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Markku Hakala

@mhakala.bsky.social
1K followers 865 following 102 posts

Protein, membranes and their interplay. Group Leader at University of Helsinki in 🇫🇮. Former postdoc at UNIGE 🇨🇭in @rouxlab.bsky.social and @kaksonen.bsky.social labs. I like bicycling, hiking, skiing, climbing and sour things.

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Reposted by Markku Hakala
Erdinc Sezgin @sciezgin.bsky.social · 17/09/2026
New paper out: Plasma membrane order maps functional diversity in immune cells We showed how biophysical state of the membranes correlates with the activity of immune cells such as migration and killing. www.nature.com/articles/s41...
nature.com
Plasma membrane order maps functional diversity in immune cells - Nature Chemical Biology
Cells undergo membrane remodeling in response to the environment to perform specific functions. Now, a cytometry-based method with immune cell biomarker analysis captures variations in plasma membrane...
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Nalle Pentinmikko @npentinmikko.bsky.social · 16/09/2026
I have an open position for a PhD student. In my newly established lab @helsinki.fi we investigate regenerative processes in the mammalian liver. The call is open until October 6th. Apply here: tinyurl.com/mh9k2nav For more information: www.pentinmikko-lab.com Please share!
tinyurl.com
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Waggoner Lab @labwaggoner.bsky.social · 11/09/2026
Plasma membrane order maps functional diversity in immune cells @natchembio.nature.com @sciezgin.bsky.social www.nature.com/articles/s41...
nature.com
Plasma membrane order maps functional diversity in immune cells - Nature Chemical Biology
Cells undergo membrane remodeling in response to the environment to perform specific functions. Now, a cytometry-based method with immune cell biomarker analysis captures variations in plasma membrane...
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Juanma García-Arcos @juanmagararc.bsky.social · 10/09/2026
3/3 Huge thanks to my co-organizers Markku Hakala @mhakala.bsky.social James Conway @jrwconway.bsky.social and Shiqi Wang, and to our sponsors @helsinki.fi, @picoquant.bsky.social, @zeiss-microscopy.bsky.social, @spirochrome.com and @ibidicells.bsky.social for making it possible! #FLIM #FCS
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Juanma García-Arcos @juanmagararc.bsky.social · 11/09/2026
Today, the last day of the #FLIM-FCS course at @helsinki.fi with great lectures from @mhakala.bsky.social and Maria Trulsson from @zeiss-microscopy.bsky.social. I got to experiment with an old projector lying around!!
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Dylan Burnette @mag2art.bsky.social · 12/07/2026
A cell videoed through a DIC microscope. The nucleus spins around. Why would it do that? #CellBiology
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Dollie LaJoie @dolliemae.bsky.social · 10/06/2026
Seeking a post-doc for the LaJoie lab at the Human Technopole, Milan, Italy! We are looking for candidates from the fields of biochemistry, cell biology, and proteomics, who are interested in studying protein interactions of the nucleus 🤓 lnkd.in/dTG2CgXF
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Felix Campelo @felixmendu.bsky.social · 18/06/2026
Hi #membrane folks! This is today, last talks to close this academic year's trafficking seminar season :) 👇
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Ricardo Henriques @henriqueslab.bsky.social · 05/06/2026
🔬🚀 It's out! Run 100s of imaging experiments before touching a microscope. #VLab4Mic reproduces them in silico from PDB/AlphaFold to help you image right first time. From rockstars Damián Martínez & Bruno Saraiva, inaugural preprint of @mariodelr.bsky.social new lab www.biorxiv.org/content/10.6...
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Turku BioImaging @turkubioimaging.bsky.social · 19/05/2026
📰The spring TBI Newsletter is out⤵️ mailchi.mp/e17363ccad8d... ▶️Finnish Advanced Microscopy Node received outstanding Euro-Bioimaging SAB evaluation ▶️Imaging in new regional strategy and Health Campus Turku theme ▶️Visits, workshops & Academy Day highlights ▶️BNMI symposium 2026, Levi🇫🇮 ▶️Grants & Events
TBI_Newsletter_Issue12_logo
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Guillaume Jacquemet @guijacquemet.bsky.social · 15/01/2026
🚨 Job Alert! 🚨 We have an opening at our Microscopy Core Facility in Turku 🇫🇮. If you love imaging 🔬 and helping scientists succeed, we want you! 👇 abo.rekrytointi.com/paikat/index... #Microscopy #ScienceJobs #CoreFacility #Imaging @turkubioscience.bsky.social
abo.rekrytointi.com
Laboratory Engineer (Senior), in Advanced Imaging, 1.5.2026-31.12.2028
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Fran Bottanelli @franbottanelli.bsky.social · 06/01/2026
Early bird deadline in 10 days!! This is going to be amazing!
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Guillaume Jacquemet @guijacquemet.bsky.social · 21/12/2025
I will be recruiting two postdocs early next year. - One image analyst - one biologist interested in working on lymphatics! Reach out if you are interested 👍
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Coskun Lipid Cellar @ ZML Dresden @lipid.bsky.social · 15/12/2025
Ups we did it again! Please mark your calender. EMBO Workshop “Lipid Code to Life”, taking place September 7–11, 2026, in Dresden, organized by Maria Fedorova, @lipid.bsky.social, Valerie O'Donnell, @holthuislab.bsky.social and @molcellbiophys-lab.bsky.social 🥳 Retweets = lipidlove
copyright Palina Nepachalovich of ZML Dresden
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Claudia Matthaeus @cmatthaeus.bsky.social · 11/12/2025
💥I am excited to present our first research paper from the lab about caveolae lipid trafficking 🎉 Led by my fantastic PhD candidate @estherocket.bsky.social Here we looked into caveolae mediated dietary lipid uptake and how this process is mechanistically facilitated 👇 1/n
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Javier Espadas @javierespadas.bsky.social · 01/12/2025
