nature.com
Muscle-derived miR-126 regulates TDP-43 axonal local synthesis and NMJ integrity in ALS models - Nature Neuroscience
Ionescu, Ankol et al. show that, in ALS mouse and iPSC models, TDP-43 aggregation at NMJs stems from aberrant axonal translation, normally repressed by muscle EV-derived miR126. Loss of miR126 in ALS increases TDP-43 buildup, impairs local synthesis and triggers degeneration.