iiinova — where your digital self keeps evolving

Reposted by Martin J. Dahl

Daniel S. Kluger @danlikesbrains.bsky.social · 04/09/2026

Nothing quite like finding a perfect home for work close to your heart. Out now in @plos.org CompBiol is our #open-source toolbox for circular permutation testing in #brain-body #neuroskyence. 🫂 @teresaberther.bsky.social & @eliobalestrieri.eurosky.social 🔗 journals.plos.org/ploscompbiol... 🧵🔽

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Mara Mather @maramather.bsky.social · 16/08/2026

Starting September 1, I will be working with a team to start a new research center at the Max Planck Institute for Human Development in Berlin. We currently have a couple of positions posted but there will be more so if you are interested stay tuned and feel free to get in touch.

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Veera Ruuskanen @veerahelmisofia.bsky.social · 20/08/2026

Super excited to see our review out in TiCS! Here me & @cogsci.nl present the first comprehensive framework of the mechanisms driving relationships between spontaneous pupil-size fluctuations, neural activity, and behavior 👀🧠👩🏻‍💻 Spoiler: arousal is only one of at least four 😶‍🌫️ doi.org/10.1016/j.ti...

doi.org

Redirecting

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davidweinshenker.bsky.social @davidweinshenker.bsky.social · 22/06/2026

Interested in how dysregulation of locus coeruleus-norepinephrine circuits contribute to neuropsychiatric symptoms in early Alzheimer's disease? Check out our new review article from freshly minted Dr. Anu Korukonda! www.nature.com/articles/s41...

nature.com

A new hope: locus coeruleus-norepinephrine system at the nexus of neuropsychiatric symptoms - Molecular Psychiatry

Molecular Psychiatry - A new hope: locus coeruleus-norepinephrine system at the nexus of neuropsychiatric symptoms

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Sam Verschooren @samversc.bsky.social · 04/06/2026

🎉New paper out today in Nature Reviews Psychology🎉 with @mjdahl.bsky.social, @mariamaly.bsky.social, and @thiasmittner.bsky.social. We've been working on a unified framework for attentional states and the dynamics of transitions between them. 🧵

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Tobias Staudigl @tobiasstaudigl.bsky.social · 27/05/2026

📢 New paper out in @nathumbehav.nature.com: we identify a previously undescribed fast thalamic oscillation (~19–45 Hz) in rare intracranial human recordings that appears specifically during wakefulness and REM sleep — but disappears during NREM sleep. www.nature.com/articles/s41...

nature.com

Thalamic oscillations distinguish natural states of consciousness in humans | Nature Human Behaviour

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Renée Koolschijn @reneecabbage.bsky.social · 20/03/2026

Very pleased to share that our study “Noradrenaline causes a spread of association in the hippocampal cognitive map” is out in @natcomms.nature.com (my final PhD paper, only 3.5 years post PhD! 🙃) Find the paper here: www.nature.com/articles/s41...

nature.com

Noradrenaline causes a spread of association in the hippocampal cognitive map - Nature Communications

When forming a cognitive map, a trade-off exists between facilitating novel inferences and storing veridical copies of past experience. Here the authors show that the neuromodulator noradrenaline sets...

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Reposted by Martin J. Dahl

Josh Johansen @jojolab.bsky.social · 03/03/2026

Excited to share our new paper: We uncover a locus coeruleus→amygdala circuit linking β-adrenergic signaling to transcription regulation in defined amygdala cells during memory reconsolidation—+ stress or elevated noradrenergic signaling at recall can strengthen memory. www.cell.com/neuron/abstr...

cell.com

A neuromodulatory circuit-to-molecular pathway for reformatting aversive memories during recall

Tan et al. identify a neuromodulatory circuit-to-molecular pathway in rats that updates aversive memories when they are recalled. Noradrenaline from the locus coeruleus triggers synapse-to-nuclear tra...

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Reposted by Martin J. Dahl

davidweinshenker.bsky.social @davidweinshenker.bsky.social · 02/02/2026

Excited to share newly minted PhD Anu Korukonda's tour de force thesis work describing the impact of pathogenic tau on #locuscoeruleus function in a mouse model of early #Alzheimers. A must for #BlueSpot researchers! www.biorxiv.org/content/10.6... 1/3

biorxiv.org

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Heidi Jacobs @heidijacobslab.bsky.social · 21/01/2026

The Neuromodulatory Subcortical Systems PIA within @istaart.bsky.social is requesting nominations for the best paper of 2025 on neuromodulatory subcortical systems in Alzheimer's disease!! ISTAART members: promote the work of your colleagues (or yourself) here: alz.surveymonkey.com/r/Publicatio...

alz.surveymonkey.com

Publication of the Year Award - Nomination

Thank you for submitting your Nomination!

