Reposted by Lars-Anders CarlsonJulian Sale @juliansalelab.bsky.social · 02/10/2026Congratulations Tanmay, on receiving the @embo.org Gold Medal! @mrclmb.ac.uk @embl.org @dunnschool.bsky.social 2344
Reposted by Lars-Anders CarlsonRCSB Protein Data Bank @rcsbpdb.bsky.social · 01/10/2026October's Molecule of the Month: Celebrating 55 Years of the PDB (on October 20) Enabling the rapid evolution of protein structure prediction and designpdb101.rcsb.orgPDB101: Molecule of the Month: Celebrating 55 Years of the PDBEnabling the rapid evolution of protein structure prediction and design 051
Reposted by Lars-Anders CarlsonBasil Greber @bjgreber.bsky.social · 01/10/2026Those who had a careful look at the methods section of our work on the #cryoEM structure of the CDK11-cyclin L-SAP30BP complex will have noticed that we added a short peptide to our sample before freezing. If you wonder why... 13718
Reposted by Lars-Anders CarlsonSvetlana Dodonova @dodonova-sveta.bsky.social · 30/09/2026New preprint from Dodonova lab 🔔! Capturing multiple states by cryo-EM❄️, we show for the first time how archaeal RNA Polymerase engages a nucleosome and forms direct contacts with histones! 🧬 Great work by Gabriele & a fantastic collaboration with Dina Grohmann! 🧵 www.biorxiv.org/content/10.6... 19835
Reposted by Lars-Anders CarlsonPhilipp Radler @radler92.bsky.social · 01/10/2026The first paper of my PostDoc in Christa Schlepers group (@archaea-vienna.bsky.social) on the dynamics of Asgard archaea is now out in Nature! www.nature.com/articles/s41... This was a great team effort and I am looking forward to uncover the complex behavior of these cells further!nature.comDynamic protrusions mediate crawling motility in Asgard archaea - NatureAnoxic live-cell imaging shows actin-dependent crawling motility and dynamic protrusions in Asgard archaea, providing insights into cellular innovations that may have contributed to eukaryotic evoluti... 59135
Lars-Anders Carlson @lacarlson.bsky.social · 01/10/2026Crawling Asgard archaea - have to read this one as soon as I find time! 000
Reposted by Lars-Anders CarlsonHauke Hillen @haukehillen.bsky.social · 30/09/2026We are looking for a new team member! Interested in structural biology, gene expression and organelles? Then apply now to our open PhD position: umg.recruiting-portal.com/r/z11okjqp6v...umg.recruiting-portal.comInstitut für Zellbiochemie -- PhD (f/m/d)PhD (f/m/d) 01618
Reposted by Lars-Anders CarlsonMwahahahahahadScientist @mads100tist.bsky.social · 29/09/2026Well, there it is. The EU is also going to use slop algorithms to put an artificial number on proposals. This is how we lose. This is a disaster 🧪 54414
Reposted by Lars-Anders CarlsonNikolai Slavov @slavov-n.bsky.social · 30/09/2026bioRxiv has a dedicated section for negative results. Use it. Share negative results. Your colleagues will appreciate it. 23213
Reposted by Lars-Anders CarlsonAsaf Levy @asaflevylab.bsky.social · 30/09/2026In October we are starting year 8 (I think) of the virtual microbiology journal club (on Zoom) with fantatstic speakers, as usual. Most talks are about bacteria. If you (PIs, trainees, anyone interested in science) want to be included in the mailing list - shoot me an email. alevy@mail.huji.ac.il 023
Reposted by Lars-Anders CarlsonKiarash Jamali @kjamali.bsky.social · 29/09/2026Please check out our cool new method, GuideFlip! Optimised for binders against disordered proteins 0113
Lars-Anders Carlson @lacarlson.bsky.social · 29/09/2026Science will prevail in the long run, but it is sometimes easier for politicians to make a "difference" in the short run: "Despite recent financial cutbacks, which are estimated to result in an additional 6.6 million new HIV infections and 4.2 million AIDS-related deaths between 2025 and 2029..." 010
Reposted by Lars-Anders CarlsonRémi Fronzes @fronzeslab.bsky.social · 29/09/2026CryoFIB SEM installed at the @bic-bordeaux.bsky.social 🍾🎉🍾🎉 3439
