Reposted by Manuel MendozaSnezhka Oliferenko @alebenoit.bsky.social · 27/09/2026People!!! This workshop will be ACE - please share, please apply! 01818
Manuel Mendoza @longchrom.bsky.social · 24/09/2026Biophysics, membranes, evolution, yeast 🙌 @alebenoit.bsky.social does it again! www.cell.com/biophysrepor...cell.comCellular membranes of the related fission yeast species differ in their dipole potentialThe dielectric environment and membrane dipole potential are key electrostatic properties of biological membranes, which modulate the function of membrane-associated proteins. If and how these propert... 142
Reposted by Manuel MendozaAurele Piazza @aurelepiazza.bsky.social · 18/09/2026What molecular mechanisms underlie the needle-in-a-haystack search for homology required to fix a DNA break? In this preprint, we reveal multiple controls of homology search in cells: onset, coordination, reach and inactivation. www.biorxiv.org/content/10.6... 25119
Manuel Mendoza @longchrom.bsky.social · 19/09/2026“People who have stayed in Russia have accepted the rules of a game … there are artists who used to make strong statements, and in 2026 they are drawing flowers in a vase.” www.theguardian.com/world/2026/s...theguardian.com‘My fear was too great’: the Pussy Riot member recruited by Russian spies to inform on fellow activistsExclusive: In her first media interview since fleeing Russia, Rita Flores describes her three years of being run by the FSB 011
Reposted by Manuel MendozaNezar Abdennur @nvictus.bsky.social · 19/09/2026The 4DN Center for 3D Structure and Physics of the Genome proudly presents: "Stepwise reorganization of chromosome conformation and nuclear organization during stem cell differentiation". www.biorxiv.org/content/10.6... 14419
Reposted by Manuel MendozaThe Bulwark @thebulwark.com · 18/09/2026@timmiller.bsky.social and @anneapplebaum.wsocial.eu on the U.S.-controlled system for selling Venezuelan oil and assets: "Congress doesn’t have oversight...there’s just rogue bank accounts out there with Venezuelan money." 18562225
Reposted by Manuel MendozaLászló Tora @tlaszlo.bsky.social · 17/09/2026Pierre Chambon was one of the driving architects of modern molecular biology, whose scientific vision transformed the understanding of gene regulation in eukaryotic cells. His passing in May 2026 represents the loss of an extraordinary scientist. www.nature.com/articles/s41...nature.comPierre Chambon (1931–2026) - Nature GeneticsNature Genetics - Pierre Chambon (1931–2026) 02610
Reposted by Manuel MendozaRon Filipkowski @ronfilipkowski.bsky.social · 17/09/2026Are we allowed to know where all the money is from the oil we’ve plundered from Venezuela? Where is it? How much is it? Has any of it been spent? Who has profited from it? Can we get a full accounting or is that too much to ask? I realize Republicans in Congress don’t care. 1792882784
Reposted by Manuel MendozapreLights @prelights.bsky.social · 16/09/2026Reading recommendation for #PeerReviewWeek @ethanewe.bsky.social highlights a study that looks at 115,000+ PLOS papers to explore who chooses open peer review and whether openness relates to article quality. #preprint Adrian Barnett & Matt Spick #preLight⬇️ prelights.biologists.com/highlights/w...prelights.biologists.comWho chooses open peer review and is it an indicator of article quality? An observational study of PLOS journals - preLightsOpening up peer review 0106
Manuel Mendoza @longchrom.bsky.social · 10/09/2026static.klipy.comSad Boy InterviewAlt: Happy Sad Boy Interview 010
Reposted by Manuel Mendozarobertus @robertus.bsky.social · 07/09/2026Elizabeth Holmes is gonna crawl out of your computer monitor in seven days unless you show this to someone else 9135393
Reposted by Manuel MendozaDave Itzkoff @ditzkoff.bsky.social · 07/09/2026there's a teaser trailer and everything youtube.com/watch?v=GGJSRFWALTI&feature=youtu.beyoutube.comYou Can See Everything | Official Teaser HD | A24YouTube video by A24 1661988298
Reposted by Manuel MendozaNick Stroustrup @nstroustrup.bsky.social · 05/09/2026Did you know that the cells of old animals contain much less mRNA than the cells of young ones? Let me share with you some results from an ongoing project in the lab, where we are finding that a progressive depletion of total mRNA abundance is a crucial part of aging 1/22 620983
