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Lars-Anders Carlson

@lacarlson.bsky.social
2K followers 307 following 438 posts

Structural virology group leader at Umeå University, Sweden. www.carlsonlab.se

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Reposted by Lars-Anders Carlson
Julian Sale @juliansalelab.bsky.social · 02/10/2026
Congratulations Tanmay, on receiving the @embo.org Gold Medal! @mrclmb.ac.uk @embl.org @dunnschool.bsky.social
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RCSB Protein Data Bank @rcsbpdb.bsky.social · 01/10/2026
October's Molecule of the Month: Celebrating 55 Years of the PDB (on October 20) Enabling the rapid evolution of protein structure prediction and design
pdb101.rcsb.org
PDB101: Molecule of the Month: Celebrating 55 Years of the PDB
Enabling the rapid evolution of protein structure prediction and design
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Reposted by Lars-Anders Carlson
Basil Greber @bjgreber.bsky.social · 01/10/2026
Those who had a careful look at the methods section of our work on the #cryoEM structure of the CDK11-cyclin L-SAP30BP complex will have noticed that we added a short peptide to our sample before freezing. If you wonder why...
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Svetlana Dodonova @dodonova-sveta.bsky.social · 30/09/2026
New preprint from Dodonova lab 🔔! Capturing multiple states by cryo-EM❄️, we show for the first time how archaeal RNA Polymerase engages a nucleosome and forms direct contacts with histones! 🧬 Great work by Gabriele & a fantastic collaboration with Dina Grohmann! 🧵 www.biorxiv.org/content/10.6...
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Philipp Radler @radler92.bsky.social · 01/10/2026
The first paper of my PostDoc in Christa Schlepers group (@archaea-vienna.bsky.social) on the dynamics of Asgard archaea is now out in Nature! www.nature.com/articles/s41... This was a great team effort and I am looking forward to uncover the complex behavior of these cells further!
nature.com
Dynamic protrusions mediate crawling motility in Asgard archaea - Nature
Anoxic live-cell imaging shows actin-dependent crawling motility and dynamic protrusions in Asgard archaea, providing insights into cellular innovations that may have contributed to eukaryotic evoluti...
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Lars-Anders Carlson @lacarlson.bsky.social · 01/10/2026
Crawling Asgard archaea - have to read this one as soon as I find time!
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Reposted by Lars-Anders Carlson
Hauke Hillen @haukehillen.bsky.social · 30/09/2026
We are looking for a new team member! Interested in structural biology, gene expression and organelles? Then apply now to our open PhD position: umg.recruiting-portal.com/r/z11okjqp6v...
umg.recruiting-portal.com
Institut für Zellbiochemie -- PhD (f/m/d)
PhD (f/m/d)
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Lars-Anders Carlson @lacarlson.bsky.social · 30/09/2026
Well done, Sweden!
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Reposted by Lars-Anders Carlson
MwahahahahahadScientist @mads100tist.bsky.social · 29/09/2026
Well, there it is. The EU is also going to use slop algorithms to put an artificial number on proposals. This is how we lose. This is a disaster 🧪
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Nikolai Slavov @slavov-n.bsky.social · 30/09/2026
bioRxiv has a dedicated section for negative results. Use it. Share negative results. Your colleagues will appreciate it.
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Asaf Levy @asaflevylab.bsky.social · 30/09/2026
In October we are starting year 8 (I think) of the virtual microbiology journal club (on Zoom) with fantatstic speakers, as usual. Most talks are about bacteria. If you (PIs, trainees, anyone interested in science) want to be included in the mailing list - shoot me an email. alevy@mail.huji.ac.il
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Kiarash Jamali @kjamali.bsky.social · 29/09/2026
Please check out our cool new method, GuideFlip! Optimised for binders against disordered proteins
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Lars-Anders Carlson @lacarlson.bsky.social · 29/09/2026
Science will prevail in the long run, but it is sometimes easier for politicians to make a "difference" in the short run: "Despite recent financial cutbacks, which are estimated to result in an additional 6.6 million new HIV infections and 4.2 million AIDS-related deaths between 2025 and 2029..."