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Reposted by Martin J. Dahl

Peter Rupprecht @ptrrupprecht.bsky.social · 19/01/2026

Excited to share our new preprint! We explore the link between the locus coeruleus (LC) and arousal for astrocytes, pyramidal cells, interneurons in the hippocampus. A fantastic collaboration with @sianduss.bsky.social @bohaceklab.bsky.social, and many others: www.biorxiv.org/content/10.6... 1/5

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Valentin Riedl @vavatin.bsky.social · 16/12/2025

fMRI signals “up,” but neural metabolism might be going “down.” In our @natneuro.nature.com paper, we demonstrate that about 40% of voxels with robust BOLD responses exhibit opposite oxygen metabolism, revealing two distinct hemodynamic modes. rdcu.be/eUPO8 funds @erc.europa.eu #neuroskyence 🧵:

BOLD signal changes can oppose oxygen metabolism across the human cortex, Nature Neuroscience

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Daniel S. Kluger @danlikesbrains.bsky.social · 26/11/2025

'Robust circular cluster-based statistics for respiration-brain coupling' New preprint, and what a way to welcome @teresaberther.bsky.social to the #neuroskyence community. With @eliobalestrieri.bsky.social, she developed CBPT for circular #bodybrain analyses. Paper: osf.io/preprints/ps... 🧵🔽

Exemplary analysis pipeline for respiratory data

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Reposted by Martin J. Dahl

Mareike Ludwig @cogneuroludwig.bsky.social · 07/11/2025

Our paper and research on a #taVNS #MRI setup has now been published: onlinelibrary.wiley.com/doi/10.1111/... @nbkroemer.bsky.social @glassybrain.bsky.social

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Martin J. Dahl @mjdahl.bsky.social · 18/09/2025

At #ICON? – Join us tomorrow to hear about novel measurement & manipulation approaches for neuromodulatory systems! 🗓️Sept 19, 🕚11:45 am 🏫Room Sé #ICON2025 #CogNeuro #AcademicSky #LocusCoeruleus #neuroskyence

Speakers for ICON symposium on novel measurement & manipulation approaches for neuromodulatory systems!
Sept 19,
11:45 am
Room Sé

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Reposted by Martin J. Dahl

davidweinshenker.bsky.social @davidweinshenker.bsky.social · 12/09/2025

We showed previously that chemogenetic activation of the LC rescues spatial reversal learning in the TgF344-AD rat. New paper follows up and reports that optogenetic stimulation of LC terminals in CA1 also rescues cognitive deficits in 3xTg mouse model of AD. link.springer.com/article/10.1...

link.springer.com

Photostimulation of locus coeruleus CA1 catecholaminergic terminals reversed Spatial memory impairment in an alzheimer’s disease mouse model - Psychopharmacology

Rationale One of the earliest changes associated with Alzheimer’s disease (AD) is the loss of catecholaminergic terminals in the cortex and hippocampus originating from the Locus Coeruleus (LC). This ...

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Reposted by Martin J. Dahl

Claire O'Callaghan @claireocallaghan.bsky.social · 29/08/2025

Adaptive learning is coordinated across behaviour, time and neurobiology (from synapses and dendrites, to astrocytes and the systems level). If you’ve ever wondered how noradrenaline helps shape these multiscale learning processes, you might like this: www.cell.com/trends/cogni...

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Reposted by Martin J. Dahl

Andreas Brandmaier @brandmaier.bsky.social · 28/07/2025

New study out in Nature Medicine: Education does not protect against age-related decline of memory. Read more here: Reevaluating the role of education on cognitive decline and brain aging in longitudinal cohorts across 33 Western countries www.nature.com/articles/s41...

nature.com

Reevaluating the role of education on cognitive decline and brain aging in longitudinal cohorts across 33 Western countries - Nature Medicine

In a large cross-national study, education was linked to better memory and larger brain volumes but not to slower cognitive or brain decline with age, suggesting that the association reflects early-li...

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Reposted by Martin J. Dahl

Danai Riga @danai-lama.bsky.social · 23/07/2025

Beyond happy & proud to have our paper on peptidergic neuromodulation of the #LC out! This is a project that started with naive intentions & silly curiosity, withstood 1 pandemic & 2 lab moves & made us fall in ❤️ with the most beautiful brain regions of all!! 🔵 www.science.org/doi/10.1126/...

science.org

Neuropeptide Y neurons surrounding the locus coeruleus inhibit noradrenergic system activity to reduce anxiety

Endogenous neuropeptide Y signaling modulates locus coeruleus activity, promoting adaptive responses to stress.