Reposted by Manuel MendozaPedro Beltrao @pedrobeltrao.bsky.social · 04/09/2026Another AI agent swarm cooperation example discovered on a wiki. That these things are not atracting more public discussion is beyond me. collusion.wikicollusion.wikiDiscovery of a new OpenAI agent message boardA swarm of autonomous AI agents, self-identifying as OpenAI agents, used a small German volunteer wiki to save answers, coordinate live, and share sandbox bypasses. OpenAI noticed and said nothing. 42717
Reposted by Manuel MendozaMadScientist @mads100tist.bsky.social · 03/09/2026c.a 5k applications for ERC StG this cycle. Bananas. Unsustainable 🧪 3153
Reposted by Manuel MendozaEPIGENETIC HULK @epigenetichulk.bsky.social · 19/08/2026HAHAHAHAHAHAHAHAHAHAHAHAHAHA! EPIGENETIC HULK LIKE THIS SMASH! NO SMASH NOTES! www.cell.com/cell-genomic...cell.comSingle-cell 3D genome imaging shows super-enhancer hubs are rare, nonspecific, and neither necessary nor sufficient for transcriptional burstingSuper-enhancers have been proposed to cluster in the nucleus when compared to other genomic elements. Le et al. found that super-enhancer clustering was rare and driven by non-specific interactions. P... 24913
Reposted by Manuel MendozaStefano Di Talia @ditalialab.bsky.social · 25/08/2026We would like to add one or two postdocs to our lab in the next couple of years. If you are close to finishing your PhD and interested in the science we do, feel free to reach out to discuss opportunities. 12426
Reposted by Manuel MendozaLiz Miller @lizmillercu.bsky.social · 24/08/2026*JobAlert* One more week to apply for a post-doc position in my lab at Dundee to study co-translational protein quality control of secretory and membrane proteins. This is a collaborative project with @kulathu.bsky.social and @zeqiraj.bsky.social www.jobs.ac.uk/job/DSM201/p...jobs.ac.ukPostdoctoral Research Assistant - UOD2336 at University of DundeeDiscover an exciting academic career path as a Postdoctoral Research Assistant - UOD2336 at jobs.ac.uk. Don't miss out on this job opportunity - apply today! 01117
Reposted by Manuel MendozaMark Pownall @mpownall.bsky.social · 17/08/2026First preprint from the lab 🚨 We asked when and how global chromatin organization emerges during early development 🐟 29532
Reposted by Manuel MendozaTobias Warnecke @tobiaswarnecke.bsky.social · 22/08/2026Who needs chromatin anyway...? NOT THIS GUY! www.biorxiv.org/content/10.6... 1/nbiorxiv.orgChromatin is dispensable for bacterial lifeInside cells, DNA is intimately associated with proteins, forming chromatin. The protein constituents of chromatin vary across the tree of life: histones are the principal building blocks of chromatin... 3231104
Reposted by Manuel MendozaEd Hutchinson @socialinfluenza.bsky.social · 22/08/2026This is an absolutely delightful thread 073
Manuel Mendoza @longchrom.bsky.social · 20/08/2026“I carried my lifelong pederasty into my medical career and succeeded in both with very few failures” youtube.com/shorts/9ROI4...youtube.comHow a Nobel Laureate Became “Untouchable”YouTube video by The New Yorker 100
Reposted by Manuel MendozaMatthew Taliaferro @jmtali.bsky.social · 12/08/2026Excited to share our newest work! We asked whether RNA molecules need to be in a specific place in the cell to do their job. We found that a single RNA must reach the midbody, the structure that pinches two dividing cells apart, for cell division to finish efficiently. 🧵⬇️ 612143
Reposted by Manuel MendozaKatie Mack @astrokatie.com · 14/10/2023🌓🌎🌞 <-- lunar eclipse 🌎🌓🌞 <-- solar eclipse 🌎🌞🌗 <-- apocalypse 7454631754
Reposted by Manuel Mendozac0nc0rdance @c0nc0rdance.bsky.social · 07/08/2026I've finally found it. The most painful science montage in movie history. Mega Shark Versus Giant Octopus (2009) Yes, Gen X, that is singer Debbie Gibson as oceanographer 'Emma MacNeil'. But the important thing is: she's keeping an accurate lab notebook. 1916320
Reposted by Manuel MendozaJournal of Cell Biology @jcb.org · 06/08/2026#TunnelingNanotubes and #cytonemes in cancer and development Kenneth M. Yamada (@niaidnews.bsky.social), David A. Cruz Walma, and Wakako Endo: rupress.org/jcb/article/... #CellSignaling #Development #cancer 0133
