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Romain Koszul

@rkoszul.bsky.social
809 followers 224 following 95 posts

#3Dgenome, #3R, #chromatin, #synbio, #microbiome... Opinions are my own.

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Reposted by Romain Koszul
Inrap @inrap.fr · 23/09/2026
🔎 Le rempart de la Lutèce gauloise retrouvé sous l’Hôtel-Dieu AP-HP à Paris Les archéologues de la Ville de @paris.fr et de l’Inrap ont mis au jour un mur de près de 20 m, caractéristique des fortifications gauloises de la fin de l’âge du Fer. En savoir plus 👉 www.inrap.fr/decouverte-a...
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Gro-Tsen @gro-tsen.bsky.social · 10/09/2026
Un billet de blog pour parler de la destruction en cours des mathématiques par les boîtes d'IA et leurs petites mains: www.madore.org/~david/weblo...
madore.org
Sur la destruction des maths par les boîtes d'IA
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Martial Marbouty @mmarbout.bsky.social · 30/08/2026
🚨 ‼️ NEW PUBLICATION ‼️ While we start to know a lot about how bacterial genomes are organized in 3D, almost nothing is known about phage genome once it enters a bacterial cell. read the paper here: www.science.org/doi/10.1126/...
science.org
Bacteriophage PAK_P3 genome structuration and dynamics during infection of Pseudomonas aeruginosa reveal specific interaction patterns
While the dynamic changes in genome organization in cellular organisms have been well described, the three-dimensional (3D) folding of phage genomes during the infection of their host is extremely lim...
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Reposted by Romain Koszul
Guillaume Laget @glag38.bsky.social · 08/08/2026
Un autre article d'un (gros) blog/site qui évoque le thème : www.meteo-paris.com/actualites/p...
meteo-paris.com
Un immense blocage planétaire enferme la France dans la chaleur 08/08/2026
Pourquoi la chaleur et la sécheresse persistent-elles en France durant l’été 2026 ? Jet-stream trop au nord, double courant-jet et sols secs entretiennent un puissant blocage anticyclonique. Meteo Par...
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Reposted by Romain Koszul
Deborah Bourc’his @deborahbourchis.bsky.social · 27/06/2026
Coupes drastiques du budget de la recherche + durcissement des règles d’attribution des financements ANR «Allez à l’ERC!» qu’ils disent, mais l’ERC saturée prend des mesures pour limiter les candidatures #deadend#recherchefrançaise Une petition semble vaine mais il faut commencer quelque part 👉
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Camille Berthelot @camilleberthelot.bsky.social · 10/06/2026
sPYce is now published in Nature Ecology and Evolution! sPYce is a method to integrate single-cell regulatory data across species, without requiring whole-genome alignments between species. More below ⬇️ www.nature.com/articles/s41...
nature.com
Alignment-free integration of single-nucleus ATAC-seq across species with sPYce - Nature Ecology & Evolution
This paper presents sPYce, a method that integrates single-nucleus ATAC-seq data across species, allowing for comparison of gene regulatory evolution across species.
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Alejandro Montenegro @aemonten.bsky.social · 13/05/2026
On this day, in 1961, two articles appeared in Nature announcing the isolation of messenger RNA (mRNA) www.cell.com/current-biol...
cell.com
Who discovered messenger RNA?
Cobb looks back at the complicated series events that led to the discovery of messenger RNA, highlighting the often difficult problem of attributing credit for scientific advances.
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Romain Koszul @rkoszul.bsky.social · 04/05/2026
A quick notice: the Hi-C scaffolder InstaGRAAL is available on PyPI, with an -endtoend mode that should facilitate homemade scaffolding project. "pip install instagraal" and info here: github.com/koszullab/in... (non contractual movie since we removed the openGL visual long ago :-)
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Reposted by Romain Koszul
Marie-Eve VAL @val-meve.bsky.social · 04/05/2026
This one means a lot. Our paper, “Large extrachromosomal replicons are widespread across bacterial lineages and show coordinated replication termination and spatial coupling with the chromosome,” is out! doi.org/10.1038/s414...
doi.org
Large extrachromosomal replicons are widespread across bacterial lineages and show coordinated replication termination and spatial coupling with the chromosome - Nature Communications
Bacterial genomes often include extrachromosomal replicons, ranging from small plasmids to chromosome-scale replicons. Here, Czarnecki et al. analyse more than 40,000 complete bacterial genomes and sh...
