Dorsal and ventral noradrenergic neurons in the locus coeruleus form topographic subpopulations whose projection patterns and activity encode choice switching, reward-prediction errors and disregard o...

Innate preferences determine how animals interact with the environment, but how experience refines the neural processes underlying those intrinsic motivations is not well understood. Here we develop a...

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Molecular Psychiatry - Pathogenic tau in the mouse locus coeruleus produces noradrenergic hyperactivity and neuropsychiatric phenotypes reminiscent of early Alzheimer’s disease

Assistant or Associate Professor faculty position in the Department of Pharmacology at University of Colorado School of Medicine in Neuroscience.

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About the Opportunity Job Summary The Shansky Lab is seeking a full-time technician to conduct National Institutes of Health (NIH)-funded behavioral neuroscience research. The position includes lab ma...

Neuropsychopharmacology - Norepinephrine regulates hippocampal mitochondrial biogenesis via β2-adrenergic receptor signaling and PGC-1α

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Read the latest articles of Addiction Neuroscience at ScienceDirect.com, Elsevier’s leading platform of peer-reviewed scholarly literature

Using a novel intersectional genetic strategy for sparse neuronal labeling, Grossouw, Heijmink, et al. reconstruct individual midbrain dopamine neurons throughout development, adulthood, and degenerat...

This study shows that GPCR-based norepinephrine and dopamine sensors display crosstalk in several brain areas. Relative innervation densities determine the extent of crosstalk, and loss-of-function co...

INTRODUCTION Animal models demonstrated that pharmacologically-induced lesioning of the locus coeruleus (LC), the brain's primary source of norepinephrine, triggered astrocyte reactivity, exacerbati...

Neuropsychopharmacology - The role of spousal relationships in shaping clinical trajectories during aging

Voluntary physical activity is a highly motivated behavior with important implications for physical and mental health, yet the neural and endocrine mechanisms underlying motivation to exercise remain ...

A biology journal that paid peer reviewers found that the approach cut the time to a first editorial decision by 85% and maintained high-quality reviews.

The generation of RNA transcripts in a cell is one of the first opportunities for interaction between DNA sequence and the environment (both at the organism and cellular level). Although many RNA transcripts get translated into proteins that are active in the cell, many other types of transcripts play critical roles in both the transcription and translation processes and ultimately, in how our bodies respond to our environment. Brain transcriptomics has the potential to mediate our acute responses to drugs of abuse and to reflect the changing cellular environment across the addiction cycle. Furthermore, RNA-based therapeutics are emerging as a significant treatment resource for many diseases. However, our knowledge about non-coding RNA transcripts, differences in transcript processing, and the interdependence among networks of transcripts is far from complete. This Special Issue features novel research into the role of transcriptomics and epigenetics in the neuroscience of addiction including predisposing factors and changing molecular phenotypes across the addiction cycle with the ultimate goal of identifying novel treatment and prevention approaches.