Radulovic et al. show that phosphatidylinositol 3-phosphate (PI3P), produced by the phosphatidylinositol 3-kinase PIK3C3, is formed on ER domains after lysosome damage. ER domain PI3P helps to recruit...

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Bhaskar Naidu and Vera Lillo et al. show that extracellular mechanical forces reciprocally regulate Golgi function. By linking cell adhesion and spreading,

The discovery of membrane trafficking proteins in Asgard archaea—the closest archaeal relatives of eukaryotes—reveals the deep evolutionary roots of the eukaryotic endomembrane system. This review syn...

Endosomal GTPases, while often used as markers for specific endosomal organelles, functionalize the surface of endosomal compartments into biochemical…

Geisterfer, Jalihal et al. show spatially distinct effects of Whi3 condensates on target translation in Ashbya syncytia. In vitro, translation is enriched at condensate–solute interfaces but repressed...

We appoint researchers from across biology and biomedicine to set up their first groups at the Crick.

Human cells face a wide range of external mechanical stimuli that vary with cell type, state, and pathological conditions. The rapidly growing field of mechanobiology investigates how cells sense and ...

We are recruiting Programme Leader Track positions focusing on 1) Metabolic Physiology using murine and/or human in vivo models and 2) Immunometabolism.

Sue et al. show that ER stress impairs insulin secretion by misplacement of permissive proteins from the plasma membrane. This results from defects in the retromer and the constitutive secretory pathway. Thus, in type 2 diabetes, ER stress mediates β cell dysfunction, not just loss of β cell mass.

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The Institut Pasteur launches an international call to recruit new junior research group leaders in the application of cutting-edge transdisciplinary approaches to the exploration of host-microbe, tis...

Kar et al. demonstrate that Balbiani body (Bb) formation is achieved via developmental condensation in zebrafish oogenesis, driven by Buc phase separation and evolving from a dynamic liquid-like state into a solid-like stable compartment. Multistep regulation by microtubules controls condensation, ensuring proper Bb formation and oocyte polarity.

The insulin inhibitory receptor (inceptor) is found to bind to insulin and to regulate insulin stores by directing proinsulin and insulin towards lysosomal degradation.

Maintenance of plasma membrane and organellar integrity is essential for cell viability. Cells must

The secretion of extracellular matrix (ECM) proteins is vital to the maintenance of tissue health. O

Adipose tissue homeostasis plays a critical role in metabolic disease but the metabolic circuitry re