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Fran Bottanelli

@franbottanelli.bsky.social
3.3K followers 2.5K following 703 posts

Solver of GTPases molecular puzzles | Membranes | CRISPR | STED super-res |Accidental immunologist | Academic mother of 2 cheeky monkeys | Assistant prof at FU Berlin. | Head of the Nanoscale Membrane Dynamics Lab

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Reposted by Fran Bottanelli
Jez Carlton @jezcarlton.bsky.social · 28/09/2026
Hey! Submit your papers, and spread the word, this will be great! Thanks for inviting us @jcellsci.bsky.social and great to work with @pihanson.bsky.social on this issue!
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Fran Bottanelli @franbottanelli.bsky.social · 27/09/2026
On my first ON TIME train with Deutsche Bahn since at least a year! See you soon Cologne science people!
static.klipy.com
Owl Riding a Toy Train
ALT: Owl Riding a Toy Train
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Fran Bottanelli @franbottanelli.bsky.social · 27/09/2026
200 papers = should have reviewed 400 papers. I bet this person reviews 0. OR papers written via generative AI should be solely reviewed with QED! Your bad if you do not make the 1% if you have 200 chances! ALSO how the hell do you find the money to publish 200 papers. So wrong in so many ways
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The Company of Biologists @biologists.bsky.social · 27/09/2026
Make sure you don't miss the latest articles from our journals. Sign up to content alerts from @dev-journal.bsky.social, @jcellsci.bsky.social, @jexpbiol.bsky.social, @dmmjournal.bsky.social & @biologyopen.bsky.social at journals.biologists.com/bio/pages/al...
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Maya Voichek @mayavoichek.bsky.social · 24/09/2026
Super excited to share my postdoctoral work at @imbavienna.bsky.social @viennabiocenter.bsky.social - We discovered that some retrotransposons, or "jumping genes" 🧬, are able to spread from cell to cell via a new viral infectivity route. A short thread: 🧵👇 (1/7)
AI-generated illustration of the soma-to-germline transmission of retrotransposons described in our work
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Christophe 🔬 Leterrier @christlet.bsky.social · 25/09/2026
Here's a balanced account of where the microscopy community stands on AI use by this year's Small World in Motion winner. My main issue is that no one seems to have seen the original data despite requests (no mention of it being reviewed by the organizers) www.the-scientist.com/allegations-...
the-scientist.com
Allegations of AI Use in Nikon Competition Spark Controversy | The Scientist
Microscopists raise concerns about inappropriate AI usage in Nikon's microscopy contest-winning video. Nikon stands their ground, citing no policy breach.
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Levayer Lab @levayerr.bsky.social · 04/09/2026
📢master or PhD student interested in cell biology ? There are spots left for the Molecular Biology of the Cell course @pasteur.fr. Check the amazing list of lecturers + 1 week practical pocking choano cytokeleton with @thibautbrunet.bsky.social team. Registration 👇 www.pasteur.fr/fr/nous-conn...
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Fran Bottanelli @franbottanelli.bsky.social · 24/09/2026
Coming back to Bluesky after 3 days and finding out we do not need microscopes anymore
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Microscope The Naked Gun
ALT: Microscope The Naked Gun
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Fran Bottanelli @franbottanelli.bsky.social · 24/09/2026
Today I sent cells to England with FedEx and they arrived the day after. As planned. No questions asked.
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Moira Rose: Can You Believe It?!
ALT: Moira Rose: Can You Believe It?!
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Giovanni D’Angelo @giodang.bsky.social · 23/09/2026
#lipidtime: It's a lipid universe. Today in Nature we publish the Lipid Brain Atlas, the first map of membrane lipid composition across the entire mouse brain, a layer of organisation that cell-type and transcript maps had left out. #lipidomics #neuroscience #BrainAtlas
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David Drubin @drubin.bsky.social · 22/09/2026
In a new preprint we provide evidence that biophysical properties of protein condensates can explain the order of events in the endocytic pathway, and that these events are tuned by protein condensate phosphorylation. www.biorxiv.org/content/10.6...
biorxiv.org
Phosphoregulation of hierarchical protein condensate formation during clathrin-mediated endocytosis
The sequential assembly of over 50 proteins during clathrin-mediated endocytosis (CME) is well documented in yeast. However, the mechanisms governing this ordered recruitment remain poorly understood....