New preprint from the lab!!🎉 We show that Asgard archaea ESCRT-III proteins can trigger membrane fission and reveal its molecular mechanism, offering clues to how these cells may have built internal compartments. But do these organisms even have these compartments? www.biorxiv.org/content/10.1...
biorxiv.org
Molecular basis for cellular compartmentalization by an ancient membrane fission mechanism
The emergence of cell compartmentalization depends on membrane fission to create the endomembrane compartments. In eukaryotes, membrane fission is commonly executed by ESCRT-III, a protein complex con...
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Juanma García-Arcos @juanmagararc.bsky.social · 11/11/2025
Launching celldynamicslab.com, the homepage of our new group at EPFL working on cell fragmentation, membrane and cortex mechanics, FLIM imaging, and microfluidics tools. MSc/PhD or postdocs interested in quantitative cell biology are welcome to reach out. We're also hiring a lab manager in 2026!
celldynamicslab.com
Main - Cell Dynamics and Fragmentation Lab
The Cell Dynamics and Fragmentation lab at We study how single cells move and fragment in complex environments using microfluidics. We bring tools and concep...
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Levental Lab @leventallab.bsky.social · 12/11/2025
Watch out folks, I don’t wanna alarm anyone, but good news is possible!!
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Turku BioImaging @turkubioimaging.bsky.social · 10/11/2025
📢Electron Microscopy Unit, Helsinki BioImaging, and ZEISS are organizing a symposium "Frontiers in Imaging: celebrating the EMBI-ZEISS partnership on volumeEM" 🗓️December 2-3, 2025 📍Institute of Biotechnology, University of Helsinki 🔗Program and registration link⤵️ www.helsinki.fi/en/infrastru...
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Desislava Glushkova @deglushk.bsky.social · 06/11/2025
Just published! We share an open-source workflow to measure membrane thickness from tomograms, including a tutorial with 3D visualizations. We analyze thickness variations across organelles and reflect on where to define a membrane boundary. @becklab.bsky.social #teamtomo rupress.org/jcb/article/...
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Markku Hakala @mhakala.bsky.social · 22/10/2025
If you are planning to do Flipper-TR experiments or FLIM imaging in general, I strongly recommend reading this beautiful method paper first! Lots of information about optimal data acquisition for reliable data analysis! Nice work from Tithi, @rouxlab.bsky.social and @juanmagararc.bsky.social !
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Merja Joensuu @joensuulab.bsky.social · 01/10/2025
🌟 Thrilled to share that my lab’s first publication is now out in @natmetabolism.nature.com. Congrats to the team 🎉 🧠 We discovered that neurons use endogenous fatty acids as an energy fuel, challenging long-standing models of sugars being the exclusive energy source for neurons. 1/3
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Biozentrum, University of Basel @biozentrum.unibas.ch · 29/09/2025
Assistant/Associate Professor in Structural Biology, Biophysics or Biological Imaging www.biozentrum.unibas.ch/open-positio... #biozentrum #University #Basel #Professor #Structural #Biology #Biophysics #Biological #Imaging
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Felix Campelo @felixmendu.bsky.social · 29/09/2025
Join us for the first @embo.org meeting on Intracellular mechanics and organelle mechanobiology! Registrations are open, submit your abstract by November 14: we have plenty of slots for short talks! #EMBOMechanobio
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Markku Hakala @mhakala.bsky.social · 29/09/2025
I have a PhD student and an undergrad student positions open at the Institute of Biotechnology @helsinki.fi We are using reconstitution, cell and structural biology to study protein-membrane interactions and membrane microdomain formation. Links to calls below! Feel free to drop a message and share!
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Beth Cimini 🔬💻📊 @bethcimini.bsky.social · 23/09/2025
Halfway to I2K is BACK, friends of all kinds! Last year, 650 people attended 30+ TOTALLY FREE image analysis workshops of all kinds, across many timezones. If you make image analysis software and want to teach it, workshop submissions are open now! We'd love to have your tool highlighted.
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Pilhofer Lab 🦠❄️🔬 @pilhoferlab.bsky.social · 10/09/2025
Story on our Asgard microtubule paper by Nikki Greenwood: www.quantamagazine.org/tiny-tubes-r... Thanks to all interviewees🎤
quantamagazine.org
Tiny Tubes Reveal Clues to the Evolution of Complex Life | Quanta Magazine
Scientists have identified tubulin structures in primitive Asgard archea that may have been the precursor of our own cellular skeletons.
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Omaya Dudin 𓂆 ¦🍉¦🦠¦🔬¦ @dudinlab.bsky.social · 10/09/2025
For all of you #Actin folks ... It's out ! Happy to help at anypoint
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Omaya Dudin 𓂆 ¦🍉¦🦠¦🔬¦ @dudinlab.bsky.social · 28/08/2025
A new #UExM probe for #Actin! Fun times thinking/developing/testing with @centriolelab.bsky.social & @lreymond.bsky.social ! Congrats to all ! If interested in #UExM, or #HAK-Actin, feel free to reach out ! Soon available at @spirochrome.com #Expansion #Microscopy #ProtistsOnSky
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Misha Kudryashev @mishakudryashev.bsky.social · 04/08/2025
Postdoc program at the MDC in Berlin, @mdc-berlin.bsky.social : take a look 👇👇 For this call, collaborative projects between two groups will be funded. Take a look at the call and the groups and drop me an email if interested. Share with colleagues too! www.mdc-berlin.de/postdocs#t-g...
mdc-berlin.de
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Vera Mikkilä @veramikkila.bsky.social · 27/06/2025
Suomen Akatemia tuomitsee jyrkästi tutkijaan kohdistuvan häirinnän ja vihapuheen. ”In Finland, academic freedom is a core value. Researchers must be able to explore, question and share knowledge openly.” ”Let’s protect the freedom to do science, and the people who make it possible.”
Suomen Akatemian LinkedIn-päivitys: 