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Rémi Fronzes @fronzeslab.bsky.social · 29/09/2026
CryoFIB SEM installed at the @bic-bordeaux.bsky.social 🍾🎉🍾🎉
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feeb | yuritober!! @magicmooshka.bsky.social · 09/01/2026
it’s come to my attention that my tumblr post has been crossposted to bluesky, so I’m posting it on my account here #AntiAI #GenAI
recently my friend's comics professor told her that it's acceptable to use gen AI for script-writing but not for art, since a machine can't generate meaningful artistic work. meanwhile, my sister's screenwriting professor said that they can use gen AI for concept art and visualization, but that it won't be able to generate a script that's any good. and at my job, it seems like each department says that AI can be useful in every field except the one that they know best.

It's only ever the jobs we're unfamiliar with that we assume can be replaced with automation. The more attuned we are with certain processes, crafts, and occupations, the more we realize that gen AI will never be able to provide a suitable replacement. The case for its existence relies on our ignorance of the work and skill required to do everything we don't.
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RCSB Protein Data Bank @rcsbpdb.bsky.social · 28/09/2026
Structural Biology and Nobel Prizes: Visit PDB-101 to explore connections between Nobel Prizes and more than 50 years of open access to the PDB archive
pdb101.rcsb.org
PDB101: Browse: Nobel Prizes and PDB structures
PDB-101: Training, Outreach, and Education portal of RCSB PDB
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Marc Robinson-Rechavi @marcrr.bsky.social · 28/09/2026
I'm not writing in the NYT and I won't word it carefully: it's clear that AI companies are stealing researchers' work (and why wouldn't they? they steal artists' and journalists' work with no consequences), and I warned my group about it this morning.
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Carl T. Bergstrom @carlbergstrom.com · 27/09/2026
Ignore for a moment the question about whether Anthropic trains on user sessions. I am I right in reading this as saying that Anthropic's "never-before-discovered" reverse transcriptase was *patented* three years ago?
Dr. Mestre first encountered the enzymes in jumbo phages in 2022 while searching for new reverse transcriptases. He worked briefly as a consultant for ReNegade Therapeutics, which filed a patent in 2023 on a number of reverse transcriptases, including the ones Dr. Mestre found. He is listed as a co-inventor on the patent filing.
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Reposted by Lars-Anders Carlson
Carl Zimmer @carlzimmer.com · 27/09/2026
Four days ago, a scientist was surprised by the news that Anthropic discovered new virus genes for making DNA. He says he’s been studying them for years—and feeding his data to Anthropic’s AI as part of his own research. Coincidence? Here’s my story. nyti.ms/3VSWayc
nyti.ms
Did Anthropic’s A.I. Really Make a Scientific Discovery on Its Own? (Gift Article)
An expert at the University of Copenhagen said his team had been sharing its research with the company’s A.I. model, Claude, and that its new finding matched their work.
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Waggoner Lab @labwaggoner.bsky.social · 26/09/2026
Mammalian cells produce and store a sulfur compound for antioxidant protection @science.org www.science.org/doi/10.1126/... www.science.org/doi/10.1126/...
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Reposted by Lars-Anders Carlson
André Nadler @nadlerlab.bsky.social · 26/09/2026
I am really curious how they're going to try and weasel out of that one. But I am sure it'll be entertaining.
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Rasmus Jensen @rasmusjensen.bsky.social · 25/09/2026
🎉 Out today in Cell: the paper I've been looking forward to sharing for a long time 🎉 We used cryo-ET to find a molecular machine nobody knew existed on the surface of a minimal bacterium, and worked out what it does. 🧵(1/7) #TeamTomo #cryoET
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Claudia Alen Amaro @claudialen.bsky.social · 25/09/2026
Today I am @diamondlightsource.bsky.social to celebrate the great contribution of Dave Stuart to Diamond and the structural biology community @walshdls.bsky.social starts the symposium with key highlights For @instruct-eric.bsky.social his vision was instrumental personally I can only say thank you!
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erzbergerlab.bsky.social @erzbergerlab.bsky.social · 25/09/2026
In-cell structures visualize human pre-ribosome assembly in the nucleolus | Science www.science.org/doi/10.1126/...
science.org
In-cell structures visualize human pre-ribosome assembly in the nucleolus
In eukaryotes, ribosome biogenesis initiates within the nucleolus, a hallmark multilayered compartment of the nucleus. Structures of pre-ribosomes have been characterized ex situ, but their assembly p...