Reposted by Lars-Anders Carlsonfeeb | yuritober!! @magicmooshka.bsky.social · 09/01/2026it’s come to my attention that my tumblr post has been crossposted to bluesky, so I’m posting it on my account here #AntiAI #GenAI 113136046608
Reposted by Lars-Anders CarlsonRCSB Protein Data Bank @rcsbpdb.bsky.social · 28/09/2026Structural Biology and Nobel Prizes: Visit PDB-101 to explore connections between Nobel Prizes and more than 50 years of open access to the PDB archivepdb101.rcsb.orgPDB101: Browse: Nobel Prizes and PDB structuresPDB-101: Training, Outreach, and Education portal of RCSB PDB 052
Reposted by Lars-Anders CarlsonMarc Robinson-Rechavi @marcrr.bsky.social · 28/09/2026I'm not writing in the NYT and I won't word it carefully: it's clear that AI companies are stealing researchers' work (and why wouldn't they? they steal artists' and journalists' work with no consequences), and I warned my group about it this morning. 01813
Reposted by Lars-Anders CarlsonCarl T. Bergstrom @carlbergstrom.com · 27/09/2026Ignore for a moment the question about whether Anthropic trains on user sessions. I am I right in reading this as saying that Anthropic's "never-before-discovered" reverse transcriptase was *patented* three years ago? 10380112
Reposted by Lars-Anders CarlsonCarl Zimmer @carlzimmer.com · 27/09/2026Four days ago, a scientist was surprised by the news that Anthropic discovered new virus genes for making DNA. He says he’s been studying them for years—and feeding his data to Anthropic’s AI as part of his own research. Coincidence? Here’s my story. nyti.ms/3VSWaycnyti.msDid Anthropic’s A.I. Really Make a Scientific Discovery on Its Own? (Gift Article)An expert at the University of Copenhagen said his team had been sharing its research with the company’s A.I. model, Claude, and that its new finding matched their work. 892122874
Reposted by Lars-Anders CarlsonWaggoner Lab @labwaggoner.bsky.social · 26/09/2026Mammalian cells produce and store a sulfur compound for antioxidant protection @science.org www.science.org/doi/10.1126/... www.science.org/doi/10.1126/... 095
Reposted by Lars-Anders CarlsonAndré Nadler @nadlerlab.bsky.social · 26/09/2026I am really curious how they're going to try and weasel out of that one. But I am sure it'll be entertaining. 041
Reposted by Lars-Anders CarlsonRasmus Jensen @rasmusjensen.bsky.social · 25/09/2026🎉 Out today in Cell: the paper I've been looking forward to sharing for a long time 🎉 We used cryo-ET to find a molecular machine nobody knew existed on the surface of a minimal bacterium, and worked out what it does. 🧵(1/7) #TeamTomo #cryoET 1023195
Reposted by Lars-Anders CarlsonClaudia Alen Amaro @claudialen.bsky.social · 25/09/2026Today I am @diamondlightsource.bsky.social to celebrate the great contribution of Dave Stuart to Diamond and the structural biology community @walshdls.bsky.social starts the symposium with key highlights For @instruct-eric.bsky.social his vision was instrumental personally I can only say thank you! 065
Reposted by Lars-Anders Carlsonerzbergerlab.bsky.social @erzbergerlab.bsky.social · 25/09/2026In-cell structures visualize human pre-ribosome assembly in the nucleolus | Science www.science.org/doi/10.1126/...science.orgIn-cell structures visualize human pre-ribosome assembly in the nucleolusIn eukaryotes, ribosome biogenesis initiates within the nucleolus, a hallmark multilayered compartment of the nucleus. Structures of pre-ribosomes have been characterized ex situ, but their assembly p... 02211
Reposted by Lars-Anders Carlsonsimon-alkema.bsky.social @simon-alkema.bsky.social · 17/09/2026Releasing TOMATO, the TOMogram Annotation TOol! A lightweight Python GUI for going through hundreds of cryo-ET tomograms. Flag what's in each one, grade its quality, and end up with a table you can filter and act on. github.com/alkemasimon/... 15825