The Research Council of Finland firmly condemns the harassment and hate speech that RCF-funded researchers have recently faced online.
 
This kind of targeting behaviour is highly inappropriate and dangerous. It threatens academic freedom, narrows public debate, and undermines trust in science and the people behind it.
 
𝗜𝗻 𝗙𝗶𝗻𝗹𝗮𝗻𝗱, 𝗮𝗰𝗮𝗱𝗲𝗺𝗶𝗰 𝗳𝗿𝗲𝗲𝗱𝗼𝗺 𝗶𝘀 𝗮 𝗰𝗼𝗿𝗲 𝘃𝗮𝗹𝘂𝗲. Researchers must be able to explore, question and share knowledge openly. The RCF funds research through open competition and international peer review, and our staff work to ensure the 𝗶𝗻𝘁𝗲𝗴𝗿𝗶𝘁𝘆 𝗮𝗻𝗱 𝗳𝗮𝗶𝗿𝗻𝗲𝘀𝘀 of the process.
 
Debate and disagreement are part of a healthy democracy. But there is a line that is crossed when the conversation turns into personal attacks or intimidation.
 
We call on everyone to help keep that line clear. 𝗟𝗲𝘁’𝘀 𝗽𝗿𝗼𝘁𝗲𝗰𝘁 𝘁𝗵𝗲 𝗳𝗿𝗲𝗲𝗱𝗼𝗺 𝘁𝗼 𝗱𝗼 𝘀𝗰𝗶𝗲𝗻𝗰𝗲, and the people who make it possible.

