Synaptic vesicle fusion is essential for neuronal communication, yet its nanoscale sequence has not been directly confirmed. Here, the authors use timed in situ cryo-electron tomography to visualize t...

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Naked mole-rat (Heterocephalus glaber) queens produce isopropyl myristate, a low-volatility ester that high-ranking animals detect and avoid, which alters prolactin and progesterone in other females t...

The long-living rodent naked mole-rat has a distinct break in its 28S ribosomal RNA. Here, the authors present cryo-EM structures showing this cleavage is stabilized by surrounding ribosomal proteins,...

A host lipid flips a viral protein’s shape to control membrane remodeling during virus replication.

Helmholtz Quantum is supporting innovative research projects that translate quantum technologies into concrete applications. The Quantum Use Challenge aims to realise the potential of quantum computin...

Synaptic vesicle fusion is essential for neuronal communication, yet its nanoscale sequence has not been directly confirmed. Here, the authors use timed in situ cryo-electron tomography to visualize t...

Working in academia can be stressful. Laurel Raffington suggests treating it as ‘just a job’ to reduce performance pressure and advocate for structural improvements.

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The naked mole-rat (Heterocephalus glaber) is a long-lived mammal with remarkable resistance to cancer and hypoxia, suggesting the evolution of robust proteostasis networks. The ribosome, the central ...

Lithium has an essential role in the brain and is deficient early in Alzheimer’s disease, which can be recapitulated in mice and treated with a novel lithium salt that restores the physiological level...

SidE family effectors from Legionella pneumophila catalyze serine ubiquitination of host proteins via phospho-ribose (PR) linkages, disrupting host compartments, facilitating the formation of Legionel...

The Max Delbrück Center for Molecular Medicine in the Helmholtz Association aims to transform tomorrow’s medicine through our discoveries of today. At locations in Berlin-Buch, Berlin-Mitte, Heidelber...

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1696 outstanding postdoctoral researchers were selected for funding among 10,360 applicants.

The big chill: Growth of in situ structural biology with cryo-electron tomography - Volume 5

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...