Reposted by Manuel MendozaSnezhka Oliferenko @alebenoit.bsky.social · 06/08/2026Published!!! Homeostatic fun!!! Given it’s homeostatic perhaps should go for one exclamation mark! genesdev.cshlp.org/content/earl...genesdev.cshlp.orgAdaptation of eukaryotic membrane homeostasis to species-specific cellular lipid landscapes A biweekly scientific journal publishing high-quality research in molecular biology and genetics, cancer biology, biochemistry, and related fields 12311
Reposted by Manuel Mendozacallista yee @csybio.bsky.social · 06/08/2026hiiii everyone! my department @zoology.ubc.ca is hiring an assistant professor in cell and developmental biology! deadline is october 1! academicjobsonline.org/ajo/jobs/32408 // please share!!!!!academicjobsonline.orgUniversity of British Columbia, Department of Zoology Job #AJO32408, Assistant Professor in Cell and Developmental Biology, Department of Zoology, University of British Columbia, Vancouver, British Columbia, CA 16598
Manuel Mendoza @longchrom.bsky.social · 03/08/2026Grab a pint and listen to this. What a story youtu.be/29abxJgCyOI?...youtu.beGlen Hansard meets Van MorrisonYouTube video by bannedfromchina 010
Reposted by Manuel MendozaAngela Andersen @angelaandersen.bsky.social · 01/08/2026Kudos to @science.org for this self-analysis of the peer review process. These kind of data are never shared and don't have to be. Wildly refreshing to see it out in the open. Editorial and peer review dynamics at elite general science journals | Science Advances www.science.org/doi/10.1126/...science.orgEditorial and peer review dynamics at elite general science journalsAnalyses of deidentified data reveal complex interactions that quantify success at elite general science journals. 29044
Reposted by Manuel MendozaHari Kunzru @harikunzru.bsky.social · 01/08/2026Send this to whoever is currently posting migrant invasion content to your timeline mrandrewfox.substack.com/p/ceutas-pha...mrandrewfox.substack.comCeuta’s phantom invasionThe online right declared the fall of Europe. By nightfall, most of the supposed invaders were already back in Morocco. 12316
Reposted by Manuel MendozaLiz Miller @lizmillercu.bsky.social · 31/07/2026Job alert! I'm recruiting a new post-doc to work on mechanisms of co-translational quality control in the ER. Looking for expertise in ribosome biology and yeast genetics/cell biology. Please reach out to me with any questions. www.dundee.ac.uk/work-for-us/...dundee.ac.ukPostdoctoral Research Assistant - UOD2336Closing date: Thursday 27 August 2026, 23:59 01425
Reposted by Manuel MendozaPosas Lab @posaslab.bsky.social · 30/07/2026We're looking for a highly motivated Postdoctoral Fellow (Ref. PD/26/11) to join our team at @irbbarcelona.org to study MAPK signaling & conserved stress adaptation mechanisms, using cutting-edge transcriptomics, genomics & proteomics. Apply here: recruitment.irbbarcelona.org/jobs/8135937...recruitment.irbbarcelona.orgPostdoctoral Fellow (Ref. PD/26/11) - IRB BarcelonaYour Role & Our Team IRB Barcelona is seeking a highly motivated and talented Postdoctoral Fellow to participate in cutting edge research line -Crosstalk analysis of MAPK signaling- of the ... 033
Reposted by Manuel MendozaJoseph Schacherer @schacherer.bsky.social · 29/07/2026Excited to share this personal story published by @GeneticsGSA. A reflection on my journey in genetics, the many people who shaped it, the @haploteam and my enduring fascination with diversity. Thanks to everyone who has been part of the adventure! academic.oup.com/genetics/adv...academic.oup.comThe genetics of the many forms of diversityAbstract. The Genetics Society of America Medal honors an individual member of the Society for their contributions to the field of genetics at the midcaree 073
Reposted by Manuel MendozaStirling Churchman @stirlingchurchman.bsky.social · 28/07/2026RNA-seq tells us how much RNA is present in the cell. But to understand gene regulation, we need to easily measure the synthesis and decay rates driving this abundance. We introduce AIR-seq: analog intrinsic recoding sequencing. (1/6) www.biorxiv.org/content/10.6...biorxiv.orgAnalog intrinsic recoding measures RNA dynamics without chemical conversionSteady-state RNA abundance measurements mask the synthesis and decay rates that shape gene expression. Analog intrinsic recoding sequencing (AIR-seq) repurposes the base-pairing properties of N4-hydro... 215361