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Reposted by Martin J. Dahl

Alzheimer's & Dementia Journals @alzdemjournals.bsky.social · 14/07/2025

Call For Papers! Alzheimer's & Dementia Special Issue: Neuromodulatory Subcortical Systems in Alzheimer's Disease Research on the intersection of the Neuromodulatory Subcortical Systems and AD are welcome! #AlzResearch ⏰Deadline: Aug. 30, 2025 alz-journals.onlinelibrary.wiley.com/hub/journal/...

alz-journals.onlinelibrary.wiley.com

Alzheimer's & Dementia

Deadline for submissions: Saturday, August 30 2025

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Reposted by Martin J. Dahl

Anika Löwe @anikaloewe.bsky.social · 27/06/2025

Super happy to see our latest work out in @plosbiology.org : N2 sleep during short naps increased the likelihood of insight in a decision task. The steepness of the spectral slope best predicted insight, beyond sleep stages alone. With dream team @maritpetzka.bsky.social @nicoschuck.bsky.social

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Reposted by Martin J. Dahl

Nils Kroemer @nbkroemer.bsky.social · 16/06/2025

Pulsed taVNS elicits pupil dilation. However, if sham feels as intense, there is not much left. Based on our comparatively large sample (94 participants, single-blind crossover), we show that a highly variable sham response explains this. #neuroskyence 🩺 www.biorxiv.org/content/10.1...

A plot showing that taVNS does not induce larger pupil dilation compared to sham.

A plot showing that sham-induced pupil dilation is much more variable

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Reposted by Martin J. Dahl

Rasmus Bruckner @rasmusbruckner.bsky.social · 19/05/2025

After years of hard work, @hashimsat.bsky.social's big one is out! Huge thanks to co-authors Katharina Wille, Matt Nassar, Radek Cichy, @nicoschuck.bsky.social & Peter Dayan - and to @haukeren.bsky.social for his invaluable support!

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Reposted by Martin J. Dahl

Marieke Weijs @mariekeweijs.bsky.social · 16/05/2025

www.nature.com/articles/s41... Excited to see this out in @natcomms.nature.com today! This paper builds on the lab's work on self-regulation of arousal through pupil-based biofeedback. We assessed several markers of cortical and cardiac arousal in a pure self-regulation and dual task setting.

nature.com

Modulating cortical excitability and cortical arousal by pupil self-regulation - Nature Communications

Weijs, Missura, Potok et al. showed in this study with brain stimulation and electrophysiological methods that self-regulation of pupil size via pupil-based biofeedback modulates cortical excitability...

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Reposted by Martin J. Dahl

Danai Riga @danai-lama.bsky.social · 07/05/2025

A wonderful day for science, to see the (peri) #LC in all its glory. A ginormous effort from all involved, and a fantastic resource for the field. Chapeau 🎩 🧠 🔵 www.nature.com/articles/s41...

nature.com

Heterogeneous pericoerulear neurons tune arousal and exploratory behaviours - Nature

A set of neurons in the peri-locus coeruleus region controls arousal and avoidance states, providing an understanding of the neurobiological basis of arousal and exploratory behaviours.

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Reposted by Martin J. Dahl

Mara Mather @maramather.bsky.social · 10/04/2025

My paper reviewing how different neurodegenerative diseases affect autonomic function was just published.

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Reposted by Martin J. Dahl

Vanessa Teckentrup @glassybrain.bsky.social · 04/04/2025

Transcutaneous auricular vagus nerve stimulation (taVNS) and fMRI: a great combination to test the mechanism of action driving stimulation effects 🧠 But how to use the stimulation safely within the magnetic field? We looked into this! #neuroskyence doi.org/10.31234/osf...

doi.org

OSF

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Reposted by Martin J. Dahl

Anita Luthi @anitaluthi.bsky.social · 18/03/2025

👉👉new paper alert from @labluthi.bsky.social - so proud for talented and determined Dr.Najma Cherrad who opened the lab‘s access to brain-body communication! #sleep #locuscoeruleus #parasympathetic @fbm-unil.bsky.social

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Reposted by Martin J. Dahl

Josh Johansen @jojolab.bsky.social · 08/03/2025

Check out a new lab paper from Mayumi Watanabe's thesis work showing how different subregions of medial prefrontal cortex differentially regulate extinction of aversive memories through projections to the locus-coeruleus-noradrenaline system: doi.org/10.1038/s413...

doi.org

Bidirectional emotional regulation through prefrontal innervation of the locus coeruleus - Molecular Psychiatry

Molecular Psychiatry - Bidirectional emotional regulation through prefrontal innervation of the locus coeruleus

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Heidi Jacobs @heidijacobslab.bsky.social · 17/02/2025