Reposted by Lars-Anders CarlsonDaniel Hurdiss @danielhurdiss.bsky.social · 25/09/2026For anyone interested in a more accessible overview of our recent norovirus paper, Utrecht University has now published a news item about the work. www.uu.nl/en/news/mole...uu.nlMolecular motor may help norovirus transport its genetic materialResearchers have uncovered new details about a key norovirus protein. They provide a new framework for future research into the virus and antiviral drugs. 1173
Reposted by Lars-Anders CarlsonBeckmann Lab @beckmannlab.bsky.social · 23/09/2026Frank Nijpels from VitriMatics paid us a visit today. Not only did he repair our broken VitroBot Mark IV and returned it in person, he also brought some extremely cool tools ❄️ for reliable cryo-EM grid freezing 🔬. Check out the VitriClip and the SupraBlot at vitrimatics.com. #cryoEM #cryoET 0258
Reposted by Lars-Anders CarlsonBen Engel @cellarchlab.com · 24/09/2026Insane in the #MemBrain 🤖🧠 #TeamTomo 🧪 0197
Reposted by Lars-Anders CarlsonVasilii Mikirtumov @vasiliimikirtumov.bsky.social · 24/09/2026thrilled to share that my main phd project is finally out in @natcomms.nature.com we present high-resolution structures of RyR1 in native membranes across multiple functional states by both cryo-ET/StA #TeamTomo and SPA! paper: www.nature.com/articles/s41... and a thread below⬇️⬇️⬇️ 45820
Lars-Anders Carlson @lacarlson.bsky.social · 24/09/2026I missed this one in August! @inprep.bsky.social inpreparation.substack.com/p/nih-simpli...inpreparation.substack.comNIH Simplifies Grant Scoring To 👍 🤷♂️ 😂BETHESDA, MD—The National Institutes of Health announced Tuesday that it would replace its 50-year-old numerical scoring system with a streamlined three-emoji format, in which grant applications will ... 010
Reposted by Lars-Anders CarlsonProf. Feynman @proffeynman.bsky.social · 24/09/2026If you think you can, you may. If you think you can't, you're right. 0111
Lars-Anders Carlson @lacarlson.bsky.social · 23/09/2026Last week, our PhD student Joanne and I attended HCV-Flavi in Copenhagen ...and so did the lab of our alumna Selma Dahmane! Photo of Carlson+Dahmane attendees on the last evening, at Tivoli Gardens. Great time! 071
Reposted by Lars-Anders CarlsonColin Carlson @colincarlson.bsky.social · 23/09/2026What's behind this tidal wave of epidemics? In the largest study ever conducted on emerging infectious diseases, we show that the popular explanation - "our relationship with nature is out of balance" - doesn't hold up. Out now in Nature, after half a decade of work: www.nature.com/articles/s41...nature.comThe anthropogenic fingerprint on emerging infectious diseases - NatureEmerging infectious disease outbreak risks are ubiquitous worldwide, and highest in landscapes where people, livestock and fragmented natural ecosystems coexist, but detection and data ... 8554278
Reposted by Lars-Anders CarlsonAnja Schmidt @anjanja1024.bsky.social · 23/09/2026So if my AI dreams up organelles in post processing... It's okay? 🙄 182
Reposted by Lars-Anders CarlsonRCSB Protein Data Bank @rcsbpdb.bsky.social · 22/09/2026How X-rays and crystals revealed the true nature of things The story behind the 100-year-old discovery that continues to render Nobel Prizes.nobelprize.orgHow X-rays and crystals revealed the true nature of things - NobelPrize.orgThe story behind the 100-year-old discovery that continues to render Nobel Prizes. 0106
Reposted by Lars-Anders CarlsonRandall Munroe @xkcd.com · 22/09/2026Tyrannosaurus xkcd.com/3300/ 92121502103
Reposted by Lars-Anders CarlsonCathy Spangler @cathyspangler.bsky.social · 22/09/2026I'm excited to share our new preprint, where we show that fine-tuning gold nanoparticle conjugation to different Fab structural elements can produce powerful, rigidly coupled, labeling tools for in-situ cryo-ET. Take a look if you want to see an AuNP in an EM map!🔬🧠 www.biorxiv.org/content/10.6... 15025