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Reposted by Romain Koszul
Emmanuel Laurentin @elaurentin.bsky.social · 19/04/2026
www.lemonde.fr/planete/arti...
lemonde.fr
L’appel à l’aide du Muséum national d’histoire naturelle, très délabré : « Les ossements minéralisés explosent littéralement »
Moisissures dans les collections, bibliothèque inondée, fissures dans les murs… Alors que l’établissement célèbre ses 400 ans, fort d’une importante fréquentation et d’une renommée scientifique intern...
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Romain Koszul @rkoszul.bsky.social · 16/04/2026
Happy to share our review of the past, recent, and future applications of synthetic genomics in studying the 3D functional organization of chromosomes, a set of approaches that are gaining momentum! www.sciencedirect.com/science/arti...
sciencedirect.com
Synthetic chromosomes for 3D functional genomics: from principles to AI-guided design
The role of genome 3D organization for fundamental chromatin processes, such as long-range promoter-activator regulatory interactions, remains ambiguo…
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Reposted by Romain Koszul
Pierre Bataille @pierrebat.cpesr.fr · 14/04/2026
Nerd alert: 10 000 bandes pirates de concert - enregistrées sur plus de 30 ans - rendues disponibles à tout le monde www.dexerto.com/entertainmen...
dexerto.com
Man who recorded over 10,000 live concerts is releasing them all online for free - Dexerto
A music fan from Chicago is digitizing and uploading his four-decade-long collection of live concert recordings to the internet.
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Reposted by Romain Koszul
Jean Léon Maître @maitrejl.bsky.social · 26/03/2026
Big change for researchers with disabilities who seek a faculty position in France. Positions are now open to any lab in the country and there are 2 positions for biology labs. carrieres.cnrs.fr/actualites/r...
carrieres.cnrs.fr
Recrutement 2026 de chercheuses et chercheurs en situation de handicap - CNRS Carrières
Les candidats retenus signent un contrat d’un an, qui peut être renouvelé pour une durée n’excédant pas celle fixée initialement. Pendant cette période, ils bénéficient des mêmes conditions de travail, droits et avantages que les chercheurs stagiaires de la fonction publique.
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Reposted by Romain Koszul
Maxim Greenberg @maxvcg.bsky.social · 09/03/2026
Very excited to announce the FIRST symposium on epigenome editing! These tools are becoming widely used in mol bio, ag & therapy. It's time to bring leaders together to discuss this rapidly growing and exciting field. And why not in Paris! Please register & share! (1/2) ctrlepiedit.sciencesconf.org
Flyer for symposium: https://ctrlepiedit.sciencesconf.org/
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SFM Microbial Pathogenesis @sfmpathogenesis.bsky.social · 27/02/2026
🔬 New work from the Mazel Lab engineers programmable conjugative plasmids to selectively target MDR bacteria and the resistance plasmid pOXA-48, blocking its spread in complex communities. ✍️ @amazeld.bsky.social & coll. @pasteur.fr 📖 shorturl.at/GZdJu #MicroSky #AntibioticResistance #Conjugation
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CRBM-Montpellier @crbm-montpellier.bsky.social · 30/01/2026
We are hiring!
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Nico Rascovan @nrascovan.bsky.social · 27/01/2026
Institut Pasteur (@pasteur.fr) is recruiting new young PIs to open new groups in the Institute. Deadline is February 9th! Don't miss the opportunity!
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Romain Koszul @rkoszul.bsky.social · 26/01/2026
Un peu de lecture @paris.fr www.nytimes.com/2025/11/30/m... www.nytimes.com/2025/11/30/b... www.theguardian.com/world/2026/j...
theguardian.com
Amsterdam prepares to ‘ban the fatbikes’ amid rise in serious accidents
Experts say souped-up e-bikes pose big risk for children aged from 12 to 15, who account for many A&E cases
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Reposted by Romain Koszul
Manuel Ares-Arroyo @aresarroyom.bsky.social · 14/01/2026
Bacteria chromosomes contain Genomic Islands that provide virulence, antibiotic resistance, MGE-defence,... They transfer between cells, but the mechanism of most remains elusive. Here we explore the conjugative capacity of these mysterious Genomic Islands. www.biorxiv.org/content/10.6...
biorxiv.org
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Gilles FISCHER @gillesfischer.bsky.social · 08/01/2026
Last work of the lab showing that Repeated losses of self-fertility shaped heterozygosity and polyploidy in yeast evolution | PNAS www.pnas.org/doi/10.1073/...
pnas.org
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
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Reposted by Romain Koszul
Frédérique Le Roux @fredoleroux.bsky.social · 07/01/2026
Seeking expressions of interest from researchers abroad for a Canada Impact+ Research Chair ($1M/year × 8 + up to $6M CFI) in AI-enabled antibiotic discovery and/or AMR, phage & phage-based derivatives. Email me a short vision, CV, and 3–5 key papers. Deadline: March 10, 2026 (Intake 2: June 15).