In 2023, we released a statement on the online targeting of researchers: https://lnkd.in/dbRrUDBu
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Derivery Lab - MRC LMB @deriverylab.bsky.social · 23/06/2025
🚨 JOB ALERT 🚨 We're hiring a Research Assistant – no PhD needed! Join us to explore the molecular mechanisms of receptor sorting in endosomes. Experience in protein expression/purification, cloning & cell culture desired 🧫🔬 Apply now 👉 www.nature.com/naturecareer... #STEMCareers #ResearchJobs
A picture of 3 rows of people on steps at the MRC LMB. From left to right - top row: Akaash, Vic, Lara - Middle row: Kerrie, Manu, Paddy - bottom row: Meg  and Julie
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Markku Hakala @mhakala.bsky.social · 23/06/2025
The EMBO workshop on ESCRT proteins is up and running at Caux Palace. The view from the hotel room to Lac Leman is rather amazing!
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Markku Hakala @mhakala.bsky.social · 22/06/2025
I'm grateful for the Research Council of Finland for granting me the Academy Research fellowship! After getting over the shock I will soon move back to Finland to start as a group leader at the Institute of Biotechnology @helsinki.fi. Looking for a PhD student soon! www.aka.fi/en/about-us/...
aka.fi
RCF winter call results: funding decisions in biosciences, health and environmental research
The Research Council of Finland’s Scientific Council for Biosciences, Health and the Environment has granted funding for 38 Academy Research Fellowships, 12 Clinical Researchers and 76 Academy P...
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Mara Duncan @mcduncanlab.bsky.social · 16/06/2025
🧪Hey Sciencers, We're looking to make a library of 50-100 plasmids that differ in ~60bp stretch. The differences will be designed (not random). The library will then be screened for a phenotype. What is the best way to do this? Cost is an issue.
An illustration showing a set of lines of different colors labeled library of oligos and a broken circle labeled backbone. Then an arrow with a question mark and ligase polymerase and on the other side a sect of circles with the colored lines added into the gap labeled library of plasmids.
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Misha Kudryashev @mishakudryashev.bsky.social · 19/05/2025
It's fellowship season in the EU. If you want to talk and join our group at the amazing MDC in Berlin on a fellowship, please write me an email. We do cryo-EM/ET, membrane proteins, data science/AI, our work: scholar.google.com/citations?so... Fellowships: Marie Curie, EMBO, HFSP, Humboldt...
scholar.google.com
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Rafeeque Mavoor @rafeequemavoor.bsky.social · 13/05/2025
🧵5 Top Free Alternatives to BioRender for Scientific Illustrations! These five websites offer free scientific illustrations for biologists. Great for presentations, research papers and other research communication needs. Save and share the post!
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Christophe 🔬 Leterrier @christlet.bsky.social · 09/04/2025
We have a new review out! In this Microscopy & Microanalysis piece, Louisa Mezache and I survey some of the latest commercially available microscope technologies: Nikon NSPARC, Re-scan Gaia, CSR Biotech MI-SIM, refinements to STED, SMLM from Bruker and Abbelight… Check it out with free access:
academic.oup.com
Advancing Super-Resolution Microscopy: Recent Innovations in Commercial Instruments
Abstract. Super-resolution microscopy techniques have accelerated scientific progress, enabling researchers to explore cellular structures and dynamics wit
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Joanna Pylvänäinen @jwpylvanainen.bsky.social · 17/03/2025
Fresh from the press! @lankylaste.bsky.social, @guijacquemet.bsky.social and I put together a practical guide on how to develop software for life science applications.
doi.org
Practical recommendations for developing software for life science applications
ABSTRACT. Developing user-friendly image analysis software is essential for advancing biological and life science research. However, the interdisciplinary gap between software developers and life scie...
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Roux Lab, Geneva @rouxlab.bsky.social · 10/02/2025