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CRBM-Montpellier @crbm-montpellier.bsky.social · 18/09/2026
🔬 Le CRBM fête ses 60 ans avec le Festival de la cellule ! Microscopes, ADN, tardigrades, poisson-zèbre, « bruit des cellules »… Explorez le vivant en famille ! 📅 8 oct. 2026, 10h–19h 📍 Halle Tropisme, Montpellier 🎟️ Gratuit
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Journal of Cell Science @jcellsci.bsky.social · 17/09/2026
We're now accepting submissions for our next special issue, which will focus on 'Proteostasis' and will be coordinated by two of our Academic Editors, Pedro Carvalho and Tamotsu Yoshimori. Submission deadline: 2 November Find out more: journals.biologists.com/jcs/pages/pr... #proteostasis
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Fran Bottanelli @franbottanelli.bsky.social · 14/09/2026
Life of a Uni professor seen through the eyes of my 6 yo who just started school. I am on the right teaching my PhD student @giorgiacarai.bsky.social on the left. Apparently I teach words and little cells. #academicmum
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Justin Taraska @taraska.bsky.social · 14/09/2026
Join us this Wednesday! "Biophysics of Clathrin Coat Assembly, Curvature, and Mechanics" Wednesday, September 16, 2026 1:00–3:00 PM Eastern Time Registration and meeting access my.biophysics.org/Events/Calen... Talks by Marko Kaksonen, Jeanne Stachowiak, Julien Berro, and Padmini Rangamani.
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Fran Bottanelli @franbottanelli.bsky.social · 14/09/2026
#membranetrafficking seminars are back for the fall session! This Thursday two exciting talks from Roger Pons Lanau from @felixmendu.bsky.social lab and @veijosalo.bsky.social #ER #lipiddroplets and lots of wonderful imaging! From single molecules to cryo EM! Please repost
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Fran Bottanelli @franbottanelli.bsky.social · 13/09/2026
World news from me: thank you Sweden and no, come on, Zverev cannot win another Grand Slam.
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Fran Bottanelli @franbottanelli.bsky.social · 09/09/2026
When I started working on figuring out endosomal trafficking I did not know I was gonna come across a problem which is even more complicated: organizing life with two location (daycare and school), friends bday parties and many activities #academicmum
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Reposted by Fran Bottanelli
Stefan Luschnig @luschnig.bsky.social · 09/09/2026
Interested in combining #Drosophila genetics, advanced imaging, and modeling to study inter-organ transport and epithelial dynamics? Apply now for #PhD position @uni-muenster.de, integrated in @sfb1348.bsky.social Graduate School. Learn more tinyurl.com/5n86bmsf and tinyurl.com/ypx74a5d
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Matthew Freeman @mjafreeman.bsky.social · 08/09/2026
Feels like an interesting one... oh, wait...!
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Anh Hoang Le, PhD 🏳️‍🌈🏴󠁧󠁢󠁳󠁣󠁴󠁿🇻🇳 @anhhle2702.bsky.social · 07/09/2026
Very happy to share my postdoc paper is out now in @natcellbio.nature.com titled "Tissue flow acts as a guidance cue for immune cell polarization and directional migration". If you love imaging and immune cells, this is for you! #microscopymonday www.nature.com/articles/s41... A 🧵: 1/n
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Fran Bottanelli @franbottanelli.bsky.social · 08/09/2026
Vibe when asked to put your presentation on another computer
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Cushelle Shrek's Hilariously Distorted Face
ALT: Cushelle Shrek's Hilariously Distorted Face
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Ishier Raote @ishier.bsky.social · 07/09/2026
Membrane Trafficking Seminar Series 2026 fall season is here! An exciting programme: membrane traffic, organelle biogenesis, lipid transport, endomembrane evolution, we have it all! Save the dates and join us for fun science and discussions. Details at felixcampelo.wixsite.com/membranetraf...
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Matthias Eberl @eberlmat.bsky.social · 06/09/2026
The last time German right-wing extremists hat 44% of the vote and such a clear lead over all other parties was in Match 1933. The rest is history.
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Fran Bottanelli @franbottanelli.bsky.social · 06/09/2026
🤮 very sad day for Germany today. Scary as Berlin and federal elections are coming up. www.bbc.com/news/article...
bbc.com
German far-right set for big win in eastern state of Saxony-Anhalt - projections
Germany's AfD has hailed a "historic result" and is projected to win more than 44% of the vote, far ahead of the conservative CDU on 18.4%.
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Fran Bottanelli @franbottanelli.bsky.social · 06/09/2026
Left England with no voice and a head full of ideas! What a wonderful conference on endosomes!