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Reposted by Romain Koszul
Association Anticor @anticor.bsky.social · 05/01/2026
#USA - Le gouvernement états-unien entend multiplier les sanctions contre des personnalités européennes, à l’image de l’ancien commissaire européen Thierry Breton, interdit de visa. Les magistrats qui ont condamné Marine Le Pen en mars dernier seraient menacés. #AnticorVeille
humanite.fr
Les magistrats ayant condamné Marine Le Pen dans le viseur de l’administration Trump - L'Humanité
Le gouvernement états-unien entend multiplier les sanctions individuelles contre des personnalités européennes, à l’image de l’ancien commissaire européen Thierry Breton,...
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Dan Vergano @danvergano.bsky.social · 16/12/2025
RFK, Jr.–Backed Lyme Disease Conspiracy Theory May Be Probed under New Bill www.scientificamerican.com/article/rfk-... President Donald Trump is expected to sign a defense bill this week that orders an investigation into whether the U.S. military bioengineered Lyme disease
scientificamerican.com
RFK, Jr.–Backed Lyme Disease Conspiracy Theory May Be Probed under New Bill
President Donald Trump is expected to sign a defense bill this week that orders an investigation into whether the U.S. military bioengineered Lyme disease
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Institut Pasteur | 130 years of biomedical research @pasteur.fr · 08/12/2025
🔬 Call to create junior research groups at the Institut Pasteur Focus: Infectious diseases, host-microbe interactions, vaccines Special interest: AI methodologies 📅 Deadline: Feb 9, 2026 👥 2-12 years post-PhD Apply now 📝 research.pasteur.fr/en/call/crea... #JobOpportunity #Research
research.pasteur.fr
Creation of new junior research groups at the Institut Pasteur - Call for applications 2026 - Research
The Institut Pasteur is launching an international call to recruit new junior research group leaders leveraging cutting-edge transdisciplinary approaches to exploring infectious diseases, host-microbe...
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CNRS @cnrs.fr · 25/11/2025
#RejoignezLeCNRS 🫵 Les concours chercheurs CNRS 2026 ouvrent le 8/12 ! Envie de faire avancer la science au sein d’un des plus grands organismes de recherche ? 👉 carrieres.cnrs.fr/concours-... #ConcoursChercheurs #Science #Recherche #Icicarecrute #recrutement
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Sam J Wilson @samjwilsonphd.bsky.social · 27/11/2025
How does fever work? Our new Science paper shows how elevated body temperature can protect against severe influenza and that avian-origin viruses escape this defence. This is likely one reason why bird flus and some pandemic influenzas can be so severe.🧵 www.science.org/doi/10.1126/...
science.org
Avian-origin influenza A viruses tolerate elevated pyrexic temperatures in mammals
Host body temperature can define a virus’s replicative profile—influenza A viruses (IAVs) adapted to 40° to 42°C in birds are less temperature sensitive in vitro compared with human isolates adapted t...
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Quantian @quantian.bsky.social · 29/10/2025
Take this quiz to die instantly www.americansurveycenter.org/quiz/
americansurveycenter.org
Beyond the Ballot Quiz - The Survey Center on American Life
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Institut Jacques Monod @ijmonod.bsky.social · 28/10/2025
#JobOffer 💼 Un poste susceptible d’être vacant de Professeur en stabilité des génomes devrait s’ouvrir pour la rentrée 2026 au sein de l’Institut Jacques Monod ➡️ Informations concernant ce poste et la procédure de candidature 🔗 www.ijm.fr/poste-de-pro...
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Greg Jefferis @jefferis.bsky.social · 15/10/2025
Excited to share our new #biorxivpreprint: “Sexual dimorphism in the complete connectome of the Drosophila male central nervous system” www.biorxiv.org/content/10.1... We describe the #connectomics reconstruction and analysis of an entire adult #maleCNS #drosophila central nervous system. 1/10
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David Bikard @dbikard.bsky.social · 11/10/2025
Entretien pour Brut sur la vie Miroir, l'ingénierie génétique et l'éthique de ces recherches: www.brut.media/fr/videos/sc...
brut.media
Manipulations génétiques, virus créés par l’IA, bactéries miroirs : quelles limites à la recherche scientifique ?