Reposted by Lars-Anders CarlsonPhilippe Le Mercier, ViralZone @viralzone.bsky.social · 22/09/2026A clever new tool for building full icosahedral capsids from AlphaFold models — from the talented team behind ViperDB. FoldaVirus, a knowledge-based icosahedral capsid prediction tool using AlphaFold www.pnas.org/doi/10.1073/... 0118
Reposted by Lars-Anders CarlsonStephane Vassilopoulos @stefvass.bsky.social · 22/09/2026Great to see this finally out! ✨ A real pleasure to contribute to this special issue celebrating 50 years of #Clathrin and to revisit how this superstar coat keeps surprising us ⚽🔬 02514
Reposted by Lars-Anders CarlsonYuan He @yuanhejhu.bsky.social · 22/09/2026A big week for the lab! Two new papers on how cells repair DNA double-strand breaks: one on getting NHEJ started in chromatin, one on processing the ends before ligation. Years of work by a fantastic team. 410840
Reposted by Lars-Anders CarlsonRichard Sever @richardsever.bsky.social · 27/08/2026$3.7 billion spent on APCs in 2025. That's ~1000X more than it costs to run bioRxiv/medRxiv. Worth thinking about as we consider how to fund infrastructure... arxiv.org/pdf/2608.16322arxiv.org 813379
Lars-Anders Carlson @lacarlson.bsky.social · 21/09/2026This is an important thing to bear in mind especially in consensus-oriented cultures like Sweden! 010
Reposted by Lars-Anders CarlsonRCSB Protein Data Bank @rcsbpdb.bsky.social · 21/09/2026September 21 is #WorldAlzheimersDay Alzheimer's disease and prion diseases are linked to unnatural aggregation of proteins into amyloid fibrils.pdb101.rcsb.orgPDB101: Molecule of the Month: AmyloidsAlzheimer's disease and prion diseases are linked to unnatural aggregation of proteins into amyloid fibrils. 264
Reposted by Lars-Anders CarlsonMax Delbrück Center @mdc-berlin.bsky.social · 18/09/2026Caveolae help cells withstand mechanical stress, take up nutrients, and regulate signaling. How are these tiny membrane structures stabilized? #mdcBerlin researchers have now resolved the structure of the EHD2 protein chain that does the job. Learn how it works: 👉 www.mdc-berlin.de/news/press/h... 094
Reposted by Lars-Anders CarlsonDaniel Hurdiss @danielhurdiss.bsky.social · 21/09/2026Excited to share that our norovirus NS3 study is now online in Nature Communications! 🎉 These enzymes, found across an entire order of RNA viruses, have long been molecular motors in search of a function. We think we’ve uncovered their role. (🧵) www.nature.com/articles/s41... #virology #cryoEM 59728
Lars-Anders Carlson @lacarlson.bsky.social · 20/09/2026Probably good to consider the MSCA application and evaluation process in the light of LLM-generated applications. At a minimum, simplify and shorten the written application. Why should reviewers read so much LLM-generated text? Could interviews be practically organised for such a huge programme? 131
Reposted by Lars-Anders CarlsonPat Schloss @patschloss.bsky.social · 18/09/2026Let me get this straight. There's a title. There's a commentary article. There's an abstract. There's a set of bullet point highlights. There's a graphical abstract. AND YOU STILL THINK I NEED YOUR AI AGENT TO SUMMARIZE THE ARTICLE FOR ME? 06921
Reposted by Lars-Anders CarlsonJeremy Reiter @reitergroup.bsky.social · 18/09/2026What in the world am I looking at here? @Nikon? www.nikonsmallworld.com/galleries/20...nikonsmallworld.comAbnormal beating of airway cilia from a child with Primary Ciliary Dyskinesia (PCD) | 2026 Small World in Motion CompetitionNing Xu - Abnormal beating of airway cilia from a child with Primary Ciliary Dyskinesia (PCD), a genetic disorder affecting respiratory function. 3413231
Reposted by Lars-Anders CarlsonJoy Jeongyoon Choi @joyjoychoi.bsky.social · 14/09/2026Excited to share our new preprint on in situ chromatin structure of the inactive X chromosome in differentiated female mouse embryonic stem cells. www.biorxiv.org/content/10.6... 🧵1/8 611743