Dorsal and ventral noradrenergic neurons in the locus coeruleus form topographic subpopulations whose projection patterns and activity encode choice switching, reward-prediction errors and disregard o...

Nature Neuroscience - Senne, Suthard and colleagues show that dorsal hippocampal astrocytes display time-compressed calcium-event sequences after foot shock and upon context re-exposure, and that...

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The amygdala is a central hub for emotional learning that is dysregulated across numerous psychiatric disorders, yet its molecular architecture in humans remains poorly defined. We here present a spat...

Memories leave lasting physical changes at the synaptic level. Although stable, larger spines are thought to support memory, the high turnover of dendritic spines and the drifting of neuronal represen...

Forgotten memories in Drosophila persist as silent memory traces and can be recovered by reminder cues. Manipulating reminders can create false memories, showing that memory reconstruction flexibly in...

Four neuroscientists got together to organize the Middle Eastern Systems Neuroscience Symposium. They hope to build a community that can find ways to transcend political barriers through scientific co...

Susumu Tonegawa, a renowned MIT professor of biology and neuroscience and a Nobel laureate, has died at the age of 86. His discovery of how the immune system generates many different antibodies earned...

Internal emotion models unify research across species and spark fresh ideas for treating anxiety and trauma

Over six decades, Fields mapped out the circuits of both pain and addiction.

IASP is deeply saddened to hear of the recent death of Honorary IASP Member, Prof Howard Fields, and we offer our condolences to his family, friends and colleagues. We are […]

Communication between distant brain regions is mediated by plastic networks of gap junction-coupled astrocytes.

Scientific Data - Dataset of cortical and subcortical single neuron activity during value-based tasks in macaque monkey

Pouget et al. identified distinct CA1 neuron ensembles active during specific moments of fear learning and uncovered the core engram essential for memory formation.

Tan et al. identify a neuromodulatory circuit-to-molecular pathway in rats that updates aversive memories when they are recalled. Noradrenaline from the locus coeruleus triggers synapse-to-nuclear tra...

If neuroscience is serious about building general principles of brain function, cross-species dialogue must become a core organizing principle.

Studying how organisms infer indirect threats and understand changing contexts can establish a common framework that bridges species and levels of analysis.

Mouse models of schizophrenia show defects in adolescent spine formation in a specific dendritic compartment of L5 neurons.

Survival depends on the ability to respond appropriately to threats, yet the selection of defensive behaviors varies among individuals with distinct b…

Following a rigorous global selection process led by co-chairs Dr. Sheena Josselyn and Dr. Thiruma V. Arumugam, who aimed at establishing a scientifically broad Scientific Program Committee (SPC) for…

Ogg et al. use in vivo imaging techniques to record activity in the locus coeruleus (LC) and the orbitofrontal cortex (OFC) during a reversal learning task in freely moving rodents. They show that man...

A growing list of medications—such as zuranolone for postpartum depression, suzetrigine for pain, and the gepants class of migraine medicines—exist because of insights from basic research.

Engrams, ensembles of neurons that store memories, exist along a continuum of retrievability. Normally, sensory cues can reactivate a latent engram to…

Evaluating the innate value of objects is critical for expressing adaptive behaviors. However, where and how this computation takes place in the brain…

Specialized cell types and links to psychiatric disorders are revealed by genetic mapping of primate amygdala neurons.

In 2025, the words we use to describe emotions matter, but their definitions are controversial. Here, I unpack the different positions in this space and the rationales behind them—and I invite 13…

Visual threat triggers contrasting freeze and escape defensive responses in two species of deer mice as a result of different activation thresholds downstream of the superior colliculus in the do...

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How the ensemble encoding of social and anxiety-related behaviors interacts with encoding of context in the prefrontal cortex of mice is not fully understood. Here authors examine how prefrontal neurons encode socioemotional behaviors in different contexts and reveal that the prefrontal cortex encodes context-invariant representations of these behaviors in parallel with representations of context.

Individual dopaminergic neurons encode future rewards over distinct temporal horizons.