Elles pourraient aider à lutter contre les cancers… mais aussi détruire toute trace de vie sur Terre ! Ce sont les bactéries miroirs. En avez-vous déjà entendu parler ? Et la vie miroir, ça vous dit q...
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The Francis Crick Institute @crick.ac.uk · 09/10/2025
We're now recruiting early career group leaders at the Crick to lead ambitious research programmes and explore bold scientific questions. Hear our Director, Edith Heard, explain why the Crick is a unique place for curiosity-driven research. Apply now ➡️ www.crick.ac.uk/careers-stud...
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Stephan Gruber @gruberlab.bsky.social · 09/10/2025
How do SMC complexes load onto DNA to get ready for loop extrusion? @roisnehamelinf.bsky.social & co discovered that Wadjet, an SMC complex involved in bacterial DNA immunity, performs some impressive molecular gymnastics 🤸‍♂️🤸‍♂️🤸‍♂️. Check out the new paper: www.cell.com/molecular-ce...
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Jean-Yves Tinevez @jytinevez.bsky.social · 07/10/2025
Job alert! We are looking for a bioimage analysis to work in an image analysis core facility in beautiful Paris. Can I ask you to share this opportunity with your networks? See also on the forum: forum.image.sc/t/research-e...
forum.image.sc
Research engineer in Bioimage Analysis for the researchers of the inIdEx FORMULA
Hi all We are looking for a bioimage analysis to work in an image analysis core facility in beautiful Paris. Can I ask you to share this opportunity with your networks? The position is in the Instit...
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Tung Le @tunglejic.bsky.social · 03/10/2025
Independent research fellowships leading to tenured positions at the John Innes Centre. Repost = nice. Thank you very much!!!
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Géraldine Laloux @lalouxlab.bsky.social · 25/09/2025
📝New preprint! #MicroSky 🕰️We chart the full, synchronized lifecycle of a predatory bacterium using Hi-C, RNA-seq, ChIP-seq & microscopy. 🧬We uncover dramatic shifts in nucleoid architecture & transcription, tightly coordinated with predation. www.biorxiv.org/content/10.1...
biorxiv.org
Dynamics and interplay of gene expression and chromosome organization across a predatory lifecycle
The obligate predatory bacterium Bdellovibrio bacteriovorus alternates between a motile attack phase and a growth phase inside another bacterium, during which it undergoes multiple rounds of DNA repli...
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Mehdi Hasan @mehdirhasan.bsky.social · 20/09/2025
What’s more astonishing: 1) that the president clearly believes, and repeatedly suggests, that asylum seekers are people from mental asylums, or 2) that no journalist has ever challenged him on this and no mainstream media outlets have done any deep dives on this story?
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Romain Koszul @rkoszul.bsky.social · 19/09/2025
New paper! We generated and/or (re)analyzed ~100 #metagenomics Hi-C datasets to provide a comprehensive analysis of bacterial and viral metagenomes across VERY different environments. Congratulations to all authors especially Amaury Bignaud and @mmarbout.bsky.social for the huge work! #metaHiC
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Gilles FISCHER @gillesfischer.bsky.social · 16/09/2025
New preprint from the lab: we show that the ability to switch mating type was lost at least 13 times independently in the evolution of S. cerevisiae. At least 27% of isolates are heterothallic with a strong association with polyploidy and heterozygosity www.biorxiv.org/content/10.1...
biorxiv.org
Repeated losses of self-fertility shaped heterozygosity and polyploidy in yeast evolution
Evolutionary transitions in mating strategy have profound consequences for genetic variation and adaptation. In Saccharomyces cerevisiae, mating-type switching is a central feature of the life cycle t...
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Harmit Singh Malik @harmitmalik.bsky.social · 17/09/2025
www.cell.com/cell/abstrac... A host organelle (in sea slugs) integrates stolen chloroplasts for animal photosynthesis
cell.com
A host organelle integrates stolen chloroplasts for animal photosynthesis
Sea slugs steal foreign chloroplasts and store them in specialized organelles that facilitate photosynthesis and eventual digestion to mediate starvation resistance.
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Tobias Warnecke @tobiaswarnecke.bsky.social · 08/09/2025
Please re-post: Interested in chromatin and its evolution? Good news! There's still time to join us in beautiful Catalonia (9-12 Dec) to discuss eukaryotic, bacterial, archaeal, and viral chromatin and how it all hangs together meetings.embo.org/event/24-evo... Abstract deadline: 30 September
meetings.embo.org
EvoChromo: Evolutionary approaches to research in chromatin
Chromatin is the complex of DNA, RNA and protein that is found making up the chromosomes in eukaryotic cells. Chromatin is essential for proper genome function and is involved in chromosome segregati…
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Institut Pasteur | 130 years of biomedical research @pasteur.fr · 01/09/2025
🎓 Applications for Institut Pasteur's PhD programs open Sept 1-Oct 20, 2025 for October 2026 entry. Apply to up to 4 projects across 6 programs: PPU, PPU-IMAGINE @institutimagine.bsky.social, PPU-@ox.ac.uk, PPU-EID @upcite.bsky.social & more 🧬 Register now ✍️ www.pasteur.fr/en/education...
