Sandhya Koushika @wormlockholmes.bsky.social · 25/09/2026Retreat DBS @tifr.res.in. lively discussion on AI and its impact on research 011
Reposted by Sandhya KoushikaSurojit Sural @surojitsural.bsky.social · 10/08/2026Glia-released serotonin drives nose touch responses in Caenorhabditis elegans www.sciencedirect.com/science/arti...sciencedirect.comGlia-released serotonin drives nose touch responses in Caenorhabditis elegansTouch is essential for survival, guiding interactions with the environment and forming the basis of social and emotional connection. While touch perce… 043
Sandhya Koushika @wormlockholmes.bsky.social · 13/08/2026Fantastic initiative, trainees do sign up 022
Sandhya Koushika @wormlockholmes.bsky.social · 25/04/2026Pathogens & membrane trafficking never cease to amaze. Pathogen-induced formation of a nascent organelle derived from mitochondria Lena Pernas, Xianhe Li, Yubai Sun, Jose M Delgado www.biorxiv.org/content/10.6...biorxiv.org 050
Reposted by Sandhya KoushikaPiali Sengupta @senguptalab.bsky.social · 22/04/2026I think of a talk like an hourglass. Start broad, get narrow, end broad. So I usually try to end with a brief visual summary (I am not a fan of bullet pointed summaries) and then try to place the work back into the big picture if I can. Good luck! 0256
Sandhya Koushika @wormlockholmes.bsky.social · 18/04/2026So cool.... A landmark finding Protein-templated synthesis of dinucleotide repeat DNA by an antiphage reverse transcriptase | Science www.science.org/doi/10.1126/...science.orgProtein-templated synthesis of dinucleotide repeat DNA by an antiphage reverse transcriptaseDefense-associated reverse transcriptases (DRTs) are widespread bacterial anti-phage systems that use unconventional mechanisms of polynucleotide synthesis. We show that DRT3, which comprises two dist... 133
Sandhya Koushika @wormlockholmes.bsky.social · 11/04/2026Really cool paper. It has been a real struggle to grow archea. Should they now be cultured with other bacteria? Also interesting to see this symbiosis. www.cell.com/current-biol...cell.com 011
Sandhya Koushika @wormlockholmes.bsky.social · 08/04/2026Nice 🧵, lovely movies. Now published advanced.onlinelibrary.wiley.com/doi/10.1002/... from the group of @lauraschaedel.bsky.socialadvanced.onlinelibrary.wiley.comKinesin‐Induced Buckling Reveals the Limits of Microtubule Self‐RepairThis study shows that kinesin-driven buckling induces extensive microtubule lattice damage that often exceeds intrinsic self-repair and leads to filament failure. While curvature, motor motility, and... 1111
Sandhya Koushika @wormlockholmes.bsky.social · 16/03/2026Trainee Uma: ATG18 catalyzes a budding process that could be directly involved in regulating morphology. Thomas Pucadyil, IISER-Pune: EHD1 is an ATP dependent cutter. Dynamin is involved in retromer trafficking & differentially regulated by EHD family members. #OBMT26 010
Sandhya Koushika @wormlockholmes.bsky.social · 16/03/2026Sunando Dutta, IISER-Bhopal introduces 2 roads to metastasis-single cell or collective invasion. Trainee Amrita: HGF/MET facilitates the invadopodia led charge of cell migration thru the ECM. KIF16B drives MET to invadopodia surface delivery #OBMT26 010
Sandhya Koushika @wormlockholmes.bsky.social · 16/03/2026Probes to quantitatively measure membrane fluidity of intracellular organeller membranes. More fluid mitochondrial inner-membranes are more respiratory. Gaurav Singh, Sunil Laxman lab, inStem #OBMT26 050
Sandhya Koushika @wormlockholmes.bsky.social · 16/03/2026Suchismita: -vely charged nanoparticles are intracellularly retained more than +vely charged NP. The intracellular compartment of +ve & -ve NPs varies as do their mobility & directionality. Content/type of NP inside vesicle may organize membrane surface compsition. Nitin Mohan lab,IIT-Kanpur #OBMT26 010
Sandhya Koushika @wormlockholmes.bsky.social · 16/03/2026Coarse grain Martini molecular model of Caveolin-binding shows that Caveolin both induces and senses membrane curvature. Caveolin binding induced curvature shows that cholesterol & PS are found in the neck. Durba Sengupta, NCL #OBMT26 010
Sandhya Koushika @wormlockholmes.bsky.social · 16/03/2026Clathrin heavy chains mutants associated with intellectual disability. Disease CHC mutants over-expressed in Dm ⬇️ ligand uptake on heat stress, no structural or functional defects at the pre-synapse NMJ but alters post-synaptic architecture and impaired learning. Deepa Subramanyam, NCCS #OBMT26 010