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Reposted by Lars-Anders Carlson
simon-alkema.bsky.social @simon-alkema.bsky.social · 17/09/2026
Releasing TOMATO, the TOMogram Annotation TOol! A lightweight Python GUI for going through hundreds of cryo-ET tomograms. Flag what's in each one, grade its quality, and end up with a table you can filter and act on. github.com/alkemasimon/...
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Daniel Hurdiss @danielhurdiss.bsky.social · 25/09/2026
For anyone interested in a more accessible overview of our recent norovirus paper, Utrecht University has now published a news item about the work. www.uu.nl/en/news/mole...
uu.nl
Molecular motor may help norovirus transport its genetic material
Researchers have uncovered new details about a key norovirus protein. They provide a new framework for future research into the virus and antiviral drugs.
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Beckmann Lab @beckmannlab.bsky.social · 23/09/2026
Frank Nijpels from VitriMatics paid us a visit today. Not only did he repair our broken VitroBot Mark IV and returned it in person, he also brought some extremely cool tools ❄️ for reliable cryo-EM grid freezing 🔬. Check out the VitriClip and the SupraBlot at vitrimatics.com. #cryoEM #cryoET
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Ben Engel @cellarchlab.com · 24/09/2026
Insane in the #MemBrain 🤖🧠 #TeamTomo 🧪
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Vasilii Mikirtumov @vasiliimikirtumov.bsky.social · 24/09/2026
thrilled to share that my main phd project is finally out in @natcomms.nature.com we present high-resolution structures of RyR1 in native membranes across multiple functional states by both cryo-ET/StA #TeamTomo and SPA! paper: www.nature.com/articles/s41... and a thread below⬇️⬇️⬇️
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Lars-Anders Carlson @lacarlson.bsky.social · 24/09/2026
I missed this one in August! @inprep.bsky.social inpreparation.substack.com/p/nih-simpli...
inpreparation.substack.com
NIH Simplifies Grant Scoring To 👍 🤷‍♂️ 😂
BETHESDA, MD—The National Institutes of Health announced Tuesday that it would replace its 50-year-old numerical scoring system with a streamlined three-emoji format, in which grant applications will ...
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Reposted by Lars-Anders Carlson
Prof. Feynman @proffeynman.bsky.social · 24/09/2026
If you think you can, you may. If you think you can't, you're right.
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Lars-Anders Carlson @lacarlson.bsky.social · 23/09/2026
Last week, our PhD student Joanne and I attended HCV-Flavi in Copenhagen ...and so did the lab of our alumna Selma Dahmane! Photo of Carlson+Dahmane attendees on the last evening, at Tivoli Gardens. Great time!
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Colin Carlson @colincarlson.bsky.social · 23/09/2026
What's behind this tidal wave of epidemics? In the largest study ever conducted on emerging infectious diseases, we show that the popular explanation - "our relationship with nature is out of balance" - doesn't hold up. Out now in Nature, after half a decade of work: www.nature.com/articles/s41...
nature.com
The anthropogenic fingerprint on emerging infectious diseases - Nature
Emerging infectious disease outbreak risks are ubiquitous worldwide, and highest in landscapes where people, livestock and fragmented natural ecosystems coexist, but detection and data ...
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Anja Schmidt @anjanja1024.bsky.social · 23/09/2026
So if my AI dreams up organelles in post processing... It's okay? 🙄
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RCSB Protein Data Bank @rcsbpdb.bsky.social · 22/09/2026
How X-rays and crystals revealed the true nature of things The story behind the 100-year-old discovery that continues to render Nobel Prizes.
nobelprize.org
How X-rays and crystals revealed the true nature of things - NobelPrize.org
The story behind the 100-year-old discovery that continues to render Nobel Prizes.
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Randall Munroe @xkcd.com · 22/09/2026
Tyrannosaurus xkcd.com/3300/
Comic. [Person with long hair pointing to diagram with Tyrannosaurus Rex standing next to a person.] PERSON: We now believe the primary prey of Tyrannosaurus Rex was these humans who kept standing next to it for scale.
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Cathy Spangler @cathyspangler.bsky.social · 22/09/2026
I'm excited to share our new preprint, where we show that fine-tuning gold nanoparticle conjugation to different Fab structural elements can produce powerful, rigidly coupled, labeling tools for in-situ cryo-ET. Take a look if you want to see an AuNP in an EM map!🔬🧠 www.biorxiv.org/content/10.6...
