Our new publication in Nature Cell Biology 🔬
How cells reseal damaged lysosomes: Ca²⁺ leak → VPS34 makes PI3P on the ER → recruits DFCP1 → clusters VPS13C lipid-transfer bridges at ER–lysosome contacts to patch the membrane. No DFCP1 = failed repair.
www.nature.com/articles/s41...
nature.com
DFCP1-containing ER microdomains mediate lysosomal membrane repair - Nature Cell Biology
Radulovic et al. show that phosphatidylinositol 3-phosphate (PI3P), produced by the phosphatidylinositol 3-kinase PIK3C3, is formed on ER domains after lysosome damage. ER domain PI3P helps to recruit...