ESCRT-III is an ancient complex, present in Archaea, with only two proteins and all membrane remodelling functions. Great work by @javierespadas.bsky.social, @diorgeps.bsky.social, @sami-c.bsky.social, thanks to the @buzzbaum.bsky.social lab! Drawing by Julie Polge. www.science.org/doi/10.1126/...
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Ishier Raote @ishier.bsky.social · 15/01/2025
Exciting news! #MembraneTrafficking online seminars with @felixmendu.bsky.social @franbottanelli.bsky.social and me are back! Check the spectacular Jan-April 2025 lineup. Details (Zoom links, calendar invites) on the mailing list, Slack group & website: felixcampelo.wixsite.com/membranetraf...
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James Briscoe @jamesbriscoe.bsky.social · 17/12/2024
Continuing the peer review discussion: @katherine-brown.bsky.social on principles for effective peer review: 1) Be respectful to authors 2) Request reasonable revisions 3) Focus on whether data support the conclusions 4) Be transparent about expertise limits thenode.biologists.com/peer-review-...
thenode.biologists.com
Peer review - why we need it and what we need - the Node
Hopefully some of you will have seen the recent editorial in Development on our approach to peer review. If you haven't read it yet, please do take a
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Beata Science Art @beatascienceart.bsky.social · 09/12/2024
Are you a San Diego local or coming to #CellBio2024? Come join our very special #SciArt Show & Reception on Dec 17, bringing together amazing researchers and artists who have been inspired by the wonders of biology. Please spread the word and RSVP here: beatascienceart.com/artshow2024/
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FocalPlane @focalplane.bsky.social · 05/12/2024
Did you know that FocalPlane now has a #cellbio events calendar? This runs alongside our #microscopy calendar, which is powered by MicroscopyDB. You’re welcome to upload your cell bio event on FocalPlane or use the calendar to help plan your year! focalplane.biologists.com/cell-biology...
Yellow icon with 'Events' in white text above a white representation of a calendar with a square circled.
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Fran Bottanelli @franbottanelli.bsky.social · 12/11/2024
Registration is open for the 2025 iteration of the wonderful @EMBOevents workshop on cell polarity and membrane dynamics #EMBOcellPolarity25 I am organizing with Ed Munro! Wonderful lineup wonderful please please sign up and share! meetings.embo.org/event/25-cel...
meetings.embo.org
Cell polarity and membrane dynamics
The ability of cells to polarize is essential for organismal development and physiology, and its impairment underlies numerous diseases. The establishment and maintenance of cell polarity requires a …
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Darren Thomson @darrenthomson.bsky.social · 03/12/2024
#MYCOscopy Tip: We rely on SUM projection images for our screening of fluorescent protein/dye content in fungal cells. It's common to use MAX projection for illustration, but for quantitative mesaurments we use SUM. Please contribute to this discussion if there are more insights!
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Ishier Raote @ishier.bsky.social · 02/12/2024
Two exciting #MembraneSeminars this week! Thu, 5 Dec 5.00 PM CET / 11.00 AM EST Jonathon Nixon-Abell (CIMR, Univ. Cambridge, UK) Protein-lipid phase coupling in lysosomal transport Itay Budin (UCSD, CA, USA) New tools for visualizing lipid trafficking between and across organelle membranes
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Chris MacDonald @yorkyeast.bsky.social · 30/11/2024
Last night I noticed this giant haploid cerevisiae cell in a plate full of normal cells - so decided to image it overnight. It did nothing for 6 hours then a giant daughter budded and the mother exploded - wtf?
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Markku Hakala @mhakala.bsky.social · 28/11/2024
Well said @frankmartela.bsky.social ! Although it’s about running multibillion dollar international companies, many of these principles apply to lab leadership too! Probably even more than in companies. I recommend checking this one out if you want to improve your leadership skills 👏👏👏
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