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Marius Lemberg @marius-lemberg.bsky.social · 01/09/2026
Our new preprint is out! We show that the intramembrane protease RHBDL4 targets multiple cargo receptor families, linking proteolytic remodeling of cargo receptor networks to the regulation of secretory pathway flux. Great work led by Susi Steigleder, @jnuechel.bsky.social and the team!
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Fran Bottanelli @franbottanelli.bsky.social · 31/08/2026
Message from husband. First day of school. We are doing well.
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RWedlichSoldner.bsky.social @rwedlichsoldner.bsky.social · 24/08/2026
It's been a while in the making, but finally out:😂🥳 We’re excited to share our new work with H. Pavenstädt, D. Braun, M. Krahn, P. Bieling and @raunser-lab.bsky.social on INF2 and global actin remodeling! Read the story here: www.biorxiv.org/content/10.6... #Actin #Cytoskeleton #CellBiology #INF2
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Lillemeier lab @lillemeier-lab.bsky.social · 28/08/2026
We are happy to share our knockout and re-expression system for efficient analysis of mutant phenotypes in primary mouse #T-cells. Check it out! www.biorxiv.org/content/10.6...
biorxiv.org
Knockout and re-expression system for mutant analysis in primary mouse T cells
We describe here an efficient method for gene editing in mouse T cells, based on well-established, high-efficiency retroviral transduction protocols. Our platform allows analysis of mutant phenotypes ...
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Fran Bottanelli @franbottanelli.bsky.social · 31/08/2026
First day of school or my oldest. Finally I will have more academic miseries to complain about #academicmum
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Erdinc Sezgin @sciezgin.bsky.social · 28/08/2026
Open postdoctoral fellow position in our lab on "𝐌𝐨𝐥𝐞𝐜𝐮𝐥𝐚𝐫 𝐇𝐨𝐬𝐭-𝐏𝐚𝐭𝐡𝐨𝐠𝐞𝐧 𝐈𝐧𝐭𝐞𝐫𝐚𝐜𝐭𝐢𝐨𝐧𝐬". Are you interested in macromolecular interactions during host-pathogen interactions both 𝐞𝐱𝐩𝐞𝐫𝐢𝐦𝐞𝐧𝐭𝐚𝐥𝐥𝐲 𝐚𝐧𝐝 𝐜𝐨𝐦𝐩𝐮𝐭𝐚𝐭𝐢𝐨𝐧𝐚𝐥𝐥𝐲? Want to join our team? apply here 👇 ki.varbi.com/what:job/job...
ki.varbi.com
Postdoktor i molekylära värd-patogeninteraktioner
Vill du bidra till medicinsk forskning av toppkvalitet? Vi söker en postdoktoral forskare som kommer att studera makromolekylära interaktioner vid värd-patogeninteraktioner med hjälp av avancerade
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Justin Taraska @taraska.bsky.social · 24/08/2026
The Biophysical Society Membrane Fusion, Fission, and Traffic Subgroup is hosting an exciting set of 4 virtual talks on Wednesday September 16th starting at 1 pm Eastern Time on clathrin structure and dynamics. Please join! www.biophysics.org/outreach/sub...
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Reposted by Fran Bottanelli
Liz Miller @lizmillercu.bsky.social · 24/08/2026
*JobAlert* One more week to apply for a post-doc position in my lab at Dundee to study co-translational protein quality control of secretory and membrane proteins. This is a collaborative project with @kulathu.bsky.social and @zeqiraj.bsky.social www.jobs.ac.uk/job/DSM201/p...
jobs.ac.uk
Postdoctoral Research Assistant - UOD2336 at University of Dundee
Discover an exciting academic career path as a Postdoctoral Research Assistant - UOD2336 at jobs.ac.uk. Don't miss out on this job opportunity - apply today!
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Fran Bottanelli @franbottanelli.bsky.social · 18/08/2026
That’s def how I imagine the TGN to look like.
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Fran Bottanelli @franbottanelli.bsky.social · 17/08/2026
Just back from this and I am struggling to find any motivation. Back to struggles and uncertainty. Certainly demotivating
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Andrew Plested @andrewplested.bsky.social · 24/07/2026
Very proud of this work, led by brilliant postdoc Marin Boutonnet, that we unveiled at the GRC last week. Skeetorial to follow…
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Juan S. Bonifacino @juanbonifacino.bsky.social · 23/07/2026
New study from our lab at NICHD, NIH! We identify TBC1D9 and TBC1D9B as novel ARL8 effectors that suppress exosome secretion by inactivating RAB11A and thus blocking exocyst-dependent fusion of multivesicular endosomes with the plasma membrane. www.pnas.org/doi/10.1073/...