Sandhya Koushika @wormlockholmes.bsky.social · 16/03/2026Allosteric activation switches of AP2. Akshay: Levels of Muniscin family members influence clathrin mediated Transferrin endocytosis. Sarvesh: Phosphorylation of AP2 via BMPK2 & AAK1 regulates clathrin-mediated endocytosis Umasankar Perunthottam lab, NCCS-DBT #OBMT26 000
Sandhya Koushika @wormlockholmes.bsky.social · 16/03/2026Deep dive into how fusion is mediated by viral fusogen proteins w/ pre-fusion, extension & post-fusion confirmations. A fusion loop tryptophan that inserts in the membrane & is enough to cause membrane structure disruption. Tirumala Kumar Chowdary, NISER #OBMT26 010
Sandhya Koushika @wormlockholmes.bsky.social · 16/03/2026EVs & lipid droplets both facilitate virus transmission. Immature JEV egress non-lytically via EVs from neuronal cells. Lipid droplets may be used to form multi vesicular bodies and EVs. Sourish Ghosh, IICB-CSIR #OBMT26 010
Sandhya Koushika @wormlockholmes.bsky.social · 16/03/2026Intro to mechanisms by which Mycobacteria subvert phagosome maturation to evade immune response. Mohd Saleem, NISER. Student Debraj: Mycobacteria release EVs spontaneously fuse w/ host plasma membrane & changes membrane tension. #OBMT26 000
Sandhya Koushika @wormlockholmes.bsky.social · 16/03/2026M. smegmatis shows hypoxia induced differential fluidity in the inner (becomes more rigid) and outer membranes. Hypoxia affects the antibiotic induced membrane permeability. Lydia Mathew, Shobhna Kapoor lab, IIT-Bombay. #OBMT26 000
Sandhya Koushika @wormlockholmes.bsky.social · 16/03/2026Success of the pathogen is the reprogramming of the host cell function. Mtb induces lysosome biogenesis & redistributes them in infected cells via an Mtb lipid. Anterograde lysosome motility is enhanced by Mtb lipids. Varadha Sundaramurthy, NCBS-TIFR #OBMT26 000
Sandhya Koushika @wormlockholmes.bsky.social · 16/03/2026Wingless trafficking occurs with its R where dissociation does not occur during the anterograde route. Wg is internalized together with its cargo R & dissociates in acidic endosomes. Varun Choudhury, IISER-Bhopal. Student Aendrila shows role of TRAPP complex in Wg trafficking. #OBMT26 000
Sandhya Koushika @wormlockholmes.bsky.social · 16/03/2026K-leak channels are non-gated, are always open, imp resting membrane potential & the E/I ratio. Help in cognitive resilience in neurodegenerative disease. 2Pore K channels are on mitochondria & modulate mitochondrial membrane potential. Swagata Ghatak, NISER #OBMT26 000
Sandhya Koushika @wormlockholmes.bsky.social · 16/03/2026Synaptic release is customized for speed and the amount of secretion & regulation may matter more for insulin/immune cell cargo. Synaptobrevin makes dimers and only a few molecules are needed for fusion, although 70 molecules are present/vesicle. Debasis Das @tifr.res.in #OBMT26 031
Sandhya Koushika @wormlockholmes.bsky.social · 16/03/2026Mon1 regulates Drosophila growth through insulin signalling and in a RAB7 independent manner on neuronal morphogenesis. Mon1 acts cell non-autonomously to control post-synaptic glutamate receptors at the NMJ. Anuradha Ratnaparkhi, Agharkar Research Institute #OBMT26 000
Sandhya Koushika @wormlockholmes.bsky.social · 15/03/2026Multistep entry of Influenza virus introduced by Indranil Banerjee, IISER-Mohali. Student Kajal Gupta shows pro-viral roles for TRIM proteins in viral entry via endocytosis. WASH & retromer have opposing roles in IAV endocytosis that is modulated by TRIM. #OBMT26 000
Sandhya Koushika @wormlockholmes.bsky.social · 15/03/2026Syntaxin 11 deficiency impaires cell-intrinsic host defence by enhancing Coxiella & Salmonella replication in monocytes & leads to immune disorders. Nisha Singh, Sandhya Ganesan lab, IISER-Trivandrum #OBMT26 120
Sandhya Koushika @wormlockholmes.bsky.social · 15/03/2026Insep/IER3IP1 loss leads to cell division defects & Rab11 vesicle accumulation in Drosophila neuroblasts/human cells. Insep interacts w/ Yip1d1, whose loss leads to cytokinesis failure & Rab11 vesicle accumulation. Sonal Jaiswal, CCMB-CSIR #OBMT26 010
