Radulovic et al. show that phosphatidylinositol 3-phosphate (PI3P), produced by the phosphatidylinositol 3-kinase PIK3C3, is formed on ER domains after lysosome damage. ER domain PI3P helps to recruit...

Yang et al. reveal that the ARLA1A-NAC089 module couples ER phagy with the UPR in plants. This dual regulatory axis fine-tunes cell survival versus death under stress, providing a mechanistic framework for maintaining ER homeostasis and enhancing environmental resilience.

Signal Transduction and Targeted Therapy - Targeting endoplasmic reticulum export disrupts metabolic resilience in multiple myeloma

Der FWF vergibt 18 FWF-ASTRA-Preise an herausragende Postdocs. Die mit jeweils rund einer Million Euro dotierten Förderungen stärken Spitzenforschung und helfen, internationale Talente für den Forschu...

The Golgi apparatus expands during differentiation and increased secretory demand, yet the transcriptional mechanisms governing its biogenesis remain poorly defined. To investigate this process, we de...

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Nature Communications - Macrophages play an important role in repair and regeneration of damaged nerves in spinal cord injury (SCI). Here, Guo et al. investigate effects of endoplasmic...

Donahue et al. show that ageing is associated with changes in ER morphology. ER-phagy drives age-associated ER remodelling through tissue-specific factors.

Nature Cell Biology - Shen, Gelashvili and Niethammer developed an inner nuclear membrane tension sensor and demonstrated that ER–nuclear membrane contiguity acts as a mechanical buffer.

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Depletion of the ER stress sensor IRE1α can reduce paclitaxel-induced peripheral neuropathy in mice.

Joel Mokyr, Philippe Aghion and Pewter Howitt share economics prize for work that underlines the importance of investing in research and development.

Kein Geist, kein Sinn. Österreich braucht keine männliche MINT-Monokultur, sondern eine starke und vielfältige Wissenschaft.

Nature Cell Biology - Zhang, Lahry, Cipurko et al. show that the microbial metabolites queuine and preQ1 modify the same host tRNA. PreQ1-tRNA reduces cell proliferation, slows tumour growth,...

Directional, non-vesicular lipid transport is responsible for fast, species-selective lipid sorting into organelle membranes.

Nature Structural & Molecular Biology - Gómez-Sánchez et al. show that generation of phagophore–endoplasmic reticulum exit sites (ERES) membrane contact sites, mediated by Atg2...

Nature Cell Biology - Rudinskiy et al. examine organellophagy receptor features, finding modules of functionally conserved intrinsically disordered regions and defining shared features despite...

Bone homeostasis relies on the coordinated activity of osteoblasts and osteoclasts that balances bone formation and resorption, and of osteocytes for biomechanical sensing and hormone secretion. A key...

Leukemia - Targeting proteostasis in multiple myeloma through inhibition of LTK

Plasma membrane–endoplasmic reticulum physical tethering is a mechanotransduction pathway.

Sassano et al. identify endoplasmic reticulum–mitochondria contact sites as the intracellular location where phospholipid peroxidation first occurs to promote ferroptosis. Manipulating these contact s...

Song et al. demonstrate that an ER tubulovesicular structure (ER tubular body [ER-TB]), shaped by the tubular ER-phagy receptors ATL3 and RTN3L, plays an important role in stress-induced Golgi bypass ...

Lysosomes are damaged in quiescent cells, and UPR regulators, IRE-1/XBP-1, promote lysosome repair for cell-cycle re-entry. Lysosome damage in quiescent cells is caused in part by macroautophagy and i...

Tailoring genetic fusions of widely used actin localization reporters by constraining the mobility of the fluorescent proteins allows measurements of actin filament organization in living cells and ti...

In the autumn of 2024, David Stephens, a prominent member of the UK cell biology community and a brilliant scientist, leader and mentor, passed away. With his pragmatism and natural authority, combine...