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Johannes Franzen @johannesfranzen.bsky.social · 23/07/2026
Die Wissenschaftsfreiheit wird am besten verteidigt, indem man Universitäten nicht zu Tode spart. Nichts höhlt die "Resilienz" der Institution mehr aus, als das katastrophale Kürzungsprogramm, das gerade abläuft.
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Club Exo Endo @clubexo-endo.bsky.social · 22/07/2026
Save the date! Club Exocytose-Endocytose half-day scientific meeting is planned 📅 1 Dec 2026, 2 pm 📍 Centre Broca Nouvelle-Aquitaine, Bordeaux Neurocampus 🎤 ~8 talks 💻 Hybrid: in person or online Registration & abstract submission open in September. Stay tuned !!
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Fran Bottanelli @franbottanelli.bsky.social · 22/07/2026
It‘s amazing to see your students spread their wings! I am so sad to see @petia-adarska.bsky.social and @probablycarmen.bsky.social leave BUT i am so happy they have found great post docs. Mixed feelings of joy and sadness
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Anne Hathaway's Fan Reaction in Princess Diaries
ALT: Anne Hathaway's Fan Reaction in Princess Diaries
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Fran Bottanelli @franbottanelli.bsky.social · 22/07/2026
What is the perfect GIF for the last few days before holidays
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SML Chef Pee Pee Making a Food Mess
ALT: SML Chef Pee Pee Making a Food Mess
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The EMBO Journal @embojournal.org · 21/07/2026
Yeast dynamin Vps1 coordinates cycles of membrane constriction and relaxation by coupling GTP hydrolysis, to scaffold membrane remodelling during retrograde trafficking Thomas Pucadyil and coworkers link.springer.com/article/10.1...
link.springer.com
Vps1 drives membrane constriction and fission necessary for endosomal protein sorting - The EMBO Journal
The trafficking of cargo between endosomes and the Golgi apparatus uses both retromer-dependent and retromer-independent routes. Disruptions to these routes lead to the mis-sorting of lysosomal cargo,...
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Luke Lavis @rhodamine110.bsky.social · 17/07/2026
Excited to see this collaboration now in print. Dye chemistry meets AI-designed proteins. Three small, orthogonal tags; lifetime modulation; split versions. Request the free dyes at dyes.janelia.org www.science.org/doi/10.1126/...
science.org
De novo design of orthogonal far-red, orange, and green fluorophore-binding proteins for multiplexed imaging
Fluorescent proteins and small-molecule dyes offer complementary advantages for biological imaging: proteins are amenable to genetic tagging, whereas dyes provide superior brightness and photostabilit...
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Fran Bottanelli @franbottanelli.bsky.social · 17/07/2026
Husband went to work with a t shirt I bought him. Somehow I do not think many non Americans would get the joke 🤣
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Fran Bottanelli @franbottanelli.bsky.social · 16/07/2026
@freieuniversitaet.bsky.social Biochemistry retreat is in full swing with coffee break with science-themed cookies! 🍪🤩
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Fran Bottanelli @franbottanelli.bsky.social · 16/07/2026
I turned up at 8 for the Biochem retreat thinking it was 9. I need a holiday…. 🏝️ and a permanent position.
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Fran Bottanelli @franbottanelli.bsky.social · 09/07/2026
Maybe this whole academia upset is good for my low blood pressure. 3 coffees and resubmitting a rejected grants and I am still 119-73…
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Thibaut Brunet @thibautbrunet.bsky.social · 09/07/2026
Les nouvelles règles envisagées pour l'ANR sont plus qu'inquiétantes. Elles porteraient un immense coup d'arrêt à la recherche fondamentale en France, surchargeraient les jeunes chercheurs, et n'attendraient sans doute même pas leur objectif (apparent) de réduction du nombre de candidatures
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Journal of Cell Biology @jcb.org · 07/07/2026
Frier, @lizconibear.bsky.social et al. show that the VPS9 GEF complex VINE unexpectedly recruits a phosphatase that stimulates GAP-mediated Rab5 inactivation, revealing dual control of Rab signaling by a single complex. rupress.org/jcb/article/... #GTPases #Organelles #Trafficking
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