Sandhya Koushika @wormlockholmes.bsky.social · 15/03/2026Vimlesh Kumar IISER-Bhopal introduces the lab. Student Priyabrata: Prefoldin is imp in tracheal luminal physiology & plasticity thru the cytoskeleton. Student Srikanth: Highwire undergoes LLPS & forms condensates in endocytic mutants. #OBMT26 010
Sandhya Koushika @wormlockholmes.bsky.social · 15/03/2026Cilia maintenance occurs despite dynamic ciliary composition & ciliary tubulin. Conditional PCM knockdowns after cilia formation leads to cilia defects that is reversible on restoring PCM components. Swadhin Jana @ncbsbangalore.bsky.social #OBMT26 021
Sandhya Koushika @wormlockholmes.bsky.social · 15/03/2026Introduces roles of FtsZ & ring formation Ramanujam Srinivasan, NISER. Student Srijita Roy shows Odin FtsZ assembles into polymeric structures in a heterologous host & can modulate GUV membrane dynamics. #OBMT26 000
Sandhya Koushika @wormlockholmes.bsky.social · 15/03/2026Centrosome is a hub for cell cycle regulation & DNA damage signaling. Mapping the functional roles of oncogenic mutations in STIL via BRCA mediated AuroraA centrosomal homeostasis. Priyanka Singh, IIT-Jodhpur #OBMT26 031
Sandhya Koushika @wormlockholmes.bsky.social · 15/03/2026Viruses usurp centrosomes & subvert their function. Flavivirus helicase target to centrosomes, a minimal fragment can target JEV proteins to centrosomes. Centrosomes are proviral in JEV infection. Karthigeyan Dhanasekaran, RCB-UNESCO #OBMT26 120
Sandhya Koushika @wormlockholmes.bsky.social · 15/03/2026Introduces how Stat Mech can be used to study biological systems. Sandeep Choubey, IMSc. Student Prakash Dey presents a theory-expt dialogue showing multi-state actin-binding protein model to account for actin-dynamics. #OBMT26 010
Sandhya Koushika @wormlockholmes.bsky.social · 15/03/2026Transgelin-2, an actin-binding protein, interacts with a subunit of dynein motor complex. Shows that Transgelin-2 plays several roles in mitosis. Sivaram Mylavarapu, RCB-UNESCO #OBMT25 030
Sandhya Koushika @wormlockholmes.bsky.social · 15/03/2026Several kinases stabilize and influence septin remodeling in budding yeast to facilitate cytokinesis. These kinases have a kinase-independent role in actomyosin ring organization & dynamics. @syncellbiolab.bsky.social IISc #OBMT26 030
Sandhya Koushika @wormlockholmes.bsky.social · 15/03/2026Conventional view: treadmilling actin, barbed ends grow & pointed-ends dont grow/shrink. Profilin inhibits actin pointed-end polymerization. In muscles, old expt suggests pointed-ends can grow. Leiomodin facilitates elongation at the pointed-end. Shashank Shekhar, Emory Univ #OBMT26 030
Sandhya Koushika @wormlockholmes.bsky.social · 15/03/2026 Chromogranin plays roles in dense core vesicle maturation & subcellular distribution, also on golgi organization without widespread trafficking defects. Bhavani Sahu, DBT-NBRC #OBMT26 010
Sandhya Koushika @wormlockholmes.bsky.social · 15/03/2026Gargi Dey: Drp6 regulatory kinase mediated phosphorylation of Drp6 leads to macronuclear expansion in Tetrahymena. Urbi Ghosh: Dynamin related proteins Drp7 & 8 are on mitochondria & regulate mitochondrial morphology in Tetrahymena. Abdur Rahaman lab, NISER #OBMT26 000
Sandhya Koushika @wormlockholmes.bsky.social · 15/03/2026 The luminal domain (LD) region of Seipin/Fld1 is dispensable for lipid droplet biogenesis & function. Fld1-∆LD has gain of function activity but the LD is imp for TAG levels in the cell. Amit Khatri, Vineet Choudhary lab, AIIMS-New Delhi #OBMT26 011
Sandhya Koushika @wormlockholmes.bsky.social · 15/03/2026Golgi organization is altered on loss of adhesion. Axl inhibition leads to AMPK activation that controls golgi organization through Arf1 activation. Shared talk w/ student Vaishnavi Raut who presents link between autophagy & golgi organization. Nagaraj Balasubramanian, IISER Pune #OBMT26 051
Sandhya Koushika @wormlockholmes.bsky.social · 14/03/2026Primary cilia formation is suppressed by VDAC. VDAC controls mitochondrial bioenergetics and dynamics and could mediate the cilia biogenesis roles. Shubhra Majumder, IHS-Presidency Univ #OBMT26 000
Sandhya Koushika @wormlockholmes.bsky.social · 14/03/2026Peroxisomes are imp in blood cell differentiation & proposes a role for peroxisomes for structural integrity of hematopoietic stem cell niches in Drosophila. @rohankhadilkar.bsky.social ACTREC-TMC #OBMT26 060