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Philippe Le Mercier, ViralZone @viralzone.bsky.social · 22/09/2026
A clever new tool for building full icosahedral capsids from AlphaFold models — from the talented team behind ViperDB. FoldaVirus, a knowledge-based icosahedral capsid prediction tool using AlphaFold www.pnas.org/doi/10.1073/...
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Stephane Vassilopoulos @stefvass.bsky.social · 22/09/2026
Great to see this finally out! ✨ A real pleasure to contribute to this special issue celebrating 50 years of #Clathrin and to revisit how this superstar coat keeps surprising us ⚽🔬
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Yuan He @yuanhejhu.bsky.social · 22/09/2026
A big week for the lab! Two new papers on how cells repair DNA double-strand breaks: one on getting NHEJ started in chromatin, one on processing the ends before ligation. Years of work by a fantastic team.
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Richard Sever @richardsever.bsky.social · 27/08/2026
$3.7 billion spent on APCs in 2025. That's ~1000X more than it costs to run bioRxiv/medRxiv. Worth thinking about as we consider how to fund infrastructure... arxiv.org/pdf/2608.16322
arxiv.org
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Lars-Anders Carlson @lacarlson.bsky.social · 21/09/2026
This is an important thing to bear in mind especially in consensus-oriented cultures like Sweden!
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RCSB Protein Data Bank @rcsbpdb.bsky.social · 21/09/2026
September 21 is #WorldAlzheimersDay Alzheimer's disease and prion diseases are linked to unnatural aggregation of proteins into amyloid fibrils.
pdb101.rcsb.org
PDB101: Molecule of the Month: Amyloids
Alzheimer's disease and prion diseases are linked to unnatural aggregation of proteins into amyloid fibrils.
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Max Delbrück Center @mdc-berlin.bsky.social · 18/09/2026
Caveolae help cells withstand mechanical stress, take up nutrients, and regulate signaling. How are these tiny membrane structures stabilized? #mdcBerlin researchers have now resolved the structure of the EHD2 protein chain that does the job. Learn how it works: 👉 www.mdc-berlin.de/news/press/h...
AI-generated scientific illustration of a caveola in a cell membrane, with a chain of proteins wrapped around its neck. Overlaid text reads: “A protein chain keeps caveolae in shape.”
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Daniel Hurdiss @danielhurdiss.bsky.social · 21/09/2026
Excited to share that our norovirus NS3 study is now online in Nature Communications! 🎉 These enzymes, found across an entire order of RNA viruses, have long been molecular motors in search of a function. We think we’ve uncovered their role. (🧵) www.nature.com/articles/s41... #virology #cryoEM
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Lars-Anders Carlson @lacarlson.bsky.social · 20/09/2026
Probably good to consider the MSCA application and evaluation process in the light of LLM-generated applications. At a minimum, simplify and shorten the written application. Why should reviewers read so much LLM-generated text? Could interviews be practically organised for such a huge programme?
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Pat Schloss @patschloss.bsky.social · 18/09/2026
Let me get this straight. There's a title. There's a commentary article. There's an abstract. There's a set of bullet point highlights. There's a graphical abstract. AND YOU STILL THINK I NEED YOUR AI AGENT TO SUMMARIZE THE ARTICLE FOR ME?
AI BS from Cell
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Jeremy Reiter @reitergroup.bsky.social · 18/09/2026
What in the world am I looking at here? @Nikon? www.nikonsmallworld.com/galleries/20...
nikonsmallworld.com
Abnormal beating of airway cilia from a child with Primary Ciliary Dyskinesia (PCD) | 2026 Small World in Motion Competition
Ning Xu - Abnormal beating of airway cilia from a child with Primary Ciliary Dyskinesia (PCD), a genetic disorder affecting respiratory function.
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Lars-Anders Carlson @lacarlson.bsky.social · 16/09/2026
“Ethanol is a privilege, not a right,”
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Joy Jeongyoon Choi @joyjoychoi.bsky.social · 14/09/2026
Excited to share our new preprint on in situ chromatin structure of the inactive X chromosome in differentiated female mouse embryonic stem cells. www.biorxiv.org/content/10.6... 🧵1/8
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