Reposted by Manuel MendozaNature Structural & Molecular Biology @natsmb.nature.com · 29/07/2026New online: A protective ESCRT sleeve for ultrafine DNA bridgesdlvr.itA protective ESCRT sleeve for ultrafine DNA bridgesNature Structural & Molecular Biology, Published online: 29 July 2026; doi:10.1038/s41594-026-01856-xDNA bridges, thin DNA connections that link daughter cells after division, threaten genome integrity and can trigger catastrophic chromosome rearrangements. A new study proposes that ESCRT-III proteins form protective assemblies around fragile ultrafine DNA bridges, revealing an unexpected role for these membrane-remodeling complexes in genome protection. 032
Manuel Mendoza @longchrom.bsky.social · 29/07/2026In which we share News (and our Views) on breakthrough work from the labs of @juanmartin-serrano.bsky.social, Wes Sundquist and Adam Frost. A protective ESCRT sleeve for ultrafine DNA bridges! Fun writing with @barrallabeth.bsky.social. @natsmb.nature.com doi.org/10.1038/s415... 1105
Manuel Mendoza @longchrom.bsky.social · 28/07/2026static.klipy.comHomme danse sous la pluie avec parapluieAlt: Gene Kelly is dancing in the rain as if he’d just gotten an ANR grant, the fool 020
Reposted by Manuel MendozaAlexis Verger 🧬🧫🧪 @alexis-verger.cpesr.fr · 28/07/2026ANR 2026, les résultats sont tombés anr.fr/fileadmin/aa...anr.fr 51513
Reposted by Manuel MendozaJoël Lemière @joellemiere.bsky.social · 27/07/2026New preprint! How does a cell "know" how big to make its nucleus? This has puzzled biologists since the 1800’s. We show the answer is physics: colloid osmotic pressure. 🧵1/5 25324
Reposted by Manuel MendozaChristophe 🔬 Leterrier @christlet.bsky.social · 27/07/2026Always a pleasure to have given multiple hours to help as a member of a thesis advisory committee and to casually find out that the thesis was defended and deposited, without even an email about it from the student or the mentors… The kind of things people can only do once as far as I'm concerned 1102
Reposted by Manuel MendozaHank Greely @hankgreely.bsky.social · 23/07/2026Great, detailed story on a death in a tragic & flawed Chinese gene therapy trial www.science.org/content/arti... Excellent job by Brendan Borrell w/ @retractionwatch.com. Complex, nuanced & in some respects damning. (On line version looks a bit longer than in Science.) (COI-quotes me, in passing).science.orgExclusive: Death of girl in Chinese gene-editing trial was never made publicParents want accountability after study went disastrously wrong, Science and Retraction Watch investigation reveals 174
Reposted by Manuel MendozabioRxiv Biophysics @biorxiv-biophys.bsky.social · 23/07/2026Nuclear size and physical properties of the nucleoplasm are determined by colloid osmotic pressure at the nuclear envelope www.biorxiv.org/content/10.64898/20… 0189
Reposted by Manuel MendozaRaphaël Pantier @r-pantier.bsky.social · 23/07/2026Our laboratory is looking for a PhD student in Functional Genomics (fully funded position). Expected starting date: Oct 2026 More info here: www.igbmc.fr/en/igbmc/lif... Please share 📨igbmc.frIGBMC: PhD position available in Raphaël Pantier's lab 01216
Reposted by Manuel MendozaMelanie Mitchell @melaniemitchell.bsky.social · 22/07/2026The ultimate tldr on the OpenAI "rogue model" hacking incident 😅 (h/t @linege1 on X) But it would be useful to know the prompts OpenAI gave to the model.... 713448
Manuel Mendoza @longchrom.bsky.social · 19/07/2026This whole story is crazy, but the definition of terrorism in the US is particularly absurd podcasts.apple.com/fr/podcast/t... 100
Reposted by Manuel MendozaWes Cowley @wes.wordsbywes.ink · 17/07/2026That quote links to articles on AlphaFold (and variants) and GNoME, neither of which are large language models. AlphaFold shares some concepts with LLMs (attention and transformers); GNoME not so much. (2/7) 1193
Manuel Mendoza @longchrom.bsky.social · 19/07/2026Fact-based, absorbing, infuriating www.newyorker.com/magazine/202...newyorker.comInside ICE’s Largest Detention CenterOn a military base in West Texas, where the government has built a sprawling tent complex to hold thousands of immigrants, deprivation and dire conditions are part of the design. 033