Pasteur-Paris University International Doctoral Programme, The call for enrollment of students in October 2026 will be open from September 1st to October 20th, 2025
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Eduardo Rocha @epcrocha.bsky.social · 08/09/2025
Willing to join us @pasteur.fr for a PhD for a project on how interactions between mobile genetic elements shape bacterial adaptation? Subject to be tailored to candidates with keen interest in evolution, genomics, computational biology, microbiology. Check www.pasteur.fr/en/education...
pasteur.fr
Pasteur-Paris University International doctoral program​ (PPU)
OverviewIn 2009, the Institut Pasteur, the world leading biomedical research institute founded by Louis Pasteur in 1887, inaugurated the Pasteur Paris-University (PPU) international doctoral program i...
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The Cecere Laboratory @cecerelab.bsky.social · 07/09/2025
🍽️🧬 How do diet and gut microbes shape fertility across generations? 🪱🔬 Our Laboratory at #InstitutPasteur is recruiting a PhD student to study epigenetic inheritance of fertility using C. elegans. Fully funded via the International PPU program. Apply now! 🌍 #PhDposition #Epigenetics #Inheritance
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Zeynep Baharoglu @zeynepbaharoglu.bsky.social · 06/09/2025
So excited our antibiotic potentiation story is out 🤩 Led by the extraordinary @manonlang.bsky.social with @fox-science.bsky.social & @amazeld.bsky.social +amazing collaborators @immunobladder.bsky.social @imaneelmeouche.bsky.social 🦠 We believe it can make a difference in #AMR infections!
science.org
Uridine as a potentiator of aminoglycosides through activation of carbohydrate transporters
Uridine boosts aminoglycoside treatment efficiency against antibiotic-susceptible as well as antibiotic-resistant E. coli strains.
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Jolan C. Bertrand @thejolan.bsky.social · 28/08/2025
(Suite) en tapant votre nom dans la barre de recherche de cette database : www.theatlantic.com/technology/a... (hésitez pas à checker plusieurs versions de votre nom, à intervertir nom et prénom etc.) pour voir si une ou plusieurs de vos oeuvres y sont. Et si vous êtes effectivement concerné-es (2/)
theatlantic.com
Search LibGen, the Pirated-Books Database That Meta Used to Train AI
Millions of books and scientific papers are captured in the collection’s current iteration.
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Elphege Nora Lab at UCSF @elphegenoralab.bsky.social · 16/08/2025
New preprint with @gfudenberg.bsky.social We find the rate of cohesin loop extrusion in cells is set by NIPBL dosage and tunes many aspects of chromosome folding. This provides a molecular basis for NIPBL haploinsufficiency in humans. 🧵👇 www.biorxiv.org/content/10.1...
biorxiv.org
NIPBL dosage shapes genome folding by tuning the rate of cohesin loop extrusion
Cohesin loop extrusion is a major driver of chromosome folding, but how its dynamics are controlled to shape the genome remains elusive. Here we disentangle the contributions of the cohesin cofactors ...
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Romain Koszul @rkoszul.bsky.social · 11/08/2025
New work from @beckof.bsky.social and our lab's collaboration, with @alengronne.bsky.social! Multifaceted influence of transcription on yeast chromosome folding... loop extrusion of course but also active promoters making loops, bypassing centromeres boundaries www.sciencedirect.com/science/arti...
sciencedirect.com
RNA Pol II-based regulations of chromosome folding
The spatial organization of eukaryotic genomes and its dynamics are of functional importance for gene expression, DNA replication, and segregation. St…
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Joan Stavo-Debauge @jostavodebauge.eurosky.social · 09/08/2025
Les Start-up françaises ont un coup à jouer : c'est les seules à pouvoir proposer des experts de niveau HDR* 😎
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J.M. Berger PRE-ORDER THE POPE'S HITMAN @jmberger.com · 09/08/2025
I feel like Harvard, or at least MIT, should be able to assemble a team of viciously-minded nerds to fight back against this bullshit using unconventional tactics
The popcorn scene from Real Genius. Real ones know.
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