forward and reverse genetics identifies the mode of action of clofazimine in the parasite Cryptosporidium. The genomic locus encoding the target is heterogeneous, and a resistance-conferring allele is...

Nature Microbiology, Published online: 11 May 2026; doi:10.1038/s41564-026-02356-wThis study presents a pooled CRISPRi screening approach in Candida albicans to investigate essential genes at scale, revealing environment- and strain-dependent gene sensitivities and conserved vulnerabilities relevant to antifungal drug discovery.

Nature Microbiology, Published online: 08 April 2026; doi:10.1038/s41564-026-02309-3Emerging multidrug-resistant Neisseria gonorrhoeae is a global health threat in the treatment of gonorrhoea. This study reports the discovery and characterization of a promising antigonorrhoea agent that addresses antibiotic resistance.

Nature Microbiology, Published online: 13 April 2026; doi:10.1038/s41564-026-02327-1Intensive control using village malaria posts and mass drug administration reduces parasite effective population size and increases genetic drift, driving founder effects and rapid shifts in resistance allele frequency.

Nature Microbiology - Phylodynamic modelling shows how the changing antibiotic landscape and genetic determinants of resistance shape real-world gonococcal dynamics. Experiments validated that...

An alternative mating system, termed parasex, produces progeny with high levels of genotypic diversity and is able to fulfil the roles of meiosis when it is absent in the fungal pathobiont Candida alb...

Candida auris can scavenge carbon dioxide from microenvironments through Nce103 to sustain fitness when colonizing human skin.

Nature Microbiology - During filamentous growth in the human fungal pathogen Candida albicans, a reduction in ribosome concentration leads to a decrease in macromolecular crowding. Inhibition of...

During filamentous growth in the human fungal pathogen Candida albicans, a reduction in ribosome concentration leads to a decrease in macromolecular crowding. Inhibition of ribosome biogenesis can tri...

Florfenicol amine hijacks intrinsic resistance in Mycobacterium abscessus, highlighting that antimicrobial resistance mechanisms can be harnessed for antibiotic activation.

Large-scale sequencing and population genomic analyses reveal frequent transmission, a highly admixed global population structure and evidence of pervasive negative selection in Haemophilus influenzae...

Insects colonized with Metarhizium fungi emit longifolene to lure new hosts for infection to disperse spores. A fungal strain was engineered to emit longifolene to attract and eliminate mosquitoes.

Human host-associated cellular products may act as induction agents for bacteriophages.

Human host-associated cellular products may act as induction agents for bacteriophages.

Enterololin is a narrow-spectrum antibiotic that selectively kills Enterobacteriaceae in vitro and in a mouse model of adherent-invasive Escherichia coli gut infection. AI-guided mechanism-of-action s...

This study presents a generative artificial intelligence approach for the high-throughput discovery of antimicrobials against multidrug-resistant bacteria.

Toxoplasma gondii forms membrane contact sites with the endoplasmic reticulum of the host cell to facilitate the transfer of biomolecules to its vacuole.

The Entelli-02 phage product containing five phages has frontline potential to address infections caused by the multidrug-resistant Enterobacter cloacae complex.

The Entelli-02 phage product containing five phages has frontline potential to address infections caused by the multidrug-resistant Enterobacter cloacae complex.

Nature Microbiology - A deep-learning algorithm unravels a collection of archaeasins, peptides from the archaeal proteome with potential antimicrobial activity and implications for the development...