Highly pathogenic avian influenza viruses (HPAIVs) derive from H5 and H7 low pathogenic avian influenza viruses (LPAIVs). Although insertion of a furin-cleavable multibasic cleavage site (MBCS) in the...

Structural and biochemical studies of influenza virus RNA-dependent RNA polymerase (FluPol) in complex with transcribing host RNA polymerase II reveal the molecular mechanisms of RNA cap snatching by FluPol.

Host body temperature can define a virus’s replicative profile—influenza A viruses (IAVs) adapted to 40° to 42°C in birds are less temperature sensitive in vitro compared with human isolates adapted t...

Host body temperature can define a virus’s replicative profile—influenza A viruses (IAVs) adapted to 40° to 42°C in birds are less temperature sensitive in vitro compared with human isolates adapted t...

Abstract. Influenza A, a negative-sense RNA virus, has a genome that consists of eight single-stranded RNA segments. Influenza co-infections can result in

Applications are now open to apply for our four year, fully-funded PhD programme in Molecular Cell Biology in Health and Disease.

Influenza viruses have caused four pandemics during the last century.1 The 1918 H1N1 pandemic claimed 20–50 million lives, the 1957 H2N2 pandemic and the 1968 H3N2 pandemic claimed 1–4 million lives e...

Restrictions have recently been put in place in England and Scotland to curb the spread of bird flu.

Influenza A virus (IAV) non-canonical replication products can be bound by various host pathogen sensors, including retinoic acid-inducible gene I (RIG-I). However, it is not clear why non-canonical I...

In early 2024, an unprecedented outbreak of H5N1 high pathogenicity avian influenza was detected in dairy cattle in the USA. The epidemic remains uncontrolled, with spillbacks into poultry, wild birds...

imageimageThe RNA polymerase complex of the Nipah virus is responsible for both replication and transcription of the viral RNA genome. This study elucidates the structure of the RNA polymerase in comp...

Past influenza pandemics contained polymerase genes from avian influenza viruses, affecting viral replication and pathogenicity.

Author summary Hantaviruses are widely distributed viruses that can undergo zoonosis where they cause severe disease in humans. Old World hantaviruses, found predominantly in Asia and Europe, can caus...

The honour recognises our previous Head of Department’s pioneering work in fundamental and therapeutic immunology research, which spearheaded the development of engineered antibodies for treatment of ...

The authors demonstrate how avian H5N1 influenza A virus polymerase interacts with human ANP32B to facilitate the replication of the viral genetic information in mammalian hosts, revealing insights in...

bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution

The influenza A virus genome is composed of eight single-stranded RNA segments. This study reconstitutes the replication of RNA genome segments in a test tube, using purified viral and host proteins, ...