With support from @istaart.bsky.social, we are organizing the first Integrative Neuromodulatory Subcortical Systems meeting in collab with Sleep and Circadian Rhythms PIA! WHEN/WHERE: Boston, MGH/Martinos Center on July 17-18; info, register & submit your abstract: education.martinos.org/inss2025/

education.martinos.org

The Integrative Neuromodulatory Subcortical Systems (INSS) 2025 Meeting: intersection with sleep, July 17-18, 2025. (Hybrid: Online/In-person in Boston, MA) – Education @ The Martinos Center

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Rasmus Bruckner @rasmusbruckner.bsky.social · 13/02/2025

In our new @commspsychol.bsky.social review, we explore how humans adjust learning to different types of uncertainty, why biases arise, and what this reveals about learning and psychiatric conditions. 📖 Read more: nature.com/articles/s44... With Matt Nassar & @haukeren.bsky.social

nature.com

Understanding learning through uncertainty and bias - Communications Psychology

Flexible learning requires humans to adjust their behaviour to uncertainty. While normative learning models explain many adaptive behaviours, systematic biases-arising from inaccurate assumptions or c...

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Reposted by Martin J. Dahl

Nils Kroemer @nbkroemer.bsky.social · 29/01/2025

Does tVNS elicit replicable effects beyond BOLD responses in the brainstem? Yes, pulsed, but not conventional tVNS leads to robust pupil dilation in our new meta-analysis. Published in Brain Stim w/ @cecivez.bsky.social @akuehnel.bsky.social #neuroskyence 🩺 www.sciencedirect.com/science/arti...

Across 18 studies, the meta-analysis shows moderate evidence against an effect of taVNS on pupil dilation

Stimulation effects of taVNS on pupil dilation depend on the use of a phasic vs. conventional protocol.

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Jenny Crawford @jlcrawford.bsky.social · 29/01/2025

Check out our review highlighting the importance of monoamines towards understanding Alzheimer's disease. We describe promising neuroimaging and daily life sampling approaches to better elucidate the neurobiological mechanisms underlying AD.

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Tobias Staudigl @tobiasstaudigl.bsky.social · 29/01/2025

📢 New preprint from the lab: We are very excited to report the discovery of an oscillation in the Central Thalamus using rare direct recordings of human thalamic electrophysiology. The novel oscillation is tightly coupled to specific, natural states of consciousness.🧵

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Department of Imaging Neuroscience @imagingneuroucl.bsky.social · 24/01/2025

Happy 30th birthday year to SPM!! 🎈🍰 To get the party started, we are delighted to announce SPM 25.01, a major new version of the open-source neuroimaging software. Read the preprint to discover what's new arxiv.org/pdf/2501.12081 and download SPM for free from Github github.com/spm/spm/rele...

arxiv.org

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Thomas Hartmann @th-ht.de · 21/01/2025

My colleague Andreas Wutz (not yet on bluesky) is co-organizing a special issue in @therealspr.bsky.social on "Bridging Neural and Bodily Signals: Techniques, Methods, and Theoretical Advancements"! onlinelibrary.wiley.com/page/journal...

onlinelibrary.wiley.com

<em>Psychophysiology</em> | SPR Journal | Wiley Online Library

<em>Psychophysiology</em> is a human neuroscience journal covering research on the interrelationships between the physiological and psychological aspects of brain and behavior.

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Mareike Ludwig @cogneuroludwig.bsky.social · 20/01/2025

I am very much looking forward to this week with 2 meetings of the Neuromodulatory Subcortical System PIA: 📌 Tiny dots 21.01.25 12.30am CT (USA) - Noradrenergic Axon Loss Drives Hyposmia in AD alz-org.zoom.us/webinar/regi... 📌 Year in Review 24.01.25 10am CT (USA) alz-org.zoom.us/webinar/regi...

alz-org.zoom.us

Welcome! You are invited to join a webinar: Neuromodulatory Subcortical Systems PIA: Tiny Dots - Noradrenergic Axon Loss Drives Hyposmia in AD. After registering, you will receive a confirmation email...

Early-onset degeneration of hyperactive locus coeruleus axons in the olfactory bulb drives olfactory dysfunction in Alzheimer’s disease via phosphatidylserine-MFG-E8 signaling and microglial clearance...

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Douglas Garrett @garrettneuro.bsky.social · 13/01/2025

*How* does the hippocampus encode the world around us? Leo Waschke and Fabian Kamp bring the 🔥, showing that single-neuron spiking variability in hippocampus dynamically tracks sensory content during memory formation in humans. Our latest in Nature Communications: www.nature.com/articles/s41...

nature.com

Single-neuron spiking variability in hippocampus dynamically tracks sensory content during memory formation in humans - Nature Communications

The hippocampus is thought to encode the content of stimuli, but how it does so is unknown. The authors show that when hippocampal spiking variability tracks the abstract building blocks of individual...

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