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Wilfling Lab

@wilflinglab.bsky.social
621 followers 498 following 24 posts

Investigating mechanisms of eukaryotic cellular quality control with a focus on autophagy @MPIbp via #cryoET, #teamtomo, #cellbiology and #massspectrometry

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Reposted by Wilfling Lab
Felix Kraus @sauerkrausi.bsky.social · 07/07/2026
Happy to share our neuronal lysosomal storage disorder toolkit has been published in PNAS! 📚Paper: www.pnas.org/doi/10.1073/...
pnas.org
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
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Reposted by Wilfling Lab
ARCTiC: Autophagy Research Centre Targeting Cancer @arcticautophagy.bsky.social · 25/05/2026
Excited to welcome the autophagy community in Oslo for the International Autophagy Conference 2026. 📍 Holmen Fjordhotell, Oslo 📅 25–28 May 2026 Looking forward to outstanding science and discussions on the future of autophagy research. Thanks to our sponsors: @tandfonline @embojournal @NoAge100
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Reposted by Wilfling Lab
Felix Kraus @sauerkrausi.bsky.social · 24/03/2026
Updated preprint 🧵 We mapped how loss of 23 LSD genes reshapes neuronal proteomes in cortical (iN) and dopaminergic (iDA) neurons New in v2: We added a computational PPI pipeline assessing KO-dependent vulnerability at the interaction and complex level.
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Reposted by Wilfling Lab
Felix Kraus @sauerkrausi.bsky.social · 24/03/2026
Huge thanks to all the fantastic co-authors and collaborators, especially @harvardcellbio.bsky.social, @harvardcellbio.bsky.social , @wilflinglab.bsky.social, Memorial Sloan Kettering Cancer Center, @citehms.bsky.social @jencwaters.bsky.social, and @hms-iac.bsky.social, @fedegasparoli.bsky.social!
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Wilfling Lab @wilflinglab.bsky.social · 20/01/2026
LLOMe has long been used to study lysosomal damage, yet how it works has remained a mystery. Using cryo-electron tomography, we show it forms amyloid structures inside lysosomes that mechanically rupture membranes – revealing a new paradigm for lysosomal failure. 🔗 doi.org/10.64898/202... #CryoET
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Wilfling Lab @wilflinglab.bsky.social · 13/01/2026
We are excited to share our new preprint which is now available to read on biorXiv: doi.org/10.64898/202... 🎉🎉🎉
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Wilfling Lab @wilflinglab.bsky.social · 20/11/2025
Yes was absolute fun! Like always a fantastic collaboration.
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Reposted by Wilfling Lab
Claudine Kraft's Lab @kraftlabfr.bsky.social · 12/03/2025
🔄 Repost because the previous link was broken! To degrade or not to degrade! We put together an Autophagic Punctum with @wilflinglab.bsky.social on our latest paper, take a look if you're interested! 🔗 www.tandfonline.com/doi/full/10....
tandfonline.com
To degrade or not to degrade: how phase separation modulates selective autophagy
Selective macroautophagy/autophagy relies on newly formed double-membrane compartments, known as phagophores, to sequester and recycle diverse cellular components, including organelles, biomolecula...
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Wilfling Lab @wilflinglab.bsky.social · 22/02/2025
Looking forward to this fantastic meeting!
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Reposted by Wilfling Lab
Claudine Kraft's Lab @kraftlabfr.bsky.social · 07/01/2025
🚨 Paper Alert! We’re starting off the year with our latest publication in @naturecellbiology.bsky.social on the role of phase separation in selective autophagy initiation! This work was a close and exciting collaboration with @wilflinglab.bsky.social 🔗 nature.com/articles/s41... Here's a thread👇
nature.com
Phase separation of initiation hubs on cargo is a trigger switch for selective autophagy - Nature Cell Biology
Licheva, Pflaum, Babic, Mancilla et al. show that low-affinity cargo–receptor interactions promote autophagy receptor mobility and condensation of the scaffold protein Atg11 to trigger initiation hub ...
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Wilfling Lab @wilflinglab.bsky.social · 08/01/2025
Check out our latest publication in @naturecellbiology.bsky.social on the role of phase separation in selective autophagy initiation! This was done in a fantastic collaboration with ‪@kraftlabfr.bsky.social‬ www.nature.com/articles/s41... Short teaser below 👇👇👇
nature.com
Phase separation of initiation hubs on cargo is a trigger switch for selective autophagy - Nature Cell Biology
Licheva, Pflaum, Babic, Mancilla et al. show that low-affinity cargo–receptor interactions promote autophagy receptor mobility and condensation of the scaffold protein Atg11 to trigger initiation hub ...
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Wilfling Lab @wilflinglab.bsky.social · 11/12/2024
Great opportunity! We are looking for a PhD student to work on novel sample preparation methods for cryo-electron tomography.
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Wilfling Lab @wilflinglab.bsky.social · 03/12/2024
Humbled and excited to join the EMBO young investigator community. Congratulations to all and looking forward to meeting you in the future. www.embo.org/press-releas...
embo.org
Twenty-seven scientists become EMBO Young Investigators – Press releases – EMBO
The group leaders join an international network of nearly 800 life scientists and receive financial support
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